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农田生产力监测中3种多源遥感数据融合方法的对比分析

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地球信息科学学报 2018年第2期20卷 268-279页

作者：罗亮闫慧敏牛忠恩中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049

借助多源遥感数据融合技术能够得到高时空分辨率的遥感数据,可以为高精度农业遥感动态监测提供强有力的支持。在诸多融合算法不断发展的情况下,评估每种方法的特点及其适用性,有助于找到最适宜的融合方法,进而应用于农田生产力监测的实... 详细信息

借助多源遥感数据融合技术能够得到高时空分辨率的遥感数据,可以为高精度农业遥感动态监测提供强有力的支持。在诸多融合算法不断发展的情况下,评估每种方法的特点及其适用性,有助于找到最适宜的融合方法,进而应用于农田生产力监测的实践之中。本研究根据高标准农田建设成效评估对高时空分辨率生产力信息的需求,以宁夏灵武市农业综合开发项目区为实验区,采用线性拟合法、时序拟合法、时空融合法3种多源遥感数据融合方法,融合空间分辨率30 m的Landsat遥感数据的空间精度信息与空间分辨率500 m、时间步长8 d的MODIS遥感数据的高时相信息并对比不同方法对于农田生产力的空间格局精细化描述能力、对于农田生产力变化监测的能力以及运算速度的差异。研究结果表明:(1)3种融合方法融合的30 m NPP数据均能显示出道路、田埂等线状裸地与田间NPP的差异,但是时序拟合法、时空融合法比线性拟合法更加清晰;在NPP相对均匀的田块内部,时空融合法比时序拟合法更能体现出农田内部均匀度的差异。(2)线性拟合法仅适用于农田生产力年季变化的评估,不能用于作物生产力的实时动态监测;时序拟合法和时空融合法适用于农田生产力变化动态监测且时序拟合法适宜于大范围监测。(3)3种方法的计算速度差异显著,线性拟合法计算速率最快,时空融合法计算速率最慢;线性拟合法计算速率分别是时序拟合法和时空融合法的1.5倍和20倍。

关键词： NPP 线性拟合时序拟合时空融合遥感数据融合

Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin

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Cellular & Molecular Immunology 2016年第4期13卷 514-523页

作者： Wei Li Jingyi yang Ejuan Zhang Maohua Zhong yang Xiao Jie Yu Dihan Zhou Yuan Cao Yi yang Yaoming Li huimin yan Mucosal Immunity Research Group State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 People's Republic of China

Bacterial flagellin is a unique pathogen-associated molecular pattern （PAMP）, which can be recognized by surface localized Toll-like receptor 5 （TLR5） and the cytosolic NOD-like receptor （NLR） protein 4 （NLRC4） receptors. Activation of the TLR5 and/or NLRC4 signaling pathways by flagellin and the resulting immune responses play important roles in anti-bacterial immunity. However, it remains unclear how the dual activities of flagellin that activate the TLR5 and/or NLRC4 signaling pathways orchestrate the immune responses. In this study, we assessed the effects of flagellin and its mutants lacking the ability to activate TLR5 and NLRC4 alone or in combination on the adaptive immune responses against flagellin. Flagellin that was unable to activate NLRC4 induced a significantly higher antibody response than did wild-type flagellin. The increased antibody response could be eliminated when macrophages were depleted in vivo. The activation of NLRC4 by flagellin downregulated the flagellin-induced and TLR5-mediated immune responses against flagellin.

关键词： flagellin NLRC4 TLR5 macrophage adaptive immunity

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen huimin yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

Research Methods of Water Resources Carrying Capacity: Progress and Prospects

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Journal of Resources and Ecology 2018年第5期9卷 455-460页

作者： LI Yi yanG yanzhao yan huimin YOU Zhen Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Carrying Capacity Assessment for Resource and Environment Ministry of Land and ResourcesBeijing 101149China

The study of water resources carrying capacity（WRCC）,a major component of resources and environment carrying capacity（RECC）,began relatively recently. However,WRCC has witnessed a rapid development in terms of concept,calculation methods,and empirical research in recent years. WRCC has become an important criterion for rational development and utilization of regional water resources. This paper first briefly reviews the development process of WRCC. It then evaluates and contrasts the representative research methods of conventional trend（CT）,system dynamics（SD）,multi-objective model analysis（MOMA）,comprehensive evaluation（CE）,and dynamic simulation recursive（DSR）. The results show that although there are various methods of WRCC,the major methods used have become out-of-date and stagnant,and new more sophisticated methods and technologies are lacking. Specifically,our analysis found that the index system,scientific robustness and comprehensiveness of evaluation criteria of current research methods are insufficient and need to be improved. In addition,the dynamic research of WRCC should receive more attention,and it requires further study to make it more applicable to real-world uses. Finally,a set of monitoring and early warning systems should be established and applied in demonstration areas to meet the urgent needs of water resource management in the new era.

关键词： water resources carrying capacity research method prospects

Global Carbon Project (GCP) Beijing Office:a new bridge for understanding regional carbon cycles

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Journal of Geographical Sciences 2006年第3期16卷 375-377页

作者： TAO Bo CAO Mingkui YU Guirui LIU Jiyuan WANG Shaoqiang yan huimin Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China

It has been widely accepted that human activities, especially burning fossil fuels and land use change, have altered the climate on earth and anthropogenic carbon fluxes have become comparable in magnitude with the natural fluxes in the global carbon cycle. The present and potential threat of adverse consequences has focused the attention of the scientists, policy makers and general public on the interaction among carbon cycle, climate change and human system. Asia is a hot spot from environmental change and sustainable development perspectives. The development pathways and environmental changes in the region have obvious consequences for the regional carbon cycle, even for global carbon budget, and the complex, diverse social, economic and environmental conditions make it highly diffficult to understand and quantify these consequences. The GCP Beijing Office ＂will have a supporting and coordinating role and will provide coordination, leadership and capacity building on carbon cycle sciences in China and to the larger region of Asia＂ and ＂liaise with the two International Project Offices based in Canberra and Tsukuba to coordinate a regional and global strategy consistent with the GCP Science and Implementation Framework＂.

关键词： GCP regional office carbon cycle China

基于土地多功能的黄土丘陵沟壑区生态保护与发展情景评估及多主体模拟

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生态学报 2023年第15期43卷 6081-6098页

作者：薛智超甄霖闫慧敏北京工商大学国际经管学院北京100048 中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049

黄土高原丘陵沟壑区生态环境脆弱,近几十年生态保护工程的实施带来显著的生态恢复效果,也对农户的生计策略与区域粮食安全产生了影响。刻画生态脆弱区人-地系统复杂响应过程,可以为区域可持续的土地利用管理模式提供依据。研究从土地多... 详细信息

黄土高原丘陵沟壑区生态环境脆弱,近几十年生态保护工程的实施带来显著的生态恢复效果,也对农户的生计策略与区域粮食安全产生了影响。刻画生态脆弱区人-地系统复杂响应过程,可以为区域可持续的土地利用管理模式提供依据。研究从土地多功能出发,着眼于黄土丘陵沟壑区河谷川地、梁峁区域、黄土塬地、土石山地以及城郊区域等不同的典型地貌类型与代表区域,采用多层次利益相关者参与式的评估框架,以农户的耕地利用行为及生态工程影响与未来发展为切入点,设置惯性发展情景、发展优先兼顾生态情景、农业优先兼顾生态情景以及生态优先兼顾发展情景,构建多智能体模型对区域土地利用与土地多功能的时空变化开展模拟。主要结果表明:(1)生态优先兼顾发展情景综合影响最高且对各维度影响相对均衡,而农业优先兼顾生态情景对区域土地的经济维度的功能和社会维度具有更为明显的提升效应;(2)根据土地多功能空间变化模拟结果,区域土地利用破碎化明显且耕地的撂荒对全域土地多功能均表现出明显的限制作用,农业优先兼顾生态情景中土地功能发生下降的面积最少;(3)发生土地功能下降的区域主要分布在土地质量较差、坡度处于5—15°范围内、地形起伏度较大以及距离道路较远的区域;本研究刻画了黄土丘陵沟壑区不同典型地貌区域的差异化土地利用系统特征,为生态保护工程实施背景下的土地管理与区域可持续利用发展提供参考。

关键词：土地多功能多利益相关者多主体模型黄土丘陵沟壑区

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叉头转录因子家族在肝细胞癌中的作用机制及其作为治疗靶点的前景

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临床肝胆病杂志 2021年第4期37卷 931-934页

作者：李恬雨闫会敏河北医科大学公共卫生学院流行病与卫生统计学教研室石家庄050017 石家庄市第五医院研究所石家庄050021

肝细胞癌(HCC)是最常见的恶性癌症之一,发病率和病死率一直居高不下,预后很差。叉头框(FOX)转录因子家族可调控细胞的生长、分化及组织发育,在肿瘤中具有重要的生物学作用。综述了FOX家族分子表达与HCC发生发展及预后的关系,分析了FOX在... 详细信息

肝细胞癌(HCC)是最常见的恶性癌症之一,发病率和病死率一直居高不下,预后很差。叉头框(FOX)转录因子家族可调控细胞的生长、分化及组织发育,在肿瘤中具有重要的生物学作用。综述了FOX家族分子表达与HCC发生发展及预后的关系,分析了FOX在HCC进展中发挥作用的机制,提出FOX家族分子有望成为HCC治疗的新靶点。

关键词：癌,肝细胞叉头转录因子类癌基因基因,肿瘤抑制

Temporal and Spatial Dynamics Analysis of Grassland Ecosystem Pressure in Kazakhstan

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Journal of Resources and Ecology 2019年第6期10卷 667-675页

作者： WEN Xin yan huimin XIE Xiaoping DU Wengpeng LAI Chenxi ZHEN Lin School of Geography and Tourism Qufu Normal UniversityRizhao 276826ShandongChina Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Affected by climate change and policy factors,Kazakhstan is the country with the most severe ecological degradation and grassland conflicts in Central ***,studying the state of grassland carrying resources in Kazakhstan is particularly important for understanding the responses of grassland ecosystems to climate change and human *** on Kazakhstan's remote sensing data and animal husbandry statistics,this study analyzes the patterns of changes in grassland ecosystems in Kazakhstan based on the supply and consumption of these *** results show that:1)From 2003 to 2017,the number of livestock raised in Kazakhstan showed a trend of sustained and steady *** to freezing damage,the scale of livestock farming decreased in 2011,but a spatial difference in the livestock farming structure was not obvious.2)The fluctuation of grassland supply in Kazakhstan has increased,while the consumption due to animal husbandry has also continued to increase,resulting in an increasing pressure on the grassland carrying capacity.3)Between 2003 and 2017,the overall grassland carrying status of Kazakhstan have been abundant,but the grassland carrying pressure index has shown a steadily increasing trend,the grassland carrying pressure is growing,and it is mainly determined by grassland *** greater pressure in lower Kyzylorda state,the southern Kazakhstan state of the cultivated land and the northern Kazakhstan state has gradually expanded to include the agro-pastoral zone and the semi-desert zone.

关键词： Kazakhstan grassland ecosystem ecological consumption ecological stress balance between forage and animals ecological bearing state

The Progress of Resources and Environment Carrying Capacity: from Single-factor Carrying Capacity Research to Comprehensive Research

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Journal of Resources and Ecology 2018年第2期9卷 125-134页

作者： FENG Zhiming SUN Tong yanG yanzhao yan huimin Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China

As a concept to describe development restrictions,resources and environment carrying capacity（RECC）research has developed over more than 100 years since it was first proposed at the beginning of the 20th *** is now regarded as a significant factor in evaluating the level of cooperation between regional population,resources,and environment;and it is currently used as an effective and operational tool to guide regional sustainable *** article first reviews the origin of RECC and its early *** then reviews the historical development of RECC from single factors,such as land resources carrying capacity,water resources carrying capacity and environmental carrying capacity（environmental capacity）,to more comprehensive research,such as comprehensive evaluation,emergy analysis,and ecological footprint *** general,it appears that comprehensive research will become increasingly important in RECC ***,there are several deficiencies in the current state of comprehensive ***,comprehensive RECC research lacks a common measurement standard,though some scholars have attempted to create ***,the RECC evaluation of open systems and dynamic studies should be ***,more attention should be paid to standardization,digitalization,and systematization to promote the applicability of RECC research to national practical demands.

关键词： resources and environment carrying capacity research methods single-factor carrying capacity research comprehensive research