检索结果-南通市图书馆

BmATAD3A mediates mitochondrial ribosomal protein expression to maintain the mitochondrial energy metabolism of the silkworm,Bombyx mori

引用

Insect Science 2025年第1期32卷 193-208页

作者： Zhanqi Dong Nachuan Liao yan Luo Ya Zhang Liang Huang Peng chen cheng Lu Minhui Pan State Key Laboratory of Resource Insects Southwest UniversityChongqingChina Key Laboratory of Sericultural Biology and Genetic Breeding Ministry of Agriculture and Rural AffairsSouthwest UniversityChongqingChina

ATAD3A is a mitochondrial membrane protein belonging to the ATPase family that contains the AAA+*** is widely involved in mitochondrial metabolism,protein transport,cell growth,development and other important life *** has previously been reported that the deletion of ATAD3A causes growth and development defects in humans,mice and Caenorhabditis *** delve into the mechanism underlying ATAD3A defects and their impact on development,we constructed a Bombyx mori ATAD3A(BmATAD3A)defect model in silkworm *** aim to offer a reference for understanding ATAD3A genetic defects and elucidating the molecular regulatory *** results showed that knockout of the BmATAD3A gene significantly affected the weight,survival rate,ATPase production and mitochondrial metabolism of individuals after 24 h of *** metabolomics and transcriptomics analysis further demonstrated that BmATAD3A knockout inhibits amino acid biosynthesis through the regulation of mitochondrial ribosomal protein ***,our findings indicate that BmATAD3A knockout impeded mitochondrial activity and ATPase synthesis and suppressed the mitochondrial oxidative phosphorylation pathway through *** mitochondrial ribosomal protein L11(BmmRpL11).These results provide novel insights into the molecular mechanisms involved in the inhibition of development caused by ATAD3A deficiency,offering a potential direction for targeted therapy in diseases associated with abnormal ATAD3A expression.

关键词： ATAD3A ATPase BmmRpL1l Bombyx mori mitochondrial ribosomal protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

引用

Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan chen yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Disease prediction by network information gain on a single sample basis

引用

Fundamental Research 2025年第1期5卷 215-227页

作者： yan, Jinling Li, Peiluan Li, Ying Gao, Rong Bi, cheng chen, Luonan School of Mathematics and Statistics Henan University of Science and Technology Luoyang 471023 China Key Laboratory of Information Fusion Technology of Ministry of Education School of Automation Northwestern Polytechnical University Xi'an 710072 China Longmen Laboratory Henan Luoyang 471003 China Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Chinese Academy of Sciences Hangzhou 310024 China Guangdong Institute of Intelligence Science and Technology Guangdong Hengqin Zhuhai 519031 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China

There are critical transition phenomena during the progression of many diseases. Such critical transitions are usually accompanied by catastrophic disease deterioration, and their prediction is of significant importance for disease prevention and treatment. However, predicting disease deterioration solely based on a single sample is a difficult problem. In this study, we presented the network information gain (NIG) method, for predicting the critical transitions or disease state based on network flow entropy (NFE) from omics data of each individual. NIG can not only efficiently predict disease deteriorations but also detect their dynamic network biomarkers (DNBs) on an individual basis and further identify potential therapeutic targets. The numerical simulation demonstrates the effectiveness of NIG. Moreover, our method was validated by successfully predicting disease deteriorations and identifying their potential therapeutic targets from four real omics datasets, i.e., an influenza dataset and three cancer datasets. © 2023

关键词： Disease prediction Drug target Dynamic network biomarker Network flow entropy Network information gain Tipping point

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trinuclear gold-catalyzed site-selective alkylation of peptides

引用

Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang chengyihan Gu Yinghan chen Wencheng yan Yong Liang Weipeng Li chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China

Selective modification of peptides has always been a challenging *** selective alkylation of peptides can alter the biological activity and physical properties of molecules,and it has gained significant research *** herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis.A wide range of structurally diverse primary,secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with theα-C(sp^(3))–H in glycine residue of *** protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups.A series of relay transformations to construct cyclic peptides,to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic *** addition,mechanistic studies and density functional theory(DFT)calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET)mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

引用

Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali chen Yiyang Li Xingping Quan Jinfen chen yan Han Li yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Achievable dual-strategy to stabilize Li-rich layered oxide interface by a one-step wet chemical reaction towards long oxygen redox reversibility

引用

Journal of Energy Chemistry 2025年第2期101卷 120-131页

作者： Bin He Yujie Dai Shuai Jiang Dawei chen Xilong Wang Jie Song Dan Xiao Qian Zhao yan Meng Wei Feng School of Mechanical Engineering Chengdu University Chongqing Institute of Metrology and Quality Inspection Institute of New Energy and Low-Carbon Technology Sichuan University

Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide（LLO）,leading to voltage and capacity ***,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room *** functional theory（DFT） calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry（DEMS） indicates that the CrxB complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li+migration,The voltage and capacity fading of the modified cathode（LLO-CrB） are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface（CEI） composed of balanced organic/inorganic ***,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g-1（with a retention rate of 95.1%）.This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.

关键词： Interfacial oxygen Lithium-rich layered oxide cathode Local gradient doping One-step wet chemical reaction Surface coating

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in Wide-Range Temperature Metal-CO_(2)Batteries:A Mini Review

引用

Nano-Micro Letters 2025年第4期17卷 435-453页

作者： Xuejing Zhang Ning Zhao Hanqi Zhang Yiming Fan Feng Jin Chunsheng Li yan Sun Jiaqi Wang Ming chen Xiaofei Hu School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003People’s Republic of China Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi’an Jiaotong UniversityXi’an 710049People’s Republic of China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China School of Chemistry and Life SciencesSuzhou University of Science and TechnologySuzhou 215009People’s Republic of China Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002People’s Republic of China

The metal-carbon dioxide batteries,emerging as high-energy-density energy storage devices,enable direct CO_(2)utilization,offering promising prospects for CO_(2)capture and utilization,energy conversion,and ***,the electrochemical performance of M-CO_(2)batteries faces significant challenges,particularly at extreme *** such as high overpotential,poor charge reversibility,and cycling capacity decay arise from complex reaction interfaces,sluggish oxidation kinetics,inefficient catalysts,dendrite growth,and unstable *** significant advancements at room temperature,limited research has focused on the performance of M-CO_(2)batteries across a wide-temperature *** review examines the effects of low and high temperatures on M-CO_(2)battery components and their reaction mechanism,as well as the advancements made in extending operational ranges from room temperature to extremely low and high *** discusses strategies to enhance electrochemical performance at extreme temperatures and outlines opportunities,challenges,and future directions for the development of M-CO_(2)batteries.

关键词： M-CO_(2)batteries Wide-range temperature Electrolytes Interfaces Electrode reactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

引用

Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang yan Wang Yueyang Liu Guoliang chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health Sciences National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University Shenyang Key Laboratory of Vascular Biology Science and Research Center Department of Pharmacology Shenyang Medical College Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University

Ischemic stroke(IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc.(commonly known as Japanese knotweed), has been recognized for its potent neuroprotective ***, the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl) quinoline(RV02), against ischemic stroke remains inadequately explored. This study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in vivo. The research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic conditions. The findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS) through mitophagy activation. Furthermore, Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in vitro. These results suggest that RV02 shows promise as a neuroprotective agent, with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3,5-dimethoxystyryl) quinoline Ischemic stroke Mitophagy Parkin Resveratrol

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The upper tropospheric-lower stratospheric ozone drives summer precipitation and wildfire changes in West Siberia

引用

Science Bulletin 2025年第2期70卷 255-262页

作者： Fei Xie yan Xia Wenshou Tian Martyn P.Chipperfield Wuhu Feng Ke gui Yingli Niu Na Liu Yuanyuan Han School of Systems Science Beijing Normal UniversityBeijing 100875China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China School of Earth and Environment University of LeedsLeedsLS29JTUK National Centre for Earth Observation University of LeedsLeedsLS29JTUK National Centre for Atmospheric Science University of LeedsLeedsLS29PHUK State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Textile Chemical Engineering Auxiliaries School of Environmental and Chemical EngineeringXi’an Polytechnic UniversityXi’an 710048China

Siberian wildfires are pivotal in determining the carbon cycle and climate dynamics,exerting a profound impact on the ecosystems of the entire Arctic *** the past few decades,variations in summer precipitation in West Siberia have significantly influenced wildfire *** study analyzed precipitation trends in West Siberia from 1982 to 2021 using observations and transient simulations,uncovering a strong correlation between precipitation variability and ozone concentrations in the upper troposphere-lower stratosphere(UTLS).Heightened UTLS ozone levels warm the upper atmosphere over West Siberia during *** warming modifies the regional polar jet stream,intensifying its southern branch and weakening the northern one,leading to a southward shift in the jet ***,cyclonic circulation anomalies emerge in the upper troposphere,characterized by a barotropic structure with unusual upward movements around 60°*** upward motion triggers corresponding anomalies in zonal winds in the lower troposphere,fostering a low-pressure system at the *** atmospheric shift results in an influx of warm,moist air from the south and cold,dry air from the north into Siberia,enhancing cloud formation and ***,our analysis suggests that the rise in summer precipitation in West Siberia between 1993 and 2010 is linked to increased UTLS ozone concentrations during this ***,the decline in UTLS ozone since 2010 may increase the risk of wildfires by suppressing *** findings underscore the pivotal role of stratospheric chemistry in shaping the regional climate and wildfire behavior.?2024 Science China *** by Elsevier *** Science China *** rights are reserved,including those for text and data mining,AI training,and similar technologies.

关键词： Upper troposphere-lower stratosphere Ozone Radiative effect Precipitation Siberia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Late Cenozoic transtensional fault belt discovered on the boundary of the Awati Sag in the northwestern Tarim Basin

Late Cenozoic transtensional fault belt discovered on the bo...

引用

中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： Yue?Jun Li Qiang Zhang Guang?Ya Zhang Hai?Jun yang Xian?Zhang yang Jun Shi Yuan Neng yan?gui chen Lei Wen Institute of Geology and Geophysics Chinese Academy of Sciences Research Institute of Petroleum Exploration and Development Petro China Tarim Oilield Company PetroChina

Late Cenozoic transtensional fault belt was discovered on Shajingzi fault belt,NW boundary of the Awati Sag in the northwestern Tarim *** numerous Quaternary normal faults were discovered on Aqia and Tumuxiuke fault belts,SW boundary of *** discovery reveals Quaternary normal fault activity in the Tarim Basin for the irst *** is also a new discovery in the southern flank of Tianshan *** transtensional fault belt is made up of numerous,small normal ***,the normal faults are arranged in right-step,en echelon patterns along the preexisting Shajingzi basement fault,forming a sinistral transtensional normal fault *** proile,they cut through the Paleozoic to the mid-Quaternary and combine to form negative flower *** Late Cenozoic normal faults on the SW boundary of Awati Sag were distributed mainly in the uplift side of the preexisting Aqia and Tumuxiuke basement-involved faults,and combined to form small horst and graben structures in *** on the intensive seismic interpretation,careful fault mapping,and growth index analysis,we conclude that the normal fault activity of Shajingzi transtensional fault belt began from Late Pliocene and ceased in Late Pleistocene(mid-Quaternary).And the normal faulting on the SW boundary of Awati Sag began from the very beginning ofQuaternary and ceased in *** normal faulting on Awati’s SW boundary began a little later than those on the NW *** origin of Shajingzi transtensional normal fault belt was due to the left-lateral strike-slip occurred in the southern flank of Tianshan,and then,due to the eastward escape of the Awati block,a tensional stress developed the normal faults on its SW boundary.

关键词： Pliocene–Pleistocene normal fault Late Cenozoic transtensional normal fault belt Left-lateral strike-slip Awati Sag Northwestern Tarim Basin Southern flank of Tianshan Mountains Seismic interpretation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：