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偏振光特性分析实验的改进

大学物理实验 2017年第6期30卷 57-60页

作者：张安国何燕周园园沈阳师范大学辽宁沈阳110121

在光学实验中,光的偏振现象的观察与分析是一个基础性实验,实验验证了马吕斯定律。但是在验证马吕斯定律的过程中,发现学生往往得不到正确的实验结论。采用控制变量的方法,通过大量的实验,分析了实验过程中导致实验结果产生偏差的可能... 详细信息

在光学实验中,光的偏振现象的观察与分析是一个基础性实验,实验验证了马吕斯定律。但是在验证马吕斯定律的过程中,发现学生往往得不到正确的实验结论。采用控制变量的方法,通过大量的实验,分析了实验过程中导致实验结果产生偏差的可能原因。结果发现以氦氖激光灯作为光源发出的光是非理想线偏振光,由于学生选择的起偏器的初始角度不同,导致有的学生可以得到正确的实验结论,而有的学生得不到。在利用学校现有实验器材的前提下,对实验过程进行改进,使得到的实验曲线能够很好的符合马吕斯定律。

关键词：偏振光实验马吕斯定律氦氖激光器偏振片

Peripheral monocyte count： an independent diagnostic and prognostic biomarker for prostate cancer - a large Chinese cohort study

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Asian Journal of Andrology 2017年第5期19卷 579-585页

作者： yan-Qing Wang Yin-Jie zhu Jia-Hua Pan Fan Xu Xiao-Guang Shao Jian-Jun Sha Qiang Liu Yi-Ran Huang Bai-Jun Dong Wei Xue Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Pathology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Increasing evidence indicates that inflammation may play important roles in tumorigenesis and progression, and an elevated peripheral monocyte count predicts a poor prognosis in various types of malignancies. Here, we evaluate the roles of peripheral monocyte count in the diagnosis and prognosis for prostate cancer in Chinese patients. A total of 1107 consecutive patients who had undergone prostate biopsy and 290 prostate cancer patients receiving androgen deprivation therapy as first-line therapy were retrospectively analyzed. The parameters were measured at the time of diagnosis. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of a positive biopsy. Patients were categorized in two groups using a cutoff point of 0.425 x 109 1-1 as calculated by the receiver-operating curve analysis for prognosis. Univariate and multivariate Cox regression analyses were performed to determine the associations of monocyte count with progression-free survival, cancer-specific survival, and overall survival. Multivariate logistic regression analyses showed that monocyte count, age, prostate-specific antigen （PSA）, free/total PSA, and prostate volume were independent predictors for prostate cancer. Multivariate Cox regression analyses identified an elevated monocyte count as an independent prognostic factor for worse cancer-specific survival （hazard ratio = 2.244, P 〈 0.05） and overall survival （hazard ratio = 1.995, P 〈 0.05）, but not progression-free survival （P = 0.117）. our results indicated that an elevated monocyte count was an independent diagnostic biomarker for prostate cancer, and pretreatment peripheral monocyte count might play a significant role in the prognosis of prostate cancer patients treated with androgen deprivation therapy.

关键词： diagnosis monocyte prognosis prostate cancer

不同加热温度和时间对菜籽油中苯并(α)芘含量影响的研究

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食品研究与开发 2015年第16期36卷 25-28页

作者：熊巍林邹燕娣金瑚张谦益李敏利道道全粮油股份有限公司国家油菜籽加工技术研发分中心湖南岳阳414000

根据苯并(α)芘的性质,考察不同加热温度和时间对菜籽油中苯并(α)芘含量的影响;模拟精炼过程,考察精炼各工序对苯并(α)芘的去除能力。结果表明:菜籽在180℃以下烘炒,时间不超过20 min时,菜籽油中的苯并(α)芘含量不会上升;炒焦不会导... 详细信息

根据苯并(α)芘的性质,考察不同加热温度和时间对菜籽油中苯并(α)芘含量的影响;模拟精炼过程,考察精炼各工序对苯并(α)芘的去除能力。结果表明:菜籽在180℃以下烘炒,时间不超过20 min时,菜籽油中的苯并(α)芘含量不会上升;炒焦不会导致菜籽油中的苯并(α)芘含量增加,但碳化后容易导致菜籽油中的苯并(α)芘大量产生。本精炼过程中的脱胶脱酸和活性炭吸附是脱除苯并(α)芘的关键工序,而单纯活性白土脱色、脱臭、脱蜡对苯并(α)芘的脱除作用小。

关键词：菜籽油温度和时间苯并(α)芘精炼

QTL analysis for plant height and fine mapping of two environmentally stable QTLs with major effects in soybean

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Journal of Integrative Agriculture 2022年第4期21卷 933-946页

作者： TIAN Yu yanG Lei LU Hong-feng zhANG Bo LI yan-fei LIU Chen GE Tian-li LIU Yu-lin HAN Jia-nan LI Ying-hui QIU Li-juan National Key Facility for Gene Resources and Genetic Improvement/Key Laboratory of Crop Germplasm Utilization Ministry of Agriculture and Rural Affairs/Institute of Crop SciencesChinese Academy of Agricultural ScienceBeijing 100081P.R.China Novogene Bioinformatics Institute Beijing 100015P.R.China School of Plant and Environmental Sciences Virginia Polytechnic Institute and State UniversityBlacksburgVA 24060USA School of Life Sciences Liaoning Normal UniversityDalian 116081P.R.China College of Forestry Northwest A&F UniversityYangling 712100P.R.China

Plant height is an important agronomic trait, which is governed by multiple genes with major or minor effects. of numerous QTLs for plant height reported in soybean, most are in large genomic regions, which results in a still unknown molecular mechanism for plant height. Increasing the density of molecular markers in genetic maps will significantly improve the efficiency and accuracy of QTL mapping. This study constructed a high-density genetic map using 4 011 recombination bin markers developed from whole genome re-sequencing of 241 recombinant inbred lines(RILs) and their bi-parents, zhonghuang 13(zh) and zhongpin 03-5373(ZP). The total genetic distance of this bin map was 3 139.15 cM,with an average interval of 0.78 cM between adjacent bin markers. Comparative genomic analysis indicated that this genetic map showed a high collinearity with the soybean reference genome. Based on this bin map, nine QTLs for plant height were detected across six environments, including three novel loci(qPH-b_11, qPH-b_17 and qPH-b_18). of them, two environmentally stable QTLs qPH-b_13 and qPH-b_19-1 played a major role in plant height, which explained 10.56-32.7% of the phenotypic variance. They were fine-mapped to 440.12 and 237.06 kb region, covering 54 and 28 annotated genes, respectively. Via the function of homologous genes in Arabidopsis and expression analysis, two genes of them were preferentially predicted as candidate genes for further study.

关键词： soybean plant height whole genome re-sequencing bin map QTL

Horizontal gene transfer of a syp homolog contributes to the virulence of Burkholderia glumae

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Journal of Integrative Agriculture 2021年第12期20卷 3222-3229页

作者： WANG Sai WANG Pei-hong NIE Wen-han CUI zhou-qi LI Hong-yu WU yan Ayizekeranmu YIMING FU Luo-yi Iftikhar AHMAD CHEN Gong-you zhU Bo School of Agriculture and Biology Shanghai Jiao Tong University/Key Laboratory of Urban Agriculture of the Ministry of Agriculture and Rural AffairsShanghai 200240P.R.China Department of Plant Pathology&Ecology the Connecticut Agricultural Experiment StationNew Haven 06504CTUSA Department of Environmental Sciences COMSATS University IslamabadVehari-CampusVehari 61100Pakistan

Horizontal gene transfer(HGT)has been proved a major driving force in prokaryotic ***,the molecular functions of these transferred genes in pathogenic bacteria especially plant pathogenic bacteria are still not fully *** this study,the whole-genome in silico analysis was performed and found a syringopeptin synthetase(syp)homolog in Burkholderia glumae,which can cause bacterial panicle blight in rice,was predicted to be horizontally transferred from Pseudomonas ancestor with solid confidence by phylogenetic *** comprehensive molecular experiments were performed to study the potential role of this gene in *** of rice panicles with the syp mutant resulted in 60%lower disease index compared with the wild type(WT)parent strain,suggesting the requirement of syp for the full virulence of *** analysis of exudates from *** showed suppression of synthesis of metabolites analogous to syringopeptin in the *** these data raise the possibility of HGT phenomenon in shaping the virulence and adaptation of *** over evolutionary time.

关键词： horizontal gene transfer burkholderia glumae syringopeptin synthetase

白及提取物对流感病毒感染MDCK细胞基因表达的干预研究

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浙江中医药大学学报 2019年第5期43卷 481-492页

作者：陈江张兵冯燕徐昌平卢亦愚程东庆浙江中医药大学杭州310053 浙江省疾病预防控制中心

[目的]研究白及提取物对流感病毒感染的MDCK细胞基因表达的影响,探讨以宿主细胞为靶点的抗流感病毒作用机制。[方法]建立甲型流感病毒H3N2感染的MDCK细胞模型,以白及提取物进行干预。Trizol法提取细胞总RNA,经琼脂糖甲醛变性凝胶电泳检... 详细信息

[目的]研究白及提取物对流感病毒感染的MDCK细胞基因表达的影响,探讨以宿主细胞为靶点的抗流感病毒作用机制。[方法]建立甲型流感病毒H3N2感染的MDCK细胞模型,以白及提取物进行干预。Trizol法提取细胞总RNA,经琼脂糖甲醛变性凝胶电泳检测其完整性后,利用基因表达谱芯片进行表达谱分析,与未加药物的病毒对照组进行表达谱散点图比对,采用blindDescription统计学模型,以变化倍数(fold change,FC)≥2为上调基因,≤0.5为下调基因。对差异表达的基因按照细胞组分、分子功能、生物学过程进行Go功能聚类分析,并采用KEGG数据库分析差异基因在甲型流感病毒通路、磷脂酰肌醇-3-激酶-蛋白激酶B(phosphoinositide-3-kinase-protein kinase B,PI3K-AKT)信号通路、视黄酸诱导基因-1样受体(retinoic acid inducible gene-1-like receptor,RIG-1-like)信号通路中的定位。对表达具有显著差异的基因,以荧光定量PCR对基因表达情况进行验证。[结果]经白及提取物干预后,流感病毒感染的MDCK细胞中856个基因表达上调,占基因总数的2.62%;1 158个基因下调,占基因总数的3.54%。Go聚类分析结果显示差异基因均涉及细胞的生理功能。KEGG分析显示,甲型流感病毒通路中热休克蛋白70(heat-shock proteins 70,HSP70)基因等11个差异基因上调,黑色素瘤分化相关抗原5(melanoma differentiation-associated antigen 5,MDA5)基因等15个基因下调;PI3K-AKT信号通路中受体酪氨酸激酶(receptor tyrosine kinase,RTK)、磷脂酰肌醇-3-激酶(phosphoinositide-3-kinase,PI3K)等15个基因上调;RIG-1-like信号通路中MDA5、RIG-1等9个基因下调。荧光定量PCR显示,与病毒对照组比较,白及提取物作用后MHCⅡ类转录激活因子(MHC classⅡtransactivator,CⅡTA)、HSP70、PI3K、核因子κB抑制因子(inhibitor of nuclear factorκB, IκB)等基因表达上调,表达量分别提高4.32倍、12.13倍、17.88倍、18.25倍;干扰素调节因子7(interferon regulatory factor 7,IRF7)、Toll样受体3(Toll-like receptor 3,TLR3)、RIG、MDA5、双链RNA依赖的蛋白激酶(double-stranded RNA-dependent protein kinase,PKR)等基因下调,分别下降2.50倍、1.83倍、20.53倍、2.37倍、6.23倍。荧光定量PCR和基因表达谱分析结果相符。[结论]流感病毒感染MDCK细胞后,白及提取物可以通过调控宿主细胞信号通路的相关基因表达水平,从而发挥抗流感病毒效果。

关键词：白及流感病毒H3N2 MDCK细胞基因表达

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聚肌胞对小鼠前列腺癌的抑制作用

吉林大学学报（医学版） 2006年第5期32卷 819-821页

作者：田原僮潘玉琢赵燕颖范文静赵丽娟赵雪俭吉林大学基础医学院病理生理学教研室吉林大学前列腺疾病防治研究中心吉林长春130021

目的:观察聚肌胞对小鼠前列腺癌的抑制作用。方法:将16只C57BL6/J纯系荷瘤小鼠按瘤重采用区组随机分组方法分为对照组和聚肌胞组,每组8只,每隔2日分别瘤内注射生理盐水和聚肌胞,第7次后切除瘤灶,称瘤重,计算瘤重抑制率,绘制前列腺癌生... 详细信息

目的:观察聚肌胞对小鼠前列腺癌的抑制作用。方法:将16只C57BL6/J纯系荷瘤小鼠按瘤重采用区组随机分组方法分为对照组和聚肌胞组,每组8只,每隔2日分别瘤内注射生理盐水和聚肌胞,第7次后切除瘤灶,称瘤重,计算瘤重抑制率,绘制前列腺癌生长曲线及荷瘤鼠生存曲线。前列腺癌组织HE染色观察形态学变化。结果:对照组和聚肌胞组瘤重分别为(4·14±1·56)和(1·58±0·67)g,两组瘤重比较差异具有显著性(P<0·05);聚肌胞组瘤重抑制率为67·85%;前列腺癌生长曲线显示,聚肌胞组小鼠前列腺癌生长较慢;聚肌胞组荷瘤小鼠的生存时间较对照组长(P<0·05);病理显示对照组较聚肌胞组前列腺癌细胞增殖活跃。结论:聚肌胞可以减慢小鼠前列腺癌的生长,延长荷瘤小鼠生存时间。

关键词：前列腺肿瘤聚肌胞苷酸死亡率

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句法宾语的主题表现力研究

语言文字应用 2018年第1期 81-89页

作者：俞岩佟悦闻燕刘小力首都师范大学北京100048

篇章主题表达作者提出的新观点、新信息,句法宾语是承载句子新信息的句法成分,若能从宾语角度分析、提取主题,必然会增加篇章主题提取的全面性和准确性。本文提出篇章内句法宾语能够表现主题的可能性,并以记叙文为分析语料,通过句末位... 详细信息

篇章主题表达作者提出的新观点、新信息,句法宾语是承载句子新信息的句法成分,若能从宾语角度分析、提取主题,必然会增加篇章主题提取的全面性和准确性。本文提出篇章内句法宾语能够表现主题的可能性,并以记叙文为分析语料,通过句末位置与格语法理论底层格动词及其搭配成分的语义关系,从形式和语义两方面锁定、提取宾语,运用语义聚合度理论计算句法宾语之间的相似度后构建篇章主题语义网络,最终呈现句法宾语表现主题的实际数据,并分析宾语在表现主题过程中存在的具体问题。

关键词：句法宾语主题表现力格语法语义网络智能评测

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAo Kai-xin yanG Yi-hong LIANG Qi MEI Li-yan LIANG You-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review