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Comparison of form-deprived myopia and lens-induced myopia in guinea pigs

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 245-250页

作者： Hui Xiao Zhong-Yi Fan Xiao-Dan Tian yan-chun xu Department of Ophthalmology the First Affiliated Hospital of China Medical University Department of Ophthalmology the 463thHospital of the People's Liberation Army Department of Ophthalmology the Fourth People's Hospital of Shenyang

AIM:To study the efficacy difference between formdeprived myopia(FDM)and lens-induced myopia(LIM),the degree of myopia,axial length and pathological changes of the posterior sclera from guinea pigs were ***:Four-week pigmented guinea pigs were randomly assigned into 3 groups,including normal control(n=6),FDM group with monocular cover(n=11)and LIM group with monocular-7D lens treatment(n=11).FDM group was form-deprived while LIM group was lens-induced for *** error and axial length were measured prior to and post treatment,*** changes of sclera were examined using both light and electronic ***:After 14d treatment,refractive errors for FDM group and LIM group were-3.05±0.71D and-2.12±1.29D,respectively,which were significantly more myopic than that of normal controls and fellow control eyes(P0.05).Under light microscope,both FDM group and LIM group showed thinned sclera,disarrangement of fibrosis and enlargeddisassociation between ***,ultrastructural examination showed degenerated fibroblasts and thinned fibers in posterior ***:Following two weeks of myopia induction in guinea pigs,with regard to the degree of myopia,axial length and pathological alterations,there was no significant difference between FDM and LIM ***,FDM and LIM are equally effective and useful as a model of experimental myopia and guinea pigs are ideal animals for induction of experimental myopia because their high sensitivity to both formdeprivation and lens-induction.

关键词： form-deprived myopia lens-induced myopia pathology

Coal Gasification Wastewater Pretreatment with Coagulation and N_2 Flotation Combined System

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Journal of Harbin Institute of Technology(New Series) 2013年第5期20卷 20-24页

作者： Hong-Jun Han Qian Zhao chun-yan xu Hai-Feng Zhuang Peng xu State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology

A N 2 flotation tank combined with coagulation was developed as a pretreatment equipment of biological process to remove oil and other pollutants in coal gasification wastewater( CGW). With optimal PAC dosage of 20 mg / L,the sole coagulation process achieves removal efficiencies of 29. 34% and 26. 83% for oil and COD,respectively. For the sole N 2 floatation process,the optimal N 2 flux and HRT are 20 m3/ h and 20 min. Meanwhile,the oil and COD removal efficiencies are 35. 41% and 14. 26%,respectively. For the combined system of coagulation and N 2 floatation,the optimal parameter values are the same as the ones of separate processes. Correspondingly,the removal efficiencies are 46. 28% and 31. 89% for oil and COD, respectively. Besides,BOD 5 / COD of the effluent is improved. In contrast with conventional dissolved air floatation,the inert gas- N 2 prevents the formation of cyclopentenone, pyridine derivatives, and other heterocyclic aromatic hydrocarbons,thus improving the biodegradability of influent for the subsequent biological processes.

关键词： N2 flotation tank coagulation coal gasification wastewater oil biodegradability

Degradation of Phenolic Compounds in Coal Gasification Wastewater by Biofilm Reactor with Isolated Klebsiella sp.

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Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 9-17页

作者： Fang Fang Hong-Jun Han chun-yan xu Qian Zhao Ling-Han Zhang State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology

This study was conducted to evaluate the degradation of phenolic compounds by one strain isolated from coal gasification wastewater( CGW). 16S rRNA gene sequences homology and phylogenetic analysis showed that the isolate is belonged to the genus Klebsiella sp. The effect of different phenolic compounds on the isolate was investigated by determining OD600and phenoloxidase activity,of which the results showed that the isolate can utilize phenol,4-methyl phenol,3,5-dimethyl phenol and resorcinol as carbon resources. The biofilm reactor( formed by the isolate) can resist the influent concentration of phenolic compounds as high as750 mg /L when fed with synthetic CGW and incubated at optimum conditions. The capacity of improving the biodegradability of CGW through degrading phenolic compounds was testified with fed the biofilm reactor with real CGW. Thus,it might be an effective strain for bioaugmentation of CGW treatment.

关键词： phenol degradation coal gasification wastewater bacteria isolate phenoloxidase

Expressions of type I collagen, α2 integrin and β1 integrin in sclera of guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 54-58页

作者： Xiao-Dan Tian Yong-Xia Cheng Gui-Bo Liu Su-Fen Guo chun-Lei Fan Li-Hui Zhan yan-chun xu Department of Ophthalmology the First Hospital Affiliated to China Medical University Department of Ophthalmology the Fourth People's Hospital of Shenyang Department of Pathology Mudanjiang Medical University Department of Anatomy Mudanjiang Medical University

AIM:To investigate the expressions of type I collagen, α2 integrin and β1 integrin in the posterior sclera of guinea pigs with defocus myopia and whether basic fibroblast growth factor (bFGF) injection inhibits the formation and development of myopia by upregulating the expression of type I collagen, α2 integrin and β1 integrin. METHODS:After 14 days of treatment, the refractive state and axial length were measured and the levels of type I collagen, α2 integrin and β1 integrin were assayed in the posterior sclerae of groups of guinea pigs that wore a monocular-7D polymethylmethacrylate (PMMA) lens or had -7D lens wear followed by the peribulbar injection of Phosphate Buffer Solution (PBS) or bFGF. The untreated fellow eye served as a control. Guinea pigs with no treatment served as normal group. ·RESULTS:The results showed that 14 days of monocular defocus increased axial eye length and refraction, while bFGF delivery inhibited them markedly. Further, it was also found that the monocular-7D lens could decrease the levels of type I collagen, α2 integrin and β1 integrin expressions, while, unlike PBS, bFGF increased them significantly in comparison to contralateral control eyes and normal eyes. CONCLUSION:bFGF can prevent the formation anddevelopment of defocus myopia by upregulating the expressions of type I collagen, α2 integrin and β1 integrin. Taken together, our results demonstrate that bFGF promotes sclera remodeling to prevent myopia in guinea pigs.

关键词： defocus myopia type I collagen α2 integrin β1 integrin bFGF

Upgrade of macromolecular crystallography beamline BL17U1at SSRF

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Nuclear Science and Techniques 2018年第5期29卷 58-64页

作者： Qi-Sheng Wang Kun-Hao Zhang Yin Cui Zhi-Jun Wang Qiang-yan Pan Ke Liu Bo Sun Huan Zhou Min-Jun Li Qin xu chun-yan xu Feng Yu Jian-Hua He Shanghai Institute of Applied Physics Chinese Academy of Sciences

Beamline BL17 U1 at Shanghai Synchrotron Radiation Facility is an energy-tunable macromolecular crystallography beamline that has been in user operation since 2009. Growing demand from the user community for a small beam and related experimental methods have motivated upgrades of the devices in the *** modes have already been developed for operation. A self-integrated diffractometer reduces the sphere of confusion of the rotatory axis to 1μm. The new diffractometer is equipped with an upgraded on-axis viewing system that can improve the resolving power. Additionally,the area detector was also upgraded to the newest generation of detectors, the EIGER X 16 M, which can collect data at 133 Hz. After these upgrades, the endstation became virtually new. This paper covers the upgrade of the endstation devices and gives the first data collection results.

关键词： Shanghai Synchrotron Radiation Facility Macromolecular crystallography Endstation Goniometer Fine-phi slicing

Synthesis and Self-assembling of Coumarin-based Low-molecular Weight Organogelators

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Chemical Research in Chinese Universities 2009年第2期25卷 178-182页

作者： CHEN Guo-jun xuE Peng-chong LU Ran SONG Dong-po BAO chun-yan xu Ting-hua ZHAO Ying-ying College of Chemistry Jilin University Changchun 130012 P. R. China

Four coumarin derivatives（4a-4d） with different alkoxy chains were synthesized. It was found that compound 4d showed a better gelation ability than the other compounds, for example, it could self-assemble into organogels in various organic fluids via ultrasound treatment or heating-cooling process, whereas compound 4c could only gel in a few mixed solvents and compounds 4a, 4b could not form organogel. The results from fluorescent and FT-IR spectra indicate that π-π interaction had an effect on the formation of the organogels of compound 4d besides H-bonding and van der Waals interaction, which were the driving forces for the self-assembling of compound 4c in gel state. The gel of compound 4d in toluene could emit strong fluorescence under UV irradiation and the [2＋2] cyclo-addition was suggested by ^1H NMR and fluorescence spectroscopy. This light-sensitive organogel might find application in optical materials.

关键词： Coumarin Organogelator Self-assembling [2+2] Cyclo-addition

Effect of rosuvastatin on the vascular endothelial function and inflammatory cytokine in patients after PCI

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Journal of Hainan Medical University 2017年第2期23卷 21-24页

作者： Hui Li yan-chun xu Emergency Rescue Center of Beijing Red Cross Society 100013 The251st Hospital of Chinese People's Liberation Army 075000

Objective:To evaluate the effect of rosuvastatin on the vascular endothelial function and inflammatory cytokine in patients after ***:A total of 120 patients with ACS who were admitted in our hospital from December, 2014 to June, 2016 were included in the study and randomized into the observation group and the control group. PCI was performed in the two groups. The patients in the control group were given routine treatments. On this basis, the patients in the observation group were given rosuvastatin (20 mg) 3 d before operation, every night before sleep, continuously for 1 month. The efficacy was evaluated 24 h and 1 month after operation. Hs-CRP, IL-10, TNF-α, vWF, ET-1, NO, TG, TC, and LDL levels before operation, 24 h and 1 month after operation in the two groups were ***:vWF and ET-1 levels 1 month after operation in the observation group were significantly lower than those in the control group, while NO was significantly higher than that in the control group. hs-CRP, IL-10, and TNF-α 24 h and 1 month after operation in the observation group were significantly lower than those in the control group. TC, TG, and LDL levels 24 h and 1 month after operation in the observation group were significantly lower than those in the control ***:Rosuvastatin can effectively reduce the serum inflammatory cytokine level, improve the vascular endothelial function, and decrease the occurrence of thrombus and restenosis in patients with ACS after PCI.

关键词： Rosuvastatin ACS PCI After operation Vascular endothelial function Inflammatory cytokine

Fate of Nitrogen from Organic and Inorganic Sources in Rice-Wheat Rotation Cropping System

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Agricultural Sciences in China 2010年第7期9卷 1017-1025页

作者： CHEN Yi,WU chun-yan,TANG xu,yanG Sheng-mao and WANG Jia-yu Institute of Environmental Resources and Soil Fertilizer,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,P.R.China Institute of Environmental Resources and Soil Fertilizer Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R. China

The lower availability of N is one of the most important limiting factors impeding crop yield enhancement among the various factors that affect crop yield under the multiple-cropping agroecosystem in *** this study,the recovery of a single application of 15N-labeled fertilizer or residues in rice-wheat cropping system was determined,in order to provide theoretical foundation for the nitrogen management in sustainable agricultural production.A continuous trace experiment was conducted for 15N microplots by using randomized block design with four treatments and four replications（T1 = 15N-labeled fertilizer with crop residue incorporation,T2 = 15N-labeled residues,T3 = 14N fertilizer to generate unlabeled crop residue,and T4 = 15Nlabeled fertilizer without crop residue incorporation）.Our results showed that,on average,17.17 and 12.01% of crop N was derived from N fertilizer and 15N-labeled residues,respectively during the first growing season,suggesting that approximately 82.83 or 87.99% of crop N was derived directly from soil N *** was a larger difference in the 15N recovery pattern in crop when N was applied as fertilizer or residues,i.e.,most of crop N derived from N fertilizer was absorbed in the first growing season（92.04%）,and the relevant value was 38.03% when 15N-labeled residues were *** implied that most of N fertilizer was recovered in the present cropping season,while a longer residue effect will be found for 15N-labeled ***,the average recovery of N fertilizer and N residue in the soil after the first growing season was 33.46 and 85.64%,*** recovery of applied N in soil when N was applied as residues was significantly higher than that when N was applied as *** was a larger difference in the total 15N recovery in plant and soil when N was applied as fertilizer or *** the end of the fifth or sixth cropping season,the total 15N recovery in plant and soil when N was applied as fertilizer or resi

关键词： crop residue fertilizer fate 15N isotope nitrogen fertilizer rice field

Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science China Chemistry 2025年第1期68卷 217-225页

作者： Ruilin Hou Xiaoxi Zhao Tingting Liang Qingyun Dou Shan xu Xingbin yan School of Materials Science and Engineering Sun Yat-sen University Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Engineering and Applied Sciences Nanjing University Center of Industrial Analysis and Testing Guangdong Academy of Science

The electrochemical stability window(ESW) is crucial for determining the energy density of electric double-layer capacitors(EDLCs). However, current ESW testing protocols of EDLCs are strongly affected by artificial factors, thereby leading to unreliable result. To solve this problem, we first identify the key shortcomings of the traditional protocols by analyzing their test principles. Subsequently, taking an aqueous carbon-based EDLC as an example, we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge methods. With the aid of this descriptor, we propose a new ESW testing protocol, which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition limitations. The protocol can be extended from the single electrode to the full device. This work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

关键词： electric double-layer capacitors electrochemical stability window testing protocol side reaction descriptor operating limitation