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Journal of Geriatric Cardiology 2019年第5期16卷 434-436页

作者： Yu XU yan-fang zhao Section of Cardiology Jinling Hospital

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,increasing in prevalence with *** ablation is recommended to symptomatic paroxysmal AF refractory or intolerant to at least one Class I or III antiarrhythmic medication.[1]Main current catheter ablation of AF with radiofrequency can give priority to,other include freezing,ultrasonic and laser ablation *** studies provides substantial information regarding the efficacy and safety of novel cryoballoon technology in creating pulmonary vein(PV)isolation.[2,3]Processed in cyroballoon ablation,some AF patients implanted with double chamber pacemaker are difficult to puncture atrial septal,because of the atrial *** case report was as follows.

关键词： Atrial fibrillation Cryoballoon Double chamber pacemaker

Synthesis and Vasodilatory Activities of New Pyrazolo[3,4-d] pyrimidin-4-one Derivatives

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Chinese Chemical Letters 2002年第7期13卷 613-616页

作者： Ping GONG yan fang zhao Dun WANG Shenyang Pharmaceutical University Shenyang 110016

A series of pyrazolo[3,4-d]pyrimidin-4-one derivatives were synthesized and tested for vasodilatory activities. All of them were new compounds and their structures were confirmed by IR, 1H NMR, MS and elemental analy... 详细信息

关键词： Pyrazolo [3,4-d] pyrimidin-4-ones synthesis vasodilatory activity.

Dispersion features of pollutants in a compound channel with vegetated floodplains

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Journal of Hydrodynamics 2022年第6期34卷 1095-1105页

作者： yan-fang zhao Jing-jing Fan Wei-jie Wang Han-qing zhao Fei Dong Zhen Han Shi-yan Wang School of Water Conservancy and Hydroelectric Power Hebei University of EngineeringHandan056038China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing100038China China Three Gorges Corporation Wuhan430010China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Nanjing210024China

The planting of the vegetation on the floodplain helps the ecological restoration,which is the main form of the river’s ecological ***,the current research of the river dynamics focuses on the water movement under a compound channel with the vegetated *** simulated vegetation species are selected in this paper for the flume simulation experiments of the floodplain vegetation,and the compound channel is divided into three subregions in the transverse *** Navier-Stokes equation and the eddy viscosity theory are applied to obtain the transverse distribution of the depth-averaged velocity and the results agree well with the experimental *** paper proposes a new method based on the analytical solution of the flow velocity distribution to calculate the average flow velocity in each *** results can effectively simulate the average flow velocity of the measured *** description of the pollutant transport processes in a moving stream requires a refined determination of the dispersion coefficients in the compound *** process of the pollutant concentrations in each zone and the reasons for their occurrence are elucidated on the basis of the experimental ***,the measured values of the longitudinal dispersion coefficients are obtained by the“routing procedure,”and a two-zone model of the pollutant dispersion is constructed on the basis of the hydrodynamic *** prediction method for the longitudinal dispersion coefficients is also *** the predicted and measured section average flow velocities to the two-zone model to predict the longitudinal dispersion coefficient,and the average relative errors are only 4.17%,7.15%,*** result indicates that the two-zone model can effectively predict the longitudinal dispersion *** calculation methods for the longitudinal dispersion coefficients from—various studies are *** results reveal that the p

关键词： Compound channel floodplain vegetation velocity distribution pollutant transport dispersion coefficient

Design,synthesis and antiproliferative activities of novel 5H-pyridazino[4,5-b]indoles

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Chinese Chemical Letters 2007年第10期18卷 1191-1194页

作者： Rong Dong Li Xin Zhai yan fang zhao Ping Gong School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmacy Hunan University of Traditional Chinese Medicine Changsha 410208 China

A novel series of 5H-pyridazino[4,5-b]indoles were designed and synthesized in order to find novel potent anticancer compounds. The structures were confirmed by ^1H NMR and MS. Their antiproliferative activities against two cancer cell lines were tested by the MTT method in vitro. Three of compounds （1e, 1g, and 1h） exhibited potent antiproliferative activities, especially compound lh （with IC50 values of 5.2 μmol/L and 1.9 μmol/L against Bel-7402 and HT-1080, respectively）. The preliminary structure-activity relationships of 5H-pyridazino[4,5-b]indole derivatives were discussed.

关键词： 5H-pyridazino[4,5-b]indole derivatives Synthesis Antiproliferative activities

Synthesis and Bronchodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

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Chinese Chemical Letters 2003年第12期14卷 1223-1226页

作者： Dun WANG yan fang zhao De Sheng YU Ping GONG Shenyang Pharmaceutical University Shenyang 110016

Twelve novel pyrazolo [4,3-d] pyrimidin-7-ones were synthesized and their structures were confirmed by IR, 1H NMR and MS. Their in vitro bronchodilatory activities were tested in guinea-pigs. The pharmacological res... 详细信息

关键词： Pyrazolo [4,3-d] pyrimidin-7-ones synthesis bronchodilatory activity.

Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells

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Chinese Chemical Letters 2017年第5期28卷 991-994页

作者： Ming-Ze Qin Lei Wang Shuang yan Jun-Jie Ma Ye Tian yan-fang zhao Ping Gong Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University) Ministry of Education School of Biomedical Sciences Huaqiao University

Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were *** compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of *** 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells（IC50;0.45,0.2μmol/L） while were much less active on A549 cancer cells（IC50;52.83,〉100μmol/L）.Both compounds could be served as promising lead compounds for further investigation.

关键词： Aminopyrimidines EGFR T790M/L858R Selectivity Anti-resistance Antiproliferative activity

Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

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Chinese Chemical Letters 2010年第9期21卷 1071-1074页

作者： Shu Lan Zhang Ya Jing Liu yan fang zhao Qiu Ting Guo Ping Gong Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A series of 1,4-substituted phthalazine derivatives were designed and *** the prepared compounds were screened for their cytotoxic activities against ***-29 and MDA-MB-231 cell lines in *** them,compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1 nmol/L to 0.92μmol/L.A preliminary SAR study of these derivatives was performed.

关键词： 1,4-Substituted phthalazine Synthesis Cytotoxicity

Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

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Chinese Chemical Letters 2013年第5期24卷 386-388页

作者： yan-fang zhao Zi-Jian Liu Xin Zhai Dan-Dan Ge Qiang Huang Ping Gong Key Lab of New Drugs Design and Discovery of Liaoning Province School of Pharmaceutical EngineeringShenyang Pharmaceutical University

A series of novel diaryl ureas containing 4-[（2-amino-6-trifluromethyl）pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer *** them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_（50） values of 0.016,0.63,0.001μmol/L, respectively.

关键词： Diaryl ureas Synthesis Antitumor activity in vitro

Design,synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety

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Chinese Chemical Letters 2012年第8期23卷 915-918页

作者： Bei Zhang yan fang zhao Xin Zhai Wei Jie Fan Jun Ling Ren Chun Fu Wu Ping Gong Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationSchool of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line （HL-60）, human lung adenocarcinoma epithelial cell line （A549） and human breast cancer cell line （MDA-MB-231） in vitro by standard MTT assay. The pharmacological results indicated that some compounds exhibited promising antitumor activities. Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC50 values of 0.13 μmol/L, 0.7 μmol/L and 0.5μmol/L, respectively.

关键词： Diaryl ureas N-acylhydrazone Antiproliferative activities

Numerical analysis of acoustic band gaps in two-dimensional periodic materials

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Journal of Marine Science and Application 2005年第4期4卷 65-69页

作者： zhao yan-cheng zhao fang YUAN Li-bo School of Science Harbin Engineering University Harbin 150001 China

Using the plane-wave expansion (PWE)method , the band gaps of the two-dimension phononic crystals composed of square, triangle and honeycomb arrays aluminum cylinders in the air are calculated numerically. The band structures of three lattices were compared and analyzed. It is concluded that the band-gap of honeycomb lattices is located at lower frequency fields, compared with square and triangle lattices. When the filling fraction is between 0.091 and 0.6046, the honeycomb lattices have larger band gaps and gain an advantage over square and triangle lattices. In addition, the gap map is introduced to illustrate the influences of filling fraction on the number, the relative width and the limit frequency of the band-gap.

关键词： phononic crystal acoustic: band gap plane-wave expansion (PWE) method lattice constant