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Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3697-3710页

作者： Chongzheng yan Huaiyou lv Yafei feng Yuhan Li Zhongxi Zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Department of Pharmacy Yantai Yuhuangding Hospital Affiliated to Qingdao UniversityYantai 264001China

Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is ***,an inhalable nanodevice(CLDCu)is constructed to successfully overcome the drawbacks of *** consists of a Cu^(2+)-chitosan shell and low molecular weight heparin-tocopherol succinate(LMWH-TOS,LT)core with disulfiram(DSF)*** prepared CLDCu can be inhaled and accumulate in large amounts in lung lesions(63.6%)with 56.5 times higher than intravenous *** tumor cells,the mild acidity triggers the co-release of DSF and Cu2+,thus generating bis(diethyldithiocarbamate)-copper(CuET)to block Cu^(+)efflux protein ATP7B and forming toxic Cu^(+),leading to enhanced ***,the released chitosan cooperates with CLDCu-induced cuproptosis to activate stimulator of interferon genes(STING)pathway,which significantly potentiates dendritic cells(DCs)maturation,as wells as evokes innate and adaptive *** lung metastatic mice model,CLDCu is found to induce cuproptosis and reverse the immunosuppressive TME by inhalation ***,CLDCu combined with anti-programmed cell death protein ligand-1 antibody(aPD-L1)provokes stronger antitumor ***,nanomedicine that combines cuproptosis with STING activation is a novel strategy for tumor immunotherapy.

关键词： Cuproptosis cGAS-STING activation Disulfiram Inhalation administration Tumor microenvironment PD-L1 checkpoint blockade Lung metastasis Immunotherapy

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Control of chiral-optical activities by magnetic field based on the transformation of achiral binary crystals into chiral ternary crystals

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Science China Chemistry 2024年第7期67卷 2300-2305页

作者： Zhiyan Chen yan lv Wei Qin College of Physics Qingdao UniversityQingdao 266071China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Linuo Photovoltaic Hi-Tech Co. Ltd.Jinan 250100China

Multicomponent self-assembled chiral systems have attracted great attention due to their promising application in the area of spin-photonics and *** this work,through introducing an achiral third component into an achiral binary crystal,a chiral organic ternary crystal is fabricated,where both pronounced chiral-optical coupling and magnetic field dependence of chiral-optical activities are *** transformation of achiral structure into chiral structure generates a significant effect on the polarized state of light and the electron spin resonance ***,the coupling between circularly polarized photon and spin is observed in chiral ternary crystal with pronounced chiral orbit,where obvious magnetic field-transmissivity loop is ***,temperature could increase the magnitude of lattice parameters to lead to a larger helix radius to increase the chiral orbit ***,this work indicates that the further exploration of photon-chiral orbit-spin interactions in organic chiral ternary crystals is promising.

关键词： organic chiral ternary crystals chiral orbit chiral-optical activities magnetic field

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Experimental signature of topological superconductivity and Majorana zero modes on β-Bi2Pd thin films

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Science Bulletin 2017年第12期62卷 852-856页

作者： yan-feng lv Wen-Lin Wang Yi-Min Zhang Hao Ding Wei Li Lili Wang Ke He Can-Li Song Xu-Cun Ma Qi-Kun Xue State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghuo UniversityBeijing 100084China Collaborative Innovation Center of Quantum Matter Beijing 100084China

The search for Majorana fermions in topological superconductors is one of paramount research targets in physics today. Using a cryogenic scanning tunneling microscopy, we here report the signature of topologically nontrivial superconductivity on a single material of β-Bi_2Pd films grown by molecular beam epitaxy. The superconducting gap associated with spinless odd-parity pairing opens on the surface and appears much larger than the bulk one due to the Dirac-fermion enhanced parity mixing of surface pair potential. Zero bias conductance peaks, probably from Majorana zero modes supported by such superconducting states, are identified at magnetic vortices. The superconductivity exhibits resistance to nonmagnetic defects, characteristic of time-reversal-invariant topological superconductors. Our study reveals β-Bi_2Pd as a prime platform to generate, manipulate and braid Majorana zero modes for quantum computation.

关键词： jEpitaxial β-Bi2Pd filmsMolecular beam epitaxyTopological superconductivityMajorana zero modesScanning tunneling microscopy

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Rupture of a giant jejunal mesenteric cystic lymphangioma misdiagnosed as ovarian torsion: A case report

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World Journal of Clinical Cases 2024年第4期12卷 847-852页

作者： Jing Xu Tie-feng lv Department of Hepatopathy Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Cystic lymphangioma is a rare benign tumor that affects the lymphatic *** lymphangiomas in the small bowel are extremely *** SUMMARY We present a 21-year-old female patient who complained of abdominal *** diagnosis of ovarian torsion was suspected after abdominopelvic unenhanced computed tomography and ultrasound revealed a large cyst in contact with the bladder,ovary,and *** patient underwent emergency laparotomy per-formed by gynecologists,but it was discovered that the cystic tumor originated from the *** surgeons were then called in to perform a *** examination confirmed the diagnosis of cystic lymphangioma of the *** patient had an uneventful postoperative *** Mesenteric lymphangiomas can cause abdominal pain,and imaging techniques can help determine their characteristics,location,and *** surgical excision and pathological examination are considered the standard treatment and diagnostic method.

关键词： Rupture Jejunum Mesenteric cystic lymphangioma Ovarian torsion Surgical excision Pathological examination Case report

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Distributed Minimum-Energy Containment Control of Continuous-Time Multi-Agent Systems by Inverse Optimal Control

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1533-1535页

作者： Fei yan Xiangbiao Liu Tao feng School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Chengdu 611756China

Dear Editor,This letter focuses on the distributed optimal containment control of continuous-time multi-agent systems(CTMASs)with respect to the minimum-energy performance index over fixed *** achieve this,we firstly investigate the optimal containment control problem using the inverse optimal control method,where all states of followers asymptotically converge to the convex hull spanned by the leaders while some quadratic performance indexes get minimized.A sufficient condition for existence of the distributed optimal containment control protocol is *** introducing the parametric algebraic Riccati equation(PARE),it is strictly proved that the global performance index can be used to approximate the standard minimumenergy performance index as the parameters tends to *** consequence,the standard minimum-energy cooperative containment control can be solved by local steady state feedback protocols.

关键词： optimal infinity algebraic

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Exceptional reversed yield strength asymmetry in a rare-earth free Mg alloy containing quasicrystal precipitates

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Journal of Magnesium and Alloys 2024年第2期12卷 687-699页

作者： Qiang yang Shuhui lv Zixiang yan Zefeng Xie Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China

This work reports an exceptional reversed yield strength asymmetry at room temperature for a rare-earth free magnesium alloy containing a mass of fine dispersed quasicrystal(I-phase)*** exhibiting traditional basal texture,it owns an exceptional CYS/TYS as high as~*** back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)examinations indicate pyramidal and prismatic dislocations plus tensile twinning being activated after immediate yielding in compression while basal and non-basal dislocations in tension.I-phase particles transferred the concentrated stress by self-twinning to provide the driving force for tensile twin initiating in neighboring grains,thereby significantly increasing the critical resolved shear stress of tensile twinning to possibly the level of pyramidal slip,finally leading to the dominance of pyramidal slip plus tensile twinning in texture *** results in a higher contribution on yield strength by~55 MPa in compression than in tension,which reasonably agrees with the experimental yield strength difference(~38 MPa).It can be concluded that I-phase particles influence deformation modes in tension and in compression,finally result in reversed yield strength asymmetry.

关键词： Magnesium alloy Reversed yield strength asymmetry Transmission electron microscopy(TEM) Twinning Dislocations

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Defect-induced synthesis of nanoscale hierarchically porous metal-organic frameworks with tunable porosity for enhanced volatile organic compound adsorption

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Nano Materials Science 2024年第4期6卷 467-474页

作者： Kuan Liang Weibiao Guo Linmei Li Huidong Cai Haiqi Zhang Jingjing Li feng Xu Jian yan Daofei lv Hongxia Xi Chongxiong Duan Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing Foshan University School of Materials Science and Hydrogen Engineering Foshan University School of Chemistry and Chemical Engineering South China University of Technology School of Environmental and Chemical Engineering Foshan University

Nanoscale hierarchically porous metal-organic frameworks （NH-MOFs） synergistically combine the advantages of nanoscale MOFs and hierarchically porous MOFs,resulting in remarkable characteristics such as increased specific surface area,greater porosity,and enhanced exposure of active ***,nanoscale hierarchically porous UIO-66 （UIO-66＿X） was synthesized using a defect-induced strategy that employed ethylene diamine tetraacetic acid （EDTA） as a *** introduced EDTA occupies the coordination sites of organic ligands,promoting the formation and growth of UIO-66 crystal nuclei and inducing defects during *** as-synthesized UIO-66＿X crystals exhibit a uniform distribution with an average size of approximately 100 *** addition,the total pore volume attains a remarkable value of 0.95 cm3g-1,with mesopores constituting 36.8%of the ***,the porosities of UIO-66＿X can be easily tuned by controlling the molar ratio of EDTA/Zr4+.In addition,the as-synthesized UIO-66＿X exhibits excellent adsorption capacities for n-hexane (344 mg g-1) and pxylene (218 mg g-1),which are 44.5%and 27.5%higher than those of conventional UIO-66,***,the adsorption behavior of n-hexane and p-xylene molecules in UIO-66＿X was investigated using density functional theory simulations.

关键词： Nanoscale hierarchically porous MOFs Tunable porosities Enhanced VOC adsorption

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Theoretical and experimental investigation of the resonance responses and chaotic dynamics of a bistable laminated composite shell in the dynamic snap-through mode

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 581-602页

作者： Meiqi WU Pengyu lv Hongyuan LI Jiale yan Huiling DUAN Wei ZHANG State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China Nanchang Innovation Institute of Peking University Nanchang 330096China Department of Mechanics Guangxi UniversityNanning 530004China

The dynamic model of a bistable laminated composite shell simply supported by four corners is further developed to investigate the resonance responses and chaotic *** existence of the 1:1 resonance relationship between two order vibration modes of the system is *** resonance response of this class of bistable structures in the dynamic snap-through mode is investigated,and the four-dimensional(4D)nonlinear modulation equations are derived based on the 1:1 internal resonance relationship by means of the multiple scales *** Hopf bifurcation and instability interval of the amplitude frequency and force amplitude curves are *** discussion focuses on investigating the effects of key parameters,e.g.,excitation amplitude,damping coefficient,and detuning parameters,on the resonance *** numerical simulations show that the foundation excitation and the degree of coupling between the vibration modes exert a substantial effect on the chaotic dynamics of the ***,the significant motions under particular excitation conditions are visualized by bifurcation diagrams,time histories,phase portraits,three-dimensional(3D)phase portraits,and Poincare ***,the vibration experiment is carried out to study the amplitude frequency responses and bifurcation characteristics for the bistable laminated composite shell,yielding results that are qualitatively consistent with the theoretical results.

关键词： bistable laminated composite shell dynamic snap-through mode Hopf bifurcation chaotic dynamics vibration experiment

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PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma

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Oncology Research 2024年第6期32卷 1063-1078页

作者： KUN feng HAO PENG QINGPENG lv YEWEI ZHANG Hepatopancreatobiliary Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Medical School Southeast UniversityNanjing210000China

Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable *** dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment *** elucidation of PHLDA2’s involvement in HCC is imperative,and the clinical value of PHLDA2 is also ***,bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of ***,the expression and function of PHLDA2 were examined via the qRT-PCR,Western Blot,and MTT *** findings indicate a substantial upregulation of PHLDA2 in HCC,correlated with a poorer *** methylation levels of PHLDA2 were found to be lower in HCC tissues compared to normal liver ***,noteworthy associations were observed between PHLDA2 expression and immune infiltration in *** addition,PHLDA2 upregulation is closely associated with stemness features and immunotherapy or chemotherapy resistance in *** vitro experiments showed that sorafenib or cisplatin significantly up-regulated PHLDA2 mRNA levels,and PHLDA2 knockdown markedly decreased the sensitivity of HCC cells to chemotherapy ***,we found that TGF-βinduced the expression of PHLDA2 in *** GSEA and in vitro experiment indicated that PHLDA2 may promote the HCC progression via activating the AKT signaling *** study revealed the novel role of PHLDA2 as an independent prognostic factor,which plays an essential role in TME remodeling and treatment resistance in HCC.

关键词： HCC Immune infiltration Drug resistance TME PHLDA2

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Introducing hydroxyl groups to tailor the d-band center of Ir atom through side anchoring for boosted ORR and HER

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Journal of Energy Chemistry 2024年第3期90卷 144-151,I0005页

作者： Qing lv Meiping Li Xiaodong Li Xingru yan Zhufeng Hou Changshui Huang Science Center for Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringInstitute of Frontier and Interdisciplinary ScienceShandong UniversityJinan 250100ShandongChina Institute of Chemistry Chinese Academy of ScienceBeijing 100191China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina

Tuning the coordination atoms of central metal is an effective means to improve the electrocatalytic activity of atomic ***,iridium(Ir) is proposed to be asymmetrically anchored by sp-N and pyridinic N of hydrogen-substituted graphdiyne(HsGDY),and coordinated with OH as an Ir atomic catalyst(Ir_(1)-N-HsGDY).The electron structures,especially the d-band center of Ir atom,are optimized by these specific coordination ***,the as-synthesized Ir_(1)-N-HsGDY exhibits excellent electrocatalytic performances for oxygen reduction and hydrogen evolution reactions in both acidic and alkaline *** from the unique structure of HsGDY,IrN_(2)(OH)_(3) has been developed and demonstrated to act as the active site in these electrochemical *** those indicate the fresh role of the sp-N in graphdiyne in producing a new anchor way and contributing to promote the electrocatalytic activity,showing a new strategy to design novel electrochemical catalysts.

关键词： Oxygen reduction reaction D-band center Graphdiyne Hydroxyl group Electrocatalysis

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