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Chinese Journal of Chemistry 2022年第1期40卷 79-90页

作者： Jin-Feng Li yan-bo zeng Wang-Sheng Li Hui Luo Hai-yan Zhang Yue-Wei Guo Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikouHainan 571101China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China Ocean College of Hebei Agricultural University QinhuangdaoHebei 066000China Key Laboratory of Zhanjiang for Research and Development Marine Microbial Resources in the Beibu Guif Rim Marine Biomedical Research InstituteGuangdong Medical UniversityZhanjiangGuangdong 524023China bohai rim Advanced Research Institute for Drug Discovery YantaiShandong 264000China

Ten new cembrane-type diterpenoids,namely xishaglaucumins A—J(1—10),along with ten known related ones(11—20),have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China *** structures were elucidated by extensive spectroscopic analysis,quantum mechanical nuclear magnetic resonance(QM-NMR)methods,X-ray diffraction analysis,chemical methods and comparison with the reported data in the *** absolute configuration of new compounds 1,5 and known compounds 11,12,16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu Kα(λ=1.5417A).In in vitro bioassay,compound 4 exhibited inhibitory effects on lipopolysaccharide(LPS)-induced inflammatory responses in BV-2 microglial cells.

关键词： Sarcophyton glaucum Cembranoids Configuration determination X-ray diffraction NMR spectroscopy

Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea

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Chinese Chemical Letters 2007年第12期18卷 1509-1511页

作者： yan bo zeng Wen Li Mei You Xing Zhao Ling Zhuang Kui Hong Hao Fu Dai State Key Biotechnology Laboratory of Tropical Crops institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming institute of Botany Chinese Academy of Sciences Kunming 650204 China

Two new epimeric pairs of iridoid scyphiphin A1 （la）, A2 （lb） and scyphiphin B 1 （2a）, B2 （2b） were isolated from Scyphiphora hydrophyllacea Gaertn. F. Their structures were elucidated by spectroscopic methods. The mixture of scyphiphin B 1 and scyphiphin B2 showed moderate cytotoxicity against human hepatoma SMMC-7721 cell line in vitro by MTT method.

关键词： Scyphiphora hydrophyllacea Gaertn. E Iridoid Cytotoxicity SMMC-7721

Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosis

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Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 70-75页

作者： yan-bo zeng Shun-Hai Zhu Hui Dong Hong-Yu Han Lian-Lian Jiang Quan Wang Jun Cheng Qi-Ping Zhao Wei-Jiao Ma Bing Huang Shanghai Veterinary Research Institute Chinese Academy of Agricultural ScienceKey Laboratory for Animal Parasitology of Ministry of Agriculture

Objective:To identify more effective and less toxic drugs to treat animal ***:Efficucy of seven kinds of sulfonamides against Toxoplasma gondii(***)in an acute murine model was *** mice used throughout the study were randomly assigned to many groups(10 mice each),which either remained uninfected or were infected intraperitoneally with lachyzoites of ***(strains RH and CN).All groups were then treated with different sulfonamides and the optimal treatment protocol was determined ***-sodium(SD)was used for ***:The oplimal therapy involved gavaging mice twice per day with 250 mg/kg bw of sulfachloropyrazine-sodium(SPZ)for five *** this protocol,the average survival time and the time-point of 50%fatalities were prolonged significantly compared with SD *** with SFZ protected 40%of mice from death,and the heart and kidney tissue of these animals was parasite-free,as determined by *** showed excellent therapeutic effects in the treatment of *** in an acute murine model and is therefore a promising drug candidate for the treatment and prevention of *** in ***:It can be concluded that the effective drug sulfachloropyrazine may be the new therapeutic options against animal toxoplasmosis.

关键词： Toxoplasmosis Sulfonamides Sulfachloropyrazine-sodium Efficacy Therapy Toxoplasma gondii Murine Therapeutic effect

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 360-363页

作者： Mao-Lin yan, Lu-Nan yan, bo Li, Yong zeng, Tian-Fu Wen, Wen-Tao Wang, Jia-Yin yang, Ming-Qing Xu, Zhi-Hui Li and Yong-Bing Chen Liver Transplantation Group of Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, China Liver Transplantation Group of Transplantation Center West China Hospital Sichuan University Chengdu 610041 China.

BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients. This study was undertaken to evaluate the outcomes of liver transplantation for patients with hepatitis B virus (HBV). METHODS: A retrospective chart analysis and a review of the organ transplant database identified 51 patients (43 men and 8 women) transplanted for benign HBV-related cirrhotic diseases between June 2002 and December 2004 who had survived more than 3 months. HBIg was administered intravenously during the first week and intramuscularly thereafter. RESULTS: At a median follow-up of 14.1 months, the overall recurrence rate in the 51 patients was 3.9% (2/51). The overall patient survival was 88.3%, and 82.4% after 1 and 2 years, respectively. A daily oral dose of 100 mg lamivudine for 2 weeks before transplantation for 10 patients enabled 57.1% (4/7) and 62.5% (5/8) of HBV-DNA and HBeAg positive patients respectively to convert to be negative. Intramuscular HBIg was well tolerated in all patients. CONCLUSION: Lamivudine combined with intramuscular HBIg can effectively prevent allograft from the recurrence of HBV after liver transplantation.

关键词： lamivudine hepatitis B immune globulin hepatitis B virus recurrence liver transplantation

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-bo Cao Sai-Jun Mo Zhi-yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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沙特麦麦高铁沙丘段路基基底处理技术

建筑机械 2017年第6期37卷 173-175,178页

作者：薄延增中铁十八局集团国际工程有限公司天津300222

以沙特麦麦高铁项目为例,依据沙丘工程地质特性,综合考虑沙丘原材料、环境特性及机械施工难度等条件,对沙特麦麦高铁沙丘段路基基底加固处理时,对不同厚度的基底砂层分别采用冲击碾压和振冲挤密的施工方法,经现场实践验证,形成适用于沙... 详细信息

以沙特麦麦高铁项目为例,依据沙丘工程地质特性,综合考虑沙丘原材料、环境特性及机械施工难度等条件,对沙特麦麦高铁沙丘段路基基底加固处理时,对不同厚度的基底砂层分别采用冲击碾压和振冲挤密的施工方法,经现场实践验证,形成适用于沙丘路基基底处理的施工技术,从而使孔隙减少达到了增加密实度加固路基基底的目的,为类似工程提供参考。

关键词：沙丘路基基底处理冲击碾压振冲挤密加固深度

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油田采出水中有机物组成分析

石油化工 2002年第6期31卷 472-475页

作者：李凌波闫松曾向东林大泉抚顺石油化工研究院辽宁抚顺113001

建立了油田采出水中有机物分析程序。可吸附组分用XAD系列树脂富集 ,树脂吸附物经索氏提取和KD浓缩后 ,用气相色谱 /质谱法定性分析。低级脂肪酸用紫外检测离子色谱法分析。分析了两种油田采出水 ,结果表明 :油田采出水的化学需氧量为 1... 详细信息

建立了油田采出水中有机物分析程序。可吸附组分用XAD系列树脂富集 ,树脂吸附物经索氏提取和KD浓缩后 ,用气相色谱 /质谱法定性分析。低级脂肪酸用紫外检测离子色谱法分析。分析了两种油田采出水 ,结果表明 :油田采出水的化学需氧量为 14 7～ 5 0 4mg/L ,其中可树脂吸附的有机物的化学需氧量占 10 .7%～ 2 5 .2 % ,低级脂肪酸占45 .3 %～ 72 .8%。可树脂吸附的有机物包括苯系物、苯酚类化合物、多环芳烃及有机酸等 ,其中苯系物及苯酚类化合物的含量相对较高。低级脂肪酸包括乙酸、丙酸、异丁酸、丁酸及异戊酸等。

关键词：油田采出水有机物组成达标排放气相色谱/质谱法离子色谱法

Modified techniques for adult-to-adult living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 173-179页

作者： Lu-Nan yan, bo Li, Yong zeng, Tian-Fu Wen, Ji-Chun Zhao, Wen-Tao Wang, Jia-Yin yang, Ming-Qing Xu,Yu-Kui Ma, Zhe-Yu Chen, Jiang-Wen Liu and Hong Wu Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University, Chengdu 610041 , China Liver Transplantation Division Department of Surgery West China Hospital Sichuan University Chengdu 610041 China. yanlunan688@***

BACKGROUND: Because of critical organ shortage, transplant professionals have utilized living donor liver transplantation (LDLT) in recent years. We summarized our experience in adult-to-adult LDLT with grafts of right liver lobe by a modified technique. METHODS: From January 2002 to August 2005, 24 adult patients underwent living donor liver transplantation with grafts of the right liver lobe at West China Hospital, Sichuan University, China. Twenty-two patients underwent modi-Bed procedures designed to improve the reconstruction of the right hepatic vein and the tributaries of the middle hepatic vein by interposing a great saphenous vein ( GSV) graft and the anastomosis of the hepatic arteries and bile ducts. RESULTS: No severe complications and death occurred in all donors. In the first 2 patients, (patients 1 and 2), operative procedure was not modified. One patient suffered from 'small-for-size syndrome' and the other died of sepsis with progressive deterioration of graft function. In the rest 22 patients (patients 3 to 24), however, the procedure of venous reconstruction was modified, and better results were obtained. Complications occurred in 7 recipients including acute rejection (2 patients), hepatic artery thrombosis (1), bile leakage (1), intestinal bleeding (1), left sub-phrenic abscess (1), and pulmonary infection (1). One patient with pulmonary infection died of multiple organ failure (MOF). The 22 patients underwent direct anastomosis of the right hepatic vein to the inferior vena cava (IVC), 9 direct anastomosis plus the reconstruction of the right inferior hepatic vein, and 10 direct anastomosis plus the reconstruction of the tributaries of the middle hepatic vein by in-terpos-ing a GSV graft to provide sufficient venous outflow. Trifurcation of the portal vein was met in 3 patients. Venoplasty or separate anastomosis was performed. The ratio of graft to recipient body weight ranged from 0.72% to 1.17%. Among these patients, 19 had the ratio <1.0% a

关键词： living donor liver transplantation adult-to-adult right lobe graft surgical technique reconstruction of hepatic vein small-for-size syndrome