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Journal of Iron and Steel Research(International) 2024年第2期31卷 377-388页

作者： Tao Pan Hong-chun Zhu Zhou-hua Jiang hua-bing li Rui Zhang Hao Feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

Polyetherketoneketone/carbon fiber composites with an amorphous interface prepared by solution impregnation

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新型炭材料（中英文） 2024年第4期39卷 692-702页

作者： ZHANG Feng li Bo-lan JIAO Meng-xiao li yan-bo WANG Xin yanG Yu yanG Yu-qiu ZHANG Xiao-hua MOE Key Laboratory of Textile Science&Technology College of TextilesInnovation Center for Textile Science and TechnologyDonghua UniversityShanghai 201620China Key Laboratory of Carbon Materials National Engineering Laboratory for Carbon Fiber TechnologyInstitute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China

Interfacial adhesion between carbon fibers(CF)and polyetherketoneketone(PEKK)is a key factor that affects the mechanical performances of their *** is therefore of great importance to impregnate the CF bundles with PEKK as effi-ciently as *** report that PEKK with a good dispersion in a mixed solution of 4-chlorophenol and 1,2-dichloroethane can be introduced onto CF surfaces by solution impregnation and curing at 280,320,340 and 360℃.The excellent wettability or infiltra-tion of the PEKK solution guarantees a full covering and its tight binding to CFs,making it possible to evaluate the interfacial shear strength(IFSS)with the microdroplet *** interior of the CF bundles is completely and uniformly filled with PEKK by solu-tion impregnation,leading to a high interlaminar shear strength(ILSS).The maximum IFSS and ILSS reached 107.8 and 99.3 MPa,*** superior shear properties are ascribed to the formation of amorphous PEKK in the small spaces between CFs.

关键词： Polyetherketoneketone Carbon fiber Wettability Amorphous adhesion Interfacial strength

Model architecture level privacy leakage in neural networks

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Science China(Information Sciences) 2024年第3期67卷 20-32页

作者： yan li Hongyang yan Teng huaNG Zijie PAN Jiewei LAI Xiaoxue ZHANG Kongyang CHEN Jin li Institute of Artificial Intelligent and Blockchain Guangzhou University Pazhou Lab

Privacy leakage is one of the most critical issues in machine learning and has attracted growing interest for tasks such as demonstrating potential threats in model attacks and creating model *** recent years, numerous studies have revealed various privacy leakage risks(e.g., data reconstruction attack, membership inference attack, backdoor attack, and adversarial attack) and several targeted defense approaches(e.g., data denoising, differential privacy, and data encryption). However, existing solutions generally focus on model parameter levels to disclose(or repair) privacy threats during the model training and/or model interference process, which are rarely applied at the model architecture level. Thus, in this paper, we aim to exploit the potential privacy leakage at the model architecture level through a pioneer study on neural architecture search(NAS) paradigms which serves as a powerful tool to automate a neural network *** investigating the NAS procedure, we discover two attack threats in the model architecture level called the architectural dataset reconstruction attack and the architectural membership inference attack. Our theoretical analysis and experimental evaluation reveal that an attacker may leverage the output architecture of an ongoing NAS paradigm to reconstruct its original training set, or accurately infer the memberships of its training set simply from the model architecture. In this work, we also propose several defense approaches related to these model architecture attacks. We hope our work can highlight the need for greater attention to privacy protection in model architecture levels(e.g., NAS paradigms).

关键词： neural architecture search data reconstruction attack membership inference attack

BSEC Method for Unveiling Open Clusters and its Application to Gaia DR3:83 New Clusters

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Research in Astronomy and Astrophysics 2024年第5期24卷 169-184页

作者： Zhong-Mu li Cai-yan Mao Institute of Astronomy and Information Dali UniversityDali 671003China

Open clusters(OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint(EC) for the members of cluster candidates using the homogeneity of color excess,compared to typical blind search codes, it is called Blind Search-Extra Constraint(BSEC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams(CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSEC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an EC, the color excess(or twocolor) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large(e.g., ΔE(G_(BP)-G_(RP)) < 0.5 mag). It makes the CMDs of 15% clusters clearer(in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess con

关键词： Galaxy stellar content-(Galaxy:)open clusters and associations general-stars fundamental parameters

USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第5期11卷 44-47页

作者： Kai li Qian Wang hua Bian Zhang Zhongjing College of Chinese Medicine Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for ImmunoregulationNanyang Institute of TechnologyNanyangHenan 473004China College of Orthopaedics and Traumatology Henan University of Chinese MedicineZhengzhouHenan 450046China

Deubiquitinases(DUBs)are a class of enzymes that are able to reverse the process of ubiquitination.1 Extensive research has revealed that there are more than 100 DUBs found in humans,which are classified into seven main families:ubiquitin-specific proteases(USPs),ubiquitin carboxyl-terminal hydrolases,the Machado-Joseph disease domain superfamily,the otubain/ovarian tumor-domain containing proteins,the ZUFSP(Zinc finger with UFM1-specific peptidase domain protein)family,the JAB1/MPN/MOV34 proteases,and the novel motif interacting with ubiquitin-containing DUB *** DUBs are cysteine proteases,except the JAB1/MPN/MOV34 proteases,which are Zn2þmetalloproteases.

关键词： esophageal cancer Zinc

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han yan-Ting liu Wei huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao Shi-hua li Xiao-Jiang li Wei-li yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Tianmouc vision chip designed for open-world sensing

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Science China Materials 2024年第9期67卷 3046-3048页

作者： Haotian li Qilin hua Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of Technology Institute of Flexible Electronics Beijing Institute of Technology

Driven by the forward development of highly interactive applications like autonomous robots and artificial intelligence[1,2], image sensors are continuously demanded to improve in terms of high speed, high resolution, wide dynamic range, and high precision [3]. However, due to inherent limitations in power and bandwidth, significant enhancements in one aspect often necessitates compromises in others [4].

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Molecular Characteristics,Functions,and Related Pathogenicity of MERS-CoV Proteins

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Engineering 2019年第5期5卷 940-947页

作者： yan-hua li Chen-Yu Hu Nan-Ping Wu Hang-Ping Yao Lan-Juan li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 31003China

Middle East respiratory syndrome(MERS)is a viral respiratory disease caused by a de novo coronavirus—MERS-CoV—that is associated with high ***,the mechanism by which MERS-CoV infects humans remains *** date,there is no effective vaccine or antibody for human immunity and treatment,other than the safety and tolerability of the fully human polyclonal Immunoglobulin G(IgG)antibody(SAB-301)as a putative therapeutic agent specific for *** rapid diagnostic and public health measures are currently being implemented,new cases of MERS-CoV infection are still being ***,various effective measures should be taken to prevent the serious impact of similar epidemics in the *** investigation of the epidemiology and pathogenesis of the virus,as well as the development of effective therapeutic and prophylactic anti-MERS-CoV infections,is *** this purpose,detailed information on MERS-CoV proteins is *** this review,we describe the major structural and nonstructural proteins of MERS-CoV and summarize different potential strategies for limiting the outbreak of *** combination of computational biology and virology can accelerate the advanced design and development of effective peptide therapeutics against *** summary,this review provides important information about the progress of the elimination of MERS,from prevention to treatment.

关键词： MERS-CoV Spike protein Structural protein Accessory protein Nonstructural protein

The crosstalk between enteric nervous system and immune system in intestinal development,homeostasis and diseases

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Science China(life Sciences) 2024年第1期67卷 41-50页

作者： Xindi Wang Chenbo Ding hua-Bing li Shanghai Institute of Immunology State Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism Shanghai Jiao Tong University School of MedicineShanghai 200025China

The gut is the largest digestive and absorptive organ,which is essential for induction of mucosal and systemic immune responses,and maintenance of metabolic-immune *** intestinal components contain the epithelium,stromal cells,immune cells,and enteric nervous system(ENS),as well as the outers,such as gut microbiota,metabolites,and *** dyshomeostasis of intestinal microenvironment induces abnormal intestinal development and functions,even colon diseases including dysplasia,inflammation and *** recent studies have identified that ENS plays a crucial role in maintaining the immune homeostasis of gastrointestinal(GI)*** crosstalk between ENS and immune cells,mainly macrophages,T cells,and innate lymphoid cells(ILCs),has been found to exert important regulatory roles in intestinal tissue programming,homeostasis,function,and *** this review,we mainly summarize the critical roles of the interactions between ENS and immune cells in intestinal homeostasis during intestinal development and diseases progression,to provide theoretical bases and ideas for the exploration of immunotherapy for gastrointestinal diseases with the ENS as potential novel targets.

关键词： enteric nervous system macrophages T cells innate lymphoid cells neuro-immune interactions

Side Information-Based Stealthy False Data Injection Attacks Against Multi-Sensor Remote Estimation

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1054-1056页

作者： Haibin Guo Zhong-hua Pang Chao li the Key Laboratory of Fieldbus Technology and Automation of Beijing North China University of TechnologyBeijing 100144China

Dear Editor,This letter investigates a novel stealthy false data injection(FDI)attack scheme based on side information to deteriorate the multi-sensor estimation performance of cyber-physical systems(CPSs).Compared with most existing works depending on the full system knowledge,this attack scheme is only related to attackers'sensor and physical process *** design principle of the attack signal is derived to diverge the system estimation ***,it is proven that the proposed attack scheme can successfully bypass the residual-based ***,all theoretical results are verified by numerical simulation.

关键词： estimation scheme system