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Three-dimensional echocardiographic assessment of left ventricular volume in different heart diseases using a fully automated quantification software

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World Journal of Clinical Cases 2022年第13期10卷 4050-4063页

作者： Chen-Ke Pan Bo-Wen Zhao Xuan-Xuan Zhang Mei Pan yan-kai mao Yuan yang Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalZhejiang University College of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Ultrasound The Fourth Affiliated Hospital of Zhejiang University College of MedicineYiwu 322200Zhejiang ProvinceChina

BACKGROUND HeartModel(HM)is a fully automated adaptive quantification software that can quickly quantify left heart volume and left ventricular *** study used HM to quantify the left ventricular end-diastolic(LVEDV)and end-systolic volumes(LVESV)of patients with dilated cardiomyopathy(DCM),coronary artery heart disease with segmental wall motion abnormality,and hypertrophic cardiomyopathy(HCM)to determine whether there were differences in the feasibility,accuracy,and repeatability of measuring the LVEDV,LVESV,LV ejection fraction(LVEF)and left atrial end-systolic volume(LAESV)and to compare these measurements with those obtained with traditional twodimensional(2D)and three-dimensional(3D)*** To evaluate the application value of HM in quantifying left heart chamber volume and LVEF in clinical *** A total of 150 subjects who underwent 2D and 3D echocardiography were divided into 4 groups:(1)42 patients with normal heart shape and function(control group,Group A);(2)35 patients with DCM(Group B);(3)41 patients with LV remodeling after acute myocardial infarction(Group C);and(4)32 patients with HCM(Group D).The LVEDV,LVESV,LVEF and LAESV obtained by HM with(HM-RE)and without regional endocardial border editing(HM-NE)were compared with those measured by traditional 2D/3D echocardiographic methods to assess the correlation,consistency,and repeatability of all ***(1)The parameters measured by HM were significantly different among the groups(P<0.05 for all).Compared with Groups A,C,and D,Group B had higher LVEDV and LVESV(P<0.05 for all)and lower LVEF(P<0.05 for all);(2)HM-NE overestimated LVEDV,LVESV,and LAESV with wide biases and underestimated LVEF with a small bias;contour adjustment reduced the biases and limits of agreement(bias:LVEDV,28.17 mL,LVESV,14.92 mL,LAESV,8.18 mL,LVEF,-0.04%).The correlations between HM-RE and advanced cardiac 3D quantification(3DQA)(r_(s)=0.91-0.95,P<0.05 for all)were higher than those between HM-NE(

关键词： HeartModel Three-dimensional echocardiography Left ventricular volume Left ventricular ejection function Left atrial volume

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His bundle pacing versus left bundle branch pacing on ventricular function in atrial fibrillation patients referred for pacing:a prospective crossover comparison

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Journal of Geriatric Cardiology 2023年第1期20卷 51-60页

作者： yang YE Bo GAO Yuan LV Tian-Tian XU Si-Si ZHANG Xiao-Li LU Ying yanG Dong-Mei JIANG Yi-Wen PAN Xia SHENG Bei WANG yan-kai mao Zu-Wen ZHANG Shi-Quan CHEN Jie-Fang ZHANG Li WANG Jiang-Fen JIANG Ya-Xun SUN yan MA Fei-Ling WANG Min WANG Hong HE Chen-yang JIANG Guo-Sheng FU Department of Cardiology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Cardiology Zhejiang Rongjun HospitalJiaxingZhejiang ProvinceChina Department of Cardiology Lishui People’s HospitalLishuiZhejiang ProvinceChina Department of Cardiology Ningbo Ninth HospitalNingboZhejiang ProvinceChina Department of Cardiology Anji people’s HospitalNingboZhejiang ProvinceChina Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

BACKGROUND His bundle pacing(HBP)and left bundle branch pacing(LBBP)both provide physiologic pacing which maintain left ventricular *** both improve heart failure(HF)symptoms in atrial fibrillation(AF)*** aimed to assess the intra-patient comparison of ventricular function and remodeling as well as leads parameters corresponding to two pacing modalities in AF patients referred for pacing in intermediate *** Uncontrolled tachycardia AF patients with both leads implantation successfully were randomized to either *** measurements,New York Heart Association(NYHA)classification,quality-of-life assessments and leads parameters were obtained at baseline and at each 6-month follow *** ventricular function including the left ventricular endosystolic volume(LVESV),left ventricular ejection fraction(LVEF)and right ventricular(RV)function quantified by tricuspid annular plane systolic excursion(TAPSE)were all *** Consecutively twenty-eight patients implanted with both HBP and LBBP leads successfully were enrolled(69.1±8.1 years,53.6% male,LVEF 59.2%±13.7%).The LVESV was improved by both pacing modalities in all patients(n=23)and the LVEF was improved in patients with baseline LVEF at less than 50%(n=6).The TAPSE was improved by HBP but not LBBP(n=23).CONCLUSION In this crossover comparison between HBP and LBBP,LBBP was found to have an equivalent effect on LV function and remodeling but better and more stable parameters in AF patients with uncontrolled ventricular rates referred for atrioventricular node(AVN)*** could be preferred in patients with reduced TAPSE at baseline rather than LBBP.

关键词： ventricular patients bundle

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie mao Zhimin Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Utility of real time 3-dimensional transesophageal echocardiography in the intraoperative assessment of mitral valve repair

Utility of real time 3-dimensional transesophageal echocardi...

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第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Department of Diagnostic Ultrasound and Echocardiography,Sir Run Run Shaw Hospital Zhejiang University College of Medicine & Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University,Hangzhou 310016,China yan-kai mao Bo-wen ZHAO Peng LI Li-long XU Li-li YU Yuan yanG Mei PAN

Objective Our study aims to evaluate the usefulness of real time 3-dimensional transesophageal echocardiography(RT-3D TEE) in identifying mitral valve(MV) pathology intraoperatively and assessing the function of nativ...

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踝关节骨折术后踝穴冠状位角度波动与关节功能恢复的关系

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中国组织工程研究 2025年第9期29卷 1820-1826页

作者：刘琰王铠吴敏泰州市中医院骨科江苏省泰州市225300

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定... 详细信息

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定参考意义。目的:探讨踝关节骨折术后踝穴冠状位角度变化对关节功能恢复的影响。方法:纳入进行手术治疗的86例踝关节骨折患者为研究对象,根据末次随访美国骨科足踝外科协会踝-后足评分结果分为优良组(n=45)和可差组(n=41),比较两组患者的一般资料。根据踝关节的踝穴位及侧位X射线片对比术后患者患侧和健侧的踝穴形态指标:包括踝穴宽度和深度、冠状位角度及矢状位角度,以及上述指标患侧和健侧之间的差值,并进一步进行组内比较分析。构建联合模型,利用Cox回归分析评估冠状位角度波动与关节功能恢复情况的关系。利用最小绝对收缩选择算子回归法和多因素Logistic回归分析影响患者关节功能恢复的危险因素。按踝穴冠状位角度从低到高等分为5分位数组(Q1-Q5),比较5组患者的临床资料特征,并采用多因素Logistic回归分析踝穴冠状位角度变化与关节功能恢复不良风险的相关性,建立限制性立方样条Logistic回归模型分析其剂量-反应关系。建立回归方程y=1-1/(1+e^(-z))预测模型并进行验证。结果与结论:①患者患侧的踝穴宽度和深度、冠状位角度及矢状位角度均显著大于健侧(P均<0.05);且与优良组患者相比,可差组患者踝穴宽度差值、深度差值、冠状位角度差值及矢状位角度差值均更大(P<0.05);②联合模型显示无论冠状位角度是否在正常范围内,冠状位角度每纵向增加1˚,关节功能恢复不良的风险增加3%;③最小绝对收缩选择算子回归和多因素Logistics回归分析显示,调整潜在混杂因素后发现年龄过大、早期功能锻炼缺乏、无跟骨牵引、内固定物未取出、术后并发症、踝冠状位角度增大均为影响患者关节功能恢复的独立危险因素(P<0.05);④术后3个月内的冠状位角度与关节功能恢复效果不良风险存在独立相关性(OR=1.57,95%CI:1.38-1.76,P=0.002),且术后各时间段冠状位角度从低到高5分位数组趋势性检验差异有统计学意义(P趋势<0.001);⑤限制性立方样条模型分析显示,男性或女性的踝穴冠状位角度变化与关节功能恢复效果不良风险均不存在非线性关系;经Bootstrap自抽样,预测模型区分度、准确度较好;⑥提示踝关节骨折术后踝穴冠状位角度减小对关节功能恢复起到明显的促进作用,因此在踝关节骨折术后重点检测踝穴冠状位角度有助于了解患者关节功能恢复情况。

关键词：踝关节骨折踝穴冠状位角度关节功能 Logistic回归分析

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng yan Yuan Zhong Karissa Kusuma Yi Liang kaiwen Bao kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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Parameterized Littlewood-Paley Operators and Area Integrals on Weak Hardy Spaces

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Acta Mathematica Sinica,English Series 2013年第10期29卷 1857-1870页

作者： yan LIN Zong Guang LIU Dong Lan mao Zhen kai SUN School of Sciences China University of Mining and Technology

In this paper, we establish the boundedness of parameterized Littlewood-Paley operator μλ^＊,p and parameterized area integralμΩ^σSp with kernel satisfying the logarithmic type Lipschitz condition on the weak Ha... 详细信息

关键词： Parameterized Littlewood-Paley operator parameterized area integral weak Hardy space

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Complex Symmetric C0-semigroups on A^2(C+)

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Acta Mathematica Sinica,English Series 2020年第10期36卷 1171-1182页

作者： kai kai HAN mao Fa WANG School of Mathematics and Statistics Hebei University of Economics and BusinessShijiazhuang 050061P.R.China School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we study complex symmetric C0-semigroups on the Bergman space A^2(C+) of the right half-plane C+.In contrast to the classical case,we prove that the only involutive composition operator on A^2(C+) is the identity operator,and the class of J-symmetric composition operators does not coincide with the class of normal composition *** addition,we divide semigroups{φt}of linear fractional self-maps of C+into two *** show that the associated composition operator semigroup{Tt}is strongly continuous and identify its infinitesimal *** an application,we characterize Jσ-symmetric C0-semigroups of composition operators on A^2(C+).

关键词： C0-semigroup Bergman space composition operator complex symmetry

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Composition Operators with Universal Translates on S^(2)(D)

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Acta Mathematica Sinica,English Series 2023年第12期39卷 2452-2464页

作者： kai kai HAN yan yan TANG School of Mathematics and Statistics Hebei University of Economics and BusinessShijiazhuang 050061P.R.China School of Mathematics and Statistics He'nan UniversityKaifeng 475004P.R.China

It is known that the Invariant Subspace Problem for Hilbert spaces is equivalent to the statement that all minimal non-trivial invariant subspaces for a universal operator are one *** this paper,we characterize all linear fractional composition operators and their adjoints that have universal translates on the space S^(2)(D).Moreover,we characterize all adjoints of linear fractional composition operators that have universal translates on the Hardy space H^(2)(D).In addition,we consider the minimal invariant subspaces of the composition operator Cφa on S^(2)(D),where φa(z)=az+1-a,a ∈(O,1).Finally,some relationships between complex symmetry and universality for bounded linear operators and commuting pairs of operators on a complex separable,infinite dimensional Hilbert space are explored.

关键词： Universal operator composition operator invariant subspace complex symmetry

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