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Relationship Between Clinical and Immunological Features with Magnetic Resonance Imaging Abnormalities in Female Patients with Neuropsychiatric Systemic Lupus Erythematosus

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Chinese Medical Journal 2016年第5期129卷 542-548页

作者： Hai-Peng wang cui-yan wang Zheng-Lun Pan Jun-Yu Zhao Bin Zhao Department of Magnetic Resonance Imaging Shandong Medical Imaging Research Institute Shandong University Jinan Shandong 250021 China Department of Internal Medicine Division of Rheumat-ology Qilu Hospital of Shandong university (Qingdao) Qingdao Shandong 266035 China Department of Internal Medicine Division of Endocrinology Shandong Province Qianfoshan Hospital Jinan Shandong 250014 China

Background：Conventional magnetic resonance imaging （MRI） is the preferred neuroimaging method in the evaluation ofneuropsychiatric systemic lupus erythematosus （NPSLE）.The purpose of this study was to investigate the association between clinical and immunological features with MRI abnormalities in female patients with NPSLE,to screen for the value of conventional MRI in ***：A total of 59 female NPSLE patients with conventional MRI examinations were enrolled in this retrospective *** patients were classified into different groups according to MRI *** clinical and immunological features were compared between MRI abnormal and normal ***-way analysis of variance was used to compare the systemic lupus erythematosus disease activity index （SLEDAI） score for MRI *** logistic regression analysis investigated the correlation between immunological features,neuropsychiatric manifestations,and MRI ***：Thirty-six NPSLE patients （61%） showed a variety of MRI *** were statistically significant differences in SLEDAI scores （P 〈 0.001）,incidence of neurologic disorders （P =0.001）,levels of 24-h proteinuria （P =0.001） and immunoglobulin M （P =0.004）,and incidence of acute confusional state （P =0.002）,cerebrovascular disease （P =0.004）,and seizure disorder （P =0.028） between MRI abnormal and normal *** the MRI abnormal group,SLEDAI scores for cerebral atrophy （CA）,cortex involvement,and restricted diffusion （RD） were much higher than in the MRI normal group （P 〈 0.001,P =0.002,P =0.038,respectively）.Statistically significant positive correlations between seizure disorder and cortex involvement （odds ratio [OR] =14.90;95% confidence interval [CI],1.50-151.70;P =0.023） and cerebrovascular disease and infratentorial involvement （OR =10.00;95% CI,1.70-60.00;P =0.012） were ***：MRI abnormalities in NPSLE,especially CA,cortex involvement,and RD might be markers of high systemic

关键词： Magnetic Resonance Imaging: Neuropsychiatric Symptoms Systemic Lupus Erythematosus Systemic Lupus Erythematosus Disease Activity Index

Porcine Interleukin-2 Expression in Insect Cells and Its Enhancement of Pig Immunity to Swine Influenza Virus Inactivated Vaccine

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Agricultural Sciences in China 2010年第8期9卷 1211-1220页

作者： CHEN Hong-ying ZHANG Hong-ying HUANG yan-quan cui Bao-an wang Zhen-ya wang yan-bin LIU Jin-peng CHAO An-jun College of Animal Husbandry and Veterinary Henan Agricultural University Zhengzhou 450002 P.R.China

Mature porcine interleukin-2 （pIL-2） gene was amplified by PCR from the plasmid pGEM-T-pIL2 and cloned into the baculovirus pFastBacTM Dual vector of the Bac-to-Bac baculovirus expression system under the control of the PH promoter. Recombinant plL-2 （rpIL-2） expressed in Sf9 insect cells was detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunofluorescence assay. Western blot analysis confirmed that the rpIL-2 protein had a molecular mass of 20 kDa, which was larger than the molecular mass of the mature protein predicted based on its peptide sequence. The rpIL-2 protein induced in vitro proliferation of ConA-stimulated porcine splenocytes and enhanced in vivo protective immune responses induced by vaccinating the pigs with inactivated oil emulsion vaccine against swine influenza virus. The results showed that the rpIL-2 expressed in Sf9 insect cells has immunoenhancement effects; the finding lays the foundation for the preparation of a specific recombinant IL-2 protein and the development of a novel immune adjuvant of vaccines against various infectious porcine pathogens to increase the immunoprotective efficacy of vaccines.

关键词： porcine interleukin-2 Sf9 insect cells expression inactivated vaccine swine influenza virus

Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

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World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： yan Ren yan-Ni cui Hong-Wei wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital ***(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet *** a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and ***,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or *** propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of *** To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and *** CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental *** cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured ***-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant ***-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead *** Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly

关键词： Hematopoietic stem cells Nicotinamide Concentration Proliferation Differentiation Sirtuin 1

Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

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Particuology 2024年第1期84卷 168-177页

作者： Qingye Meng Shuangling Zhong Jingfei wang Zhenqian Zhang yan Gao Xuejun cui College of Chemistry Jilin University Changchun130012China College of Resources and Environment Jilin Agricultural University Changchun130118China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun130012China Weihai Institute for Bionics-Jlin University Weihai264400China

In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor *** strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical *** EAC in the microcapsule core is volatile,which can be recycled and reused to reduce *** prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in ***-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in *** is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.

关键词： Reductive-responsive Sodium alginate Microcapsule Targeted delivery Sonochemical

“Buckets effect”in the kinetics of electrocatalytic reactions

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Journal of Energy Chemistry 2024年第2期89卷 388-396,I0010页

作者： Haowen cui yan-Xia Chen Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic *** results demonstrate a rectangular hyperbolic relationship,i.e.,the ORR current excluding the effect of other variables increases with proton concentration and then tends to a constant *** consider that this is caused by the limitation of ORR kinetics by the trace oxygen concentration in the solution,which determines the upper limit of ORR kinetics.A model of effective concentration is further proposed for rectangular hyperbolic relationships:when the reactant concentration is high enough to reach a critical saturation concentration,the effective reactant concentration will become a constant *** could be due to the limited concentration of a certain reactant for reactions involving more than one reactant or the limited number of active sites available on the *** study provides new insights into the kinetics of electrocatalytic reactions,and it is important for the proper evaluation of catalyst activity and the study of structureperformance relationships.

关键词： Oxygen reduction reaction Kinetics Zero order Rectangular hyperbolic relationship pH effect

Gradient-structure-enhanced dielectric energy storage performance of flexible nanocomposites containing controlled preparation of defective TiO_(2) and ferroelectric KNbO_(3) nanosheets

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Nano Research 2024年第5期17卷 4079-4088页

作者： yan wang Lili Zhao Ruicong Chen Wenhui Zhao Dengwei Hu Haoran wang Bin cui Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Shaanxi Key Laboratory of Physico–Inorganic Chemistry Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China School of Information Science and Technology Northwest UniversityXi’an 710127China Engineering Research Center for Titanium Based Functional Materials and Devices in Universities of Shaanxi Province Faculty of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China

Next generation power system needs dielectrics with increased dielectric energy ***,the low energy density of dielectrics limits their ***,an asymmetric trilayered nanocomposite,with a transition layer(TL),an insulation layer(IL),and a polarization layer(PL),is designed based on poly(vinylidene fluoride)-polymethyl methacrylate(PVDF-PMMA)matrix using KNbO_(3)(KN)and TiO_(2)(TO)as the *** morphology and defect control of the two-dimensional nano KN and nano TO fillers are realized via a hydrothermal method to increase the composite breakdown strength(E_(b))and the composite energy density(U_(e)).The asymmetric trilayered structure leads to a gradient electric field distribution,and the KN and TO nanosheets block charges transfer along z *** a result,the development path of the electrical trees is greatly curved,and E_(b) is effectively *** the Ue value of the nanocomposites reaches 17.79 J·cm^(-3) at 523 MV·m^(-1).On the basis,the composite Ue is further improved by defect control in TO *** nanocomposite KN/TO/PVDF-PMMA containing TO with less oxygen vacancy concentration(calcined at oxygen atmosphere)acquires a high Ue of 21.61 J·cm^(-3) at 548 MV·m^(-1).This study provides an idea for improving the energy storage performance by combining the design of the composite dielectric structure and the control of nanofillers’defect and morphology.

关键词： asymmetric trilayered structure two-dimensional energy density oxygen vacancies breakdown strength dielectric

Deciphering the linear relationship in the activity of the oxygen reduction reaction on Pt electrodes:A decisive role of adsorbates

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Journal of Energy Chemistry 2024年第7期94卷 70-77页

作者： Haowen cui yan-Xia Chen Hefei National Research Center for Physical Sciences at Microscale and Department of Chemical Physics University of Science and Technology of ChinaHefei 230026AnhuiChina

Despite substantial efforts in developing high-performance catalysts for the oxygen reduction reaction(ORR),the persistent challenge lies in the high onset overpotential of the ORR,and the effect of the elec-trolyte solution cannot be ***,we have systematically investigated the impact of adsorbate species and concentration,as well as solution pH,on the ORR activity on Pt(111)and Pt(poly)*** results all tend to establish a linear quantitative relationship between the onset potential for ORR and the adsorption equilibrium potential of the *** finding indicates the decisive role of adsorbates in the onset potential for ORR,suggesting that the adsorption potential of adsorbates can serve as an intuitive criterion for ORR *** support for this conclusion is derived from experimental results obtained from the oxygen evolution reaction on Pt(poly)with different adsorbate species and from the hydrogen evolution reaction on Pt(111)with iodine *** further propose both an empirical equation for the onset potential for ORR and the concept of a potential-regulated adsor-bate shielding effect to elucidate the influence of adsorbates on ORR *** study provides new insights into the high onset overpotential of the ORR and offers potential strategies for predicting and enhancingORRactivity inthefuture.

关键词： Oxygen reduction reaction Activity Adsorbate Equilibrium potential Pt(111)

Advances in controlled-release fertilizer encapsulated by organic-inorganic composite membranes

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Particuology 2024年第1期84卷 236-248页

作者： Xueping wang Yongyan yang Shuangling Zhong Qingye Meng Yiwei Li Jia wang yan Gao Xuejun cui College of Chemistry Jilin UniversityChangchun130012China College of Resources and Environment Jilin Agricultural UniversityChangchun130118China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun130012China Weihai Institute for Bionics-Jilin University Weihai264400China

Heavy use of conventional fertilizers can lead to negative environmental ***-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of ***,it is imperative to develop and use CRFs as an alternative to traditional *** review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of *** is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.

关键词： Controlled-release fertilizers Organic-inorganic composite membranes Surface treatments

Disastrous effects of climate change on High Mountain Asia

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Advances in Climate Change Research 2024年第3期15卷 365-366页

作者： Peng cui Yao-Ming MA yan wang Bin-Binwang Institute of Geographic Sciences and Natural Resources Research The Chinese Academy of Sciences(CAS)Beijing 100101China Institute of Mountain Hazards and Environment CASChengdu 610041China China-Pakistan Joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchCASBeijing 100101China

High Mountain Asia(HMA),encompassing the Tibetan Plateau and the surrounding high mountain ranges of the Hindu Kush and Tianshan,is a region characterised by large terrain,complex topography and the interplay of vario... 详细信息

关键词： terrain Tianshan Tibetan