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Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2065-2072页

作者： Yu-Juan Li yong-yan Chen Xia-Lan Lin Wei-Zhi Zhang Department of Anesthesiology Shanxi Provincial Children’s HospitalTaiyuan 030013Shanxi ProvinceChina

BACKGROUND Acute appendicitis(AA)is the most common cause of acute abdomen in *** significantly influences the surgical treatment of AA in children,making the scientific and effective selection of anesthetics *** To assess the clinical effect of atropine(ATR)in combination with remifentanil(REMI)in children undergoing surgery for *** In total,108 cases of pediatric AA treated between May 2020 and May 2023 were selected,58 of which received ATR+REMI[research group(RG)]and 50 who received REMI[control group(CG)].Comparative analyses were conducted on the time to loss of eyelash reflex,pain resolution time,recovery time from anesthesia,incidence of adverse events(AEs;respiratory depression,hypoxemia,bradycardia,nausea and vomiting,and hypotension),intraoperative responses(head shaking,limb activity,orientation recovery,safe departure time from the operating room),hemodynamic parameters[oxygen saturation(SPO2),mean arterial pressure,heart rate,and respiratory rate],postoperative sedation score(Ramsay score),and pain level[the Face,Legs,Activity,Cry,Consolability(FLACC)Behavioral Scale].RESULTS Compared with the CG,the RG showed significantly shorter time to loss of eyelash reflex,pain resolution,recovery from anesthesia,and safe departure from the operating ***,the incidence rates of overall AEs(head shaking,limb activity,etc.)were lower,and influences on intraoperative hemodynamic parameters and stress response indexes were *** Ramsay score at 30 min after extubation and the FLACC score at 60 min after extubation were significantly lower in the RG than in the *** ATR+REMI is superior to REMI alone in children undergoing AA surgery,with a lower incidence of AEs,fewer influences on hemodynamics and stress responses,and better post-anesthesia recovery.

关键词： Atropine Remifentanil Pediatric acute appendicitis Surgery Clinical efficacy

Photochromic radical states in 3D covalent organic frameworks with zyg topology for enhanced photocatalysis

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National Science Review 2024年第7期11卷 177-188页

作者： Tian-Tian Ma Guo-Zhang Huang Xiao-Han Wang yan Liang Run-Han Li Bin Wang Su-Juan Yao Jia-Peng Liao Shun-Li Li yong yan Ya-Qian Lan School of Chemistry South China Normal University Department of Chemistry Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and Technology

Covalent-organic frameworks（COFs） with photoinduced donor-acceptor（D-A） radical pairs show enhanced photocatalytic activity in principle. However, achieving long-lived charge separation in COFs proves challenging due to the rapid charge recombination. Here, we develop a novel strategy by combining[6 + 4] nodes to construct zyg-type 3D COFs, first reported in COF chemistry. This structure type exhibits a fused Olympic-rings-like shape, which provides a platform for stabilizing the photoinduced D-A radical pairs. The zyg-type COFs containing catalytically active moieties such as triphenylamine and phenothiazine（PTZ） show superior photocatalytic production rates of hydrogen peroxide（H2O2）. Significantly, the photochromic radical states of these COFs show up to 400% enhancement in photocatalytic activity compared to the parent states, achieving a remarkable H2O2synthesis rate of 3324 μmol g-1h-1, which makes the PTZ-COF one of the best crystalline porous photocatalysts in H2O2production. This work will shed light on the synthesis of efficient 3D COF photocatalysts built on topologies that can facilitate photogenerating D-A radical pairs for enhanced photocatalysis.

关键词： 3D covalent-organic frameworks photochromic radical states donor and acceptor hydrogen peroxide photocatalysis

Predictive effect of lipopolysaccharide-stimulated inflammatory cytokines on symptoms of generalized anxiety disorder

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World Journal of Psychiatry 2024年第9期14卷 1308-1318页

作者： Wen-Yuan Wang Na Liu Xiao-Xiao Qi Bing Han Jing-Na Sun Zheng-Li Chen Ming-Wei Wang yan-yong Wang Department of Neurology The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Neurology Hebei HospitalXuanwu HospitalCapital Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Neurological Examination at Treatment Center The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Clinical Laboratory The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Generalized anxiety disorder(GAD)is a relatively common mental ***,inflammation,an important factor for the development of depression,has attracted increasing *** studies have shown that inflammatory cytokines can affect the pathophysiological processes of several nervous system *** hypothesized that there is a correlation between the levels of lipopolysaccharide(LPS)-stimulated inflammatory cytokines and the clinical symptoms of *** To investigate the predictive effect of LPS-stimulated inflammatory cytokines on symptoms of *** This was a cross-sectional study in which 89 patients with GAD diagnosed at The First Hospital of Hebei Medical University from January 2022 to December 2022 and 70 individuals without anxiety and depression(controls)during the same period were *** venous blood was collected from all the subjects in heparin tubes,and another 3 ml of blood was supplemented with LPS(10 ng/ml).The plasma levels of 12 cytokines[Interleukin(IL)-1β,IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,IL-17A,IL-12p70,and IFN-α]were *** Post-LPS stimulation,the levels of IL-1β,IL-6,IL-8,IL-10,and TNF-αin both the control and GAD groups were significantly elevated above those in the nonstimulated groups,with IL-6 and IL-8 showing marked *** in IL-8 and TNF-αwere statistically significant in the GAD group(P<0.05).IL-1β,IL-6,IL-8,IL-10,and TNF-αwere found to be significantly correlated with Hamilton Anxiety Rating Scale(HAMA)scores(P<0.05).A negative correlation was observed between IL-10 levels and HAMA *** analysis revealed that TNF-αwas associated with mental anxiety,whereas IL-1β,IL-8,and IL-10 were associated with physical anxiety symptoms,with IL-10 showing a negative correlation with physical ***-6 was associated with both mental and physical aspects of *** The physical symptoms of GAD are related to infla

关键词： Lipopolysaccharide Cytokine Generalized anxiety disorder Inflammatory cytokines Anxiety

High-performance eight-channel system with fractal superconducting nanowire single-photon detectors

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Chip 2024年第2期3卷 45-52页

作者： Zifan Hao Kai Zou Yun Meng Jun-yong yan Fangyuan Li yongheng Huo Chao-Yuan Jin Feng Liu Thomas Descamps Adrian Iovan Val Zwiller Xiaolong Hu School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Optoelectronic Information Science and Technology Ministry of EducationTianjin 300072China State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 300072China Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Department of Applied Physics Royal Institute of Technology(KTH)SE-10691 StockholmSweden

Superconducting nanowire single-photon detectors(SNSPDs)have become a mainstream photon-counting technology that has been widely applied in various *** far,most multi-channel SNSPD systems,either reported in literature or commercially available,are polarization sensitive,that is,the system detection efficiency(SDE)of each channel is dependent on the state of polarization of the to-be-detected ***,we reported an eight-channel system with fractal SNSPDs working in the wavelength range of 930 to 940 nm,which are all featured with low polarization *** a close-cycled Gifford-McMahon cryocooler system with the base temperature of 2.2 K,we installed and compared the performance of two types of devices:(1)SNSPD,composed of a single,continuous nanowire and(2)superconducting nanowire avalanche photodetector(SNAP),composed of 16 cascaded units of two nanowires electrically connected in *** highest SDE among the eight channels reaches 96+^(4)_(-5%),with the polarization sensitivity of 1.02 and a dark-count rate of 13 counts per *** average SDE for eight channels for all states of polarization is estimated to be 90±5%.It is concluded that both the SNSPDs and the SNAPs can reach saturated,high SDE at the wavelength of interest,and the SNSPDs show lower dark-count(false-count)rates,whereas the SNAPs show better properties in the time *** the adoption of this system,we showcased the measurements of the second-order photon-correlation functions of light emission from a singlephoton source based on a semiconductor quantum dot and from a pulsed *** is believed that this work will provide new choices of systems with single-photon detectors combining the merits of high SDE,low polarization sensitivity,and low noise that can be tailored for different applications.

关键词： Superconducting nanowire single-photon detector Superconducting strip photon detector Fractal Quantum optics Photon correlation

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闻言促谏:春秋时代社会转型中的礼乐坚守

南京大学学报（哲学．人文科学．社会科学） 2024年第1期61卷 106-121,164页

作者：张雁勇山西大学历史文化学院山西省太原市030006

春秋时代,在贤臣大夫的谏君行为中,有一种以“臣闻(之)”和其他“自称+闻(之)”等领起的征引现象,可称之为“闻言”。这些“闻言”大多具有常理性质,均是以第三方权威话语的形式出现,实为贤臣大夫试图通过“重提”礼乐社会中的贵族共识... 详细信息

春秋时代,在贤臣大夫的谏君行为中,有一种以“臣闻(之)”和其他“自称+闻(之)”等领起的征引现象,可称之为“闻言”。这些“闻言”大多具有常理性质,均是以第三方权威话语的形式出现,实为贤臣大夫试图通过“重提”礼乐社会中的贵族共识,来建构自身话语的权威性、合理性、合法性,进而捍卫礼乐制度的政治表述,具有很强的现实指向。这种征引现象是三代咨议和谏言传统的衍生,根植于施舍聚民、以家代国式的中国早期国家产生方式。虽因时势与说服对象的不同,征引“闻言”会产生不同效果,而且“闻言”呈现出渐次退场的态势,但其价值并非仅限于当时。作为早已存在的公共话语,“闻言”借由贤臣谏君的特殊场域被“重提”与阐述,加之史官在场载录以及后续整理、保存、传播的助力,明确了其作为公共话语的重要价值,进而在中国传统文化中被经典化,获得了恒久的生命力。

关键词：春秋闻言贤臣谏君礼乐

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人工智能“复活”逝者的伦理风险及其治理

云南社会科学 2024年第5期 144-151页

作者：杜严勇同济大学人文学院

近些年来,人工智能“复活”逝者及其引发的社会问题引起公众普遍关注和讨论。基于人工智能技术建构的虚拟生命可以在一定程度上满足人们试图保持与逝者沟通交流的愿望,但也会引发深刻的伦理风险。虚拟生命的应用可能侵犯逝者隐私和尊严... 详细信息

近些年来,人工智能“复活”逝者及其引发的社会问题引起公众普遍关注和讨论。基于人工智能技术建构的虚拟生命可以在一定程度上满足人们试图保持与逝者沟通交流的愿望,但也会引发深刻的伦理风险。虚拟生命的应用可能侵犯逝者隐私和尊严,也存在不当使用以及恶意使用的风险。同时,虚拟生命可能影响用户的心理健康,阻碍用户完成一个成功的悲伤过程,技术方面的因素也可能使用户反复受到伤害。包括政府管理部门、科技企业、科技工作者与用户在内的所有利益相关者应当各尽其责,共同努力防范虚拟生命的伦理风险。

关键词：人工智能虚拟生命伦理风险治理路径

玉米杂交群体产量性状及其特殊配合力全基因组关联分析

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作物学报 2024年第2期50卷 363-372页

作者：马娟曹言勇河南省农业科学院粮食作物研究所河南郑州450002

提高产量是玉米育种的长期目标,解析产量相关性状及其配合力的遗传基础对选育高产玉米新品种具有重要意义。本研究选用123份玉米自交系和8份测验种作为亲本,根据NCⅡ(North Carolina design Ⅱ)获得540份杂交种为材料,在新乡和周口试验... 详细信息

提高产量是玉米育种的长期目标,解析产量相关性状及其配合力的遗传基础对选育高产玉米新品种具有重要意义。本研究选用123份玉米自交系和8份测验种作为亲本,根据NCⅡ(North Carolina design Ⅱ)获得540份杂交种为材料,在新乡和周口试验田调查F1杂交种的单穗粒重、单穗重、百粒重、行粒数等8个产量及构成性状,利用玉米5.5K液相育种芯片检测亲本基因型,推断F1杂交种的基因型,利用BLINK(Bayesian information and linkage-disequilibrium iteratively nested keyway)加性和显性模型开展F1杂交种表型与其特殊配合力(special combining ability, SCA)的全基因组关联分析。结果表明,利用加性和显性模型对F1杂交种分别检测到10个和31个显著关联位点。利用显性模型检测到8个SNPs(single nucleotide polymorphisms)与SCA显著关联。不同性状和模型间共定位位点有7个,其中1个为单穗重与其SCA同时关联位点。通过对主效和共定位SNPs的扫描,共鉴定到26个候选基因,其中转录因子MYBR85、NLP9、PHD3、生长素上调小RNA(SAUR11和SAUR12)、FCS-like锌指蛋白基因FLZ16等可能是控制F1杂交种产量性状与其SCA的重要候选基因。

关键词：玉米杂交种特殊配合力全基因组关联分析

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方剂组学高质量发展要义

中国中药杂志 2024年第3期49卷 569-570页

作者：王永炎王忠中国中医科学院中医临床基础医学研究所北京100700

现代组学技术的发展,如组学相关技术的引进促进了方剂作用原理的研究,创新发展了一些新的方剂复杂药理分析技术,但总体而论以前的思路仅仅在应用层面,未能与方剂的学科内涵结合起来,更不能在方剂学科未来发展及指导临床有效性与安全性... 详细信息

现代组学技术的发展,如组学相关技术的引进促进了方剂作用原理的研究,创新发展了一些新的方剂复杂药理分析技术,但总体而论以前的思路仅仅在应用层面,未能与方剂的学科内涵结合起来,更不能在方剂学科未来发展及指导临床有效性与安全性深入研究方面发挥应有的作用,不忘本来,兼容外来,面向未来,因此该文提出“整体、宏观、实践”三要义以探索方剂组学高质量发展的未来发展方向。

关键词：方剂组学整体宏观实践

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新型基础设施建设与中国经济高质量发展

管理评论 2024年第6期36卷 81-93页

作者：童健张聪闫勇中央财经大学财政税务学院北京100084 中国石油集团经济技术研究院北京100724

统筹推进基础设施建设是党的二十大报告的明确要求,“新”“老”基建协同发展是中国经济高质量发展的关键。在明确“老基建”的生产外部性和“新基建”的网络外部性基础上,本文突破静态研究框架,从动态视角研究了经济增长路径上基础设... 详细信息

统筹推进基础设施建设是党的二十大报告的明确要求,“新”“老”基建协同发展是中国经济高质量发展的关键。在明确“老基建”的生产外部性和“新基建”的网络外部性基础上,本文突破静态研究框架,从动态视角研究了经济增长路径上基础设施投资结构变迁效应,并发现,“老基建”的短期经济刺激效应强于“新基建”,“新基建”的长期经济刺激效应和创新激励效应明显强于“老基建”。同时,“任期约束”是政府设定基础设施投资结构转型时点的关键变量,对短期经济增长目标关注程度越高、关注期限越短的政府往往选择延迟基础设施投资结构转型时点,但这会带来经济增长的“下台阶”现象。实证结果进一步验证了,“老基建”在经济增长初期充分发挥了生产外部性作用,但现在对经济增长和创新发展的激励效应明显减弱,而“新基建”对经济增长和创新发展的激励效应显著增强。因此,政府应因地制宜结合“新”“老”基建边际产出相对变化,尽早推进“新”“老”基建转型,统筹推动经济质的有效提升和量的合理增长。

关键词：新基建老基建任期约束经济增长创新发展