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Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells

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Biomedical and Environmental Sciences 2017年第1期30卷 75-78页

作者： huaNG Li hua yanG huan su Xin GAO yan Rong XUE Hai Nan WANG su hua School of Public Health Baotou Medical College Baotou 014030 Inner Mongolia China

We investigated whether Nd_2O_3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar *** viability assessed by the MTT assay revealed that Nd_2O_3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd203 caused cell damage and enhanced synthesis and release of inflammatory chemokines. A Western blot analysis showed that protein expression levels of caspase-3, nuclear factor-KB （NF-KB） and its inhibitor IKB increased significantly in response to Nd203 treatment. Both NF-KB and caspase-3 signaling were activated, suggesting that both pathways are involved in Nd203 cytotoxicity.

关键词： Caspase caspase macrophages alveolar viability assessed cytotoxicity manner underlying supernatant

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峡部依赖性心房扑动不典型心电图分析

中华心律失常学杂志 2008年第2期12卷 95-98页

作者：闫素华程文娟陈明友孙洁徐希云山东省千佛山医院心内科 250014

目的分析峡部依赖性心房扑动（AFL）不典型心电图的特点及其形成机制。方法分析峡部依赖性AFL患者体表心电图扑动波（FL波）形态，并通过心内电生理检查观察冠状静脉窦（CS）传导顺序及传导时间等。结果根据下壁导联FL波形态，逆钟向传... 详细信息

目的分析峡部依赖性心房扑动（AFL）不典型心电图的特点及其形成机制。方法分析峡部依赖性AFL患者体表心电图扑动波（FL波）形态，并通过心内电生理检查观察冠状静脉窦（CS）传导顺序及传导时间等。结果根据下壁导联FL波形态，逆钟向传导AFL分为4组，组1负向FL波，组2负向FL波为主，终末端为正向，CS传导顺序均为近端至远端，传导时间分别为（33．41±13．43）ms、（35．23±15．56）ms；组3正向FL波为主，CS传导为远端至近端或融合传导，时间为（-21．3±11．41）ms；组4FL波为等电位波或低振幅波，CS传导为近端至远端。顺钟向传导AFL分为3组，组1为正向FL波，CS传导为融合传导或近端至远端，时间为（5．43±17．59）ms；组2为负向FL波，CS传导为近端至远端；组3FL波为等电位波或低振幅波，CS传导为融合传导。结论峡部依赖性AFL体表心电图下壁导联FL波形态与左心房除极顺序有关，而左心房除极顺序取决于心房间的传导连接部位，心房间传导连接的传导延迟或阻滞，可导致其体表心电图出现不典型的FL波形态。

关键词：心房扑动不典型心电图电生理

Characteristics and interpretation of the seismic signal of a field-scale landslide dam failure experiment

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Journal of Mountain Science 2017年第2期14卷 219-236页

作者： yan yan CUI Peng CHEN su-chin CHEN Xiao-qing CHEN hua-yong CHIEN Yi-liang Key Laboratory of Mountain surface Process and Hazards/Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China Department of Soil and Water Conservation National Chung Hsing UniversityTaichung 40227Chinese Taipei

Outburst floods caused by breaches of landslide dams may cause serious damages and loss of lives in downstream areas; for this reason the study of the dynamic of the process is of particular interest for hazard and risk assessment. In this paper we report a field-scale landslide dam failure experiment conducted in Nantou County, in the central of *** seismic signal generated during the dam failure was monitored using a broadband seismometer and the signal was used to study the dam failure *** used the short-time Fourier transform(STFT) to obtain the time–frequency characteristics of the signal and analyzed the correlation between the power spectrum density(PSD) of the signal and the water level. The results indicate that the seismic signal generated during the process consisted of three components: a low-frequency band(0–1.5 Hz), an intermediate-frequency band(1.5–10 Hz) and a highfrequency band(10–45 Hz). We obtained the characteristics of each frequency band and the variations of the signal in various stages of the landslide dam failure process. We determined the cause for the signal changes in each frequency band and its relationship with the dam failure process. The PSD sediment flux estimation model was used to interpret the causes of variations in the signal energy before the dam failure and the clockwise hysteresis during the failure. Our results show that the seismic signal reflects the physical characteristics of the landslide dam failure process. The method and equipment used in this study may be used to monitor landslide dams and providing early warnings for dam failures.

关键词： Landslide dam Dam failure process Field-scale experiment Seismic signal

盐酸西替利嗪滴剂的制备、质量控制及稳定性考察

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中南药学 2010年第9期8卷 688-691页

作者：颜素华李健和易利丹彭六保曹俊华阳巧凤曾小慧中南大学湘雅二医院药学部长沙410011

目的制备盐酸西替利嗪滴剂,建立其质量控制方法并考察其稳定性。方法采用β-环糊精包合技术制备盐酸西替利嗪滴剂,高压液相色谱法测定有关物质和含量,影响因素试验、加速试验和长期试验考察其稳定性。结果本制剂口感适宜,较好地掩盖主... 详细信息

目的制备盐酸西替利嗪滴剂,建立其质量控制方法并考察其稳定性。方法采用β-环糊精包合技术制备盐酸西替利嗪滴剂,高压液相色谱法测定有关物质和含量,影响因素试验、加速试验和长期试验考察其稳定性。结果本制剂口感适宜,较好地掩盖主药的苦涩味;盐酸西替利嗪检测浓度在25.1～251.0μ***-1与峰面积线性关系良好(r=0.999 9),其平均回收率为99.9%,RSD为0.86%;恒温加速试验6个月和长期留样试验12个月,其性状、pH值、溶液的颜色、有关物质、含量以及微生物限度等均未见明显改变。结论该制剂处方工艺合理可行,质量可控,稳定性良好。

关键词：盐酸西替利嗪制备工艺质量控制稳定性

A multi-objective multi-memetic algorithm for network-wide conflict-free 4D flight trajectories planning

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Chinese Journal of Aeronautics 2017年第3期30卷 1161-1173页

作者： su yan Kaiquan CAI School of Electronics and Information Engineering Beihang University Beijing 100191 China Beijing Key Laboratory of Network Enabled Collaborative ATM Beijing 100191 China

Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories（4DTs）（3D position and time） for all the flights in the whole airway *** that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this ***,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is *** consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm（MOMMA） that incorporates an evolutionary global search framework together with three problem-specific local search operators is *** is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level ***,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global *** studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP *** solutions achieved are competitive for elaborate decision support under a TBO environment.

关键词： Air traffic flow management 4D trajectory planning Multi-memetic algorithm Multi-objective optimization Network-wide strategic conflict management

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抗钩端螺旋体化学合成药的筛选

军事医学科学院院刊 1982年第2期 185-194页

作者：严共华王淑芬胡九如金仁慈军事医学科学院微生物流行病研究所

钩端螺旋体病(以下简称钩体病)是一种分布广泛的自然疫源性传染病,特别是在温、热带地区,发病多,时间长,对人畜健康和农牧业生产危害很大。多年来临床上都是依靠青霉素等抗菌素进行治疗。每到流行季节,药物常常不能充分满足需要,如果遇... 详细信息

钩端螺旋体病(以下简称钩体病)是一种分布广泛的自然疫源性传染病,特别是在温、热带地区,发病多,时间长,对人畜健康和农牧业生产危害很大。多年来临床上都是依靠青霉素等抗菌素进行治疗。每到流行季节,药物常常不能充分满足需要,如果遇到对青霉素过敏的重症患者,更是感到困难。因此,需要增加抗钩体药物的品种或寻找更好的新抗钩体药。

关键词：化合物效价院刊乙基甲基滴度链烷基有效剂量中国人民解放军军事医学科学院动物感染钩体病化学合成药

高血压合并颈动脉斑块患者内皮功能的变化及其影响因素

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中华临床医师杂志（电子版） 2013年第13期7卷 64-67页

作者：贠琳徐瑞张莉李国华黄帅姚玉才李佳旻闫素华山东大学附属千佛山医院心内二科济南250014 济南大学山东省医学科学院医学与生命科学学院山东省医学科学院山东大学附属千佛山医院超声科济南250014

目的评价高血压合并颈动脉斑块患者的内皮功能的变化并探讨可能的影响因素。方法选取2011年1月至2012年1月在我院就诊的高血压合并颈动脉斑块患者71例,同期选取来我院体检的健康者20例作为正常对照组。以血流介导的内皮依赖性血管舒张功... 详细信息

目的评价高血压合并颈动脉斑块患者的内皮功能的变化并探讨可能的影响因素。方法选取2011年1月至2012年1月在我院就诊的高血压合并颈动脉斑块患者71例,同期选取来我院体检的健康者20例作为正常对照组。以血流介导的内皮依赖性血管舒张功能(FMD)和硝酸甘油引起的非内皮依赖性血管舒张功能(NMD)作为内皮功能的检测指标。另外检测入选人群的内中膜厚度(IMT)、尿微量白蛋白、血清肌肝(Cr)、尿酸(UA)、血糖(Glu)、血脂、超敏C反应蛋白(hs-CRP)等生化指标,并计算尿白蛋白排泄率(UAER)、内生肌酐清除率(Ccr)。结果 (1)两组间FMD、NMD、IMT、收缩压(SBP)、舒张压(DBP)、Cr、UA、Glu、总胆固醇(TC)、低密度脂蛋白(LDL)、hs-CRP、UAER的对数(LgUAER)差异均有统计学意义(P<0.05)。(2)△FMD%与SBP(r=-0.442,P=0.000)、IMT(r=-0.217,P=0.040)、Glu(r=-0.356,P=0.001)、TC(r=-0.381,P=0.000)、LDL(r=-0.267,P=0.011)、hs-CRP(r=-0.234,P=0.026)、LgUAER(r=-0.596,P=0.000)呈负相关;△NMD%与年龄(r=-0.207,P=0.049)、SBP(r=-0.271,P=0.009)、IMT(r=-0.296,P=0.004)、Glu(r=-0.220,P=0.036)、LgUAER(r=-0.311,P=0.003)呈负相关。(3)多元线性回归分析FMD的主要危险因素是UAER、TC(调整的R2=0.329,P=0.027);NMD的主要危险因素是UAER、年龄(调整的R2=0.076,P=0.044)。结论高血压合并颈动脉斑块患者的内皮功能减低,UAER、TC、年龄是其内皮功能障碍的主要危险因素。

关键词：高血压动脉粥样硬化内皮危险因素斑块

Clinical characteristics and 28-d outcomes of bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure

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World Journal of Clinical Cases 2020年第6期8卷 1042-1055页

作者： Chen Li Hai-Bin su Xiao-yan Liu Jin-hua Hu Liver Failure Treatment and Research Center The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Acute-on-chronic liver failure (ACLF),which includes hepatic and multiple extrahepatic organ failure,is a severe emergency condition that has high *** can rapidly progress and requires an urgent assessment of condition and referral for liver *** infections (BIs) trigger ACLF and play pivotal roles in the deterioration of clinical *** To investigate the clinical characteristics and 28-d outcomes of first Bis either at admission or during hospitalization in patients with hepatitis B virus (HBV)-ACLF as defined by the Chinese Group on the Study of Severe Hepatitis B(COSSH).METHODS A total of 159 patients with HBV-ACLF and 40 patients with acute decompensation of HBV-related chronic liver disease combined with first BIs were selected for a retrospective analysis between October 2014 and March 2016 The characteristics of BIs,the 28-d transplant-free survival rates,and the independent predictors of the 28-d outcomes were *** A total of 194 episodes of BIs occurred in 159 patients with *** the episodes,13.4 To were community-acquired,46.4 To were healthcare-associated,and 40.2% belonged to nosocomial *** (40.7%),spontaneous bacterial peritonitis (SBP)(34.5%),and bloodstream infection (BSI)(13.4%) were the most *** the ACLF grade increased,the incidence of SBP showed a downward trend (P=0.021).Sixty-one strains of bacteria,including 83.6% Gramnegative bacteria and 29.5% multidrug-resistant organisms,were cultivated from 50 patients with *** coli (44.3%) and Klebsiella pneumoniae (23.0%)were the most common *** the ACLF grade increased,the 28-d transplant-free survival rates showed a downward trend (ACLF-1,55.7%;ACLF-2,29.3%;ACLF-3,5.4%;P <0.001).The independent predictors of the 28-doutcomes of patients with HBV-ACLF were COSSH-ACLF score (hazard ratio[HR]=1.371),acute kidney injury (HR=2.187),BSI (HR=2.339),prothrombin activity (HR=0.967),and invasive cathete

关键词： Hepatitis B virus Acute-on-chronic liver failure Bacterial infections Outcomes Chronic liver disease Spontaneous bacterial peritonitis

Review of the first principles calculations and the design of cathode materials for Li-ion batteries

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Advances in Manufacturing 2014年第4期2卷 358-368页

作者： Liu-Ming yan Jun-Ming su Chao sun Bao-hua Yue Department of Chemistry College of SciencesShanghai University Department of Physics College of SciencesShanghai University

Cathode materials are the most critical chal- lenge for the large scale application of Li-ion batteries in electric vehicles and for the storages of electricity. The first principles calculations play an important role in develop- ment and optimization of novel cathode materials. In this paper, we overview the first principles calculations of energy, volume change, band-gap, phase diagram, and Li- ion transport mechanism of cathode materials with an emphasis on the design of such materials. We also over- view the recent progress of data mining techniques and the high-throughput first principles calculations for the design and development of cathode materials. Finally, we preview the challenges and opportunities of this rapidly developing field.

关键词： Materials design First principles Densityfunctional theory (DFT) Li-ion batteries Diffusioncoefficient