检索结果-南通市图书馆

Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

Stroke & Vascular Neurology 2024年第4期9卷 367-379,I0022-I0031页

作者： Tianchi Tang Li-bin Hu Chao Ding Zhihua Zhang Ning Wang Tingting Wang Hang Zhou Siqi Xia Linfeng Fan Xiong-jie Fu feng yan Xiangnan Zhang gao Chen Jianru Li Department of Neurosurgery Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 2NeurosurgeryZhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 3Zhejiang University School of MedicineHangzhouZhejiangChina 4Zhejiang University Department of PharmacologyHangzhouZhejiangChina

Background Ischaemic stroke triggers neuronal mitophagy,while the involvement of mitophagy receptors in ischaemia/reperfusion(I/R)injury-induced neuronal mitophagy remain not fully ***,we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1(FUNDC1)and its modulation in neuronal mitophagy induced by I/R *** Wild-type and FUNDC1 knockout mice were generated to establish models of neuronal I/R injury,including transient middle cerebral artery occlusion(tMCAO)in vivo and oxygen glucose deprivation/reperfusion in *** outcomes of mice with two genotypes were *** mitophagy was analysed both in vivo and in *** of FUNDC1 and its regulator Src were *** impact of Src on FUNDC1-mediated mitophagy was assessed through administration of Src antagonist *** To our surprise,FUNDC1 knockout mice subjected to tMCAO showed stroke outcomes comparable to those of their wild-type *** neuronal mitophagy could be activated by I/R injury,FUNDC1 deletion did not disrupt neuronal *** activation of FUNDC1,represented by dephosphorylation of Tyr18,was detected in the early stages(within 3hours)of neuronal I/R injury;however,phosphorylated Tyr18 reappeared and even surpassed baseline levels in later stages(after 6hours),accompanied by a decrease in FUNDC1-light chain 3 *** inactivation of FUNDC1 was associated with Src activation,represented by phosphorylation of Tyr416,which changed in parallel with the level of phosphorylated FUNDC1(Tyr18)during neuronal I/R ***,FUNDC1-mediated mitophagy in neurons under I/R conditions can be rescued by pharmacological inhibition of *** FUNDC1 is inactivated by Src during the later stage(after 6hours)of neuronal I/R injury,and rescue of FUNDC1-mediated mitophagy may serve as a potential therapeutic strategy for treating ischaemic stroke.

关键词： FUNDC1 involvement injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An ultrahigh energy storage efficiency and recoverable density in Bi_(0.5)Na_(0.5)TiO_(3)with the modification of Sr_(0.85)La_(0.1)TiO_(3)via viscous polymer process

引用

Journal of Materiomics 2024年第3期10卷 566-577页

作者： Fukang Chen Lishun yang Haoran feng Qin Li Xinyu Zeng Kun Yu Chunlin Song yan yan Li Jin Dou Zhang School of Materials and Energy Southwest UniversityChongqing400715China Electronic Materials Research Laboratory Key Laboratory of the Ministry of EducationSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Currently,the development of dielectric ceramic capacitors is restricted by the contradiction between high efficiency and high recoverable ***,a novel strategy was designed to achieve a su-perior balance between ***,introducing Sr_(0.85)La_(0.1)TiO_(3)can enhance the content of the weak polar phase(P4bm)to become the main component,which can optimize the relaxor behaviour and improve ***,the electric breakdown strength was effectively enhanced by grain refinement and viscous polymer ***,a high recoverable energy density of~5.3 J/cm^(3)and an excellent efficiency of~92.2%were attained in 0.9Bi_(0.5)Na_(0.5)TiO_(3)-0.1Na_(0.8)Sr_(0.1)NbO_(3)ceramic with the addition of 0.35Sr_(0.85)La_(0.1)TiO_(3)after viscous polymer *** piezoelectric force microscope had been applied to prove the high activity of the polar nanoregions and finite element analysis was adopted to explain the reasons for the enhancing electric breakdown *** addition,this ceramic exhibits good tem-perature and frequency stability,and a fast discharging rate of 0.11 ms,making it a potential candidate for the actual application.

关键词： Lead-free ceramics Energy storage BNT Landau-free energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of the nutritional support management system for patients in intensive care units

引用

World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-Xian Guo Hai-Nu gao Xian-Shan Jin yan-Li Wu Lu-Han Chen Zhi-Xian feng Department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative Office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation *** To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological *** The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU *** Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively *** proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 *** The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects

引用

China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng JIA Lu-sheng CHEN yan-fei ZHANG Qi ZHONG Rong-feng WANG Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China

引用

Ecological Processes 2024年第2期13卷 218-230页

作者： feng Jiang Tao Pu Zi-Jing Xue yan-Wei Ma Xiao-Yi Shi Fu-Xi Shi College of Geography and Environmental Sciences Zhejiang Normal University Yulong Snow Mountain Glacier and Environment Observation and Research Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University

Background Stable carbon isotope composition(δ13Cp) can be used to estimate the changes in intrinsic water use efficiency（iWUE） in plants,which helps us to better understand plants' response strategies to climate *** study focused on the variations in δ13Cpand iWUE for the different life-form plants（i.e.,herbs,shrubs,and trees）along an altitudinal gradient（3300,3600,3900,4100,4300,and 4500 m） on the eastern slope of Yulong Snow Mountain,southeastern margin of the Qinghai-Tibet *** response mechanisms of δ13Cpand iWUE for different life-form plants to altitude were thoroughly analyzed in this mountain *** The δ13Cpvalues of plants on the eastern slopes of Yulong Snow Mountain ranged from-30.4‰to-26.55‰,with a mean of-28.02‰,indicating a dominance of *** δ13Cpand iWUE values varied among different life-form plants in the order of herbs> shrubs> trees,particularly in 3600,3900,and 4300 ***δ13Cpand iWUE values for herbs and shrubs increased with altitude and were mainly controlled by air *** two parameters for trees exhibited a trend of initial decrease followed by an increase with *** 3900 m,the δ13Cpand iWUE values decreased with altitude,influenced by soil ***,above 3900 m,the two parameters increased with altitude,mainly regulated by air *** addition,iWUE was positively correlated with leaf P content but negatively correlated with leaf N:P ratio,especially for herbs and trees,suggesting that P plays a key role in modulating iWUE in this *** The diffe rentiated responses of water availability for different life-form plants to a higher altitudinal gradient are regulated by air temperature,soil moisture,and leaf P content in the Yulong Snow *** results provide valuable insights into understanding the wate r-carbon relationships in high-altitude ecosystems.

关键词： Stable carbon isotope Water use efficiency Altitude Life form Yulong Snow Mountain

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Enhanced preparation of dendritic metallic vanadium in recyclable NaCl-KCl-VCl_(2) molten salt by V_(2)CO electrolysis

引用

Rare Metals 2024年第8期43卷 3961-3973页

作者： Jia-Liang An Ming-Yong Wang Yong-Zheng Jia Jin-Tao Zhang Bao-yan feng Shu-Qiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China College of Material Science and Engineering Hebei Province Laboratory of Inorganic Nonmetallic MaterialsNorth China University of Science and TechnologyTangshan 063210China

A promising method for the preparation of pure metallic vanadium via V_(2)CO anode electrolysis was proposed and *** simple and controllable synthesis of a molten chloride salt containing VCl_(2) by an insitu reaction between VCl_(3) and metallic vanadium was verified through thermodynamic analysis and ***-KCl-VCl_(2) molten salt exhibited excellent recycling performance and could be repetitively used to prepare metallic vanadium by V_(2)CO *** V^(2+) ions remained in the molten salt after *** electrolysis conditions,such as the cathode diameter,current density,V^(2+) ion concentration,and temperature,were optimised to maximise the current *** was also simulated to reveal the regulatory *** highest current efficiency was 85%.The purity of metallic vanadium was up to 99.8%.In this study,an easy and efficient preparation of pure metallic vanadium was achieved.

关键词： V_(2)CO Metallic vanadium Current efficiency Molten salt electrolysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning the crystallinity of titanium nitride on copper-embedded carbon nanofiber interlayers for accelerated electrochemical kinetics in lithium-sulfur batteries

引用

Carbon Energy 2024年第6期6卷 40-55页

作者： Yinyu Xiang Liqiang Lu feng yan Debarun Sengupta Petra Rudolf Ajay Giri Prakash Kottapalli Yutao Pei Advanced Production Engineering Engineering and Technology Institute GroningenUniversity of GroningenGroningenThe Netherlands Zernike Institute for Advanced Materials University of GroningenGroningenThe Netherlands

The development of lithium-sulfur(Li-S)batteries is hindered by the disadvantages of shuttling of polysulfides and the sluggish redox kinetics of the conversion of sulfur species during discharge and ***,the crystallinities of a titanium nitride(TiN)film on copper-embedded carbon nanofibers(Cu-CNFs)are regulated and the nanofibers are used as interlayers to resolve the aforementioned crucial issues.A low-crystalline TiN-coated Cu-CNF(L-TiN-Cu-CNF)interlayer is compared with its highly crystalline counterpart(H-TiN-Cu-CNFs).It is demonstrated that the L-TiN coating not only strengthens the chemical adsorption toward polysulfides but also greatly accelerates the electrochemical conversion of *** to robust carbon frameworks and enhanced kinetics,impressive highrate performance at 2 C(913 mAh g^(-1)based on sulfur)as well as remarkable cyclic stability up to 300 cycles(626 mAh g^(-1))with capacity retention of 46.5%is realized for L-TiN-Cu-CNF interlayer-configured Li-S *** under high loading(3.8 mg cm^(-2))of sulfur and relatively lean electrolyte(10μL electrolyte per milligram sulfur)conditions,the Li-S battery equipped with L-TiN-Cu-CNF interlayers delivers a high capacity of 1144 mAh g^(-1)with cathodic capacity of 4.25 mAh cm^(-2)at 0.1 C,providing a potential pathway toward the design of multifunctional interlayers for highly efficient Li-S batteries.

关键词： crystallinity electrochemical kinetics interlayer lithium-sulfur batteries titanium nitride

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges in applying REE-based thermobarometers: Insights from mafic-ultramafic granulites in Indian southern granulite terrain

引用

Science China Earth Sciences 2024年第11期67卷 3448-3464页

作者： Xiaofei XU Longlong GOU Chengli ZHANG Junsheng LU yan ZHAO Wenhao AO Yuhua HU feng ZHOU Faculty of Land Resources Engineering Kunming University of Science and Technology State Key Laboratory of Continental Dynamics Department of Geology Northwest University

High-temperature diffusion of major elements may obscure the records of early and peak metamorphic stages in granulites,while trace elements are more likely to preserve these records due to their lower diffusion ***,using calibrated REE-based thermobarometers has proved essential for reconstructing these key stages,drawing considerable attention and application from ***,the precision of these thermobarometers depends on including both major and trace elements from coexisting minerals to define the correlation coefficients（A,B,and D） among mineral pairs,indicating that the elemental composition of these pairs can affect the *** study examines the mafic-ultramafic granulites in the southern granulite terrain,India,employing integrated methods such as petrography,mineral chemistry,phase equilibrium modeling,and REE-based *** aim to determine their metamorphic conditions and evolutionary history and to identify potential challenges in using REE-based *** garnet,clinopyroxene,and orthopyroxene in the mafic-ultramafic granulite samples display homogeneous compositional profiles,with pronounced Fe-Mg diffusion zones at the interfaces between garnet and ***,the profiles of trace elements within garnet and clinopyroxene are better *** into Fe-Mg exchange and randomly selected mineral pairs significantly influence the accuracy of REE-based ***-Mg exchange can increase in coefficient A,while decreasing coefficient B for light rare earth elements（LREEs） and increasing it for heavy rare earth elements（HREEs）,ultimately resulting in overestimations when calculating REE-based *** example,selecting major compositions with an Ex(=(XMgC-XMg0)/XMg0×100%;where XMgCis the value after Fe-Mg exchange,XMg0is the value before Fe-Mg exchange;XMg=Mg/(Fe2++Mg)) value of ～10 for calculation using the REE-in-Grt-Cpx thermobarometer will result in pressures and t

关键词： Granulites REE-based thermobarometer Fe-Mg exchange Randomly selected mineral pairs

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optimal V_(2)O_(3) extraction by sustainable vanadate electrolysis in molten salts

引用

Tungsten 2024年第1期6卷 141-149页

作者： Bao-yan feng Zhong-Hua Zhao Yong-Zheng Jia Jia-Liang An Ming-Yong Wang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China

Recently,an environmentally friendly electrolysis process of soluble vanadates is proposed and successfully confirmed for V_(2)O_(3) *** this paper,the solubilities of various vanadates(***_(3),Na_(4)V_(2)O_(7) and Na_(3)VO_(4))in NaCl molten salt are *** dependences of V_(2)O_(3) extraction on vanadate form,anode material and molten salt system are studied.A long-term electrolysis is carried *** result indicates that the solubilities of all vanadates are high and meet electrolytic *** to Na_(4)V_(2)O_(7) and Na_(3)VO_(4),NaVO_(3) exhibits larger current efficiency and lower electricity *** using SnO_(2) anode instead of graphite anode,the current efficiency of NaVO_(3) electrolysis can be increased to 58.1%and carbon pollution is avoided at 700℃.The extraction rate of V_(2)O_(3) reaches 81.3%after long-term electrolysis of 51 *** work optimizes the electrochemical preparation process of V_(2)O_(3) from various vanadates and contributes to the improvement of current efficiency and extraction rate.

关键词： Molten salt electrolysis Vanadate Vanadium trioxide Current efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Characterization of Biobased Dehydroabietyl Polyethylene Glycol Glycidyl Ether-Grafted Hydroxyethyl Cellulose with High Emulsifying Property

引用

Journal of Renewable Materials 2024年第1期12卷 103-117页

作者： Zhengqing Ding Quan yang Xinyan yan feng Gu Xujuan Huang Zhaosheng Cai School of Chemical and Chemistry Yancheng Institute of TechnologyYancheng224051China

Dehydroabietyl polyethylene glycol glycidyl ether-grafted hydroxyethyl cellulose(HEC)polymer surfactant(DA(EO)5GE-g-HEC)was prepared using ring-opening polymerization with biobased rosin and hydroxyethyl cellulose as *** polyethylene glycol glycidyl ether(DA(EO)5GE)was formed by condensation of dehydroabietyl alcohol polyoxyethylene ether(Rosin derivative:DA(EO)5H)and *** grafting degree of DA(EO)5GE-g-HEC was manipulated by adjusting the mass ratio of HEC and DA(EO)5GE and confirmed by *** to the formula,when m(HEC)/m(DA(EO)2GE)was 1:1~1:5,the grafting rate of DA(EO)5GE in DA(EO)5GE-g-HEC varied from 34.43%to 38.33%.The surface activity and foam properties of DA(EO)5GE-g-HEC aqueous solution were *** results showed that with the increase in grafting rate,the critical micellar concentration(CMC)in aqueous solution changed from 1.28 to 0.96 g/*** results of the thermogravimetric analysis showed that the temperature range of the main stage of mass loss of DA(EO)5GE-g-HEC was 310°C~410°C,and the thermal decomposition processes of the samples with five mass ratios were *** oil in water emulsion was prepared by choosing cyclohexane as the oil phase and DA(EO)5GE-g-HEC as the *** effect of DA(EO)5GE-g-HEC mass fraction on emulsion particle size and stability was *** results suggested that when the oil-water ratio was 8:2 with 0.4%emulsifier,the emulsion droplets were the smallest in terms of particle size and were the most *** rheological test results showed that the apparent viscosity decreased with the increase in shear rate and showed a typical elastic gel phenomenon.

关键词： Rosin hydroxyethyl cellulose surfactant emulsion rheological behaviour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：