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Low-power laser irradiation promotes the proliferation and osteogenic differentiation of human periodontal ligament cells via cyclic adenosine monophosphate

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International Journal of Oral Science 2013年第2期5卷 85-91页

作者： Jyun-Yi Wu Chia-Hsin Chen Li-Yin Yeh Ming-Long Yeh Chun-Chan Ting yan-hsiung wang Institute of Biomedical Engineering National Cheng Kung University Department of Physical Medicine and Rehabilitation Kaohsiung Medical University Hospital Department of Physical Medicine and Rehabilitation Faculty of MedicineCollege of MedicineKaohsiung Medical University Department of Physical Medicine and Rehabilitation Kaohsiung Municipal Ta-Tung Hospital Department of Oral Hygiene College of MedicineKaohsiung Medical University School of Dentistry College of Dental MedicineKaohsiung Medical University Orthopaedic Research Center College of MedicineKaohsiung Medical University

Retaining or improving periodontal ligament （PDL） function is crucial for restoring periodontal defects. The aim of this study was to evaluate the physiological effects of low-power laser irradiation （LPLI） on the proliferation and osteogenic differentiation of human PDL （hPDL） cells. Cultured hPDL cel Is were irradiated （660 nm） daily with doses of O, 1, 2 or 4 J .cm-2. Cell proliferation was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide （MTT） assay, and the effect of LPLI on osteogenic differentiation was assessed by Alizarin Red S staining and alkaline phosphatase （ALP） activity. Additionally, osteogenic marker gene expression was confirmed by real-time reverse transcription-polymerase chain reaction （RT-PCR）. Our data showed that LPLI at a dose of 2 ***-2 significantly promoted hPDL cell proliferation at days 3 and 5. In addition, LPLI at energy doses of 2 and 4 ***-2 showed potential osteogenic capacity, as it stimulated ALP activity, calcium deposition, and osteogenic gene expression. We also showed that cyclic adenosine monophosphate （cAMP） is a critical regulator of the LPLI-mediated effects on hPDL cells. This study shows that LPLI can promote the proliferation and osteogenic differentiation of hPDL cells. These results suggest the potential use of LPLI in clinical applications for periodontal tissue regeneration.

关键词： cell proliferation cyclic adenosine monophosphate human periodontal ligament cells low-power laser irradiation osteogenic differentiation

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Low-power laser irradiation inhibits arecoline-induced fibrosis:an in vitro study

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International Journal of Oral Science 2017年第1期9卷 38-42页

作者： Mei-Chun Yeh Ker-Kong Chen Min-Hsuan Chiang Chia-Hsin Chen Ping-Ho Chen Huey-Er Lee yan-hsiung wang School of Dentistry College of Dental MedicineKaohsiung Medical UniversityKaohsiungTaiwan Department of Dentistry Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwan Orthopaedic Research Center College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan Department of Physical Medicine and Rehabilitation Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical UniversityKaohsiungTaiwan and Department of Physical Medicine and Rehabilitation Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwan

Oral submucous fibrosis （OSF） is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation （LPLI） has been reported to be beneficial in fibrosis prevention in different damaged organs. The aim of this study was to investigate the potential therapeutic effects of LPLI on arecoline-induced fibrosis. Arecoline- stimulated human gingival fibroblasts （HGFs） were treated with or without LPLI. The expression levels of the fibrotic marker genes alpha-smooth muscle actin （a-SMA） and connective tissue growth factor （CTGF/CCN2） were analysed by quantitative real- time reverse transcription polymerase chain reaction （RT-PCR） and western blots. In addition, the transcriptional activity of CCN2 was further determined by a reporter assay. The results indicated that arecoline increased the messenger RNA and protein expression of CCN2 and a-SMA in HGF. Interestingly, both LPLI and forskolin, an adenylyl cyclase activator, reduced the expression of arecoline-mediated fibrotic marker genes and inhibited the transcriptional activity of CCN2. Moreover, pretreatment with SQ22536, an adenylyl cyclase inhibitor, blocked LPLI＇s inhibition of the expression of arecoline-mediated fibrotic marker genes. Our data suggest that LPLI may inhibit the expression of arecoline-mediated fibrotic marker genes via the cAMP signalling pathway.

关键词： adenylate cyclase alpha-smooth muscle actin connective tissue growth factor fibrosis low-power laser irradiation

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Features associated with progression of small pancreatic cystic lesions: A retrospective study

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World Journal of Gastroenterology 2015年第47期21卷 13309-13315页

作者： Hong-Ming Tsai Chiao-hsiung Chuang yan-Shen Shan Yi-Sheng Liu Chiung-Yu Chen Department of Radiology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University

AIM: To investigate the progression rate of small pancreatic cystic lesions and identify characteristics associated with their ***: Patients with pancreatic cystic lesions with at least 1-year of follow-up were evaluated retrospectively. We excluded patients with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 patients were evaluated. The interval progression of the cysts was examined. Characteristics were compared between patients with and without ***: The pancreatic cysts ranged from 3 to 29 mm. The mean follow-up period was 4.5 ± 2.3 years and the mean progression rate was 1.0 ± 1.3 mm/year. Ninety patients showed interval progression and were divided into two groups; the minimal-change group(n = 41), who had cyst progression at less than 1 mm/year, and the progression group(n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct(P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular ***: Small pancreatic cysts progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.

关键词： Pancreas Cystic lesion Progression Imaging features Observation

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Implementation of the Line Maze Robot with Diagonal Motion Control

Implementation of the Line Maze Robot with Diagonal Motion C...

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第26届中国控制与决策会议

作者： Hsin-hsiung Huang Juing-Huei Su Chyi-Shyong Lee Jheng-yan Syu Shih-Wei Chao Yi-Wei Chang Department of Electronic Engineering Lunghwa University of Science and Technology

The wheeled robots have become the interesting and important training kits for students to learn to integrate those skills about hardware circuit designs, firmware programming, motion control, and path planning techniques in these past days. Therefore, a novel line maze robot kit with diagonal path planning capabilities is presented as an example in this paper to help students. The robot uses a 32-bit microcontroller with floating point processing unit to 1) detect the track curve by using optical sensors, 2) use gyro sensor to correct moving angles, 3) control the linear and angular velocities of the robot, and 4) plan a diagonal path from the start to the target. Although students could learn the abovementioned topics in a special topic project, they may also design their own mechanical structures and hardware circuits to improve furthermore the performance of their robots, and they are happy to join to win prizes in related contests.

关键词： Line Maze Robot Diagonal Movement Gyro Feedback Shortest Path Algorithm.

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A Long Term Effect of Tumor Necrosis Factor Alpha on Embryo Development

A Long Term Effect of Tumor Necrosis Factor Alpha on Embryo ...

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第五届全国优生科学大会

作者： yan - Der Hsuuw , Jia - Yau Doog, Chen - Kang Chang and Wen - hsiung Chan Department of Nutrition and Health Science, Fooyi Institute of Technology, Taiwan, China

Previous studies showed that mouse blastocysts express both receptors of tumor neerosis factor alpha (TNF-α),and that TNF-α has selective inhibition on the cell growth of the inner cell mass (ICM).These observations sug-gested that TNF-α might impair the development of blastocyst in the time of,or after *** determine theeffect of TNF-α on those embryo viabilities in the time of implantation,blastocysts were cultured on the fibronectin-coated dish followed the TNF-α *** abilities of embryos to implant were examine by means of morphologi-

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明钱谷《纪行图册》、张复《水程图》之大运河现地研究与GIS呈现(之一)

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数字人文研究 2023年第1期3卷 50-60页

作者：简锦松廖泫铭王勇张淑君唐宸严程谢定纮台湾中山大学中文系中国台湾台湾中研院人社中心中国台湾东莞理工学院中文系江西省农村信用社联合社安徽大学文学院清华大学人文学院台湾大学中文系中国台湾

钱谷《纪行图册》以王世贞隆庆四年(1570)六月《适晋纪行》为蓝本,绘成仓山小祗园至扬州扬子桥三十二幅;张复《水程图》因王世贞于万历二年(1574)二月入领太仆之役,附舟而北,绘成邵伯至通州水程五十二幅。两卷皆以写实为之,在明人画中... 详细信息

钱谷《纪行图册》以王世贞隆庆四年(1570)六月《适晋纪行》为蓝本,绘成仓山小祗园至扬州扬子桥三十二幅;张复《水程图》因王世贞于万历二年(1574)二月入领太仆之役,附舟而北,绘成邵伯至通州水程五十二幅。两卷皆以写实为之,在明人画中堪称独绝。文章以现地研究法进行三项处理:一、此次王世贞北行,正在隆庆新河既成,泇河之议方生的明代大运河变动期,文章将二人所经过之水程全部数字化;二、钱谷自言“维欲记其目前真境”,文章利用明清旅行日记、方志、古今地图及笔者现地考察所得,将各图逐一解说,指出图面所绘内容,验证画者写真实践的程度;三、此八十余幅之价值,如同发现一大箱明代的拍摄影带,文章发挥其自身的影像本色,形象化地指出明代大运河的真正面目。

关键词：数字人文明代大运河现地研究钱谷《纪行图册》张复《水程图》

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明钱榖《纪行图册》、张复《水程图》之大运河现地研究与GIS呈现(之三)

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数字人文研究 2023年第3期3卷 59-128页

钱榖《纪行图册》以王世贞隆庆四年(1570)六月《适晋纪行》为蓝本,绘成仓山小祗园至扬州扬子桥三十二幅;张复《水程图》因王世贞于万历二年(1574)二月入领太仆之役,附舟而北,绘成邵伯至通州水程五十二幅。两卷皆以写实为之,在明人画中... 详细信息

钱榖《纪行图册》以王世贞隆庆四年(1570)六月《适晋纪行》为蓝本,绘成仓山小祗园至扬州扬子桥三十二幅;张复《水程图》因王世贞于万历二年(1574)二月入领太仆之役,附舟而北,绘成邵伯至通州水程五十二幅。两卷皆以写实为之,在明人画中堪称独绝。文章以现地研究法进行三项处理:一、此次王世贞北行,正在隆庆新河既成,泇河之议方生的明代大运河变动期,文章将二人所经过之水程全部数字化;二、钱榖自言“维欲记其目前真境”,文章利用明清旅行日记、方志、古今地图及笔者现地考察所得,将各图逐一解说,指出图面所绘内容,验证画者写真实践的程度;三、此八十余幅之价值,如同发现一大箱明代的拍摄影带,文章发挥其自身的影像本色,形象化地指出明代大运河的真正面目。

关键词：数字人文明代大运河现地研究钱榖《纪行图册》张复《水程图》

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明钱榖《纪行图册》、张复《水程图》之大运河现地研究与GIS呈现(之二)

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数字人文研究 2023年第2期3卷 50-115页

关键词：数字人文明代大运河现地研究钱榖《纪行图册》张复《水程图》

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明钱穀《纪行图册》张复《水程图》之大运河现地研究与GIS呈现(之四)

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数字人文研究 2023年第4期3卷 78-128页

作者：简锦松廖泫铭王勇张淑君唐宸严程谢定紘台湾中山大学中文系中国台湾台湾中研院人社中心中国台湾东莞理工学院中文系上海大学江西省农村信用社联合社安徽大学文学院清华大学人文学院台湾大学中文系中国台湾

关键词：数字人文明代大运河现地研究钱榖《纪行图册》张复《水程图》

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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