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Chinese Chemical Letters 2011年第2期22卷 237-240页

作者： yan feng luo Key Lab of Biorheological Science and Technology (Chongqing University) Ministry of Education College of Bioengineering Chongqing University Chongqing 400030 China Research Center of Bioinspired Material Science and Engineering College of Bioengineering Chongqing University Chongqing 400030 China Department of Biology Chongqing University of Science and Technology Chongqing 401331 China Received 29 June 2010

A series of novel poly（urethane-urea）（PUU） was synthesized from poly（lactide-co-p-dioxanone） macrodiol（HO-P（LA-co-PDO）-OH）, hexamethylene diisocyanate（HDI） and butanediamine（BDA）.The obtained PUU,which is recorded as P（LA-co-PDO）-PUU here,may demonstrate enhanced phase separation and thus improved shape memory *** was employed to characterize the copolymers,and the effects of NCO/OH molar ratios on Tg of PUU was investigated by means of differential scanning calorimetry （DSC）.The results revealed the successful synthesis of P（LA-co-PDO）-*** addition,the Tg of P（LA-co-PDO）-PUU increased from 37.9℃to 44.2℃with the increase NCO/OH ratios from 1.1 to *** P（LA-co-PDO）-PUU with Tg close to body temperature will have potential applications as shape memory polymers in biomedical fields,especially in minimally invasive surgery.

关键词： Poly(urethane-urea) Polylactic acid p-Dioxanone Butanediamine Shape memory polymer

The Subvariety Lattice of the Join of Two Semigroup Varieties

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Acta Mathematica Sinica,English Series 2009年第6期25卷 971-982页

作者： Wen Ting ZHANG yan feng luo Department of Mathematics Lanzhou University Lanzhou 730000 P. R. China

The join A ∨ B of two semigroup varieties A and B is investigated. The latrine of subvarieties of A ∨ B is completely described, It is shown that this lattice is finite and non-modular and that all varieties in it a... 详细信息

关键词： semigroups varieties identities lattice

On the Finite Basis Problem for Certain 2-limited Words

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Acta Mathematica Sinica,English Series 2013年第3期29卷 571-590页

作者： Jian Rong LI Wen Ting ZHANG yan feng luo Department of Mathematics Lanzhou University

Let X＊ be a free monoid over an alphabet X and W be a finite language over X. Let S（W） be the Rees quotient X＊/I（W）, where I（W） is the ideal of X＊ consisting of all elements of X＊ that are not subwords of W. Then S（W） is a finite monoid with zero and is called the discrete syntactic monoid of W. W is called finitely based if the monoid S（W） is finitely based. In this paper, we give some sufficient conditions for a monoid to be non-finitely based. Using these conditions and other results, we describe all finitely based 2-limited words over a three-element alphabet. Furthermore, an explicit algorithm is given to decide that whether or not a 2-limited word in which there are exactly two non-linear letters is finitely based.

关键词： Finite basis problem 2-limited words discrete syntactic monoid

Abundant Semigroups with a Quasi-ideal Quasi-adequate Transversal

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1653-1664页

作者： Xiang Fei NI yan feng luo Hai Zhou CHAO Department of Mathematics Lanzhou University Lanzhou 730000 P. R. China Department of Mathematics LongQiao School of Lanzhou Commerical College Lanzhou 730000 P. R. China

Characterization theorems for abundant sernigroups having a quasi-ideal quasi-adequate transversal are obtained. Our results generalize and amplify the related results of Satio on regular semigroup obtained in 1985 and Kong obtained in 2007 respectively. Some recent results on this topic given by Guo-Shum are strengthened. In particular, the structure of such an abundant semigroup is described.

关键词： abundant semigroup quasi-ideal Q-transversal

Synthesis of the Biomimetic Polymer: Aliphatic Diamine and RGDS Modified Poly(d,l-lactic acid)

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Chinese Chemical Letters 2005年第8期16卷 1035-1038页

作者： Xu feng NIU Yuan Liang WANG yan feng luo Jun PAN Li Xia GUO Key Lab of Biomechanics ＆ Tissue Engineering （Chongqing University） Ministry of Education Bioengineering College of Chongqing University Chongqing 400044

A novel poly（d, /-lactic acid）（PDLLA） based biomimetic polymer was synthesized by grafting maleic anhydride, butanediamine and arg-gly-asp-ser （RGDS） peptides onto the backbone of PDLLA, aiming to overcome the acidity and auto-accelerating degradation of PDLLA during degradation and to improve its biospecificity and biocompatibility. The synthetic copolymer was characterized by FTIR, ^13C NMR and amino acid analyzer （AAA）.

关键词： Poly(d,l-lactic acid) maleic anhydride butanediamine arg-gly-asp-ser modification.

Design,synthesis and characterization of a novel pH-sensitive hydrogel

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Chinese Chemical Letters 2008年第12期19卷 1475-1478页

作者： Jiao Xia Sun yan feng luo Hui Peng Zhi Wei Han College of Chemistry ＆ Chemical Engineering Chongqing University Chongqing 400030 China College of Bioengineering Chongqing University Chongqing 400030 China

A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediaminetetraacetic dianhydride （EDTAh） and butanediamine （BDA） with dicyclohexylcarbodiimide （DCC） as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by ^13C NMR, ^1H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.

关键词： pH-sensitive hydrogel Ethylenediaminetetraacetic dianhydride Butanediamine

Enhanced mechanical properties of linear segmented shape memory poly（urethane-urea） by incorporating flexible PEG400 and rigid piperazine

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Frontiers of Materials Science 2012年第4期6卷 326-337页

作者： Xiao-yan ZHANG Yu-Fei MA Yong-Gang LI Pin-Pin WANG Yuan-Liang WANG yan-feng luo Key Lab of Biorheological Science and Technology(Ministry of Education) Research Center for Bio-inspired Material Science and EngineeringCollege of BioengineeringChongqing UniversityChongqing 400030China

The goal of this study is to design and synthesize a linear segmented shape memory poly（urethane-urea）（SMPUU） that possesses near-body-temperature shape memory temperature （Ttran） and enhanced mechanical properties by incorporating flexible poly（ethylene glycol） 400 （PEG400） to form poly（D,L-lactic acid）-based macro- diols （PDLLA-PEG400-PDLLA） and then rigid piperazine （PPZ） as a chain extender to form the desired SMPUUs （PEG400-PUU-PPZ）. PEG400 increased Mn while maintaining a lower Tg of PDLLA-PEG400-PDLLA, which together with PPZ improved the mechanical properties of PEG400-PUU-PPZ. The obtained optimum SMPUU with enhanced mechanical properties （O＇y = 24.28 MPa; zf = 698%; Uf = 181.5 MJIm3） and a Tg of 40.62~C exhibited sound shape memory properties as well, suggesting a promising SMPUU for in vivo biomedical applications.

关键词： poly(urethane-urea) poly(D,L-lactic acid) poly(ethylene glycol) piperazine,shape memory property mechanical property

Application of Bionic Technology in Marine Cruise Equipment:Research Progress and Development Trends

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Journal of Bionic Engineering 2024年第3期21卷 1117-1155页

作者： Kunhui luo Lan yan Zhiyi Zhu Zhongqiu Wang Hongru Wang feng Jiang School of Electromechanical and Automation Huaqiao UniversityXiamen36102China National Local Joint Engineering Research Center for Intelligent Manufacturing Technology of Brittle Material Products Xiamen361021China Institute of Oceanographic Instrumentation Shandong Academy of SciencesQilu University of Technology(Shandong Academy of Sciences)Qingdao266100China Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment Technology Qingdao266100China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao266100China Institute of Manufacturing Engineering Huaqiao UniversityXiamen361021China

This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development *** cruising is a crucial means of gaining insights into the marine environment and conducting scientific ***,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine *** technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread *** article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface *** summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising ***,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising *** application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.

关键词： Marine cruising equipment Bionic technology Propulsion methods Drag reduction Surface antifouling

Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(Life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo luo Fei Hengyi Yu yan Li yan feng Shaowei Wu yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly(p-dioxanone)

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Chinese Chemical Letters 2009年第6期20卷 743-746页

作者： Chan Yu Zhang yan feng luo Su Jun Wang Zhao Liu Yuan Liang Wang Zhi Qing Liang College of Bioengineering Chongqing University Research Center of Bioinspired Material Science and Engineering (BIMSEC) Chongqing 400030 China Department of Gynecology and Obstetrics Southwest Hospital Third Military Medical University Chongqing 400038 China

Integrating poly（lactic acid）（PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone （PDO） was employed to copolymerize with DL-lactide （LA） via ring-opening melt polymerization using Sn（Oct）2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols （HO-P（LA-co-PDO）-OH） were just such a copolymer consisting of PLA, GA and EG. 1HNMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P（LA-co-PDO）-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P（LA-co-PDO）-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition, the molecular weights of HO-P（LA-co-PDO）-OH increased with decreasing PDO/LA ratios.

关键词： Macrodiol Poly(lactici acid) p-Dioxanone Ethylene glycol Drug delivery carder Bone morphogenetic protein