检索结果-南通市图书馆

Efficient Synthesis of Dicycloalkenopyridines:One-pot Multicomponent Condensation of Aldehydes with Cyclic Ketones

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2009年第5期25卷 657-661页

作者： CAI Xi-mei WANG Qi-fang yan Chao-guo College of Chemistry ＆ Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China

Under microwave irradiation, the one-pot multicomponent condensation reaction of three moles of aromatic aldehydes with two moles of cyclic ketones having free a,a＇-methylene positions such as cyclopentanone or cyclohexanone in the presence of ammonium acetate and acetic acid afforded dicycloalkenopyridines with two a-arylidene groups in high yields. Under the similar reaction condition, the reaction of aromatic aldehydes with 1-tetralone having only one a-methylene position alternatively resulted in 10-aryl-2,3：5,6-dibenzoacridines.

关键词： Pyridine Acridine Microwave irradiation Aromatic aldehyde Cyclic ketone Aldol condensation

Electrochemical Determination of Epinephrine with a Pyrolytic Graphite Electrode in the Presence of Ascorbic Acid and Dopamine

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第5期17卷 657-660页

作者： Xiu Hui LIU yan ZHANG guo fang ZUO Xiao Quan LU College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070

A method for determination of epinephrine（EP） in the presence of ascorbic acid （AA） and dopamine （DA） with bare pyrolytic graphite electrodes has been described for the first time. In pH 7.0 phosphate buffer solution, the linear relationship was observed between the reduction peak current of EP and its concentration over the range from 1×10^-4 to 5×10^-7 mol/L, the related coefficient is 0.9992 （N=8）.

关键词： Differential pulse voltammetry epinephrine ascorbic acid dopamine pyrolytic graphite electrodes

Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第42期23卷 7584-7593页

作者： Cheng-Xing Long Lu He yan-fang guo Ya-Wei Liu Nen-Qun Xiao Zhou-Jin Tan Department of Microbiology Hunan University of Chinese Medicine College of Mathematics and Finance Hunan University of HumanitiesScience and Technology Loudi 417000Hunan Province China

AIM To investigate the diversity of bacterial lactase genes in the intestinal contents of mice with antibiotics-induced *** Following 2 d of adaptive feeding, 12 specific pathogenfree Kunming mice were randomly divided into the control group and model group. The mouse model of antibiotics-induced diarrhea was established by gastric perfusion with mixed antibiotics(23.33 m L·kg^(-1)·d^(-1)) composed of gentamicin sulfate and cephradine capsules administered for 5 days, and the control group was treated with an equal amount of sterile water. Contents of the jejunum and ileum were then collected and metagenomic DNA was extracted, after which analysis of bacterial lactase genes using operational taxonomic units(OTUs) was carried outafter amplification and *** OTUs were 871 and 963 in the model group and control group, respectively, and 690 of these were identical. There were significant differences in Chao1 and ACE indices between the two groups(P < 0.05). Principal component analysis, principal coordination analysis and nonmetric multidimensional scaling analyses showed that OTUs distribution in the control group was relatively intensive, and differences among individuals were small, while in the model group, they were widely dispersed and more diversified. Bacterial lactase genes from the intestinal contents of the control group were related to Proteobacteria, Actinobacteria, Firmicutes and unclassified bacteria. Of these, Proteobacteria was the most abundant phylum. In contrast, the bacterial population was less diverse and abundant in the model group, as the abundance of Bradyrhizobium sp. BTAi1, Agrobacterium sp. H13-3, Acidovorax sp. KKS102, Azoarcus sp. KH32 C and Aeromonas caviae was lower than that in the control group. In addition, of the known species, the control group and model group had their own unique genera, *** Antibiotics reduce the diversity of bacterial lactase genes in the intestinal contents, decreas

关键词： Antibiotics-induced diarrhea Lactase genes Gene diversity Intestinal bacteria High-throughput sequencing

Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第21期121卷 2124-2128页

作者： ZHANG Wei XU yan-cheng guo fang-jian MENG Ye LI Ming-li Department of Endocrinology Zhongnan Hospital ot Wunan University Wuhan Hubei 430071 China

Background Retinol binding protein 4 （RBP4）, as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 （GLUT4） in insulin resistance （IR） state and to have an intimate relationship with IR and type 2 diabetes mellitus （T2DM）. The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde （Cin）, berberine （Ber）, and metformin （Met） as well as their impacts on the RBP4-GLUT4 system. Methods Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups： the control group, the diabetes group, the diabetes＋Ber group, the diabetes＋Cin group, and the diabetes＋Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions （P 〈0.01） compared with the control group. Their effects on lowering fasting plasma glucose （FPG）, low density lipoprotein-cholesterol （LDL-C） and homeostasis model assessment of insulin resistance （HOMA-IR） seem even better than that of Met. Cin and Ber markedly lowered serum RBP4 levels and up-regulated the expression of tissue GLUT4 protein, and Cin seemed more notable in affecting these two proteins. Conclusions Both Cin and Ber display an exciting anti-diabetic efficacy in this study and may be of great value for the treatment of type 2 diabetes. Their mechanisms involve the RBP4-GLUT4 system, during which the serum RBP4 levels are lowered and the expression of tissue GLUT4 protein is up-regulated.

关键词： cinnamaldehyde berberine type 2 diabetes meUitus insulin resistance retinol binding protein 4 glucose transporter 4

Sex discrepancy characterization revealed by somatic DNA alterations in muscle-invasive bladder carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第20期132卷 2492-2494页

作者： Tian-Zhi Wu Cheng-Yong Lei Jin-Ming Li yan-fang guo Institute of Bioinformatics School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the editor: Bladder cancer exhibits significant sex differences in incidence, diagnosis, management, and survival.[1] The incidence of bladder cancer in males is approximately three-fold higher than that in females. Although women are generally less likely to develop bladder cancer than men, once females acquire this disease, the prognosis is less favorable. However, the molecular basis of these sex disparities in bladder cancer remains poorly understood. Studies suggest that bladder cancer has more somatic DNA alterations than almost any other cancer types, but the specific differences between males and females remain unknown.

关键词： bladder alterations prognosis

“花儿”的性禁忌(演唱空间的限制)与性话语表达——二元对立的阐释

在线全文

学校读者我要写书评

暂无评论

西北民族研究 2006年第3期 128-132页

作者：闫国芳新疆昌吉学院中文系

从“花儿”的性禁忌（演唱空间的限制）和性话语表达的二元对立模式中，我们可以看到，一方面性的话语被正统的主流文化压抑，另一方面它在民间被鼓励言说。“花儿”是人们在主流性话语抑制之下的一个突破口和情感的释放媒介。

关键词： “花儿” 性话语性禁忌

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

The linear self-attracting diffusion driven by the weighted-fractional Brownian motion II: The parameter estimation

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2025年

作者： Litan yan Rui guo Wenyi Pei Department of Statistics College of Science Donghua University School of Statistics and Mathematics Zhejiang Gongshang University

Let Ba,bbe a weighted-fractional Brownian motion with Hurst indexes a and b such that a>-1and 0≤b<1∧（1+a）.In this paper,we consider the linear self-attracting diffusion ■ interacting diffusion (see Cranston and Le Jan （1995）).Under the continuous observation,we study asymptotic ■ converges in distribution to the sum of the chi-square random variable with 1 degree of freedom and the random variable Z1a,b.

关键词：