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Large animal models for Huntington's disease research

Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien liang Xiao-jiang li Shihua li Sen yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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Free-walking:Pedestrian inertial navigation based on dual foot-mounted IMU

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Defence Technology（防务技术） 2024年第3期33卷 573-587页

作者： Qu Wang Meixia Fu Jianquan Wang Lei Sun Rong Huang Xianda li Zhuqing jiang yan Huang Changhui jiang School of Automation Science and Electrical Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFo Shan528399China Research Institute of China Unicom Beijing100190China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100876China Department of Automation Tsinghua University Beijing100084China GEOLOC Laboratory Universite Gustave EiffelParis77454France

The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time ***,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with *** paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual *** at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent *** at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding *** at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude *** conduct extensive and well-designed experiments to evaluate the performance of the proposed *** experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance.

关键词： Indoor positioning Inertial navigation system(INS) Zero-velocity update(ZUPT) Internet of things(IoTs) Location-based service(LBS)

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miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-inducedβ-cells by targeting EZH2

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World Journal of Diabetes 2023年第3期14卷 209-221页

作者： Xiao-Kai Duan Yong-Xiang Sun Hong-Yun Wang yan-yan Xu Shi-Zhen Fan Jin-Ya Tian Yong Yu yan-YunZhao yan-li jiang Department of General Practice Zhengzhou First People’s HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Diabetes is a chronic metabolic disease,and a variety of miRNA are involved in the occurrence and development of *** clinical studies,miR-124 is highly expressed in the serum of patients with diabetes and in pancreatic isletβ-***,few reports exist concerning the role and mechanism of action of miR-124 in *** To investigate the expression of miR-124 in diabetic mice and the potential mechanism of action in isletβ-*** The expression levels of miR-124 and enhancer of zeste homolog 2(EZH2)in pancreatic tissues of diabetic mice were *** targeted relationship between miR-124 and EZH2 was predicted by Targetscan software and verified by a double luciferase reporter *** isletβ-cells Min6 were grown in a high glucose(HG)medium to mimic a diabetes *** insulin secretion,proliferation,cell cycle and apoptosis of HG-induced Min6 cells were detected after interference of miR-124a and/or *** The expression of miR-124 was upregulated and EZH2 was downregulated in the pancreatic tissue of diabetic mice compared with control mice,and the expression of miR-124 was negatively correlated with that of ***-124 was highly expressed in HG-induced Min6 *** of miR-124 promoted insulin secretion and cell proliferation,induced the transition from the G0/G1 phase to the S phase of the cell cycle,and inhibited cell apoptosis in HG-induced Min6 ***2 was one of the targets of ***-transfection of miR-124 inhibitor and siRNA-EZH2 could reverse the effects of the miR-124 inhibitor in HG-induced Min6 *** miR-124 is highly expressed in diabetic mice and HG-induced Min6 cells and regulates insulin secretion,proliferation and apoptosis of isletβ-cells by targeting EZH2.

关键词： miR-124 Enhancer of zeste homolog 2 Diabetes Insulin secretion Proliferation Apoptosis

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Low Concentration of Wenyang Tonglin Decoction Promotes Conjugation and Transfer of Drug-Resistant Plasmids among Heterologous Strains

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Chinese Journal of Integrative Medicine 2024年第8期30卷 721-728页

作者： WANG Bi-yan BU Hong-shi XIA li-bo jiang Xiang-yu TONG yan-qing Department of Traditional Chinese Medicine Changchun University of Traditional Chinese MedicineChangchun130000China

Objective To investigate the effect of low concentration of Wenyang Tonglin Decoction(WTD)on the binding conditions of R45 plasmid conjugative transfer under liquid phase conjugation and its *** Escherichia coli CP9(R45)and Staphylococcus aureus RN450RF were cultured in medium containing WTD,and their minimum inhibitory concentration(MIC)values were *** promoter fusion technology,*** CP9(R45)containing a promoter fusion was obtained.β-Galactosidase activity of TrfAp and TrbBp was tested,and the mRNA expression of regulatory factors(TrbA,KorA,and KorB)was detected by real-time fluorescent quantitative polymerase chain *** The MIC of *** CP9(R45)was 400 g/L and that of *** RN450RF was 200 g/*** the drug concentration in the culture medium was 200 g/L,the highest number of conjugants was(3.47±0.20)×10^(7) CFU/mL At 90 h of conjugation,the maximum number of conjugants was(1.15±0.06)×10^(8) CFU/mL When the initial bacterial concentration was 10^(8) CFU/mL,the maximum number of conjugants was(3.47±0.20)×10^(7) CFU/*** the drug concentration was 200 g/L,theβ-galactosidase activity of TrfAp and TrbBp significantly increased;the relative quantification of TrbA,KorA and KorB were significantly *** Low concentration of WTD promoted the development of bacterial resistance by affecting promoters and inhibiting the expression of regulatory factors.

关键词： urinary tract infection Chinese medicine drug-resistant plasmid heterozygous strains conjugation transfer

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Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： jiang Yu-xia ZHAO yan-na YU Xiao-ling YIN li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(plicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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An Improved Modulation Strategy for Single-phase Three-level Neutral-point-clamped Converter in Critical Conduction Mode

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 981-990页

作者： Ning li Yujie Cao Xiaokang liu yan Zhang Ruotong Wang lin jiang Xiao-Ping Zhang School of Electrical Engineering Xi’an University of TechnologyXi’anChina the Department of Electronics Information and BioengineeringPolitecnico di MilanoMilanItaly Xi’an Jiaotong University Xi’anChina the Department of Electrical Engineering and Electronics University of LiverpoolLiverpoolU.K. the Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirminghamU.K.

Two-level totem-pole power factor correction(PFC)converters in critical conduction mode(CRM)suffer from the wide regulation range of switching ***,in highfrequency applications,the number of switching times increases,resulting in significant switching *** solve these issues,this paper proposes an improved modulation strategy for the single-phase three-level neutral-point-clamped(NPC)converter in CRM with *** optimizing the discharging strategy and switching state sequence,the switching frequency and its variation range have been efficiently *** detailed performance analysis is also presented regarding the switching frequency,the average switching times,and the effect of voltage gain.A 2 k W prototype is built to verify the effectiveness of the proposed modulation strategy and analysis *** with the totem-pole PFC converter,the switching frequency regulation range of the three-level PFC converter is reduced by 36.48%and the average switching times is reduced by 45.10%.The experimental result also shows a 1.2%higher efficiency for the three-level PFC converter in the full load range.

关键词： Critical conduction mode(CRM) on-board charger switching frequency range switching times power factor correction(PFC) three-level converter

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L^p(R^n)-Boundedness of certain commutators

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 185-191页

作者： DI yan-mei jiang li-ya Department of Mathematics Zhejiang University of Technology Hangzhou 310023 China

In this paper, the LP（Rn）-boundedness of the commutators generalized by BMO（Rn） function and the singular integral operator T with rough kernel Ω∈ L log＋ L（Sn-1）is proved by using the Bony＇s formula for the... 详细信息

关键词： Commutators paraproduct littlewood-Paley theory.

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Large eddy simulation study of 3D wind field in a complex mountainous area under different boundary conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 541-556页

作者： yan li Lei yan Xuhui HE School of Civil Engineering Central South UniversityChangsha410075China National Engineering Research Center for High-speed Railway Construction Changsha410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structures Changsha410075China

Large eddy simulations generally are used to predict 3D wind field characteristics in complex mountainous *** simulation boundary conditions,such as the height and length of the computational domain or the characteristics of inflow turbulence,can significantly impact the quality of *** this study,we examined these boundary conditions within the context of the mountainous terrain around a long-span cable-stayed bridge using a wind tunnel *** sizes of computational domains and turbulent incoming wind velocities were used in large eddy *** results show that when the height of the computational domain is five times greater than the height of the terrain model,there is minimal influence from the top wall on the wind field characteristics in this complex mountainous *** the length of the wake region of the computational domain has negligible effects on the wind *** in the inlet boundary reduces the length of the wake region on a leeward hill with a low slope,but has less impact on the mean wind velocity of steep hills.

关键词： Large eddy simulation(LES) Spectral representation method Recycling method High mountainous canyon Wind characteristics Atmospheric boundary layer Computational domain

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Wideband spectrum sensing using step-sampling based on the multipath nyquist folding receiver

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Defence Technology（防务技术） 2024年第1期31卷 523-536页

作者： Kai-lun Tian Kai-li jiang Sen Cao Jian Gao Ying Xiong Bin Tang Xu-ying Zhang yan-fei li University of Electronic Science and Technology of China Chengdu611731China China Electronics Technology Group Corporation 29th Research Institute Chengdu610036China

Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical *** Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated *** this case,a multipath NYFR architecture with a step-sampling rate for the different paths is *** different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these ***,high-precision parameter estimation is performed by utilizing the NYFR *** with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm *** simulation experiments verify the effectiveness of the proposed architecture in this paper.

关键词： Wideband spectrum sensing Sub-Nyquist sampling Step-sampling Nyquist folding receiver(NYFR) Multisignal processing

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Experimental and numerical study on atmospheric-pressure air dielectric barrier discharge via 50 Hz/5000 Hz dual-frequency excitation

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High Voltage 2024年第2期9卷 391-402页

作者： Junwen He Bangfa Peng Guanglin Yu Ronggang Wang Nan jiang Jie li yan Wu School of Electrical Engineering Dalian University of TechnologyDalianChina Canmax Technologies Co. Ltd.SuzhouChina

A dual-frequency(DF)dielectric barrier discharge,excited by the superposition of a 50 Hz low frequency(LF)and a 5000 Hz intermediate frequency(IF),is proposed to enhance *** effect of the LF voltage component on the breakdown behaviour of the DF discharge during different periods has been studied both experimentally and *** number of high-current pulses rises as the LF voltage *** statistical analysis shows that the number of the current pulse amplitude above 80 mA in the DF discharge reaches nearly 6 times that in the IF ***,the total discharge energy in the DF discharge is significantly higher than that in the IF *** simulation re-produces the temporal variation of the breakdown behaviours in the DF *** simulated results reveal that the maximal electric field strength of the breakdown process is greater in the DF discharge compared to the IF discharge during a half-period of ***,the comparison between the IF and DF discharges exhibits that the LF voltage regulates the accumulation of residual charged species on the dielectric surface after the breakdown by modulating the residual voltage between the air gap.

关键词： dielectric excitation excited

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