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Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients

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World Journal of Gastroenterology 2021年第19期27卷 2376-2393页

作者： Xiao-Juan yang Dan Liu hong-yan ren Xiao-Ya Zhang Jun Zhang Xiao-Jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Shanghai Mobio Biomedical Technology Co. Shanghai 201318China

BACKGROUND Sepsis is a common disease in intensive care units,with high morbidity and *** microecology plays a vital part in the development and progression of this disease,possibly because sepsis and its treatment cause specific changes in the composition of the intestinal *** To investigate the characteristics of intestinal flora disturbance in sepsis patients treated with *** In this prospective comparative study,we enrolled ten patients with sepsis(sepsis group),hospitalized in the Department of Critical Care Medicine of the General Hospital,Ningxia Medical University,China(a class IIIa general hospital)from February 2017 to June 2017;ten patients without sepsis hospitalized in the same period(non-sepsis group)and ten healthy individuals(control group)were also *** samples collected from the three groups were subjected to 16S rRNA gene sequencing and the intestinal flora diversity,structure,and composition were ***,the dynamics of the intestinal flora diversity,structure,and composition in sepsis patients were investigated via 16S rRNA gene sequencing of samples collected 0 d,3 d,and 7 d after admittance to the intensive care *** between the serum levels of procalcitonin,endotoxin,diamine oxidase,and D-lactic acid and the intestinal flora composition of sepsis patients were also *** Compared with the healthy control group,sepsis and non-sepsis patients showed reduced intestinal floraα-diversity and a distinct flora structure,with Firmicutes as the dominant phylum,and significantly decreased proportions of Bacteroidetes,as well as Prevotella and Lachnospira,among other *** note,the proportion of Enterococcus was significantly increased in the intestinal tract of sepsis ***,theα-diversity in the sepsis group decreased gradually,from days 1 to 7 of ***,pairwise comparisons showed that both the diversity and structure of the int

关键词： Sepsis Intestinal flora 16S rRNA gene sequencing Dynamic changes Intestinal barrier index Procalcitonin

Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

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Military Medical Research 2023年第2期10卷 162-174页

作者： Guang-Ying Cui Ben-Chen Rao Zhao-Hai Zeng Xue-Mei Wang Tong ren Hai-Yu Wang hong Luo hong-yan ren Chao Liu Su-Ying Ding Jun-Jie Tan Zhen-Guo Liu Ya-Wen Zou Zhi-Gang ren Zu-Jiang Yu Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene Hospital of Henan Province/Precision Medicine Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Infectious Diseases Guangshan County People’s HospitalGuangshan CountyXinyang 465450HenanChina Department of Breast Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450052China Shanghai Mobio Biomedical Technology Co. LtdShanghai 201111China Health Management Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Due to the outbreak and rapid spread of coronavirus disease 2019(COVID-19),more than 160 million patients have become convalescents worldwide to *** alterations have occurred in the gut and oral microbiome and metabonomics of patients with ***,it is unknown whether their characteristics return to normal after the 1-year ***:We recruited 35 confirmed patients to provide specimens at discharge and 1 year later,as well as 160healthy controls.A total of 497 samples were prospectively collected,including 219 tongue-coating,129 stool and 149 plasma ***-coating and stool samples were subjected to 16S rRNA sequencing,and plasma samples were subjected to untargeted metabolomics ***:The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to *** the recovery process,the microbial diversity gradually *** acid-producing microbes and Bifidobacterium gradually increased,whereas lipopolysaccharideproducing microbes gradually *** addition,sphingosine-1-phosphate,which is closely related to the inflammatory factor storm of COVID-19,increased significantly during the recovery ***,the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year ***:This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of *** key microbiome and metabolites in the process of recovery were identified,and provided new treatment ideas for accelerating *** the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.

关键词： Coronavirus disease 2019(COVID-19) Gut microbiome Oral microbiome Plasma metabonomics Convalescents Individual outcomes Patient stratifcation Predictive Preventive and personalized medicine(3PM)

Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology

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World Journal of Gastroenterology 2023年第13期29卷 2034-2049页

作者： Xiao-Juan yang Xiao-hong Wang Ming-Yue yang hong-yan ren Hui Chen Xiao-Ya Zhang Qin-Fu Liu Ge yang Yi yang Xiao-Jun yang Department of Critical Care Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Emergency Medicine Affiliated Hospital of Jining Medical UniversityJining 272030Shandong ProvinceChina Shanghai Mobio Biomedical Technology Co. Ltd.Shanghai 201318China Department of Critical Care Medicine Southeast University School of MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Sepsis exacerbates intestinal microecological disorders leading to poor *** modalities of nutritional support can improve nutrition,immunity,and intestinal *** To identify the optimal modality of early nutritional support for patients with sepsis from the perspective of intestinal *** Thirty patients with sepsis admitted to the intensive care unit of the General Hospital of Ningxia Medical University,China,between 2019 and 2021 with indications for nutritional support,were randomly assigned to one of three different modalities of nutritional support for a total of 5 d:Total enteral nutrition(TEN group),total parenteral nutrition(TPN group),and supplemental parenteral nutrition(SPN group).Blood and stool specimens were collected before and after nutritional support,and changes in gut microbiota,short-chain fatty acids(SCFAs),and immune and nutritional indicators were detected and compared among the three *** In comparison with before nutritional support,the three groups after nutritional support presented:(1)Differences in the gut bacteria(Enterococcus increased in the TEN group,Campylobacter decreased in the TPN group,and Dialister decreased in the SPN group;all Prent trends in SCFAs(the TEN group showed improvement except for Caproic acid,the TPN group showed improvement only for acetic and propionic acid,and the SPN group showed a decreasing trend);(3)significant improvement of the nutritional and immunological indicators in the TEN and SPN groups,while only immunoglobulin G improved in the TPN group(all P<0.05);and(4)a significant correlation was found between the gut bacteria,SCFAs,and nutritional and immunological indicators(all P<0.05).CONCLUSION TEN is recommended as the preferred mode of early nutritional support in sepsis based on clinical nutritional and immunological indicators,as well as changes in intestinal microecology.

关键词： Sepsis Nutritional support Intestinal microecology Short-chain fatty acids Nutritional and immunological indicators Total enteral nutrition Total parenteral nutrition Supplemental parenteral nutrition

Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-nave patients with schizophrenia

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Neuroscience Bulletin 2015年第1期31卷 31-42页

作者： Ming-Li Li Bo Xiang Yin-Fei Li Xun Hu Qiang Wang Wan-Jun Guo Wei Lei Chao-Hua Huang Lian-Sheng Zhao Na Li hong-yan ren Hui-Yao Wang Xiao-hong Ma Wei Deng Tao Li The Mental Health Center and the Psychiatric Laboratory West China HospitalSichuan University State Key Laboratory of Biotherapy West China HospitalSichuan University Huaxi Biobank West China HospitalSichuan University

The catechol-O-methyltransferase（COMT） gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene,Val158/158 Met,has been proposed to influence gray matter volume（GMV）. However,the effects of this polymorphism on cortical thickness/surface area in schizophrenic patients are less clear. In this study,we explored the relationship between the Val158 Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-nave patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual,medial temporal,parietal,and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover,a diagnosis × genotype interaction was found for the GMV of the left precuneus,and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition,a pattern ofincreased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia,and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area.

关键词： schizophrenia COMT gray matter imaging genetics

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

Spatiotemporal characteristics and primary influencing factors of typical dengue fever epidemics in China

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Infectious Diseases of Poverty 2019年第2期8卷 94-94页

作者： Lan Zheng hong-yan ren Run-He Shi Liang Lu Key Laboratory of Geographic Information Science Ministry of EducationEast China Normal UniversityShanghaiChina State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina 不详

Background:Dengue fever(DF)is a common mosquito-borne viral infectious disease in the world,and increasingly severe DF epidemics in China have seriously affeaed people's health in recent ***,investigating spatiotemporal patterns and potential influencing factors of DF epidemics in typical regions is critical to consolidate effective prevention and control measures for these regional ***:A generalized additive model(GAM)was used to identify potential contributing faaors that influence spatiotemporal epidemic patterns in typical DF epidemic regions of China(e.g.,the Pearl River Delta[PRD]and the Border of Yunnan and Myanmar[BYM]).In terms of influencing faaors,environmental factors including the normalized difference vegetation index(NDVI),temperature,precipitation,and humidity,in conjunaion with socioeconomic factors,such as population density(Pop),road density,land-use,and gross domestic product,were ***:DF epidemics in the PRD and BYM exhibit prominent spatial variations at 4 km and 3 km grid scales,characterized by significant spatial clustering over the Guangzhou-Foshan,Dehong,and Xishuangbanna *** GAM that integrated the Pop-urban land ratio(ULR)-NDVI-humidity-temperature factors for the PRD and the ULR-Road density-NDVI-temperaturewater land ratio-precipitation faaors for the BYM performed well in terms of overall accuracy,with Akaike Information Criterion values of 61859.89 and 826.65,explaining a total variance of 83.4 and 97.3〇/〇,*** indicated,socioeconomic factors have a stronger influence on DF epidemics than environmental faaors in the study *** these faaors,Pop(PRD)and ULR(BYM)were the socioeconomic faaors explaining the largest variance in regional epidemics,whereas NDVI was the environmental faaor explaining the largest variance in both *** addition,the common factors(ULR,NDVI,and temperature)in these two regions exhibited different effeas on regional ***:The spatiotemp

关键词： Spatiotemporal pattern China Dengue fever Generalized additive model Socioeconomic faaor Environmental faaor

Direct medical costs of hospitalized patients with idiopathic pulmonary fibrosis in a tertiary hospital in China

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Chinese Medical Journal 2020年第20期133卷 2498-2500页

作者： Xiao-Fen Zheng Bing-Bing Xie yan Liu Ming Zhu Shu Zhang Cheng-Jun Ban Jing Geng Ding-Yuan Jiang yan-hong ren Hua-Ping Dai Chen Wang Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China The Second Affiliated Hospital of Zhejiang Chinese Medical University HangzhouZhejiang 310000China Department of Pulmonary and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100012China Department of Respiratory Medicine Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Idiopathic pulmonary fibrosis(IPF)incidence shows wide variations in different countries,ranging from 3 to 9 per 100,000 inhabitants per year in North America and Europe,while in South America and Asia,incidence is lo... 详细信息

关键词： patients pulmonary Idiopathic

山区峡谷非均匀风场下大跨度斜拉桥静风稳定性分析

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中国公路学报 2019年第10期32卷 158-168页

作者：胡朋颜鸿仁韩艳蔡春声肖勇刚长沙理工大学土木工程学院湖南长沙410114 路易斯安那州立大学土木与环境工程系路易斯安那巴吞鲁日LA70803

为研究山区峡谷地形下非均匀风场对大跨度桥梁静风稳定性的影响,以一座跨越典型山区峡谷地形的大跨度斜拉桥为工程背景,首先,采用计算流体动力学(CFD)软件Fluent对桥址区地形的风场特性进行分析,计算出沿主梁方向的非均匀风速和非均匀... 详细信息

为研究山区峡谷地形下非均匀风场对大跨度桥梁静风稳定性的影响,以一座跨越典型山区峡谷地形的大跨度斜拉桥为工程背景,首先,采用计算流体动力学(CFD)软件Fluent对桥址区地形的风场特性进行分析,计算出沿主梁方向的非均匀风速和非均匀风攻角分布;然后,采用ANSYS APDL技术实现能考虑非均匀风速和非均匀风攻角下大桥静风稳定性的非线性分析方法。在此基础上,综合考察非均匀风攻角分布、非均匀风速分布、非均匀风速非均匀风攻角分布等风场条件对大桥静风稳定性的影响,分析各工况下主梁的静风变形与跨中处拉索刚度变化。研究结果表明:与均匀风场条件下的静风响应不同,非均匀风攻角或非均匀风速下主梁静风响应最大值点位于风荷载峰值点与跨中之间,在针对非均匀风场下大桥的静风稳定性分析时,应更注重静风响应最大值点而不是跨中处;非均匀风攻角下大桥的静风失稳临界风速要远低于均匀风攻角的静风失稳临界风速,且其静风稳定性能主要受最大风攻角而不是主跨部分非均匀风攻角的平均值来控制;非均匀风速下大桥的静风失稳临界风速主要由主跨部分的风速平均值和最大值共同影响;主梁的竖向位移和扭转角形状主要由风攻角因素来控制,而横向位移的变化规律相对较独立,其形状基本上以跨中线对称,且其值主要由风速因素来决定。

关键词：桥梁工程静风稳定 CFD 非均匀风速非均匀风攻角

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen Ning yan Hao ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors