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Effects of interstitial cluster mobility on dislocation loops evolution under irradiation of austenitic steel

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Nuclear Science and Techniques 2024年第8期35卷 69-78页

作者： Xin‑Hua yan Lu Sun Du Zhou Teng Xie Chang Peng ye‑Xin yang Li Chen Zhen‑Feng Tong North China Electric Power University Beijing 102206China China Nuclear Power Operations Co. LtdShenzhen 518000China

The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD *** CD predictions are compared with experimental results in the *** number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the *** CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.

关键词： Cluster dynamics Dislocation loops In-cascade interstitial clusters Austenitic steels

Characterization and prediction of tailpipe ammonia emissions from in-use China 5/6 light-duty gasoline vehicles

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 71-81页

作者： Lewei Zeng Fengbin Wang Shupei Xiao Xuan Zheng Xintong Li Qiyuan Xie Xiaoyang Yu Cheng Huang Qingyao Hu yan You ye Wu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Engines Tianjin UniversityTianjin 300072China China Automotive Technology and Research Center Co.Ltd. Tianjin 300300China CATARC Automotive Test Center(Guangzhou)Co.Ltd. Guangzhou 511300China State Environmental Protection Key Laboratory of Cause and Prevention of Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China National Observation and Research Station of Coastal Ecological Environments in Macao Macao Environmental Research InstituteMacao University of Science and TechnologyMacao SAR 999078China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China

On-road tailpipe ammonia (NH3) emissions contribute to urban secondary organic aerosol formation and have direct or indirect adverse impacts on the environment and human health. To understand the tailpipe NH3 emission characteristics, we performed comprehensive chassis dynamometer measurements of NH3 emission from two China 5 and two China 6 light-duty gasoline vehicles (LDGVs) equipped with three-way catalytic converters (TWCs). The results showed that the distance-based emission factors (EFs) were 12.72 ± 2.68 and 3.18 ± 1.37 mg/km for China 5 and China 6 LDGVs, respectively. Upgrades in emission standards were associated with a reduction in tailpipe NH3 emission. In addition, high NH3 EFs were observed during the engine warm-up period in cold-start cases owing to the intensive emissions of incomplete combustion products and suitable catalytic temperature in the TWCs. Notably, based on the instantaneous NH3 emission rate, distinct NH3–emitting events were detected under high/extra high velocity or rapid acceleration. Furthermore, NH3 emission rates correlated well with engine speed, vehicle specific power, and modified combustion efficiency, which were more easily accessible. These strong correlations were applied to reproduce NH3 emissions from China 5/6 LDGVs. The predicted NH3 EFs under different dynamometer and real-world cycles agreed well with existing measurement and prediction results, revealing that the NH3 EFs of LDGVs in urban routes were within 8.55–11.62 mg/km. The results presented here substantially contribute to improving the NH3 emission inventory for LDGVs and predicting on-road NH3 emissions in China.

关键词： NH3 instantaneous emissions Catalytic temperature Vehicle specific power Combustion efficiency Emission prediction

Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

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Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo yanG Le-hao REN Feng WANG Pi-lin WANG Wen-yan WANG Shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models

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Chinese Chemical Letters 2024年第3期35卷 394-398页

作者： Hongyao Liu yan Yu Taixiong Xue Cailing Gan Yuting Xie Doudou Wang Peilin Li Zhiyong Qian Tinghong ye Department of Gastroenterology and Hepatology Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer and Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell *** various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and *** is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of ***,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced *** addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary ***,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver ***,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological *** together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates.

关键词： Fibrosis H_(2)O_(2) Electrochemical sensor NOX4 Nintedanib

Autonomous eVTOL:A summary of researches and challenges

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Green Energy and Intelligent Transportation 2024年第1期3卷 55-69页

作者： Senwei Xiang Anhuan Xie Minxiang ye Xufei yan Xiaojia Han Hongjiao Niu Qiang Li Haishan Huang Research Center for Intelligent Robotics Zhejiang LabHangzhou 311121China TianMuShan Laboratory Hangzhou 310023China

Due to the rising concept of advanced air mobility(AAM),electric vertical take-off and landing(eVTOL)aircraft has become the hotspot for academic research and commercial *** paper provides a comprehensive review of latest researches related to autonomous *** examines key technologies involved in autonomous eVTOL,including automated flight control,sensing&perception,safety&reliability,and decision *** also addresses the technical,regulatory,and societal challenges associated with the wholesale adoption of autonomous eVTOL into *** paper concludes with a discussion of future trends and recommendations,including the importance of integration with air traffic management,urban infrastructure and human–machine *** aims to be a useful resource for those involved in the research,policy,and industry of autonomous eVTOL technology.

关键词： eVTOL AAM Autonomy Key technology Challenge

Enhancing nitrogen removal in constructed wetlands: The role of influent substrate concentrations in integrated vertical-flow systems

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Environmental Science and Ecotechnology 2024年第5期21卷 103-112页

作者： Tongtong Liu Da Li yan Tian Jiajie Zhou ye Qiu Dongyi Li Guohong Liu Yujie Feng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyNo.73 Huanghe RoadNangang DistrictHarbin 150090China Institute of Chemical Engineering in Heilongjiang Province 3#Nanhu loadHigh Tech R&D Zone of Harbin CityHarbin 150028China

Recent advancements in constructed wetlands(CWs)have highlighted the imperative of enhancing nitrogen(N)removal ***,the variability in influent substrate concentrations presents a challenge in optimizing N removal strategies due to its impact on removal efficiency and *** we show the interplay between influent substrate concentration and N removal processes within integrated vertical-flow constructed wetlands(IVFCWs),using wastewaters enriched with NO_(3)^(-)-N and NH4þ-N at varying carbon to nitrogen(C/N)ratios(1,3,and 6).In the NO_(3)^(-)-N enriched systems,a positive correlation was observed between the C/N ratio and total nitrogen(TN)removal efficiency,which markedly increased from 13.46±2.23%to 87.00±2.37%as the C/N ratio escalated from 1 to ***,in NH4þ-N enriched systems,TN removal efficiencies in the A-6 setup(33.69±4.83%)were marginally 1.25 to 1.29 times higher than those in A-3 and A-1 systems,attributed to constraints in dissolved oxygen(DO)levels and *** community analysis and metabolic pathway assessment revealed that anaerobic denitrification,microbial N assimilation,and dissimilatory nitrate reduction to ammonium(DNRA)predominated in NO_(3)^(-)-N systems with higher C/N ratios(C/N 3).In contrast,aerobic denitrification and microbial N assimilation were the primary pathways in NH4þ-N systems and low C/N NO_(3)^(-)-N systems.A mass balance approach indicated denitrification and microbial N assimilation contributed 4.12-47.12%and 8.51e38.96%in NO_(3)^(-)-N systems,respectively,and 0.55e17.35%and 7.83e33.55%in NH4þ-N systems to TN *** enhance N removal,strategies for NO_(3)-N dominated systems should address carbon source limitations and electron competition between denitrification and DNRA processes,while NH4þ-N dominated systems require optimization of carbon utilization pathways,and ensuring adequate DO and alkalinity supply.

关键词： Constructed wetland Nitrogen removal pathway Denitrification Microbial nitrogen assimilation Enhanced strategy

Ecological filter walls for efficient pollutant removal from urban surface water

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Environmental Science and Ecotechnology 2024年第5期21卷 230-237页

作者： Menglong Liao ye Qiu yan Tian Zeng Li Tongtong liu Xinlei Feng Guohong Liu Yujie Feng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Heilongjiang Academy of Chemical Engineering No 3Nanhu StreetCentury DistrictHigh-Tech ZoneHarbin150028China

Urban surface water pollution poses significant threats to aquatic ecosystems and human *** nitrogen removal technologies used in urban surface water exhibit drawbacks such as high consumption of carbon sources,high sludge production,and focus on dissolved oxygen(DO)concentration while neglecting the impact of DO ***,we show an ecological filter walls(EFW)that removes pollutants from urban surface *** utilized a polymer-based three-dimensional matrix to enhance water permeability,and emergent plants were integrated into the EFW to facilitate biofilm *** observed that varying aeration intensities within the EFW's aerobic zone resulted in distinct DO gradients,with an optimal DO control at 3.19±0.2 mg L^(-1) achieving superior nitrogen removal ***,the removal efficiencies of total organic carbon,total nitrogen,ammonia,and nitrate were 79.4%,81.3%,99.6%,and 79.1%,*** community analysis under a 3 mg L^(-1) DO condition revealed a shift in microbial composition and abundance,with genera such as Dechloromonas,Acinetobacter,unclassified_f__Comamonadaceae,SM1A02 and Pseudomonas playing pivotal roles in carbon and nitrogen ***,the EFW facilitated shortcut nitrification-denitrification processes,predominantly contributing to nitrogen *** low manufacturing cost,flexible application,small artificial trace,and good pollutant removal ability,EFW has promising potential as an innovative approach to urban surface water treatment.

关键词： Urban water remediation Ecological filter walls Shortcut nitrification-denitrification Dissolved oxygen gradient Nitrogen removal

Cerebral syphilitic gumma misdiagnosed as brain abscess: A case report

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World Journal of Clinical Cases 2024年第3期12卷 650-656页

作者： Li-Kun Mu Li-Feng Cheng Jing ye Meng-yan Zhao Jin-Long Wang Department of Neurosurgery Shengli Oilfield Central HospitalDongying 257099Shandong ProvinceChina

BACKGROUND Cerebral syphilitic gumma is a relatively rare clinical *** clinical manifest-ations are non-specific,and the imaging manifestations are similar to other in-tracranial occupying lesions,often misdiagnosed as tumors or *** are few reports on this disease in the relevant *** our knowledge,we have reported the first case of cerebral syphilitic gumma misdiagnosed as a brain *** report this case and provide useful information for clinical doctors on neurosyphilis *** SUMMARY We report the case to explore the diagnostic essentials of cerebral syphilitic gumma and attempt to mitigate the rates of misdiagnosis and missed diagnosis by equipping physicians with knowledge of neurosyphilis *** cli-nical diagnosis and treatment of a patient with cerebral syphilitic gumma were *** manifestations,classifications,and diagnostic points were retro-spectively *** patient was admitted to the hospital with fever and limb *** magnetic resonance imaging showed multiple space-occupying lesions and a positive serum Treponema pallidum gelatin agglutination *** patient was misdiagnosed as having a brain abscess and underwent a craniotomy.A postoperative pathological diagnosis of syphilis gumma was *** patient improved and was discharged after penicillin anti-syphilis ***-up recovery was *** Cerebral syphilitic gumma is rare in clinical practice,and it is often misdiagnosed and *** diagnosis should be considered in combination with multiple examinations.

关键词： Neurosyphilis Cerebral syphilitic gumma Brain abscess Misdiagnosis Treatment Case report

Effects and mechanisms of Helicobacter pylori infection on the occurrence of extra-gastric tumors

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World Journal of Gastroenterology 2024年第37期30卷 4090-4103页

作者： Shi-Qing Zhao Hui-Ling Zheng Xiao-Tian Zhong Zi-ye Wang Yi Su yan-yan Shi Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Health Science Center Peking UniversityBeijing 100191China Department of Gastroenterology Peking University Third HospitalBeijing 100191China

Helicobacter pylori(***)colonizes the human stomach and many studies have discussed the mechanisms of *** infection leading to gastric diseases,including gastric ***,increasing data have shown that the infection of *** may contribute to the development of extra-gastric diseases and ***,systemic immune responses,microbiome disorders,and hypergastrinemia caused by *** infection are associated with many extra-gastric *** review highlights recent discoveries;discusses the relationship between *** and various extra-gastric tumors,such as colorectal cancer,lung cancer,cholangiocarcinoma,and gallbladder carcinoma;and explores the mechanisms of extra-gastric carcinogenesis by ***,these findings refine our understanding of the pathogenic processes of ***,provide guidance for the clinical treatment and management of ***-related extra-gastric tumors,and help improve prognosis.

关键词： Helicobacter pylori Extra-gastric tumors Immune system response Mucosal barrier Gut microbiome