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Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virusrelated hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第2期23卷 232-241页

作者： Xiu-ting He Hong-qin xu Xiao-Mei Wang Xiu-shu He jun-qi Niu Pu-jun Gao Department of Geriatrics The First Hospital of Jilin University Department of Hepatology The First Hospital of Jilin University Department of Toxicology Guangxi Medical University

AIM to determine the relationship between five A3 G gene single nucleotide polymorphisms and the incidence of hepatitis B virus(HBV) infection and hepatocellular carcinoma(HCC). METHODS this association study was designed as a retrospective study, including 657 patients with chronic HBV infection(CHB) and 299 healthy controls. All subjects were ethnic Han Chinese. Chronic HBV-infected patients recruited between 2012 and 2015 at the First Hospital of Jilin University(Changchun) were further classified into HBV-related HCC patients(n = 287) and non-HCC patients(n = 370). Frequency matching by age and sex was performed for each group. Human genomic DNAwas extracted from whole blood. Gene polymorphisms were identified using a mass spectroscopic *** there were no significant differences between the genotype and allele frequencies of the rs7291971, rs5757465 and rs5757463 A3 G gene polymorphisms, and risk of CHB and HBV-related HCC. the AG genotype and G allele for rs8177832 were significantly related to a decreased risk of CHB(OR = 0.67, 95%CI: 0.47-0.96; OR = 0.69, 95%CI: 0.50-0.95, respectively) and HCC(OR = 0.53, 95%CI: 0.34-0.84; OR = 0.58, 95%CI: 0.39-0.87, respectively). A significant relationship was found between rs2011861 computed tomography, tt genotypes and increased risk of HCC(OR = 1.69, 95%CI: 1.02-2.80; OR = 1.82, 95%CI: 1.08-3.06, respectively). Haplotype analyses showed three protective and four risk haplotypes for HCC. Also, one protective haplotype was found against *** this study indicates that the A3 G rs8177832 polymorphism is associated with a decreased risk of CHB infection and HCC, while the rs2011861 polymorphism is associated with an increased risk of HCC.

关键词： Hepatitis B viral hepatocellular carcinoma APOBEC3s polymorphism progression

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Generation and detection of squeezed state

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Optoelectronics Letters 2008年第3期4卷 231-233页

作者： SHANG xu-dong YU Li FENG xue-dong yanG Bo-jun Key Laboratory of Optical Communication and Light wave Technologies Ministry of Education Beijing University ofPosts and Telecommunications Beijing 100876 China

Soliton amplitude squeezed state is obtained and dctected by using asymmetric Sagnac interferometer and balanced homodyne detecting system. An improved photo detector circuit for quantum state detection is introduced. The circuit has a bandwidth of 10MHz and the saturation power is about 19 mW. A maximum photocurrent noise reduction of 1.1 dB below the shot noise is achieved. Taking the detection efficiency into account,the squeezing will be about 1.5 dB.

关键词：压缩态检测技术孤波不对称性

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Effects of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos

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Journal of Environmental Sciences 2012年第2期24卷 209-213页

作者： jun＇an Cui Zhiyong Zhang Wei Bai Ligang Zhang Xiao He Yuhui Ma yan Liu Zhifang Chai Key Laboratory of Nuclear Analytical Techniques and Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Qingdao University of Science and Technology College of Environment and Safety Engineering Qingdao 266042 China

In recent years,with the wide applications and mineral exploitation of rare earth elements,their potential environmental and health effects have caused increasing public *** of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos were *** embryos were exposed to La3＋ or Yb3＋ at 0,0.01,0.1,0.3,0.5 and 1.0 mmol/L,*** life stage parameters such as egg and embryo mortality,gastrula development,tail detachment,eyes,somite formation,circulatory system,pigmentation,malformations,hatching rate,length of larvae and mortality were *** results showed La3＋ and Yb3＋ delayed zebrafish embryo and larval development,decreased survival and hatching rates,and caused tail malformation in a concentration-dependent ***,heavy rare-earth ytterbium led to more severe acute toxicity of zebrafish embryo than light rare-earth lanthanum.

关键词： zebrafish embryo development lanthanum ytterbium toxicity

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MgO-laden biochar enhances the immobilization of Cd/Pb in aqueous solution and contaminated soil

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Biochar 2021年第2期3卷 175-188页

作者： yan Wang Lu Wang Zhangtao Li Dong yang Jianming xu Xingmei Liu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

Great progress has been made in recent years to alleviate the heavy metal pollution,but the development of low-cost and eco-friendly adsorbents is still *** this work,MgO-loaded biochar,as a potential adsorbent,was successfully synthesized via copyrolysis of corn straw and MgCl2∙6H2O at 600℃and used for heavy metal immobilization in aqueous solution and contaminated *** pollution index and potential ecological risk index methods were also used to assess the potential ecological risk of the metals in soil after *** results showed MgO-laden biochar exhibited a much higher Cd2+adsorption capacity than the pristine ***-second-order and Langmuir/Langmuir-Freundlich equations could describe the adsorption kinetics and isotherm of Cd2+*** maximum adsorption capacity of Cd2+could reach to 1058.8 mg g−1 estimated by Langmuir-Freundlich ***2+adsorption on MgO-laden biochar composite mainly involved the hydrolyzation of MgO,ionization of Mg(OH)2 and precipitation of Cd2+and OH−.In addition,complexes with oxygen-containing groups and adsorption by Mg(OH)2 also enhanced Cd *** result of soil-leaching test showed that the concentrations of TCLP-leaching(Toxicity Characteristic Leaching Procedure)Cd and Pb reduced by 22.4%and 29.0%,respectively,after 4%of MgO-laden biochar amendment,and the integrated pollution index and potential ecological risk decreased by 28.9%and 28.5%,*** results suggest that MgO-laden corn straw biochar may be promising for application as a low-cost adsorbent for wastewater treatment and soil remediation.

关键词： MgO Biochar Cadmium Lead Pollution Ecological risk

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The Effects of Ultrasonic Treatment on the Molecular Structure of Residual Oil

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China Petroleum Processing & Petrochemical Technology 2017年第4期19卷 82-88页

作者： Pelayo Envo Esono Maye yang Jingyi yan Taoyan xu Xinru State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237

To upgrade residual oil, the residual oil was subjected to ultrasonic treatment with an output of 800 W, at a temperature of 70 ℃ and at intervals ranging from 0 to 11 minutes. The experiment illustrated that 7 minutes of ultrasonic treatment reduced viscosity and carbon residue by 14.1% and 7.4%, respectively. This also produced an increase in saturates content and a decrease in the content of aromatics, resins and asphaltenes. Furthermore, the parameters of the average molecular structure were characterized by FT-IR, and ~1 H-NMR, while an increasingly greater change in the parameters were produced by an ultrasonic treatment interval of up to 7 minutes. The mechanical stirring and cavitation from ultrasonic treatment caused a series of changes in the molecules of residual oil. Microscopic changes affected the parameters of the average molecular structure, as usually shown in SARA fractions. The changes in the thermal reaction properties of residual oil after ultrasonic treatment were analyzed by thermogravimetry. As the ultrasonic treatment time increased, the apparent activation energy needed for pyrolysis decreased gradually, as did the temperature.

关键词： ultrasonic treatment residual oil carbon residue SARA fractions

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Microstructure,mechanical properties and fracture behavior of a new WE43 alloy

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Rare Metals 2021年第8期40卷 2197-2205页

作者： Gui-Long Jia Li-Ping Wang Yi-Cheng Feng Er-jun Guo yan-Hong Chen Chang-Liang Wang School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin150040China

The microstructures,mechanical properties and fracture behaviors of a new WE43 alloy(Mg-4 Y-1.6 Nd-2 Sm-0.5 Zr)were *** microstructure of the as-cast alloy includes a Mg matrix,Mg_(41)Sm_(5),Mg_(41)Nd_(5)and Mg_(24)Y_(5)eutectic phases,as well asβ-*** an optimal solution treatment,the eutectic phases are almost completely dissolved;only a few spots of blocky Mg-Y compounds remain at grain *** an aging treatment,a large amount ofβ’-phases are dispersed and precipitated at the grain interior,which provides good comprehensive mechanical properties of the alloy,particularly in the under-aged *** tensile strength is up to290 MPa,the yield strength reaches 209 MPa,and the elongation is slightly ***,the fracture behaviors of the studied alloy in different states significantly *** addition,a comparison of mechanical properties of the new WE43,traditional WE43 and other modified WE43 alloys is presented.

关键词： Mg-Y-Nd-Sm-Zr Microstructure Mechanical properties Fracture behavior Heat treatment

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A Li_(3)Bi/LiF interfacial layer enabling highly stable lithium metal anode

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Rare Metals 2023年第12期42卷 4081-4090页

作者： Lei Tan Peng Chen Qiao-Yun Chen Xing Huang Kang-Yu Zou yan-Mei Nie Ling-jun Li Changsha University of Science and Technology Changsha 410114China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Lithium metal anode is considered the alternative to graphite anode due to its ultra-high theoretical capacity of 3860 mAh·g^(-1).However,serious Li dendrite growth and drastic electrolyte side reactions restrain the commercial application of Li metal *** this work,a Li_(3)Bi/LiF interfacial layer is constructed on the surface of the Li metal anode by a spontaneous substitution *** composite interfacial layer possesses excellent ionic conductivity,high mechanical strength,and great electrolyte wettability,which ensures fast Li-ion transfer and uniform Li deposition of the Li_(3)Bi/LiF@Li ***,the Li_3Bi/LiF@Li symmetric cell provides a cycle life of more than 400 h with only 73 mV voltage polarization at 10 mA·cm^(-2).By pairing with commercial NCM622 cathode,the Li_(3)Bi/LiF@Li full cell exhibits a long cycle at a rate of 2 C.

关键词： Lithium metal anode Li_(3)Bi LiF interfacial layer Dendrite-free High current density

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On Incentive and Coordination Mechanism of Service Outsourcing Based on Principal-Agent Theory and Blockchain Technology

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Journal of Artificial Intelligence and Technology 2023年第1期3卷 1-9页

作者： Chenglong yan Xiao Wang Xiaonan Zhang Ruzhi xu School of Finance Qilu University of TechnologyJinan 250353China Huangdao Custom People’s Republic of ChinaQingdao 266555China Shandong Innovation Development Institute Jinan 250101China

To address the issue of information asymmetry between the two parties and moral hazard among service providers in the process of service outsourcing,this paper builds the Stackelberg game model based on the principal-agent framework,examines the dynamic game situation before the contract being signed,and develops four information *** analysis reveals a Pareto improvement in the game’s Nash equilibrium when comparing the four models from the standpoint of the supply *** the complete information scenario,the service level of the service provider,the customer company’s incentive effectiveness,and the supply chain system’s ultimate profit are all ***,a coordinating mechanism for disposable profit is built in this *** paper then suggests a blockchain-based architecture for the service outsourcing process supervision and a distributed incentive mechanism under the coordination mechanism in response to the inadequacy of the principal-agent theory to address the information asymmetry problem and the moral hazard *** experiment’s end findings demonstrate that both parties can benefit from the coordination mechanism,and the application of blockchain technology can resolve these issues and effectively encourage service providers.

关键词： service outsourcing coordination mechanism distributed incentive mechanism blockchain

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Influence of the Alkali Treatment of HZSM-5 Zeolite on Catalytic Performance of PtSn-Based Catalyst for Propane Dehydrogenation

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China Petroleum Processing & Petrochemical Technology 2013年第2期15卷 11-18页

作者： Huang Li Zhou Shijian Zhou Yuming Zhang Yiwei xu jun Wang Li School of Chemistry and Chemical Engineering Southeast University Nanjing Wolaide Energy Technology Co. LTD

The porous material ATZ with micro-mesopore hierarchical porosity was prepared by alkali treatment of parent HZSM-5 zeolite and applied for propane dehydrogenation. The zeolite samples were characterized by XRD, N2- physisorption, and NH3-TPD analysis. The results showed that the alkali treatment can modify the physicochemical prop- erties of HZSM-5 zeolite. In this case, the porous material ATZ showed larger extemal surface area with less acid sites as compared to the HZSM-5 zeolite. It was found out that the alkali treatment of HZSM-5 zeolite could promote the catalytic performance of PtSn/ATZ catalyst. The possible reason was ascribed to the low acidity of ATZ. Furthermore, the presence of mesopores could reduce the carbon deposits on the metallic surface, which was also favorable for the dehydrogenation reaction.

关键词： HZSM-5 zeolite alkali-treatment propane dehydrogenation propene

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Roles of Na^+/Ca^(2+) exchanger 1 in digestive system physiology and pathophysiology

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World Journal of Gastroenterology 2019年第3期25卷 287-298页

作者： Qiu-Shi Liao Qian Du jun Lou Jing-Yu xu Rui Xie Department of Gastroenterology Affiliated Hospital to Zunyi Medical College

The Na^+/Ca^(2+) exchanger(NCX) protein family is a part of the cation/Ca^(2+) exchanger superfamily and participates in the regulation of cellular Ca^(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal *** review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.

关键词： Na^+/Ca^2+exchanger Digestive system diseases Ion channel Sodium Calcium

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