检索结果-南通市图书馆

Metabolism-associated genes in occurrence and development of gastrointestinal cancer:Latest progress and future prospect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第8期13卷 758-771页

作者： yan-dong miao Lin-Jie Mu Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Affiliated Hospital Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

Gastrointestinal(GI)cancer remains one of the most prevalent cancers in the *** occurrence and progression of GI cancer involve multiple *** reprogramming is one of the hallmarks of cancer and is intricately related to *** metabolic genes are involved in the occurrence and development of GI *** approaches combining tumor genomics and metabolomics are more likely to provide deeper insights into this *** this paper,we review the roles of metabolism-associated genes,especially those involved in the regulation pathways,in the occurrence and progression of GI *** provide the latest progress and future prospect into the different molecular mechanisms of metabolism-associated genes involved in the occurrence and development of GI cancer.

关键词： Gastrointestinal cancer Gastric cancer Colorectal cancer Metabolismassociated genes

Comment on“Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第1期14卷 366-368页

作者： Xiao-Long Tang yan-dong miao Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Dean's Office Gansu Academy of Traditional Chinese MedicineLanzhou730000Gansu ProvinceChina

The present letter to the editor is in response to the research“Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”by Elshaarawy et al in World J Gastroenterol 2021;13(5):424–*** preoperative assessment of the liver reserve function in hepatocellular carcinoma(HCC)patients with cirrhosis is crucial,and there is no universal consensus on how to assess *** on a retrospective study,Elshaarawy et al investigated the impact of various classical clinical indicators on liver failure and the prognosis after hepatectomy in HCC patients with *** recommend that we should strive to explore new appraisal indicators,such as the indocyanine green retention rate at 15 min.

关键词： ICG-R15 Hepatectomy Cirrhosis Hepatocellular carcinoma

Comment on“Diagnostic approach to faecal incontinence:What test and when to perform?”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第33期27卷 5622-5624页

作者： Jiang-Tao Wang yan-dong miao Quan-Lin Guan The First Clinical Medical College of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Oncology The First Hospital of Lanzhou UniversityLanzhou UniversityLanzhou 730000Gansu ProvinceChina

We recently read with interest the article"Diagnostic approach to faecal incontinence:What test and when to perform?".This is a comprehensive and practical review,which has particular significance for guiding clinicians to improve the examination *** we appreciate their work very much,based on the in-depth analysis of this research,we found some detailed problems in the article and will give our comments in this *** the author can further improve the relevant research,it will be valuable.

关键词： Faecal Incontinence Manometry Diagnostic Pathophysiology Tools

Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第29期9卷 8671-8693页

作者： yan-dong miao Zhi-Yong Kou Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Colon adenocarcinoma(COAD)is one of the most common and fatal malignant tumors,which increases the difficulty of prognostic ***,new biomarkers for the diagnosis and prognosis of COAD should be *** is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide ***,the predictive value of ferroptosis-related genes(FRGs)for COAD still needs to be further *** To identify some critical FRGs and construct a COAD patient prognostic signature for clinical *** The Cancer Genome Atlas database(TCGA)and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical *** expressed FRGs were recognized using R and Perl *** constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression *** patients from the Gene Expression Omnibus cohort were utilized for *** Our research showed that most of the FRGs(85%)were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD *** FRGs were related to overall survival(OS)in the univariate Cox analysis(all P1,P<0.01).The predictive capacity of the model was verified by a receiver operating characteristic curve *** addition,a nomogram based on the expression of five hub FRGs and risk score can precisely predict the OS of individual COAD cancer p

关键词： Colon adenocarcinoma Ferroptosis Immune status Prognosis Overall survival

Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma:A bioinformatics analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第30期28卷 4221-4226页

作者： yan-dong miao Xiao-Long Tang Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina yantai Affiliated Hospital of Binzhou Medical University The Second Clinical Medical College of Binzhou Medical UniversityYantai 264000Shandong ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

The expression of angiopoietin(ANGPT)1,ANGPT2,vascular endothelial growth factor(VEGF)A,VEGFB,VEGFC,VEGFD,and placental growth factor(PGF)is significantly higher in tumor tissues than in normal tissues in both unpaired and paired hepatocellular carcinoma(HCC)***2,VEGFB,VEGFC,and PGF are primarily involved in regulating the activation of the epithelialmesenchymal transition pathway;ANGPT1 is primarily involved in regulating the activation of the RAS/mitogen-activated protein kinase and receptor tyrosine kinase(RTK)pathways;VEGFA is engaged in regulating the RTK activation pathway;and VEGFD is mainly involved in regulating the activation of the tuberous sclerosis protein/mammalian target of rapamycin *** is a significant difference in overall survival between HCC patients with high and low expression of ANGPT2,PGF,VEGFA,and *** free survival(DFS)is significantly shorter in HCC patients with high ANGPT2,PGF,and VEGFA expression than in those with low ANGPT2,PGF,and VEGFA expression.

关键词： Hepatocellular carcinoma Angiogenesis Marker Bioinformatics analysis Pathway

Prevention of late complications of endoscopic resection of colorectal lesions with a coverage agent:Current status of gastrointestinal endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第2期14卷 543-546页

作者： yan-dong miao Xiao-Long Tang Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Dean's office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

Endoscopic ectomy of large nonpedunculated colorectal lesions(≥20 mm)might cause significant adverse incidents,such as delayed perforation and delayed bleeding,despite the closure of mucosal lesions with *** conventional utilization of prophylactic clipping has not decreased the risk of postprocedural delayed adverse events,and additional outcomes and cost-effectiveness research is needed for patients with proximal lesions≥20 mm,in whom prophylactic clipping might be *** of the wound after endoscopic excision offers shield protection against delayed concomitant diseases.

关键词： Endoscopic resection Non-pedunculated colorectal lesions Complication Delayed bleeding Delayed perforation Coverage agents

Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第47期27卷 8194-8198页

作者： yan-dong miao Jiang-Tao Wang Xiao-Long Tang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Dean's office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

CXCL12 expression was significantly lower in tumor samples than in corresponding normal ***12 expression was significantly positively related to the infiltration levels of T cells,dendritic cells(DCs),immature DCs,cytotoxic cells,Tfh cells,mast cells,B cells,Th1 cells,natural killer(NK)cells,pDCs,neutrophils,and T helper cells(Spearman correlation coefficient>0.5,P<0.001)and negatively correlated with the infiltration level of NK CD56bright *** addition,pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelialmesenchymal transition activation pathway.

关键词： CXCL12 Pancreatic cancer Splicing isoforms Bioinformatics analysis Tumor microenvironment Pathway

Intestinal barrier in inflammatory bowel disease:A bibliometric analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第45期29卷 6017-6021页

作者： Wen-Yu Luan Zhe yang Xiao-dong Chen Tong-Tong Zhang Fang Zhang yan-dong miao Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2^(nd)Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

The primary objective of this investigation was to examine the evolving trajectories and pivotal focal points within the domain of research on intestinal barriers with regard to inflammatory bowel disease(IBD).Publications germane to the intestinal barrier in the context of IBD were procured from the Science Citation Index Expanded within the Web of Science Core Collection *** scrutiny and visualization were executed employing the R package"bibliometrix"through the R software platform(version:4.3.0).A comprehensive compilation of 7344 English-language articles spanning from January 1,2001 to December 31,2021 was meticulously identified and included in the ***,China emerged as the preeminent force in the realm of intestinal barrier research in relation to *** significance of the intestinal barrier in the context of IBD has been progressively and comprehensively *** recognition has ushered in a fresh therapeutic perspective that offers the promise of enhancing the management of inflammation and prognostication.

关键词： Intestinal barrier Inflammatory bowel disease Bibliometric analysis Bibliometrix Gastroenterology

Current and future research directions in cellular metabolism of colorectal cancer:A bibliometric analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3732-3737页

作者： Bo-Wen Jiang Xiu-Hua Zhang Rui Ma Wen-Yu Luan yan-dong miao Department of Emergency Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Oncology Laiyang Central HospitalYantai 265200Shandong ProvinceChina Department of Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

The primary aim of this study was to analyze the evolving trends and key focal points in research on cellular metabolism of colorectal cancer(CRC).Relevant publications on cellular metabolism in CRC were sourced from the Science Citation Index Expanded within the Web of Science Core Collection *** analysis and visualization were conducted using VOSviewer(version 1.6.18)software and CiteSpace 6.1.R6(64-bit)Basic.A comprehensive compilation of 4722 English-language publications,covering the period from January 1,1991 to December 31,2022,was carefully identified and included in the *** the authors,“Ogino,Shuji”contributed the most publications in this field,while“Giovannucci,E”garnered the highest number of *** journal“Cancer Research”ranked first in both publication volume and ***,“Shanghai Jiao Tong University”emerged as the top contributor in terms of published articles,while“Harvard University”led in citation *** country-based analysis,the United States held the top position in both publication output and citations,closely followed by *** increasing recognition of the significance of cellular metabolism in CRC underscores its potential for novel therapeutic approaches aimed at improving CRC management and prognosis.

关键词： Cellular metabolism Colorectal cancer Bibliometric analysis Metabolic reprogramming Cellular metabolism