检索结果-南通市图书馆

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

引用

World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping Guo yan-Mei Lu Bei-Lin wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CLINICAL OBSERVATION ON OPHTHALMOPLEGIA TREATED BASED ON SYNDROME DIFFERENTIATION

引用

Journal of Integrative Medicine 2014年第3期 320-320页

作者： Zhong-ren Sun dong-yan wang Chun-xia wang Heilongjiang University of TCM

Clinical pathway of TCM in treating ophthalmoplegia, established by The 2nd Affiliated Hospital of Heilongjiang University of TCM, has been brought into the 2nd batch of clinical pathway of the State Administration of *** conducted a multicenter comparative study with 14 hospitals within the state.A total of 260 patients were randomly divided into a treatment group and a comparative *** in treatment group was typed into supranuclear, nuclear, internuclear and ocular, and patients were treated by the combination of scalp cluster needling, ocular acupuncture and distal point selection according to the clinical *** ophthalmoplegia patients were given scalp cluster needling on parietal and nuchal region; internuclear ophthalmoplegia patients were given scalp cluster needling on occipital and nuchal region with ocular acupuncture; nuclear ones were given scalp cluster needling on occipital and nuchal region with ocular acupuncture combining with distal point selection; and ocular ones were given ocular acupuncture combining with distal point *** therapy lasted 30 min once daily, and 4 weeks as 1 *** control group received 1.5 mg/d of mecobalamin in three divided doses after meals for 4 *** effects were determined by TCM criterion of therapeutic *** research resulted 92% effective rate in the treatment group and 75% in the control group with significant difference(P<0.05).That proves that treating ophthalmoplegia based on syndrome differentiation is superior to the mecobalamin group and the therapy is worth extension and application.

关键词： CLINICAL OBSERVATION ON OPHTHALMOPLEGIA TREATED BASED ON SYNDROME DIFFERENTIATION

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling wang Jing Ren Chenguang Zheng Jiajia yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microglia lactylation in relation to central nervous system diseases

引用

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui yang Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

雷珠单抗治疗BRVO-ME的临床疗效及视力预后相关因素分析

引用

国际眼科杂志 2020年第4期20卷 673-679页

作者：杨静张月玲杨娜顾朝辉王丽英王冬艳承德医学院研究生学院河北承德067000 河北省保定市第一中心医院眼二科 067000

目的:分析雷珠单抗治疗视网膜分支静脉阻塞继发黄斑水肿(BRVO-ME)患者黄斑区视网膜结构和功能的改善情况,并探讨影响视力预后的相关因素。方法:前瞻性临床研究。选取2018-06/2019-05于我院眼科确诊的BRVO-ME患者25例25眼,均接受每月1次... 详细信息

目的:分析雷珠单抗治疗视网膜分支静脉阻塞继发黄斑水肿(BRVO-ME)患者黄斑区视网膜结构和功能的改善情况,并探讨影响视力预后的相关因素。方法:前瞻性临床研究。选取2018-06/2019-05于我院眼科确诊的BRVO-ME患者25例25眼,均接受每月1次,连续3次玻璃体腔注射雷珠单抗治疗。分别于治疗前和第3次玻璃体腔注射1mo后检测最佳矫正视力(BCVA),并利用相干光断层扫描成像(OCT和OCTA)技术检测黄斑中心凹厚度(CMT),评估浅层视网膜毛细血管网的血管长度密度(VLD)、血管灌注密度(VPD)、中心凹无血管区面积(FAZ),通过多焦视网膜电流图(mf-ERG)分析一环和二环(中央凹)的N1、P1波潜伏期及P1波振幅密度。结果:治疗后,本组患者BCVA(LogMAR)较治疗前显著改善(0.323±0.086 vs 0.773±0.304,P0.05);一环和二环N1波潜伏期、P1波潜伏期显著降低,且P1波振幅密度值显著提高(P<0.05)。Pearson相关性分析显示,年龄、治疗前BCVA、VLD、VPD、FAZ与治疗前后视力变化值具有显著相关性(均P<0.05)。结论:玻璃体腔内注射雷珠单抗治疗BRVO-ME可显著降低黄斑水肿,改善视力及黄斑区结构和功能,年龄、基线BCVA、黄斑区微结构参数可作为评估视力改善的预测指标。

关键词：视网膜分支静脉阻塞抗VEGF治疗相干光断层扫描血管成像多焦视网膜电图

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng yang Jian wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

引用

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang yan Congai Chen yanhui He Yuyu Shi Fafeng Cheng Qingguo wang Changxiang Li Xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高强钢板冲裁断面质量的分析与优化

引用

塑性工程学报 2018年第5期25卷 99-104页

作者：谢晖周玉彬王杭燕程威张文彦王东福吴璐湖南大学汽车车身先进设计制造国家重点试验室湖南长沙410082 上海拖拉机内燃机有限公司上海200433

为分析高强度钢板在冲裁过程中边缘破裂现象的产生机理,通过实验和有限元数值模拟两个方面研究板料断面质量的影响因素,并进一步改善冲裁断面质量。基于正交试验和灰色关联分析方法,通过冲孔试验和数值模拟分析,研究了冲孔孔径、凸凹模... 详细信息

为分析高强度钢板在冲裁过程中边缘破裂现象的产生机理,通过实验和有限元数值模拟两个方面研究板料断面质量的影响因素,并进一步改善冲裁断面质量。基于正交试验和灰色关联分析方法,通过冲孔试验和数值模拟分析,研究了冲孔孔径、凸凹模间隙、摩擦因素和冲孔速度等因素对高强度双相钢DP780板料冲孔后断面质量的影响。结果表明：各个试验因素对板料断面质量的影响顺序为：凸凹模间隙〉冲孔速度〉冲孔孔径〉摩擦因素。同时,通过对裂缝边缘图像的观察和对有限元数值模拟的分析,揭示了剪切边缘的应力、应变分布以及边缘形貌的差异,为研究板料破裂提供了一种新方法。

关键词：高强钢断面质量冲压缺陷多目标优化灰色关联分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibitory Effect of Crude Extract of Burn Eschar on Mitochondrial Function in Rats

引用

Journal of Medical Colleges of PLA 1987年第1期 40-45页

作者：陈宗荣冯江董燕王松保 Research Laboratory Department of Public Health Third Military Medical College Chongqing

Full thickness burns(20% TBSA)was produced in male Wistar *** mitochondrial function was determined polarographicallly on the 9th daypostburn(PB).In another group of animals,burn eschar was removed on the 9thday PB and extracted with 0.9% NaCl solution(CEBE).Extract of normal ratskin(ENS)was prepared *** mitochondria were prepared fromnormal rats and incubated with CEBE or *** respiratory function wasthen *** was found that the respiratory control ratio(RCR)in the burned animalswas much depressed(63.7%)as compared with the normal *** the secondset of experiment,RCR was also inhibited in the CEBE-treated mitochondria,mainly due to the elevation of the state 4 respiration *** RCR value in theENS-treated mitochondria also showed certain degree of inhibition but it wasmuch weaker than that in the CEBE-treated group(P<0.01).The inhibitoryeffect was totally absent in higher dilutions in the ENS group while in theCEBE-treated group slight but definite inhibition was found up to the dilutionof 1:*** of inner membrane was also affected by CEBE(3 experiments).When normal mitochondria were incubated with CEBE,the“blue shift”phenomenon was either diminished or totally ***,the extent ofdecrease of the maximal absorbancy was much smaller than that of the controlsafter the administration of *** inhibitory effects were also observedin more concentrated suspensions of *** mechanism of this inability ofmembrane energization was briefly discussed.

关键词： burns burn toxin extract of burn eschar mitochondrial function mitochondrial membrane energization

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

机场加油车动态调度问题研究

引用

计算机工程与设计 2017年第5期38卷 1382-1388页

作者：衡红军晏晓东王芳李海丰中国民航大学计算机科学与技术学院天津300300

机场特种车辆的调度效率将直接影响地勤服务成本和航班正点率。针对机场加油车动态调度问题,构建具体时刻的车辆调度模型;利用航班预计到港/出港消息,设计一种基于规划时间窗的车辆实时调度算法,将动态问题转化为一系列静态问题,实现车... 详细信息

机场特种车辆的调度效率将直接影响地勤服务成本和航班正点率。针对机场加油车动态调度问题,构建具体时刻的车辆调度模型;利用航班预计到港/出港消息,设计一种基于规划时间窗的车辆实时调度算法,将动态问题转化为一系列静态问题,实现车辆总行驶路程最短、所需车辆最少和每辆车的服务任务量均衡的目标。以机场实际数据验证了其合理性和有效性。

关键词：多目标优化带时间窗动态车辆路径问题规划时间窗算法机场加油车实时调度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：