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Magnetic Resonance Gd？RGD Imaging Study of Hepatocellular Carcinoma with High and Low Metastatic Potential before and after Human Bone Marrow？derived Mesenchymal Stem Cell Intervention

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Chinese Medical Journal 2017年第21期130卷 2591-2600页

作者： Tian-Ran li Ming-Hui Yu Xiao-Bin Huang Zhi-Jie yang Guang-Ming Lu yan-jun li Department of Radiology The 1st Affiliated Hospital of Chinese PLA General Hospital Beijing 100048 China Department of Radiology Chinese PLA 95th Hospital Putian Fujian 351100 China Department of Radiology Chinese PLA Nanjing General Hospital Nanjing Jiangsu 210000 China

Background： Biotherapy based on human bone marrow-derived mesenchymal stem cells （BMSCs） is currently the focus of research, especially in the field of autologous stem cell transplantation. A novel type of metastasis-associated magnetic resonance （MR） molecular imaging probe was constructed, and the changes in metastasis and proliferation of hepatocellular carcinoma （HCC） before and after BMSC intervention were observed through MR imaging （MRI）. Methods：Metastasis-associatedMRmolecularimagingprobe,integrin αvβ3 ligandcRGD-PEG-DGL-DTPA-Gd （Gd-RGD）,wereconstructed. After human BMSC intervention was performed for 6weeks, tumor weight inhibition rates were calculated, and the RGD molecular probe was imaged through MRI with molecular imaging agent Gd-DTPAas *** signal-to-noise ratio （SNR） and contrast-to-noise ratio （CNR） in the MRI experiment were used as semi-quantitative indicators. Polymerase chain reaction method was performed to detect proliferation- and metastasis-associated indicators, transforming growth factor β-1 （TGFβ1）, osteopontin （OPN）, and integrin subunit αv and β3. Results： The highest tumor weight inhibition rates were observed 3 weeks after the BMSC transplantation. The MR Gd-RGD in the HCC tissues after the BMSC intervention showed less enhancement than Gd-DTPA. The Gd-DTPAMRI of control group had higher SNR and CNR than Gd-RGD MRI in the experimental groups （P 〈 0.05）. For high metastatic potential hepatocellular carcinoma （MHCC97-H）, significant differenceswereobservedintheSNRsandCNRsofGd-RGDMRIbeforeandaftertheBMSCintervention（P〈0.05）.Forlowmetastaticpotential hepatocellular carcinoma （MHCC97-L）, the CNRs of Gd-RGD MRI were statistically different before and after BMSC intervention （P 〈 0.05）. With regard to MHCC97-H, OPN, β3, and TGFβ1 expression significantly decreased after BMSC intervention （P 〈 0.05）. In MHCC97-L and OPN, β3, TGFβ1, and αv expression after BMSC intervention decreased, and the difference was statistically significant （

关键词： Arginine-Glycine-Aspartic Acid: Bone Marrow-derived Mesenchymal Stem Cells High Metastatic Potential Hepatocellular Carcinoma Integrin: Low Metastatic Potential Hepatocellular Carcinoma

Prospective study of scoring system in selective intraoperative cholangiography during laparoscopic cholecystectomy

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World Journal of Gastroenterology 2003年第4期9卷 865-867页

作者： Xiao-Dong Sun Xiao-yan Cai jun-Da li Xiu-jun Cai Yi-Ping Mu Jin-Min Wu Department of General Surgery,The Affiliated Sir Run Run Shaw Hospital,Zhejiang University Medical College,Hangzhou 310016,Zhejiang Province,China Department of General Surgery The Affiliated Sir Run Run Shaw Hospital Zhejiang University Medical College Hangzhou 310016 Zhejiang Province China. s.xiaodong@***

AIM: To evaluate of scoring system in predicting choledocholithiasis in selective intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC).METHODS: The scoring system of predicting choledocholithiasis was developed during the retrospective study in 264 cases, and was tested in 184 to evaluate its predictive value in ***: The scoring system was developed in a retrospective study of 264 cases, the statistical analyses showed the predictive factors included sex, transaminase levels, alkaline phosphatase level, bilirubin level, and common bile duct diameter on ultrasonography. The scoring system was used in 184 cases prospectively, of which, 3 of 162 (1.9%) cases scoring ＜3 had choledocholithiasis, 17 of 22 (77.3 %) cases scores≥3 had choledocholithiasis. A case of scores≥3 or more prospectively should be considered highly intraoperative cholangiography during laparoscopic ***: The scoring system can predict choledocholithiasis and is helpful in selection patietns for intraoperative cholangiography.

关键词：术中选择性胆管造影术腹腔镜胆囊切除术胆道疾病计分系统临床研究

Effects of somatostatin analogues on human sphincter of Oddi pressure

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 302-305页

作者： Shuo-Dong Wu, Zhen-Hai Zhang, Jing Kong, yan-jun li, jun-Zhe Jin, Wei Wang, Dong-yan li and Min-Fei Wang Shenyang, China No.2 Department of General Surgery, Second Affilia- ted Hospital, China Medical University, Shenyang 110004, China Department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUND: Somatostatin, a neuropeptide and hor- mone , exists in the biliary tract of several species. The effects of somatostatin and its analogues on the sphincter of Oddi motility have been controversial. The aim of this study was to observe the action of stilamin and sandostatin on the sphincter of Oddi via choledochofiberscope manometry. METHODS: Twenty patients who had had'T' duct after cholecystectomy and choledochotomy were divided into 2 groups randomly: stilamin and sandostatin. They were subjected to manometry via a choledochofiberscope through the'T' duct tract. The following data recorded in- cluded duodenal pressure (DP), sphincter of Oddi basal pressure (SOBP), sphincter of Oddi contractive amplitude (SOCA), frequency of the sphincter of Oddi (SOF), dura- tion of the sphincter of Oddi, and the common bile duct pressure (CBDP). RESULTS: After intravenous administration of stilamin at a dose of 250 μg/h, the mean SOCA increased from 89.18 (26.50) to 128.57(54.21) mmHg (P lined to 92.18(42.81) mmHg (Plined from 17.63(13.36) to 8.16(4.01) mmHg (Plined from 9.25(2.45) to 7.46(1.52) n/min, it was not significantly influenced. After intravenous administration of sandostatin at a dose of 100 μg, the mean CBDP increased obviously. CONCLUSIONS: Intravenous administration of stilamin at a dose of 250 μg/h stimulates the motility of the sphincter of Oddi whereas the injection of stilamin at a dose of 500 μg/h inhibits its motility. Intravenous injection of sandosta- tin of 100 μg has no effect on the sphincter of Oddi.

关键词： biliary manometry via choledochofiberoscopy sphincter of Oddi somatostatin stilamin sandostatin

Hepatoprotective Effects of Yintian Granule on Experimental liver Injury in Mice

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Chinese Herbal Medicines 2014年第3期6卷 247-252页

作者： yan-jun li Sheng yang yan-jing Zhou Fang-hong Shang Xiao-yu Xu College of Pharmaceutical Sciences & College of Traditional Chinese Medicine and Pharmacology Southwest University Institute of Chinese Medicine Southwest University Pharmacology of Chinese Materia Medica Key Constructing Discipline by the State Administrative Bureau of Traditional Chinese Medicine

Objective Yintian Granule （YTG）, as a type of local preparation and applied for Chinese patent, is mainly composed of several traditional Chinese herbs used as both drug and food such as Lonicera macranthoides, Gardenia jasminoides, and Asparagus cochinchinenis, and has been reported to demonstrate the beneficial effects on human health in other researches, in this paper, the protective effects of YTG against experimental acute liver injury of mice were investigated to assess the value of this innovative Chinese herbal compound. Methods Carbon tetrachloride （CCl4） and 50% ethanol were used respectively to induce the acute liver injury model in mice pre- administered with YTG. Lai＇s method was used to detect the level of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in serum, Coomassie brilliant blue method was used for the determination of superoxide dismutase （SOD） activity and malondialdehyde （MDA） content, and hematoxylin-eosin （HE） staining was used for the observation of liver histomorphometry. Results YTG significantly lowered the elevated ALT and AST levels, increased the SOD activity, decreased the MDA content, and inhibited the deterioration of liver. Conclusion YTG exerts protective effected against hepatocyte damage in mice induced by CCl4 and 50% ethanol, respectively.

关键词： Hepatoprotection liver injury Yintian Granule

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Mechanism of reheat cracking in electron beam welded Ti2Al Nb alloys

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Transactions of Nonferrous Metals Society of China 2019年第9期29卷 1873-1881页

作者： yan-jun li Ai-ping WU Quan li Yue ZHAO Rui-can ZHU Guo-qing WANG Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Beijing Institute of Radio Measurement Beijing 100854China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationTsinghua UniversityBeijing 100084China Capital Aerospace Machinery Company Beijing 100076China China Academy of Launch Vehicle Technology Beijing 100076China

In order to clarify the characteristics and formation mechanism of the reheat cracking in Ti2AlNb weldments,a series of heat treatment conditions were performed to the circular joints welded by electron beam,and then the macrostructures and microstructures were investigated using optical microscopy,scanning electron microscopy,X-ray diffractometry,and transmission electron *** results show that the reheat cracking occurs primarily along the grain boundaries in the weld when the Ti2AlNb circular welded joints are heated up to about 700℃.During the heat treatment,an almost complete transformation of B2→O happens while the temperature goes up through the O single-phase ***,O→B2+O phase transformation occurs primarily along the grain boundaries as the weld metal continues to heat up to the B2+O dual-phase *** the high tension stress consisting of welding residual stress and phase transformation stress,reheat cracking occurs at the interface between the B2+O dual-phase layer and the O-phase matrix.

关键词： reheat cracking electron beam welding Ti2AlNb alloy microstructure evolution

Effects of welding parameters on weld shape and residual stresses in electron beam welded Ti_2AlNb alloy joints

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Transactions of Nonferrous Metals Society of China 2019年第1期29卷 67-76页

作者： yan-jun li Ai-ping WU Quan li Yue ZHAO Rui-can ZHU Guo-qing WANG Department of Mechanical Engineering Tsinghua University Beijing 100084 China Beijing Institute of Radio Measurement Beijing 100854 China State Key Laboratory of Tribology Tsinghua University Beijing 100084 China Key Laboratory for Advanced Materials Processing Technology Ministry of Education Tsinghua University Beijing 100084 China Capital Aerospace Machinery Company Beijing 100076 China China Academy of Launch Vehicle Technology Beijing 100076 China

In order to estimate the residual stresses in Ti2AlNb alloy jointed by electron beam welding (EBW), a computational approach based on finite element method was developed. Meanwhile, experiments were carried out to verify the numerical results. The comparison between the simulation results and measurements suggests that the developed computational approach has sufficient accuracy to predict the welding residual stress distributions. The results show that the central area of the fusion zone suffers tensile stresses in three directions. When the other parameters remain unchanged, the focus current has great impact on the weld shape and size, and then affects the residual stress level significantly. Moreover, the thick plate full-penetrated EBW weld suffers near 1000 MPa tensile stress of Z-direction in the center of the fusion zone. The wider weld has lower tensile stress in Z-direction, resulting in lower risk for cracking.

关键词： Ti2AlNb alloy residual stress numerical simulation electron beam welding

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嵌套分区算法框架下基于序的优化方法研究

计算机集成制造系统 2008年第1期14卷 50-55页

作者：闫利军李宗斌卫军胡西安交通大学机械工程学院机械制造系统工程国家重点实验室陕西西安710049

为有效解决随机资源分配问题,提出了一种嵌套分区算法框架下基于序的优化方法。该方法将序优化与最优计算量分配技术融入嵌套分区算法框架,利用"序比较"思想进行算法的局部寻优,极大地降低了算法的计算负担,而最优计算量分配技术则能够... 详细信息

为有效解决随机资源分配问题,提出了一种嵌套分区算法框架下基于序的优化方法。该方法将序优化与最优计算量分配技术融入嵌套分区算法框架,利用"序比较"思想进行算法的局部寻优,极大地降低了算法的计算负担,而最优计算量分配技术则能够智能地对有限的计算量进行合理的分配,进一步提高序优化的收敛速度及结果的可靠性。嵌套分区方法保证了每一步均对全体可行域进行采样,从而保证了算法的全局收敛性。给出了算法实施的具体步骤并证明了收敛性。用该算法解决标准作业车间调度问题,并将仿真结果与其他算法进行比较,证明了本文算法的收敛速度与优化质量均优于其他算法。

关键词：随机资源分配嵌套分区序优化最优计算量分配作业车间调度

10-Hydroxycamptothecin Mediates Antiproliferative Effects and Induces Autophagy in H1299 Cells

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10-Hydroxycamptothecin Mediates Antiproliferative Effects an...