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中国有色金属学会会刊：英文版 2001年第6期11卷 843-846页

作者： yan, HG Chen, zh Kang, ZT Chen, G Hunag, PY Hunan Univ Sch Mat Sci & Engn Changsha 410082 Peoples R China Cent S Univ Dept Mat Sci & Engn Changsha 410083 Peoples R China

The phase formation regularities in nanometer powders of ternary alloys prepared by gas evaporation process with induction current as the heating source were investigated. Al-Cu-Mn and Al-Cu-Cr were chosen as the samples in this study. The experimental results show that the necessary conditions for forming ternary compound phases in a ternary alloy nanometer powder are that they must be able to form in a conventional bulk alloy. To obtain a ternary compound phase in nanometer powders, composition of the master alloy must be in a certain range. Changing the composition of the master alloy and evaporation temperature can control the kinds of the phases and their relative amount in the alloy nanometer powders. In present study, AlMn, Al8Mn5 and AlCu2Mn phases formed in as-prepared nanometer powders of Al-Cu-Mn alloy, and the highest relative amount of AlCu2Mn phase is about 99%. In nanometer powders of Al-Cu-Cr alloy,Cu9Al4, Al2Cu3, AlCr2 and Al13Cr2 phases formed without any ternary compound phase.

关键词： nanometer powder gas evaporation alloy powder

Synthesis and hydrodesulfurization of zirconium binary nitrides

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Chinese Science Bulletin 1997年第15期42卷 1274-1278页

作者： zhang, YJ zh.o, XG zhou, zh yan, WH Ying, PL Xin, Q CHINESE ACAD SCI DALIAN INST CHEM PHYSDALIAN 116023PEOPLES R CHINA

As a new material to be used widely in catalytic field, γ-Mo2N with high specific surface area(usually, SBET>100 m2·g-1 has recently aroused much attention. Its catalytic activities re-semble those of noble metals （Rh, Pd and Pt） in hydrogenation of hydrocarbon. Especially,it has some marvelous characteristics for deep hydrodesulfurization （HDS）, hydrodeni-

关键词： high surface area binary nitrides hydrodesulfurization H2-TPD.

Designing a practical ATM Campus Network

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High Technology Letters 1995年第1期1卷 61-65页

作者： Bin, L. Yong, zh. Shiduan, Ch. yan, M. Beijing Univ of Posts and Telecommunications Beijing China

A typical distributed ATM campus network——BUPT(Beijing University of Posts andTelecommunications)ATM Campus Network is presented in this *** network iscomposed of several small ATM switches in a distributed manner and will be connected tothe China Education and Research Network(CERNET).First,an architecture of BUPTATM Campus Network is *** the interworking and protocol conversion be-tween ATM network and existing 802.X LAN are ***,some of the typicalbroadband applications such as multimedia communications,virtual workgroups,remotevideo-teaching and LAN emulation are described.

关键词： ATM Campus network LAN CERNET Broadband services

A　Conformational　Study　on　the　Interaction　of　Saporin-S6　with　Phospholipid　Vesicles

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Chemical Research in Chinese Universities 1998年第1期14卷 42-45页

作者： Hao, Q Guan, zh yan, L zhang, Y yan, GL Liu, GH Dong, QC Li, QS Wang, YZ Jilin Univ Dept Mol Biol Changchun 130023 Peoples R China Jilin Univ Natl Lab Enzyme Engn Changchun 130023 Peoples R China Peoples Hosp Jilin Prov Med Testing Dept Changchun 130021 Peoples R China

ＡＣｏｎｆｏｒｍａｔｉｏｎａｌＳｔｕｄｙｏｎｔｈｅＩｎｔｅｒａｃｔｉｏｎｏｆＳａｐｏｒｉｎ－Ｓ６ｗｉｔｈＰｈｏｓｐｈｏｌｉｐｉｄＶｅｓｉｃｌｅｓＨＡＯＱｉａｎｇ，ＧＵＡＮＺｈｏｎｇ－ｈｕｉ，ＹＡＮＬｉ，ＺＨＡＮＧＹａ... 详细信息

ＡＣｏｎｆｏｒｍａｔｉｏｎａｌＳｔｕｄｙｏｎｔｈｅＩｎｔｅｒａｃｔｉｏｎｏｆＳａｐｏｒｉｎ－Ｓ６ｗｉｔｈＰｈｏｓｐｈｏｌｉｐｉｄＶｅｓｉｃｌｅｓＨＡＯＱｉａｎｇ，ＧＵＡＮＺｈｏｎｇ－ｈｕｉ，ＹＡＮＬｉ，ＺＨＡＮＧＹａｎ，ＹＡＮＧａｎｇ－ｌｉｎ，ＬＩＵ...

关键词： Interaction the Phospholipid Saporin-S6

瘦素受体与核转录因子-κB在结直肠腺癌组织中的表达及意义

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世界华人消化杂志 2006年第28期14卷 2759-2764页

作者：熊枝繁晏泽辉华中科技大学同济医学院附属梨园医院消化内科湖北省武汉市430077

目的:研究瘦素受体(ob-R)在结直肠腺癌组织中的表达,探讨ob-R在肿瘤血管生成中的作用及其可能机制．方法:免疫组织化学方法检测35例结直肠腺癌组织、24例结直肠腺瘤组织和35例正常对照组织中ob-R、CD105、核转录因子-κBp65(NF-κBp65)... 详细信息

目的:研究瘦素受体(ob-R)在结直肠腺癌组织中的表达,探讨ob-R在肿瘤血管生成中的作用及其可能机制．方法:免疫组织化学方法检测35例结直肠腺癌组织、24例结直肠腺瘤组织和35例正常对照组织中ob-R、CD105、核转录因子-κBp65(NF-κBp65)的表达,以图像分析软件进行半定量测定．结果:以CD105标记的微血管密度(MVD)在癌症组、腺瘤组、正常对照组间呈递减改变(23．63±2．08 vs 10．83±1．25 vs 1．97±0.37．Pob-R和NF-κB(p65)的表达部位相似．癌症组中ob-R和NF-κB(p65)的积分光密度均比对照组高(27．41±2．21 vs 20．45±1．63, 45．88±5．46 vs 29．11±3．89,Pob-R,NF-κBp65的积分光密度,MVDS三者间呈两两正相关．癌症组63．6％的标本中可见ob-R血管内皮细胞染色阳性,其MVD较阴性者高(38．21±2．78 vs 27．50±2．95,t=2．602, Pob-R和NF-κBp65的表达与结直肠腺癌临床病理因素间未见相关性．结论:结直肠腺癌组织中ob-R表达增多对肿瘤血管生成起促进作用,并且该作用可能是通过NF-κB途径来实现的．

关键词：瘦素受体核转录因子-κB 结直肠腺癌

Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng zhang Fei Li Yiqing Wu Chunhong Huang Xiaolong yang Joachim Kremerskothen Jianmin zhang Chunbo zhang Shuo Tu zhihua Li zhĳun Luo zhenghong Lin Xiaohua yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of Nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

A New Method for Locating Calculation of Arbitrary Spatial Straight Line or Plane in NC Machining

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厦门大学学报（自然科学版） 2002年第S1期41卷 149-150页

作者： yan Shu-tian, LIU Tao, WU Zai-xin, HU Chi-bing, HU Li-zh i (College of Mechano-Electronic Engineering, Gansu University of Techn ology, Lanzhou 730050, China)

In the manufacturing process, we often encounter so me location machining of space arbitrary straight lines and planes that are not on ly unparalleled but also not vertical with the machine tool spindle or the cutti ng tool. In the past, we can do the location machining through the methods of dr awing line and making level in the ordinary machine tool. In the numerical contr ol machining of the CNC machine tool and manufacturing center, however, the spac e location and angle of the arbitrary straight lines and planes must be precisel y calculated in advance. So that precisely locating can be guaranteed in machini ng. Therefore, how to work out the space location angle of the arbitrary straigh t lines and planes to be machined both conveniently and precisely, turns out to be the must-be-solved chief problem in the numerical control machining. In thi s paper, through the deeply research of this problem, a new kind of calculating formula that calculates and defines the space location angle of the arbitrary st raight lines and planes by using the methods of analytic calculating. The formul a has been applied in the practical manufacturing calculation. It is proved that the new space angle calculating methods of arbitrary straight lines and planes is convenient in calculating and precise in locating. And it provides us a n ew, brief and precise calculating method in the numerical control machining of t he numerical control machine tool and manufacturing center.

关键词： arbitrary straight line arbitrary plane pr ojected angle inclination location

Mechanism of HBV-related Liver Failure

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Mechanism of HBV-related Liver Failure

Behavior, distribution and environmental influence of arsenic in a typical lead smelter

第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者： zh yan YM Wang GH Deng X zhou YZ Tang L Liu Department of Infectious Diseases Southwest HospitalThird Military Medical University

Summary The pathogenesis of HBV-associated liver failure is very complicated and it has achieved great progress in recent *** the recent literature,combining with the novel findings of our research team,here,we summarized the pathogenesis of HBV-associated liver failure as follows:l)both host and viral factors are contributed to the pathogenesis of HBV-associated liver failure.2)polymorphisms G-201A from CXCL10,-592C and -819C from IL-10 are closely related to hepatitis flares and liver failure.3)genotype C and B,particularly B/C co-infection,are correlated with liver failure.4) quasispecies studies during antiviral therapy by using NAs is quite important.5)attention should be paid to missed detection in HBV DNA by real-time PCR. Liver failure is a condition in which rapid deterioration of liver function results in altered mentation and *** etiology of liver failure shows worldwide variations,and its prominent causes include drug-induced liver injury,viral hepatitis,autoimmune liver disease and shock or *** most other countries,in China,liver failure has been termed as severe hepatitis and is caused mainly by hepatitis B virus(HBV) infection(at least 60%-80%).1 According to the diagnostic and treatment guidelines for liver failure recommended by the Chinese Medical Association in 2006,2 liver failure could be classified four difference types as table 1. Persistent HBV infection and HBV-related liver diseases have been considered as a multi-factorial and polygenic disorder with viral,environmental and host genetic *** pathogenesis of HBV-associated liver failure is very complex and needs more studies to *** host and viral factors are contributed to the pathogenesis of HB V-associated liver *** the literature in recent years,combining with the novel findings of our research team,here,we summarized the pathogenesis of HBV-associated liver failure as follows. The Progress of Pathogenesis Host Factors

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Journal of Central South University 2015年第4期22卷 1276-1286页

作者：柴立元史美清梁彦杰汤景文李青竹 School of Metallurgy and Environment Central South University Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution (Central South University)

A field study was conducted to determine the behavior and distribution of arsenic during the pyrometallurgy process in a typical SKS(Shuikoushan) lead smelter in Hunan province, China. Environmental influences of arsenic in selected samples were evaluated. Arsenic contents in all input and output samples vary from 0.11% in raw lead to 6.66% in collected dust-2. More arsenic is volatilized in blast furnace and fuming furnace(73.02% of arsenic input) than bottom blowing furnace(10.29% of arsenic input).There are 78.97%, 13.69%, 7.31% of total arsenic distributed in intermediate materials, stockpiled materials and unorganized emissions, respectively. Matte slag-2, collected dust-1 and secondary zinc oxide are hazardous based on the arsenic concentrations of toxicity characteristic leaching procedure. According to risk assessment code(RAC) guideline, arsenic in collected dust-1 poses a very serious risk to the surrounding environment, arsenic in speiss, matte slag-2, water-quenched slag and secondary zinc oxide show low risk, while arsenic in matte slag-1, collected dust-2 and post dust has no risk to the environment.

关键词： arsenic behavior distribution environmental influence SKS lead smelter