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Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

Chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： XIU ye WANG Sihao ZHANG Ping LI Chengwei WU Zhixin WEN Jincai XU Yingjie LV Guiji ZHAO Xiaomei DONG Xu CHEN Yichong LI Junjie WANG yan ZOU Liang XIAO Xiaohe BAI Zhaofang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and *** this,the clinical approval of drugs targeting the cGAS-STING pathway has been *** Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our *** found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1(THP-1)*** inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 10(CXCL10),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling *** vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

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Plant virology in the 21st century in China:Recent advances and future directions

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Journal of Integrative Plant Biology 2024年第3期66卷 579-622页

作者： Jianguo Wu Yongliang Zhang Fangfang Li Xiaoming Zhang Jian ye Taiyun Wei Zhenghe Li Xiaorong Tao Feng Cui Xianbing Wang Lili Zhang Fei yan Shifang Li Yule Liu Dawei Li Xueping Zhou Yi Li State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops Vector-borne Virus Research CenterCollege of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Plant Environmental Resilience and Ministry of Agriculture Key Laboratory of Soil Microbiology College of Biological SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Department of Plant Pathology The Key Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Plant VirologyNingbo UniversityNingbo 315211China MOE Key Laboratory of Bioinformatics Center for Plant BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China

Plant viruses are a group of intracellular pathogens that persistently threaten global food *** advances in plant virology have been achieved by Chinese scientists over the last 20 years,including basic research and technologies for preventing and controlling plant viral ***,we review these milestones and advances,including the identification of new crop-infecting viruses,dissection of pathogenic mechanisms of multiple viruses,examination of multilayered interactions among viruses,their host plants,and virus-transmitting arthropod vectors,and in-depth interrogation of plantencoded resistance and susceptibility ***,various plant virus-based vectors have also been successfully developed for gene function studies and target gene expression in *** also recommend future plant virology studies in China.

关键词： China emerging plant viruses plant virology plant resistance/susceptibility to viral infection plant-virus transmission vector interactions plant virus-based vectors viral pathogenesis

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Three-dimensional visualization technology for guiding one-step percutaneous transhepatic cholangioscopic lithotripsy for the treatment of complex hepatolithiasis

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World Journal of Gastroenterology 2024年第28期30卷 3393-3402页

作者： Yong-Qing ye Ya-Wen Cao Rong-Qi Li En-Ze Li Lei yan Zhao-Wei Ding Jin-Ming Fan Ping Wang Yi-Xiang Wu Department of Hepatobiliary Surgery The Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization *** with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)*** This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for *** patients were divided into two groups:The 3D-PTOBF group and the PTOBF *** clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were *** Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)*** immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF *** complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF *** Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary *** perioperative and long-term outcomes are satisfactory for patients with complicated primary *** minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.

关键词： Hepatolithiasis One-step percutaneous transhepatic cholangioscopic lithotripsy Biliary disease Three-dimensional visualization Clinical efficacy

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Characterization of Polymer Aging:A Review

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Chinese Journal of Polymer Science 2024年第11期 1642-1660页

作者： Xuan Liu Rui yang Zhi-Ping Xu yan ye Guo-Shuo Tang Min Zhao Qian Zhang Xiang-Ze Meng School of Chemical and Pharmaceutical Engineering Hefei Normal University Department of Chemical Engineering Tsinghua University

Polymer aging under environmental conditions causes deterioration of service *** the aging behavior and mechanism is important not only for lifetime prediction,but also for material improvement and ***,comprehensive characterization of polymer materials during aging is *** this review,various analytical methods for characterization of chemical changes,physical changes and service properties are *** on that,methods for stabilization evaluation and lifetime prediction,especially sensitive evaluation methods are *** changes include molecular weight changes by chain scission and crosslinking,functional group changes on the surface and in the bulk,formation of free radicals,formation of small molecular species as the degradation products,and chemical distribution by heterogeneous aging and additives *** changes include crystallization changes (post-or chemi-crystallization)and morphology changes (cracking,debonding,etc.).Service property changes include deterioration of processability,mechanical properties,electrical properties and *** the end,existing problems and future research perspective are proposed,including relationship between chemical/physical changes and service properties,introduction of modern mathematical and computer tools.

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尼达尼布致不良反应文献分析

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中国新药杂志 2024年第3期33卷 307-312页

作者：陈喆秦艳叶岩荣复旦大学附属中山医院药剂科上海200032

目的:分析尼达尼布不良反应的发生规律与特点,为临床合理用药提供参考。方法:检索建库至2022年10月中国知网、维普数据库、万方数据库、Web of Science数据库与PubMed数据库中有关尼达尼布不良反应的文献并进行统计分析。结果:尼达尼布... 详细信息

目的:分析尼达尼布不良反应的发生规律与特点,为临床合理用药提供参考。方法:检索建库至2022年10月中国知网、维普数据库、万方数据库、Web of Science数据库与PubMed数据库中有关尼达尼布不良反应的文献并进行统计分析。结果:尼达尼布相关不良反应案例报道共19篇,涉及21例患者,其中年龄分布以60岁以上老年人较多(17例,80.95%),不良反应多发生在用药后30 d内(8例,38.10%),不良反应累及的系统-器官以胃肠道疾病占比最高(6例,28.57%)。3例停药后好转,9例停药并接受对症治疗后好转,4例停药并接受手术治疗后好转,4例未停药并接受对症治疗后好转,1例未停药并接受手术治疗后好转。结论:尼达尼布相关不良反应需引起临床高度警惕,要加强用药监测,在最大临床获益的同时将不良反应的危害降至最低。

关键词：尼达尼布药物不良反应文献分析

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党的领导制度体系:构成要素、理论意蕴与内容结构

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探索 2024年第3期 50-65页

作者：魏艳周烨重庆交通大学马克思主义学院重庆400074 西南大学马克思主义学院重庆400715

运用系统思维研究党的领导制度体系是前瞻性思考、全局性谋划、战略性部署、整体性构建党的领导制度体系的基础性思想和工作方法。从党的领导系统视角切入,分析党的领导制度体系构成要素、理论意蕴及内容结构,为深化党的领导制度体系理... 详细信息

运用系统思维研究党的领导制度体系是前瞻性思考、全局性谋划、战略性部署、整体性构建党的领导制度体系的基础性思想和工作方法。从党的领导系统视角切入,分析党的领导制度体系构成要素、理论意蕴及内容结构,为深化党的领导制度体系理论研究提供了可靠的理论路径。组成党的领导系统的领导者、被领导者、领导领域、领导方式、领导目标相互关联、相互影响,共同作用于领导系统运行,影响系统效能。从制度对象来看,党的领导制度体系就是以党的领导系统组成要素为调整对象的制度集成。植根中国特定政治社会语境,结合马克思主义政党领导属性,党的领导系统组成要素具有一定的理论意蕴,党的领导制度体系应以各要素理论意蕴为价值取向,形成由党的先进性保障制度、党领导人民群众当家作主制度、党的全面领导制度、党的领导方式改进制度以及确保党坚守为人民服务的初心使命制度为二级制度内容,维护党中央权威和集中统一领导制度等15类三级制度内容、“两个维护”制度等41类四级制度内容构成的分层分类制度体系。

关键词：中国共产党领导制度体系党的领导党的领导制度体系

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基于Pushover方法的耗能自复位铰节点框架结构抗震性能分析

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东南大学学报（自然科学版） 2024年第3期54卷 608-615页

作者：鲁亮颜浩天叶雨立同济大学土木工程学院上海200092 华东建筑设计研究院有限公司上海200002

基于Pushover分析方法研究设置耗能自复位铰节点(EDSC-HJ)的钢筋混凝土框架结构的抗震性能.首先介绍EDSC-HJ框架的结构形式,并建立了EDSC-HJ框架结构的有限元模型,通过与振动台试验结果对比验证数值模拟的正确性;其次使用Pushover方法计... 详细信息

基于Pushover分析方法研究设置耗能自复位铰节点(EDSC-HJ)的钢筋混凝土框架结构的抗震性能.首先介绍EDSC-HJ框架的结构形式,并建立了EDSC-HJ框架结构的有限元模型,通过与振动台试验结果对比验证数值模拟的正确性;其次使用Pushover方法计算EDSC-HJ框架有控结构与无控结构的抗震性能并设计节点弹性恢复装置和耗能装置的力学参数.结果表明:EDSC-HJ框架结构节点相对转动刚度比的合理取值区间为0.05~0.5;设置节点阻尼器的EDSC-HJ有控结构的层间位移响应下降了76%,且满足限值要求;由于节点阻尼器的设置提高了结构的附加抗侧刚度,有控结构的基底剪力响应提高了23%.EDSC-HJ框架结构的抗震性能明显优于钢筋混凝土框架(RCF)结构,具有良好的韧性结构特征.

关键词： Pushover分析抗震性能耗能自复位铰节点有限元模型阻尼器

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穿孔板-膜腔复合型隔声罩隔声特性研究

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哈尔滨工程大学学报 2024年第6期45卷 1093-1101页

作者：叶天贵胡世尧靳国永闫燕哈尔滨工程大学动力与能源工程学院黑龙江哈尔滨150001

针对低频隔声问题,本文提出一种穿孔板-膜腔复合型隔声结构。基于有限元法建立了隔声结构单胞模型,开展了单胞模型声学特性分析及构型优化;在此基础上,建立大尺寸穿孔板-膜腔复合型隔声板数值仿真模型,探究其隔声性能及框架对隔声性能... 详细信息

针对低频隔声问题,本文提出一种穿孔板-膜腔复合型隔声结构。基于有限元法建立了隔声结构单胞模型,开展了单胞模型声学特性分析及构型优化;在此基础上,建立大尺寸穿孔板-膜腔复合型隔声板数值仿真模型,探究其隔声性能及框架对隔声性能的影响规律,结合仿真结果开展多层薄膜型隔声板隔声性能研究;建立穿孔板-膜腔复合型隔声罩仿真分析模型,分析多层薄膜型隔声罩的隔声性能,设计附加吸声材料的多层薄膜型隔声罩;研制隔声罩样件,实验证明该样件具备较好的低频隔声性能。

关键词：低频隔声有限元法多层薄膜低频宽带隔声罩穿孔板插入损失实验验证

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Multimodel Ensemble Forecast of Global Horizontal Irradiance at PV Power Stations Based on Dynamic Variable Weight

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Journal of Tropical Meteorology 2024年第3期30卷 327-336页

作者： YUAN Bin SHEN yan-bo DENG Hua yanG yang CHEN Qi-ying ye Dong MO Jing-yue YAO Jin-feng LIU Zong-hui Public Meteorological Service Center China Meteorological AdministrationBeijing 100081 China Key Laboratory of Energy Meteorology China Meteorological AdministrationBeijing 100081 China Guangzhou Institute of Tropical and Marine Meteorology China Meteorological AdministrationGuangzhou 510641 China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 China Center for Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081 China Institute of Desert Meteorology China Meteorological AdministrationUrumqi 830002 China

In the present study,multimodel ensemble forecast experiments of the global horizontal irradiance(GHI)were conducted using the dynamic variable weight *** study was based on the forecasts of four numerical models,namely,the China Meteorological Administration Wind Energy and Solar Energy Prediction System,the Mesoscale Weather Numerical Prediction System of China Meteorological Administration,the China Meteorological Administration Regional Mesoscale Numerical Prediction System-Guangdong,and the Weather Research and Forecasting Model-Solar,and observational data from four photovoltaic(PV)power stations in yangjiang City,Guangdong *** results show that compared with those of the monthly optimal numerical model forecasts,the dynamic variable weight-based ensemble forecasts exhibited 0.97%-15.96%smaller values of the mean absolute error and 3.31%-18.40%lower values of the root mean square error(RMSE).However,the increase in the correlation coefficient was not ***,the multimodel ensemble mainly improved the performance of GHI forecasts below 700 W m-2,particularly below 400 W m-2,with RMSE reductions as high as 7.56%-28.28%.In contrast,the RMSE increased at GHI levels above 700 W *** for the key period of PV power station output(02:00-07:00),the accuracy of GHI forecasts could be improved by the multimodel ensemble:the multimodel ensemble could effectively decrease the daily maximum absolute error(AE max)of GHI ***,with increasing forecasting difficulty under cloudy conditions,the multimodel ensemble,which yields data closer to the actual observations,could simulate GHI fluctuations more accurately.

关键词： GHI forecast multimodel ensemble dynamic variable weight PV power station

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All-silicon low-loss THz temporal differentiator based on microring waveguide resonator platform

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Light(Advanced Manufacturing) 2024年第2期5卷 14-23页

作者： Yunjie Rui Shuyu Zhou Xuecou Tu Xu yan Bingnan yan Chen Zhang Ziyao ye Huilin Zhang Jingya Xie Qing-Yuan Zhao La-Bao Zhang Xiao-Qing Jia Huabing Wang Lin Kang Jian Chen Peiheng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Hefei National Laboratory Hefei 230088China Purple Mountain Laboratories NanjingJiangsu 211111China Terahertz Technology Innovation Research Institute Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai200093China

Microring resonators have been widely used in passive optical devices such as wavelength division multiplexers,differentiators,and *** on terahertz(THz)components has been accelerated by these photonics *** and integrated time-domain differentiators that enable low-loss,high-speed THz signal processing are necessary for THz *** this study,an on-chip THz temporal differentiator based on all-silicon photonic technology was *** device primarily consisted of a microring waveguide resonator and was packaged with standard waveguide *** performed time-domain differentiation on input signals at a frequency of 405.45 GHz with an insertion loss of 2.5 dB and a working bandwidth of 0.36 *** periodic waveforms could be handled by this *** device could work as an edge detector,which detected step-like edges in high-speed input signals through differential *** development holds significant promise for future THz data processing technologies and THz communication systems.

关键词： Silicon photonics Whispering gallery mode resonator THz silicon waveguide

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