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The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients

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Food Science and Human Wellness 2024年第2期13卷 1079-1092页

作者： Qingqing Xu Weifei Wang Dongxiao Sun-Waterhouse Qian Zou Menglei yan Xuan Liu Dongming Lan yonghua Wang School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural and Agri-Food Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510610China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these patients.Linseed oil-based DAG(LD)and linseed oil(LT)were selected.LD-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously reported.Indigestion conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid compositions.LD-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients.

关键词： Diacylglycerol In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency

1949—2022年四川省职业性尘肺病患者调查和随访管理

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预防医学情报杂志 2024年第4期40卷 369-373,384页

作者：邓璐马传梁吴瑕倪红珍严永华左云王海蓉谭利民四川省疾病预防控制中心成都610041

目的掌握四川省职业性尘肺病患者底数和分布特征,分析四川省职业性尘肺病发病特点和变化趋势,了解尘肺病患者健康状况和保障情况。方法以四川省截至2019年底报告的所有职业性尘肺病患者为调查对象,开展回顾性调查;并于2020—2022年期间... 详细信息

目的掌握四川省职业性尘肺病患者底数和分布特征,分析四川省职业性尘肺病发病特点和变化趋势,了解尘肺病患者健康状况和保障情况。方法以四川省截至2019年底报告的所有职业性尘肺病患者为调查对象,开展回顾性调查;并于2020—2022年期间对存活病例进行随访管理。通过联系有关职能部门、职业病防治机构和尘肺病患者所在地查询相关资料,对尘肺病患者进行电话或上门随访,收集尘肺病患者相关情况。采用SPSS 21.0软件对尘肺病患者的性别、年龄、工龄和尘肺种类以及保障情况等进行描述性统计分析。结果共调查1949—2019年四川省诊断的66578例职业性尘肺病例,男女性别比为220.93∶1,壹期尘肺42384例(63.65%)、贰期尘肺17506例(26.29%),叁期尘肺5481例(8.23%)。随访到职业性尘肺病例存活44305例(66.55%),死亡18280例(27.46%),失访3993例(6.00%)。存活患者病种分布以矽肺、煤工尘肺为主,平均年龄为(63.00±10.88)岁,平均接尘工龄为(13.82±10.90)年,享受工伤保险保障23333例(52.66%),用人单位赔付6221例(14.4%),基本医疗保险42891例(96.81%),大病医疗保险26358例(59.49%),其他保障(医疗救助与扶贫救助等)4649例(10.49%)。44305例存活病例在2020—2022年期间死亡2587例,其中死亡原因前3位为由于含硅/矽粉尘引起的尘肺371人(14.2%),煤炭工尘肺167人(6.4%)和未特指的尘肺158人(6.1%)。截至2022年12月,存活的患者中有5251人自述患有尘肺合并症,其中3203人(7.7%)患有慢性阻塞肺疾病(COPD),有2012人(4.8%)患有肺及支气管感染、632人(1.5%)患肺结核,515人(1.2%)患肺心病,有1084人(2.6%)同时患有2种或2种以上的合并症。结论四川省尘肺病防治工作重点为矽肺和煤工尘肺,应加强对粉尘严重危害行业和地区的监管,制定切实可行的尘肺病防控策略,加强尘肺病患者的保障。

关键词：尘肺病随访调查保障措施并发症

液滴撞击固体壁面铺展特性的格子Boltzmann方法研究

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液滴撞击固体壁面铺展特性的格子Boltzmann方法研究

Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

中国力学大会-2017暨庆祝中国力学学会成立60周年大...

作者：陈琬钰杨帆 yan yonghua 郭雪岩上海理工大学能源与动力工程学院 Department of Mathematics and Computer Science Alcorn State University

基于单组分多相伪势模型的格子Boltzmann方法,模拟了三维液滴撞击水平及倾斜固体壁面的运动过程,获得了液滴铺展因子、相对宽度和相对高度随时间的变化情况,研究了壁面浸润性、壁面倾斜角度、以及雷诺数、邦德数等参数对液滴运动过程的... 详细信息

基于单组分多相伪势模型的格子Boltzmann方法,模拟了三维液滴撞击水平及倾斜固体壁面的运动过程,获得了液滴铺展因子、相对宽度和相对高度随时间的变化情况,研究了壁面浸润性、壁面倾斜角度、以及雷诺数、邦德数等参数对液滴运动过程的影响。结果表明,对于水平壁面,减小静态接触角和增大液滴韦伯数能够使液滴铺展过程的震荡幅度增大,并且增大壁面亲水性会使得液滴最终铺展因子增大,相对高度减小。对于倾斜壁面,增大壁面浸润角和增大壁面倾角都能使液滴铺展总长度减小,相对铺展宽度减小,相对高度增大;减小液滴的粘性和增大液滴邦德数都能使初始阶段和铺展阶段的周向铺展和收缩阶段的液滴向前沿聚集更为明显。

关键词：格子Boltzmann方法单组分多相伪势模型液滴固体壁面

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong Zhu Chengwu Feng Jing Chen Wei Gan Yuan Ma yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains unclear.Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD onset.Methods A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since 2014.CVD risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register data.Results Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were identified.Higher FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's disease.Comparing the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause dementia.Interactions were not detected for FGCRS and PRS on the risk of any dementia subtype.We observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS category.For brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.The association of cardiovascular risk burden wit

关键词： Cardiovascular diagnosis burden

Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms

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中华医学杂志(英文版) 2024年第10期137卷 2023 Aug 30页

作者： Feng Yi Feng yonghua Hu Mingyao Xu Hongen Wang Zhigang Xu Shicheng yan Yongchuang Feng Chenghao Li Zhou Feng Guiwen Shang Wenjun Department of Renal Transplantation The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Precision Medicine Center Academy of Medical Science Zhengzhou University Zhengzhou Henan China

Background: Growth retardation is a common complication of chronic kidney disease in children, which can be partially relieved after renal transplantation. This study aimed to develop and validate a predictive model for growth patterns of children with end-stage renal disease (ESRD) after kidney transplantation using machine learning algorithms based on genomic and clinical variables.Methods: A retrospective cohort of 110 children who received kidney transplants between May 2013 and September 2021 at the First Affiliated Hospital of Zhengzhou University were recruited for whole-exome sequencing (WES), and another 39 children who underwent transplant from October 2021 to March 2022 were enrolled for external validation. Based on previous studies, we comprehensively collected 729 height-related single-nucleotide polymorphisms (SNPs) in exon regions. Seven machine learning algorithms and 10-fold cross-validation analysis were employed for model construction.Results: The 110 children were divided into two groups according to change in height-for-ageZ-score. After univariate analysis, age and 19 SNPs were incorporated into the model and validated. The random forest model showed the best prediction efficacy with an accuracy of 0.8125 and an area under curve (AUC) of 0.924, and also performed well in the external validation cohort (accuracy, 0.7949; AUC, 0.796).Conclusions: A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning algorithms. The model is expected to guide clinicians in the management of children after renal transplantation, including the use of growth hormone, glucocorticoid withdrawal, and nutritional supplementation, to alleviate growth retardation in children with ESRD.

关键词： Growth Machine learning Pediatric kidney transplantation Single-nucleotide polymorphism

使用接收函数自相关约束渤海湾北部沉积层结构

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地球物理学报 2024年第6期67卷 2291-2303页

作者：王秋实李永华武岩中国地震局地球物理研究所北京100081 中国地震局震源物理重点实验室北京100081

地震灾后调查表明盆地对地震动有显著的放大效应.低速、松散的沉积层和下伏基岩之间的物性差异,通常被认为是导致地震破坏增加的直接原因,它会显著增加盆地内地震动的持续时间、放大地震动幅度.可靠的沉积层结构和基阶共振频率有利于估... 详细信息

地震灾后调查表明盆地对地震动有显著的放大效应.低速、松散的沉积层和下伏基岩之间的物性差异,通常被认为是导致地震破坏增加的直接原因,它会显著增加盆地内地震动的持续时间、放大地震动幅度.可靠的沉积层结构和基阶共振频率有利于估计沉积层的放大作用并评估该区地震危险性.本研究利用渤海湾地区43个流动地震台站的远震波形资料提取了P波接收函数,进一步通过接收函数自相关得到了台站下方沉积层的共振频率,并依照钻孔资料推导出的共振频率和沉积层厚度之间的经验关系,给出了研究区的沉积层厚度.研究区共振频率存在由东北向西南减小的趋势,其中研究区东北部共振频率主要介于0.30~0.77 Hz之间,对应的沉积层厚度介于120~500 m;研究区西南平原地区绝大部分台站的共振频率低于0.30 Hz,沉积层厚度介于500~1252 m.本文结果与前人采用HVSR方法给出的共振频率具有较好的一致性,通过与已有反射和钻孔资料对比研究,推测本文所给出的沉积厚度为晚第三纪-第四纪(N+Q)的沉积盖层厚度.

关键词：接收函数自相关沉积层结构渤海湾盆地

除湿止痒合剂对湿热蕴结型特应性皮炎患者肠道菌群的影响

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皮肤科学通报 2024年第3期41卷 305-312页

作者：徐晓倩吉凯峰郑玉婷陆冰萱闫泳桦高尚璞李晓睿李燕娜程塞渊吴孙思张香坡肖青青宋瑜上海市中医药大学附属龙华医院皮肤科上海200032

目的探讨除湿止痒合剂对特应性皮炎(AD)患者肠道菌群的影响。方法选取2021年5月—2022年10月上海中医药大学附属龙华医院皮肤科收治的154例AD患者,其中79例为试验组,予口服除湿止痒合剂4周,75例为对照组,予口服左西替利嗪4周;试验组、... 详细信息

目的探讨除湿止痒合剂对特应性皮炎(AD)患者肠道菌群的影响。方法选取2021年5月—2022年10月上海中医药大学附属龙华医院皮肤科收治的154例AD患者,其中79例为试验组,予口服除湿止痒合剂4周,75例为对照组,予口服左西替利嗪4周;试验组、对照组在治疗前后均各采集粪便样品1次。通过高通量基因测序法分析治疗前后肠道菌群变化。结果本研究基于16rsDNA技术发现对照组、试验组用药后肠道菌群α多样性、β多样性差异不显著;试验组用药后肠道多种优势益生菌丰度上升,致病菌丰度下降,LefSe分析结果显示,用药后试验组在科水平上,乳杆菌科(Lactobacillaceae)、丛毛单胞菌科(Comamondaceae)、伯克氏菌科(Burkholderiaceae)为优势菌,在属水平上,真杆菌属(Eubacterium hallii group)、普雷沃氏菌属(Alloprevotella)、消化梭菌属(Peptoclostridium)、贪噬菌属(Variovorax)为优势菌;与对照组相比,试验组以霍尔德曼氏菌属(Holdemanella)、Catenisphaera为优势菌。结论除湿止痒合剂对AD患者肠道菌群生物多样性影响不显著,但能提升有益菌丰度,降低致病菌丰度。

关键词：特应性皮炎肠道菌群皮-肠轴除湿止痒合剂

基于YOLOv7-Tiny算法的无人机实时跟踪野生动物方法

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野生动物学报 2024年第2期45卷 251-261页

作者：阎婧宇谢永华东北林业大学计算机与控制工程学院哈尔滨150040

借助无人机边缘计算技术监测野生动物的运动状态和种群发展变化已成为科研工作者广泛使用的技术手段。传统跟踪算法算力高,机载边缘设备硬件资源算力不足,在户外复杂的自然环境下难以实现实时跟踪。为解决野外环境中无人机跟踪野生动物... 详细信息

借助无人机边缘计算技术监测野生动物的运动状态和种群发展变化已成为科研工作者广泛使用的技术手段。传统跟踪算法算力高,机载边缘设备硬件资源算力不足,在户外复杂的自然环境下难以实现实时跟踪。为解决野外环境中无人机跟踪野生动物时遇到树木遮挡和背景干扰导致无法准确实时跟踪的问题,选取东北地区东北虎(Panthera tigris altaica)、狍(Capreolus pygargus mantschuricus)和驯鹿(Rangifer tarandus phylarchus)为研究对象,以YOLOv7-Tiny+Bot-SORT作为检测跟踪的基础框架,提出了一种轻量化的无人机跟踪算法。首先,采用FasterNet网络减少模型冗余计算,增强特征图中目标区域关注度;其次,采用高效通道注意力机制实现局部跨通道交流,降低复杂环境对检测网络的影响,提升网络检测能力;最后,为降低计算成本,替换重识别网络,提高无人机跟踪速度。结果显示:提出的实时跟踪方法准确度(MOTA)和精确度(MOTP)分别达到79.93%和73.48%,跟踪速度从3.4帧/s提升到43.4帧/s。研究表明,提出的算法不仅在提升跟踪精度和速度方面表现出色,而且更适用于算力有限的边缘设备,为保护野生动物的多样性和群体行为研究提供了强大的技术支持。

关键词：多目标跟踪 YOLOv7-Tiny算法野生动物无人机轻量化

Statistical Study on Cement-Soil Mixture Strength

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Transactions of Tianjin University 2005年第3期11卷 223-229页

作者：于志强曹永华闫澍旺 Institute of Geotechnical Engineering Tianjin University Tianjin 300072 China

This paper presents an investigation on strength of cement deep mixing （CDM） mixture. Four typical works of offshore or land-based projects are introduced. With samples from these projects and laboratory tests, statistical analysis is made on the increment law of the strength of cement-soil mixture with different amount of cement, and strengths under different working conditions are compared. It is found that the amount of cement in the cement-soil mixture is closely related to the unconfined compressive strength of the mixture. At the age of 90 d,the unconfined compressive strength of the cement-soil mixture increased by 0.054 MPa—0.124 MPa with each cement increasing 10 kg/m3 in the cement-soil mixture, averagely increased by 0.085 MPa, while that at the age of 120 d increased by 1100 in comparison.The quality of the cement-soil mixture should be comprehensively evaluated in accordance with the trimmed average of strength, coefficient of variation and rock quality designation （RQD） indicators of sampling ratio.

关键词： CDM混合物取样无约束压力统计学分析质量评估水泥粘合剂