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Shining in the dark:the big world of small peptides in plants

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aBIOTECH 2023年第3期4卷 238-256页

作者： yan-zhao feng Qing-feng Zhu Jiao Xue Pei Chen yang Yu Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Key Laboratory of South China Modern Biological Seed IndustryMinistry of Agriculture and Rural AffairsAgro-Biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640China

Small peptides represent a subset of dark matter in plant *** differential expression patterns and modes of action,small peptides act as important regulators of plant growth and devel*** the past 20 years,many small peptides have been identified due to technical advances in genome sequencing,bioinformatics,and chemical *** this article,we summarize the classifi-cation of plant small peptides and experimental strategies used to identify them as well as their potential use in agronomic *** review the biological functions and molecular mechanisms of small peptides in plants,discuss current problems in small peptide research and highlight future research directions in this *** review provides crucial insight into small peptides in plants and will contribute to a better understanding of their potential roles in biotechnology and agriculture.

关键词： Small peptide Biological function Regulatory mechanism Crop improvement

A novel X-ray tube spectra reconstruction method based on transmission measurements

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Nuclear Science and Techniques 2016年第2期27卷 73-78页

作者： Jing Cao Chun-Yu Jiang yan-feng zhao Qing-Wei yang Ze-Jie Yin State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China Southwestern Institute of Physics Chengdu 610041 China

A novel X-ray tube spectrum reconstruction method has been proposed based on transmission measurements. Aluminum bars of varying lengths attenuate the X-rays to different levels. The detectors are of lutetium yttrium oxyorthosilicate scintillator and silicon photomultiplier. With the detected X-ray intensities, the X-ray spectrum is unfolded using the least square method. The detectors, aluminum bars, and collimating apertures are integrated in a detection module made of lead. Its response to X-ray is calculated by Monte Carlo codes Geant4. Due to the high photon flux, the detectors work in current *** electronics system, consisting of 24-bit high-precision ADCs with 144 KSPS sampling rate and field programmable gate array, makes the data acquisition process effective and precise. Measurements on a 70-k Vp tungsten anode X-ray were taken to verify the method. The unfolded spectrum agrees well with the simulated spectrum,demonstrating that the method is reliable and practical.

关键词： X射线管重建方法传输测量光谱现场可编程门阵列透射 Geant4 蒙特卡罗程序

Influence of Cu content on the mechanical properties and corrosion resistance of Mg-Zn-Ca bulk metallic glasses

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International Journal of Minerals,Metallurgy and Materials 2014年第5期21卷 487-493页

作者： yan-feng zhao Jian Zhu Li Chang Jing-guo Song Xiao-hua Chen Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

（***28.8Cas）10o-xCux （at%, x = 0, 1, 3, and 5） bulk metallic glasses （BMGs） of 2 mm in diameter were prepared by the conventional copper mold injection casting method. Besides, the influence of Cu content on the microstructure, thermal stability, mechanical properties, and corrosion behavior of Mg-Zn--Ca BMGs was investigated. It is found that the addition of Cu decreases the glass-forming ability of Mg-Zn-Ca BMGs. Crystalline phases are precipitated at a higher Cu content, larger than 3at%. The compressive fracture strength of Mg-Zn-Ca BMGs is enhanced by the addition of Cu. With the formation of in-situ composites, the compressive strength of the Mg-Zn-Ca alloy with 3at% Cu reaches 979 MPa, which is the highest strength among the Mg-Zn-Ca alloys. Furthermore, the addition of Cu also results in the increase of corrosion potential and the decrease of corrosion current density in Mg-Zn-Ca BMGs, thereby delaying their biodegradability.

关键词： metallic glass glass-forming ability compressive strength corrosion thermal stability

Clinical and microbiological characteristics of patients with biliary disease

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World Journal of Gastroenterology 2020年第14期26卷 1638-1646页

作者： Xue-Xiang Gu Meng-Pei Zhang yan-feng zhao Guang-Ming Huang Department of Gastroenterology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuaian 223001Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Center of Laboratory Medicine The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina

BACKGROUND Biliary diseases are common digestive system disorders which may combine with biliary tract infection such as cholecystitis or ***,rapid identification of the bacteria and their antibiotic susceptibility profiles are crucial for reducing the mortality of patients with biliary tract *** To identify bacterial species and antibiotic susceptibility for antibacterial therapy and analyze bile cultivation risk factors for increasing detection *** This retrospective study was conducted from July 2008 to July *** total,1339 bile samples which were collected during therapeutic endoscopic retrograde cholangiopan-creatography or percutaneous transhepatic cholangiodrainage or other biliary surgeries or biliary drainage were obtained to characterize pathogen spectra,antibiotic susceptibility,and clinical *** data including age,sex,comorbidities,clinical symptoms,protopathies,and history of biliary tract diseases and surgeries were collated from hospital medical *** identification and initial drug susceptibility were further identified by biochemical characterization using the VITEK 2 Compact *** Positive microbiological findings were observed in 738 *** most frequently encountered strains were gram-negative bacteria(74.94%),including Escherichia coli(37.78%),Pseudomonas aeruginosa(8.96%),and Klebsiella pneumoniae(10.29%).Bile bacteria were largely sensitive to carbapenems,piperacillin/tazobactam,and ***-negative strains had low susceptibility to ceftriaxone,quinolones and *** the same microorganisms were present in patients with malignant and benign *** number of samples with Klebsiella pneumoniae in the bile culture were significantly different between patients with malignant and benign diseases(55 vs 30;P=0.019).Age(P<0.001),fever(P<0.001),history of biliary tract diseases and surgeries(both P<0.001),benign disease(P=0.002),and the comorbidity chronic re

关键词： Microorganism Antibiotic susceptibility Bile culture Biliary diseases Retrospective study Detection rate

The Grey Analysis, Kriging and Selection Index of Flower Yield in Rugosa Rose

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Agricultural Sciences in China 2007年第12期6卷 1420-1425页

作者： LI yan-yan feng Zhen zhao Lan-yong MO Zhen-hua ZHANG Bao College of Forestry Shandong Agricultural University Tai＇an 271018 P. R. China

The analysis of grey system, kriging interpolation, and integration selection index were employed to investigate the relationships between the flower yield/plant （FY） and 15 other quantitative traits of 20 rugosa rose cultivars. The result showed that： The grey relational grade （GRG） of the number of flowers/plant （NF）, the number of branches/plant （NB）, the width of floral bud （WB）, and the weight/flower （WF） to the FY were larger （〉 0.5）; FY improved with the increase of NF and NB. Moreover, the indirect selection of either trait could not achieve improvement of FY. It is necessary to improve FY by multi-trait selection. The integration selection index （ISI） equation of FY was established with the characters NF, NB, WB, and WF： I= 0.3187x1 - 318.6x2 ＋ 670.1 x4 ＋ 6.3xa, index heritability = 0.8014, selective response of the integration breeding value = 245.8811. This will provide a theoretic basis for the genetic breeding of rugosa rose.

关键词： rugosa rose grey relational grade quantitative traits kriging interpolation index selection

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数字图像相关方法散斑质量的评价

价值工程 2024年第26期43卷 133-135页

作者：李芹涛郑洁王秀会冯延昭刘同莱州汇金矿业投资有限公司烟台261400 中国矿业大学(北京) 北京100083

作为试件变形信息的载体,散斑图质量好坏直接影响到数字图像相关法(DIC)的测量结果。因此,如何定量评价散斑图的优劣是数字图像相关方法测量精度提高的关键所在。针对此问题,本文基于灰度分布直方图、平均尺寸、平均灰度梯度与平均灰度... 详细信息

作为试件变形信息的载体,散斑图质量好坏直接影响到数字图像相关法(DIC)的测量结果。因此,如何定量评价散斑图的优劣是数字图像相关方法测量精度提高的关键所在。针对此问题,本文基于灰度分布直方图、平均尺寸、平均灰度梯度与平均灰度等散斑特征参数进行多维度分析,遴选最优散斑,并通过零位移实验验证,为DIC测量精度的提高提供参考依据。

关键词：数字图像相关法灰度分布直方图平均灰度梯度平均灰度平均尺寸最优散斑

Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3697-3710页

作者： Chongzheng yan Huaiyou Lv Yafei feng Yuhan Li Zhongxi zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Department of Pharmacy Yantai Yuhuangding Hospital Affiliated to Qingdao UniversityYantai 264001China

Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is ***,an inhalable nanodevice(CLDCu)is constructed to successfully overcome the drawbacks of *** consists of a Cu^(2+)-chitosan shell and low molecular weight heparin-tocopherol succinate(LMWH-TOS,LT)core with disulfiram(DSF)*** prepared CLDCu can be inhaled and accumulate in large amounts in lung lesions(63.6%)with 56.5 times higher than intravenous *** tumor cells,the mild acidity triggers the co-release of DSF and Cu2+,thus generating bis(diethyldithiocarbamate)-copper(CuET)to block Cu^(+)efflux protein ATP7B and forming toxic Cu^(+),leading to enhanced ***,the released chitosan cooperates with CLDCu-induced cuproptosis to activate stimulator of interferon genes(STING)pathway,which significantly potentiates dendritic cells(DCs)maturation,as wells as evokes innate and adaptive *** lung metastatic mice model,CLDCu is found to induce cuproptosis and reverse the immunosuppressive TME by inhalation ***,CLDCu combined with anti-programmed cell death protein ligand-1 antibody(aPD-L1)provokes stronger antitumor ***,nanomedicine that combines cuproptosis with STING activation is a novel strategy for tumor immunotherapy.

关键词： Cuproptosis cGAS-STING activation Disulfiram Inhalation administration Tumor microenvironment PD-L1 checkpoint blockade Lung metastasis Immunotherapy

A real-time intelligent lithology identification method based on a dynamic felling strategy weighted random forest algorithm

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Petroleum Science 2024年第2期21卷 1135-1148页

作者： Tie yan Rui Xu Shi-Hui Sun zhao-Kai Hou Jin-Yu feng School of Petroleum Engineering Northeast Petroleum UniversityDaqing163318HeilongjiangChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya572025HainanChina

Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face many challenges. This paper studies the problems of difficult feature information extraction,low precision of thin-layer identification and limited applicability of the model in intelligent lithologic identification. The author tries to improve the comprehensive performance of the lithology identification model from three aspects: data feature extraction, class balance, and model design. A new real-time intelligent lithology identification model of dynamic felling strategy weighted random forest algorithm(DFW-RF) is proposed. According to the feature selection results, gamma ray and 2 MHz phase resistivity are the logging while drilling(LWD) parameters that significantly influence lithology identification. The comprehensive performance of the DFW-RF lithology identification model has been verified in the application of 3 wells in different areas. By comparing the prediction results of five typical lithology identification algorithms, the DFW-RF model has a higher lithology identification accuracy rate and F1 score. This model improves the identification accuracy of thin-layer lithology and is effective and feasible in different geological environments. The DFW-RF model plays a truly efficient role in the realtime intelligent identification of lithologic information in closed-loop drilling and has greater applicability, which is worthy of being widely used in logging interpretation.

关键词： Intelligent drilling Closed-loop drilling Lithology identification Random forest algorithm Feature extraction

H-and J-aggregation of conjugated small molecules in organic solar cells

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Journal of Energy Chemistry 2024年第6期93卷 174-192,I0005页

作者： Qiaoqiao zhao feng He State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353ShangdongChina Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055GuangdongChina

As H-and J-aggregation receive more and more attention in the research of organic solar cells(OSCs),especially in small molecular systems,deep understanding of aggregation behavior is needed to guide the design of conjugated small molecular structure and the fabrication process of OSC *** this end,this review is ***,the review firstly introduced the basic information about H-and J-aggregation of conjugated small molecules in ***,the characteristics of H-and J-aggregation and the methods to identify them were ***,it reviewed the research progress of H-and J-aggregation of conjugated small molecules in OSCs,including the factors influencing H-and J-aggregation in thin film and the effects of H-and J-aggregation on OPV performance.

关键词： H-aggregation J-aggregation Organic solar cells Small molecules Efficiency Stability