检索结果-南通市图书馆

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin xue yan Feng cUI Bao Qiu LIU Hong SHEN Xin Xin Shandong Provincial Research center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province cancer Hospital/Shanxi Hospital Affiliated to cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLc6A4,GRIN2A,GRIN2c,ScN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,cHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

current status of Mycoplasma pneumoniae infection in china

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第1期20卷 1-4页

作者： chao yan Guan-Hua xue Han-Qing Zhao yan-Ling Feng Jing-Hua cui Jing Yuan Department of Bacteriology Capital Institute of PediatricsNo.2Yabao RoadBeijing 100020People's Republicof China

Mycoplasma pneumoniae(***)is one of the most important pathogens for community-acquired pneumonia worldwide,especially in children and adolescents[1,2].*** is easily transmitted through droplets or direct contact in densely populated,enclosed,or poorly ventilated *** incubation period is 1-3 weeks,and it is contagious from the incubation period to a few weeks after clinical symptom *** infection can occur in any season,and there are differences in the epidemic seasons among regions in china[3].The most suitable culture temperature for *** is between 35℃c and 37 c,and therefore,hot weather may make it survive longer in the environment and spread *** is more common in autumn and winter in northern china,while it is more prevalent in summer and autumn in southern china.

关键词： winter weather autumn

Research on LD-Pumped dual wavelength Nd:YAG Laser with high beam quality for machining

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research on LD-Pumped dual wavelength Nd:YAG Laser with high...

Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

20th congress of the International commission for optics

作者： Jianfeng cui a b c1 Zhongwei Fana c d chunhua Zhaoa b c Jing Zhanga b c Gang Niua b c Zhaohui Shia b c Bo Peic d Guoxin Zhang c yan xue c achangchun institute of optics Fine Mechanics and physics chinese Academy of Sciences No.16 the Dongnanhu Road changchun china bAcademy of graduate chinese Academy of Sciences cBeijing GK Laser Technology co. Ltd. No.1 the 4thStreet Shangdi Haidian District Beijing china dAcademy of Opto-electronics chinese Academy of Sciences No.1 the 4thStreet Shangdi Haidian District Beijing china

considering laser medium thermal lens effect and thermal focal length changes with pumping power, conventionally, lasers are designed to operate in the middle of thermal stable zones, where the fundam

关键词： laser technique self-select mode cavity all solid laser LBO crystal external frequency-doubled

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao xue cai yan-yan xue Weigang Ge Liang Yue Xiao-yan Li Rong-Rong Lin Guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-Ping Jia Tiannan Guo Zhi-Ying Wu Department of Neurology and Research center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China cAS center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(cSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 cSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 cSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 cSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein cSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(McI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein cSF biomarker panel also effectively discriminated patients with McI due to AD from patients with other neurodegenerative ***,we identified 21 cSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

Determination of liquid viscosity based on dual-frequency-bandparticle tracking

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Physics B 2024年第9期33卷 359-364页

作者： Lihua yan Boyin xue Yuanji Li Jinxia Feng Xingkang Wu Kuanshou Zhang State Key Laboratory of Quantum optics and Quantum optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China collaborative Innovation center of Extreme optics Shanxi UniversityTaiyuan 030006China Modern Research center for Traditional chinese Medicine Shanxi UniversityTaiyuan 030006China

An optical-tweezers-based dual-frequency-band particle tracking system was designed and fabricated for liquid viscositydetection. On the basis of the liquid viscosity dependent model of the particle’s restricted Brownian motion with theFax´en correction taken into account, the liquid viscosity and optical trap stiffness were determined by fitting the theoreticalprediction with the measured power spectral densities of the particle’s displacement and velocity that were derived from thedual-frequency-band particle tracking data. When the SiO2 beads were employed as probe particles in the measurements ofdifferent kinds of liquids, the measurement results exhibit a good agreement with the reported results, as well as a detectionuncertainty better than 4.6%. This kind of noninvasive economical technique can be applied in diverse environments forboth in situ and ex situ viscosity detection of liquids.

关键词： liquid viscosity optical tweezers dual-frequency-band particle tracking power spectral density

Ground-layer Adaptive optics for the 2.5 m Wide-field and High-resolution Solar Telescope

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第3期24卷 224-236页

作者： Ying yang Lan-Qiang Zhang Nan-Fei yan Jin-Sheng yang Zhen Li Teng-Fei Song xue-Jun Rao chang-Hui Rao Key Laboratory on Adaptive optics Chinese Academy of SciencesChengdu 610209China institute of optics and Electronics Chinese Academy of SciencesChengdu 610209China School of Electronic Electrical and Communication Engineering of the University of Chinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Beijing 100049China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern A&A Ministry of EducationNanjing 210023China Yunnan Observatories Chinese Academy of SciencesKunming 650216.China

The 2.5 m wide-field and high-resolution solar telescope(WeHoST)is currently under developing for solar *** aims to achieve high-resolution observations over a super-wide field of view(FOV)of5′×5′,and a desired resolution of 0.3″.To meet the scientific requirements of WeHoST,the ground-layer adaptive optics(GLAO)with a specially designed wave front sensing system is as the primary *** introduce the GLAO configuration,particularly the wave front sensing *** analytic method,we simulate the performance of both classical AO and GLAO systems,optimize the wave front sensing system,and evaluate GLAO performance in terms of PSF uniformity and correction improvement across whole *** results indicate that,the classical AO will achieve diffraction-limited resolution;the suggested GLAO configuration will uniformly improve the seeing across the full 5′×5′FOV,reducing the FWHM across the axis FOV to less than0.3″(λ≥705 nm,r0≥11 cm),which is more than two times *** specially designed wave front sensor schedule offers new potential for WeHoST’s GLAO,particularly the multi-FOV GLAO and the flexibility to select the detected *** capabilities will significantly enhance the scientific output of the telescope.

关键词： instrumentation adaptive optics-instrumentation detectors-instrumentation high angular resolution-methods numerical-telescopes-Sun activity

Generation and regulation of electromagnetic pulses generated by femtosecond lasers interacting with multitargets

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 96-107页

作者： Ya-Dong Xia De-Feng Kong Qiang-You He Zhen Guo Dong-Jun Zhang Tong yang Hao cheng Yu-Ze Li yang yan Xiao Liang Ping Zhu Xing-Long Xie Jian-Qiang Zhu Ting-Shuai Li chen Lin Wen-Jun Ma xue-Qing yan State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTPeking UniversityBeijing 100871China Beijing Laser Acceleration Innovation center Beijing 101407China institute of Guangdong Laser Plasma Technology Guangzhou 510540China National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and FineChinese Academy of SciencesShanghai 201800China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) W/cm^(2))femtosecond(fs)lasers with metal flat,plastic flat,and plastic nanowire-array(NWA)*** analyses are conducted on the EMPs in terms of their spatial distribution,time and frequency domains,radiation energy,and *** results indicate that EMPs from metal targets exhibit larger amplitudes at varying angles than those generated by other types of targets and are enhanced significantly for NWA *** a plastic target holder and increasing the laser focal spot can significantly decrease the radiation energy of the ***,the composite shielding materials indicate an effective shielding effect against *** simulation results show that the NWA targets exert a collimating effect on thermal electrons,which directly affects the distribution of *** study provides guidance for regulating EMPs by controlling the laser focal spot,target parameters,and target rod material and is beneficial for electromagnetic-shielding design.

关键词： Electromagnetic pulses Laser plasma interaction Electromagnetic shielding Electron distribution

The Porous Nanocarbons with Polynuclear Aromatic cores

在线全文

学校读者我要写书评

暂无评论

ccS chemistry 2024年第10期6卷 2427-2438页

作者： chenxi Zhou Ruoning Li yan chen Xinyue Liu Haisong Zhao xue-Qing yang Zhongjie Ren Dong Wang Zhaohui Wang Lei Zhang Beijing Advanced Innovation center for Soft Matter Science and Engineering State Key Lab of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029 cAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190 Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084

Three porous nanocarbons,1–3 that comprise pyrene,corannulene,and coronene cores encircled by cyclo-meta-phenylene(cMP)interconnections,have been synthesized and *** interconnected cMPs caused different curvatures of the cores and imparted high solubility,large bathochromic shift,strong fluorescence,and low reduction potential to the *** solution,these porous nanocarbons existed as a complex mixture of dynamic processes that certainly influenced one another within any single molecule,leading to a set of rather simple proton nuclear magnetic resonance(^(1)H NMR)*** crystal X-ray diffraction and computational minimum energy analysis revealed the boatand saddle-like conformations of 1–3 in the solid state,significantly deviating from their conformations on the Au(111)***,both 1 and 2 could form 2:1 complexes with c_(60),accompanied by adaptive geometry *** addition,1 served as a sky-blue emitter for an organic light-emitting diode(OLED).This work gives access and insights into a model system consisting of porous nanocarbons with intriguing supramolecular and optoelectronic properties.

关键词： porous nanocarbon cyclophenylenes aromatic core structural dynamics crystal packing

MOF-derived cu embedded into N-doped mesoporous carbon as a robust support of PdAu nanocatalysts for ethanol electrooxidation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu Huang Peng Wu Jun-Ping Tang Jian yang Jing Li Shuai chen xue-Ling Zhao chengchen Bin-Wei Zhang yan-Yun Ma Wei-Heng Shi Dong-Hai Lin Shi-Gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of Physical chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of chemistry and chemical Engineering Chongqing UniversityChongqing401331China center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel cu-NcNs(cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and cu-ZIF-8 together,and then,Pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare PdAu@cu-NcNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for PdAu *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of Pd and ***,the best-performed Pd_(2)Au_(2)@cu-NcN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial Pd/c(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFcs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon PdAu Ethanol electrooxidation