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基于Delft3D的大辽河水动力水质数值模拟

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水电能源科学 2024年第1期42卷 32-35,161页

作者：杜甫闫晓惠陈小强大连理工大学建设工程学院辽宁大连116024 安阳国家气候观象台/安阳市黄淮生态气象重点实验室河南安阳455003 四川省教育厅气象信息与信号处理重点实验室四川成都610225

近年来,大辽河流域工业化发展迅速,带来了一系列水质恶化问题。因此,通过实测大辽河水文和水质数据,基于Delft3D建立大辽河二维水动力模型,对其进行水位和水温验证,计算值与实测值基本吻合;在水动力模型的基础上建立水质模型,对其进行NH... 详细信息

近年来,大辽河流域工业化发展迅速,带来了一系列水质恶化问题。因此,通过实测大辽河水文和水质数据,基于Delft3D建立大辽河二维水动力模型,对其进行水位和水温验证,计算值与实测值基本吻合;在水动力模型的基础上建立水质模型,对其进行NH^(+)_(4)-N(氨氮)和DO(溶解氧)验证,计算结果基本能够反映真实水质变化趋势。通过验证后的水动力水质耦合模型分析大辽河水动力水质输移特征。结果表明,大辽河具有明显的半日潮特征,河口处的流速低于内陆河道的流速;NH^(+)_(4)-N浓度年际分布较为均匀,DO浓度夏季较低,冬季较高;涨潮时,河口处NH^(+)_(4)-N浓度降低,落潮时河口处NH^(+)_(4)-N浓度升高;汛期排放的污染物浓度峰值高于枯水期的值,峰现时间也早于枯水期,在枯水期,污染物更容易在河口处滞留;整合排污口和减排两种方式均能降低河道内污染物浓度,靠近河道上游整合排污口方式优于减排方式,靠近河口减排方式略优于整合排污口。研究成果可为大辽河水质管理提供参考。

关键词：大辽河 Delft3D 二维水动力模型水质模型

马铃薯早疫病病原菌分离鉴定及不同植物提取物、茵陈二炔酮抑菌活性研究

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西南农业学报 2024年第4期37卷 714-721页

作者：廖仕梅俞舒谊杨态娇罗建梅李青闫晓慧西南林业大学生物多样性保护学院/云南省高校森林灾害预警与控制重点实验室昆明650224

[目的]明确曲靖市会泽县马铃薯早疫病的病原菌,并探究不同植物提取物和茵陈二炔酮对病原菌的抑菌活性,为马铃薯早疫病的生物防治提供科学依据。[方法]采用组织分离法分离纯化病原菌,通过形态学和分子生物学方法鉴定病原菌,利用菌丝生长... 详细信息

[目的]明确曲靖市会泽县马铃薯早疫病的病原菌,并探究不同植物提取物和茵陈二炔酮对病原菌的抑菌活性,为马铃薯早疫病的生物防治提供科学依据。[方法]采用组织分离法分离纯化病原菌,通过形态学和分子生物学方法鉴定病原菌,利用菌丝生长速率法筛选对病原菌有抑制效果的植物提取物,同时测定茵陈二炔酮抑菌毒力以及对菌丝形态、干重、还原糖、总蛋白含量的影响。[结果]曲靖市会泽县马铃薯病叶分离纯化的病原菌经鉴定为交链格孢菌(Alternaria alternata)。12种植物提取物(1 mg/mL)中椴叶鼠尾草和紫茎泽兰提取物的抑菌效果最好,抑菌率分别为55.19%和40.76%。茵陈二炔酮抑菌效果随着浓度升高而增强,经毒力测定其EC_(50)在16.418~46.576μg/mL。茵陈二炔酮使菌丝形态发生细微变化,干重显著减轻,还原糖、总蛋白含量显著降低。[结论]曲靖市会泽县马铃薯早疫病病原菌为交链格孢菌,椴叶鼠尾草和紫茎泽兰提取物对交链格孢菌有良好的抑菌效果,茵陈二炔酮通过阻碍菌丝细胞物质合成与能量代谢,影响菌丝正常生长以达到较好的抑菌效果。

关键词：马铃薯早疫病病原菌鉴定植物提取物茵陈二炔酮抑菌活性

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基于CDIO理念的海洋工程专业研究生工程实践能力培养体系建设

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教育教学论坛 2024年第9期 172-176页

作者：唐国强乔东生吕林闫晓惠大连理工大学港航与海洋工程学院辽宁大连116024

随着新时期海洋工程产业的快速发展,对海洋工程领域的专业人才提出了日益严格的要求,多学科的知识储备和出色的工程实践能力已成为不可或缺的素养。针对目前海洋工程专业研究生工程实践能力培养体系建设方面存在的一些不足之处,在CDIO... 详细信息

随着新时期海洋工程产业的快速发展,对海洋工程领域的专业人才提出了日益严格的要求,多学科的知识储备和出色的工程实践能力已成为不可或缺的素养。针对目前海洋工程专业研究生工程实践能力培养体系建设方面存在的一些不足之处,在CDIO理念的导向下,围绕实验平台建设、校企实践合作及科技创新训练三个方面,提出了一套研究生工程实践能力培养体系的改进方案。这些改进方案对于国内众多高校海洋工程专业研究生培养体系的建立具有直接参考价值,并为其他专业领域教学改革提供了示范和辐射推广作用。

关键词：研究生培养海洋工程 CDIO教学理念创新能力工程实践能力

USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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当代医学科学（英文） 2024年第4期44卷 707-717页

作者： xiao-hui yan Yin-na ZHU yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and Hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective:Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods:HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2'-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** USP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and ***:In HG+FFA-challenged HK-2 cells,USP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,USP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROS)generation in HK-2 ***,USP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the USP19 knockdown-mediated phenotypic changes and PINKl/Parkin pathway activation in HG+FFA-challenged HK-2 ***:The findings revealed that USP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells USP19 deubiquitination dysfunction free fatty acid high glucose

Switching from human insulin to biphasic insulin aspart 30 treatment gets more patients with type 2 diabetes to reach target glycosylated hemoglobin 〈7%： the results from the China cohort of the PRESENT study

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Chinese Medical Journal 2010年第9期123卷 1107-1111页

作者： GAO yan GUO xiao-hui Department of Endocrinology Peiking University First HospitalBeijing 100034China

Background The clinical importance of glycaemic control in patients with diabetes has been well established. This study aimed to explore twice-daily biphasic insulin aspart 30 （BIAsp 30） for insulin initiation in patients with type 2 diabetes mellitus （T2DM） who had poor glycaemic control with human insulins （His）. We use data from a Chinese cohort of the PRESENT *** In the 3-month study, Chinese subjects with T2DM started insulin therapy with BIAsp 30 in routine care. Glycaemic control was measured by glycosylated hemoglobin （HbA1c）, fasting plasma glucose （FPG） and posting plasma glucose （PPG）. The safety assessment included hypoglycaemia and other adverse *** A total of 1989 subjects previously treated with His were switched to BIAsp 30 for 3-month treatment. Mean HbA1c, FPG and PPG were significantly improved after the therapy. The overall rate of hypoglycaemia decreased at the end of the trial except for the patients previously treated with long-acting insulin. Most of the events were minor and diurnal hypoglycaemia. Only one serious adverse drug reaction （SADR）, a local hypersensitivity, was reported. The majority of the patients （296.7%） and physicians （≥84.7%） were either satisfied or very satisfied with the treatment using BIAsp 30 compared with previous HI *** The BIAsp 30 treatment improved both glycaemic control and patients＇ satisfaction without increasing hypoglycaemia in T2DM subjects inadequately controlled by Hls.

关键词： diabetes mettitus, type 2 insulin hemoglobin A, glycosylated

Effects of Ni-Doping on Microstructures and Properties of Zn-20Sn High-Temperature Lead-Free Solders

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Chinese Journal of Structural Chemistry 2019年第7期38卷 1107-1115页

作者： TIAN Jun HONG Li-Hua HONG Chun-Fu yan xiao-hui DAI Pin-Qiang School of Materials Science and Engineering Fuzhou University Fuzhou 350116 China School of Materials Science and Engineering Fujian University of Technology Fuzhou 350118 China Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350118 China

In the present work, the effect of Ni doping on the microstructures and properties of Zn-20 Sn high temperature lead-free solder has been investigated. Interestingly,Ni was present as the form of Ni-Zn compounds in the microstructure of Zn-20 Sn-xNi *** the Ni-doping amount was 0.2~0.4 wt.%, the presence of δ phase was found, and when the doping amoun was 0.8 wt.%, the presence of γ phase was observed. With the increase of Ni content, the liquidus temperature increased but the solidus temperature did not change obviously. In addition, the microhardness and electrical resistivities of Zn-20 Sn-xNi solder increased gradually. And the spreading area and shear strength increased firstly but decreased afterwards. When the content of Ni was 0.4 wt.%, the spreading area and shear strength of solder reached to be maximum. After the addition of 0.4 wt.% Ni, the microstructure of the interfacial intermetallic compound(IMC) layer of the interface didn't change, but the total thickness of the IMC layer reduced. The δ-phase was embedded in the grain boundary of ε-Cu Zn5, which hindered the diffusion of atoms. The thickness of IMC layer at the interface reduced, which led to the improvement of the shear strength of the interface.

关键词： lead-free solder high temperature solders Zn-20Sn alloy Ni intermetallic compounds microstructure

Quantum squeezing induced nonreciprocal phonon laser

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 20-30页

作者： Tian-Xiang Lu yan Wang Keyu Xia Xing xiao Le-Man Kuang hui Jing College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

Phonon lasers or coherent amplifications of mechanical oscillations are powerful tools for fundamental studies on coherent acoustics and hold potential for diverse applications,ranging from ultrasensitive force sensing to phononic information ***,we propose the use of an optomechanical resonator coupled to a nonlinear optical resonator for directional phonon *** find that by pumping the nonlinear optical resonator,directional optical squeezing can occur along the pump *** a result,we can achieve the directional mechanical gain using directional optical squeezing,thereby leading to nonreciprocal phonon lasing with a well-tunable directional power *** work proposes a feasible way to build nonreciprocal phonon lasers with various nonlinear optical media,which are important for a wide range of applications,such as directional acoustic amplifiers,invisible sound sensing or imaging,and one-way phononic networks.

关键词： nonreciprocal phonon laser directional quantum squeezing optomechanics

CO_(2) corrosion of X80 steel welded joints under micro-turbulence induced by welding reinforcement height

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Journal of Iron and Steel Research International 2024年第4期31卷 1015-1032页

作者： xiao-hui Dou Bin Li Zong-hao He Xin-wei Zhang Da-lei Zhang yan Li School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Corrosion failure accidents owing to flow erosion and pipeline corrosion frequently occur during *** welding reinforcement height(WRH)can induce locally micro-turbulent flow field,which aggravates local corrosion of welded joints.A high wall shear stress(WsS)experimental setup was established to conduct the online electrochemical corrosion *** influence of WRH sizes on local corrosion of welded joints was studied at different flow *** electrochemical signals of the local corrosion of X80 welded joints at different flow rates were monitored in real time using electrochemical impedance spectroscopy and wire beam *** addition,the corrosion products composition and properties were *** results show that the micro-turbulent flow fields induced by the WRHs can enhance ion mass transfer near the welded *** corrosion products on the WRH surface also present different microscopic morphologies at different flow *** strong flow fields,the locally enhanced wsS can peel off the dense corrosion product partially,leading to the electrochemical distribution of large cathode and small anode,which accelerates the occurrence and development processes of the local corrosion of welded *** scientific guidelines for the corrosion protection of long-distance oil and gas pipelines can be potentially provided.

关键词： X80 steel welded joint Welding reinforcement height Micro-turbulence CO_(2)corrosion-Ion mass transfer

Metamorphic P-T conditions and ages of garnet-biotite schists in the Dahongshan Group from the southwestern yangtze Block

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Acta Geochimica 2024年第4期43卷 707-718页

作者： Jun-xiao Ma Guang-shu yang Yong-feng yan xiao-Fei Xu Yun-hua Ren hui Zhao xiao-jun Zheng Yuan Qin Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-Ferrous Metals Geological Bureau Kunming 650217China Yunnan Provincial Bureau of Non-Ferrous Geology Kunming 650051China

The Dahongshan Group,situated at the southwestern margin of the yangtze Block,represents a geological unit characterized by relatively high-grade metamorphism in the *** paper investigates the garnet-biotite schist from the Laochanghe Formation of the Dahongshan Group,employing an integrated approach that includes petrological analysis,phase equilibrium modeling,and zircon U-Pb *** schist is mainly composed of garnet,biotite,plagioclase,quartz,rutile,and *** equilibrium modeling revealed the peak metamorphic conditions of 8-9 kbar and 635-675°*** further integrating the prograde metamorphic profile of garnet and geothermobarometric results,a clockwise P-T metamorphic evolution path is constructed,which includes an increase in temperature and pressure during the prograde ***-ICP-MS zircon U-Pb dating and zircon Ti thermometry constrains the post-peak metamorphic age of 831.2±7.2 *** with previously reported results,it is revealed that the southwestern margin of the yangtze Block experienced a large-scale regional metamorphism during the Neoproterozoic(890-750 Ma),which is related to the collisional orogenic *** may be associated with the late-stage assembly of the Rodinia supercontinent or with local compression and subduction processes during the breakup of the Rodinia supercontinent.

关键词： Southwestern yangtze Block Dahongshan Group Phase equilibrium modeling Zircon U-Pb dating Neoproterozoic metamorphism