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Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature

World Journal of Clinical Cases 2019年第23期7卷 4119-4129页

作者： Yue-Mei Xu Zhi-Wen Li hong-yan wu Xiang-Shan Fan Qi Sun Department of Pathology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

BACKGROUND Pancreatic mixed serous-neuroendocrine neoplasms(MSNNs)are mixed tumors containing two components with different pathologies,namely,pancreatic serous cystic neoplasm(PSCN)and pancreatic neuroendocrine tumor(PanNET).For MSNNs,diffuse PSCN involving the whole pancreas is extremely rare,with only eight previous case *** SUMMARY A 45-year-old Chinese woman,with a free previous medical history and no obvious symptoms,was found to have a pancreatic neoplasm and admitted to our hospital for further diagnosis in March *** palpation revealed a painless,mobile mass in the epigastrium,and no abnormalities were observed in an examination of the nervous system and ocular system.A computed tomography scan showed multiple cystic lesions involving the whole pancreas ranging in diameter from 0.4 to 2 cm and also revealed an enhanced mass,2.2 cm in diameter,in the head of the ***,multiple cysts were found in the kidneys bilaterally,and the right lobe of the liver contained a small cyst.A Whipple operation with total pancreatectomy and splenectomy was performed.A diagnosis of pancreatic MSNN was established,consisting of diffuse serous microcystic cystadenoma with a concomitant grade 2 *** note,the patient had no personal or family history of Von Hippel-Lindau syndrome or other *** We report the first case of MSNN with a diffuse PSCN component involving the entire pancreas in a Chinese *** is important to be aware of its relationship with VHL syndrome,and close clinical follow-up is recommended.

关键词： Mixed serous-neuroendocrine neoplasm Pancreatic serous cystic neoplasm Pancreatic neuroendocrine tumor Von Hippel-Lindau syndrome Case report

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Predicting submerged vegetation drag with a machine learning-based method

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Journal of Hydrodynamics 2024年第3期36卷 534-545页

作者： Meng-yang Liu hong-wu Tang Sai-yu Yuan Jing yan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China Key Laboratory of Hydrologic-Cycle and Hydrodynamic-System of Ministry of Water Resources Hohai UniversityNanjing210098China

Accurate estimation of the drag forces generated by vegetation stems is crucial for the comprehensive assessment of the impact of aquatic vegetation on hydrodynamic processes in aquatic *** coupling relationship between vegetation layer flow velocity and vegetation drag makes precise prediction of submerged vegetation drag forces particularly *** present study utilized published data on submerged vegetation drag force measurements and employed a genetic programming(GP)algorithm,a machine learning technique,to establish the connection between submerged vegetation drag forces and flow and vegetation *** using the bulk velocity,U,as the reference velocity scale to define the drag coefficient,C_(d),and stem Reynolds number,the GP runs revealed that the drag coefficient of submerged vegetation is related to submergence ratio(H^(*)),aspect ratio(d^(*)),blockage ratio(ψ^(*)),and vegetation density(λ).The relation between vegetation stem drag forces and flow velocity is implicitly embedded in the definition of C_(d).Comparisons with experimental drag force measurements indicate that using the bulk velocity as the reference velocity,as opposed to using the vegetation layer average velocity,U_(v),eliminates the need for complex iterative processes to estimate U_(v)and avoids introducing additional errors associated with U_(v)*** approach significantly enhances the model’s predictive capabilities and results in a simpler and more user-friendly formula expression.

关键词： Drag coefficient genetic programming algorithm submerged vegetation flow resistance cylinder array

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Remaining Useful Life Prediction Method for Multi-Component System Considering Maintenance:Subsea Christmas Tree System as A Case Study

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China Ocean Engineering 2024年第2期38卷 198-209页

作者： wu Qi-bing CAI Bao-ping FAN hong-yan WANG Guan-nan RAO Xi GE Weifeng SHAO Xiao-yan LIU Yong-hong CNOOC Safety Technology Services Co. Ltd.Tianjin 300456China College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Safety&Environmental Protection BranchTianjin 300456China

Maintenance is an important technical measure to maintain and restore the performance status of equipment and ensure the safety of the production process in industrial production,and is an indispensable part of prediction and health ***,most of the existing remaining useful life(RUL)prediction methods assume that there is no maintenance or only perfect maintenance during the whole life cycle;thus,the predicted RUL value of the system is obviously lower than its actual operating *** complex environment of the system further increases the difficulty of maintenance,and its maintenance nodes and maintenance degree are limited by the construction period and working conditions,which increases the difficulty of RUL *** RUL prediction method for a multi-omponent system based on the Wiener process considering maintenance is *** performance degradation model of components is established by a dynamic Bayesian network as the initial model,which solves the uncertainty of insufficient data *** on the experience of experts,the degree of degradation is divided according to Poisson process simulation random failure,and different maintenance strategies are used to estimate a variety of condition maintenance *** example of a subsea tree system is given to verify the effectiveness of the proposed method.

关键词： remaining useful life Wiener process dynamic Bayesian networks maintenance subsea Christmas tree system

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Optical Microsphere Nano-Imaging:Progress and Challenges

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Engineering 2024年第5期36卷 102-123页

作者： Guangxing wu Minghui hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale *** the past decade,the optical microsphere nanoimaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about k6k8 in a real-time and label-free manner,making it highly competitive among numerous super-resolution imaging *** this review,we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement:first,to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level;second,to compose the microsphere compound lens;and third,to engineer the geometry or ingredients of *** also analyze challenges yet to be overcome in optical microsphere nano-imaging,followed by an outlook of this technique.

关键词： Microsphere Nano-imaging Virtual imaging Microsphere compound lens Engineered microsphere

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Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin wu yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

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Cognition and Sociodemographic Determinants for Effective Pain Control in Patients with Cancer Pain: a Cross-sectional Survey in China

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Current Medical Science 2020年第2期40卷 249-256页

作者： Xiao-fang SHANGGUAN Zao-qin YU Lu JI yang-yang CHEN hong-yan wu Rui HUANG Cheng-liang ZHANG School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Deparment of Pharmacy Tongji HospialTongji Medical CollegeHuazhong University of Science and TechmologyWuhan 430030China School of Medicine and Health Management Tongji Medical CollegeHuazhong University of Science cand TechnologyWuhan 430030China Deparment of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Nursing Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

This cross-sectional study aimed to investigate cancer patients'cognitive level of pain control and to evaluate the patient-related factors or barriers to effective cancer pain management in *** seven tertiary hospitals across China,372 patients experiencing cancer pain were surveyed through a self-designed questionnaire to assess the factors associated with effective pain ***'demographic data and pain control-related factors were *** sampling and binary logistic regression models were used to investigate the association between predictive factors and effective pain *** survey showed that the majority of the patients were more than 45 years old(76.3%),and 64.4%had an average annual income of more than 20000 ***-third of the patients suffered from cancer pain for more than 3 months,and 75.1%received professional guidance during *** barriers to pain control for patients included preference to enduring pain and refusing analgesics(62.9%),negligence towards drug usage(28.5%),concerns about the addiction(48.2%)and adverse reaction(56.4%).The average annual family income,pro fessional guidance,knowledge of pain medication,adherence to analgesics,and concerns about addiction to analgesics were significantly correlated to the effect of patients'pain *** study presents major barriers to optimal pain control among patients with cancer in *** findings suggest that educational programs and medical insurance reimbursement support from the government are urgently needed to overcome the cognitive barriers toward effective pain management and to relieve the economic burden among patients with cancer pain in China.

关键词： cancer pain cognition sociodemographic determinants pain control pain management

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Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer's Disease Rat Model

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Current Medical Science 2022年第1期42卷 39-47页

作者： Hu-ping WANG hong-yan wu Chun-lin MA Qing-tao ZENG Kai-min ZHU Shu-mei CUI Hai-long LI Guo-tai wu Zhi-wei wu Jian-zheng HE Basic Medicine College Gansu University of Chinese MedicineLanzhou 730000 Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000 Pharmacy College Gansu University of Chinese MedicineLanzhou 730000

Objective:Angelica(A.)sinensis is used as a traditional medical herb for the treatment of neurodegeneration,aging,and inflammation in *** optimal formula(AOF)is the best combination in *** that has been screened to rescue the cognitive ability in P-amyloid peptide(Ap25-35)-treated Alzheimer’s disease(AD)*** objective of this study was to investigate the effect of AOF on the learning and memory of AD rats as well as to explore the underlying mechanisms.

关键词： optimal formula of Angelica sinensis Alzheimer's disease amyloid P aggregation oxidative stress neuroinflammation

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Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis

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Science China Chemistry 2024年第11期67卷 3798-3806页

作者： Qi-Chao Shan yan Zhao Yong wu hong-Fei Liu Xin-Hua Duan Li-Na Guo Department of Chemistry School of Chemistry Energy Research Center of Energy Storage Materials and Devices Ministry of EducationXi'an Jiaotong University State Key Laboratory of Applied Organic Chemistry Lanzhou University

A regioselective C-C bond cleavage/aminocarbonylation cascade is presented. In recent years, tremendous progress has been made in the alkoxyl radical-mediated C-C bond cleavage of unstrained monocarbocycles. In contrast, the deconstruction and functionalization of bicyclic skeletons has been less developed and has mainly focused on the ring expansion process. Inspired by the aromatization-driven C-C bond cleavage, here we demonstrate a ring-opening/aminocarbonylation cascade under copper catalysis, in which the formation of a stable γ-lactam or succinimide skeleton reverses the selectivity of C-C cleavage. Remarkably, the photo and thermal assistance is not required when the succinimide skeleton is formed during the ring opening process. DFT calculations revealed that this unexpected ring-opening process is thermodynamically and kinetically favourable.

关键词： C-C bond cleavage controllable regioselectivity aminocarbonylation bicyclic alkoxy radical

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Advancing from scalar to vectorial liquid crystal holography:a paradigm shift

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Light(Science & Applications) 2024年第9期13卷 1696-1697页

作者： yan Li Shin-Tson wu Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Optics and Photonics University of Central FloridaOrlandoFL 32816USA

A versatile and tunable vectorial holography is demonstrated based on single-layer single-material liquid crystal *** novel approach advances the process from scalar to vectorial holography,opening new opportunities f... 详细信息

关键词： liquid crystal versatile

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Mixed H_(∞)/Passive Exponential Synchronization for Delayed Memristive Neural Networks with Switching Event-Triggered Control

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Journal of Systems Science & Complexity 2024年第1期37卷 294-317页

作者： wu Wenhuang GUO Lulu CHEN hong Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with H∞and passivity *** aim is to guarantee the exponential synchronization and mixed H∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed H_(∞)and passivity ***,an event-triggered controller design scheme is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.

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