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Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 628-634页

作者： Yu-Qi Wu Hong-yan Wang Mu-Min Shao Lin xu Xiao-yan Jiang Shao-Ju Guo department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina department of pathology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGrOUND Collision tumors involving the small intestine,specifically the combination of a hamartomatous tumor and a lipoma,are extremely *** our knowledge,no previous case report has described a collision tumor composed of two benign tumors of different origins in the small *** SUMMArY Here,we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm×32 mm×30 mm in the terminal *** on computed tomography scan findings,the mass was initially suspected to be a lipoma.A subsequent colonoscopy revealed a pedunculated submucosal elevation consisting of two distinct parts with a visible demarcation line.A biopsy of the upper portion suggested a juvenile polyp(Jp).Owing to the patient’s advanced age,multiple comorbidities,and poor surgical tolerance,a modified endoscopic submucosal dissection was *** examination of the excised mucosal mass revealed a lipoma at the base and a Jp at the top,demonstrating evidence of rupture and associated *** patient’s overall health remained satisfactory,with no recurrence of hematochezia during the six-month follow-up *** This case report provides new evidence for the understanding of gastrointestinal collision tumors,emphasizing their diverse clinical presentations and histopathological *** also offers diagnostic and therapeutic insights as well as an approach for managing benign collision tumors.

关键词： Collision tumor Gastrointestinal bleeding Hamartomatous tumor Lipoma Modified endoscopic submucosal dissection Case report

revealing the atomic mechanism of diamond–iron interfacial reaction

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Carbon Energy 2024年第3期6卷 255-263页

作者： Yalun Ku Kun xu Longbin yan Kuikui Zhang Dongsheng Song Xing Li Shunfang Li Shaobo Cheng Chongxin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhouChina department of Mechanical Engineering Stanford UniversityStanfordCaliforniaUSA Information Materials and Intelligent Sensing Laboratory of Anhui province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefeiChina Institute of Quantum Materials and physics Henan Academy of SciencesZhengzhouChina

Diamond,with ultrahigh hardness,high wear resistance,high thermal conductivity,and so forth,has attracted worldwide ***,researchers found emergent reactions at the interfaces between diamond and ferrous materials,which significantly affects the performance of diamond-based ***,combing experiments and theoretical calculations,taking diamond–iron(Fe)interface as a prototype,the counter-diffusion mechanism of Fe/carbon atoms has been ***,it is identified that Fe and diamond first form a coherent interface,and then Fe atoms diffuse into diamond and prefer the carbon vacancies ***,the relaxed carbon atoms diffuse into the Fe lattice,forming Fe_(3)***,graphite is observed at the Fe_(3)C surface when Fe_(3)C is over-saturated by carbon *** present findings are expected to offer new insights into the atomic mechanism for diamondferrous material's interfacial reactions,benefiting diamond-based device applications.

关键词： coherent interface counter-diffusion diamond iron phase transition

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano research 2024年第6期17卷 5424-5434页

作者： Jinna ren Jingying Hu Fan Dong yan xu yang peng Yuping Qian Guanmeng Zhang Min Wang Yuguang Wang department of prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIp department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in china

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Genes & Diseases 2024年第5期11卷 17-20页

作者： Yikun Chen yan Shi Yuan Gao yan Hu Linying Zhou Jingmei Hong Shirui Gan Xiang Lin Wanjin Chen Guorong xu Jin He department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Fujian Key Laboratory of Molecular Neurology Institute of NeuroscienceFujian Medical UniversityFuzhouFujian 350005China Electron Microscopy Lab of public Technology Service Center Fujian Medical UniversityFuzhouFujian 350005China

Adult polyglucosan body disease(ApBD)is a rare and highly heterogeneous glycogen storage disorder due to biallelic variants in GBE1.1 Typical ApBD presentations include gait abnormalities with polyneuropathy,leukodystrophy,neurogenic bladder,and mild cognitive *** diagnosis of ApBD encompasses a large spectrum of conditions including axonal and demyelinating sensorimotor polyneuropathy,progressive spastic paraparesis,and leukodystrophies.

关键词： GBE bladder diagnosis

Integral spinor norms in dyadic local fields Ⅲ

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Science china mathematics 2010年第9期53卷 2425-2446页

作者： L Jianrui1 & xu Fei2,1department of mathematics,Jinan university,Guangzhou 510632,china 2School of mathematics,Capital normal university,Beijing 100048,china department of mathematics Jinan University Guangzhou China School of mathematics Capital Normal University Beijing China

In this paper we give an alternative computation of integral spinor norms over dyadic local fields by using the Jordan decomposition of *** particular,we emphasize the striking similarity between the theory over dyadi... 详细信息

关键词： integral lattice spinor norm Jordan decomposition

A Test of U-type for Goodness-of-fit in regression Models Through Martingale Difference Divergence

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 979-1000页

作者： Kai xu yan-qin NIE Dao-jiang HE School of mathematics and Statistics Anhui Normal UniversityWuhu 241002China

Based on the martingale difference divergence,a recently proposed metric for quantifying conditional mean dependence,we introduce a consistent test of U-type for the goodness-of-fit of linear models under conditional mean ***,our test allows heteroscedastic regression models without imposing any condition on the distribution of the error,utilizes effectively important information contained in the distance of the vector of covariates,has a simple form,is easy to implement,and is free of the subjective choice of ***,our mathematical analysis is of own interest since it does not take advantage of the empirical process theory and provides some insights on the asymptotic behavior of U-statistic in the framework of model *** asymptotic null distribution of the proposed test statistic is derived and its asymptotic power behavior against fixed alternatives and local alternatives converging to the null at the parametric rate is also *** particular,we show that its asymptotic null distribution is very different from that obtained for the true error and their differences are interestingly related to the form expression for the estimated parameter vector embodied in regression function and a martingale difference divergence *** the asymptotic null distribution of the test statistic depends on data generating process,we propose a wild bootstrap scheme to approximate its null *** consistency of the bootstrap scheme is *** studies are undertaken to show the good performance of the new test.

关键词： bootstrap goodness-of-fit test linear mean regression martingale difference divergence martingale difference divergence matrix

prediction of pathological complete response and prognosis in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2520-2530页

作者： Yi-Jun xu Dan Tao Song-Bing Qin Xiao-yan xu Kai-Wen yang Zhong-xu Xing Ju-Ying Zhou yang Jiao Li-Li Wang department of radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina department of radiation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of radiation Medicine and protection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGrOUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death *** chemoradiotherapy(nCrT)is standard for locally advanced rectal cancer(LArC).Except for pathological examination after resection,it is not known exactly whether LArC patients have achieved pathological complete response(pCr)before *** date,there are no clear clinical indicators that can predict the efficacy of nCrT and patient *** To investigate the indicators that can predict pCr and long-term outcomes following nCrT in patients with *** Clinical data of 128 LArC patients admitted to our hospital between September 2013 and November 2022 were retrospectively *** were categorized into pCr and non-pCr *** analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting *** 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank *** Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMr),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with *** results showed that CEA≤5 ng/mL(p=0.039),LMr>2.73(p=0.023),and time interval>10 wk(p=0.039)were independent predictors for *** analysis demonstrated that patients in the pCr group had significantly higher 5-year DFS rates(94.7%vs 59.7%,p=0.002)and 5-year OS rates(95.8%vs 80.1%,p=0.019)compared to the non-pCr *** deposits(TDs)were significantly correlated with shorter DFS(p=0.002)and OS(ppretreatment CEA,LMr,and time interval contribute to predicting nCrT efficacy in LArC *** pCr demonstrates longer DFS and *** correlate with poor pr

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit prognosis

The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients

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Food Science and Human Wellness 2024年第2期13卷 1079-1092页

作者： Qingqing xu Weifei Wang Dongxiao Sun-Waterhouse Qian Zou Menglei yan xuan Liu Dongming Lan Yonghua Wang School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural and Agri-Food research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510610China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these *** oil-based DAG(LD)and linseed oil(LT)were ***-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously *** conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid ***-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients.

关键词： Diacylglycerol In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency

Hydrogen production from hydrolysis of NaBH_(4) solution over Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst

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rare Metals 2024年第6期43卷 2648-2659页

作者： yan Wang Jia-Xin Ma Jian ren Di Zhang Feng-yan xu Ke Zhang Zhong-Qiu Cao Qiu-Ju Sun Guo-De Li Shi-Wei Wu Hong-Hui Chen College of Chemistry and Chemical Engineering Shenyang Normal UniversityShenyang 110034China Experimental Center Shenyang Normal UniversityShenyang 110034China Hunan Shande Energy Storage New Materials research Institute Limited Company Changde 415000China

In this study,the double loaded Co-Fe-B@g-C_(3)N_(4)/NF(NF:Ni foam)thin film catalysts were prepared for the first time via chemical deposition method at room *** optimizing the reducing agent concentration to 0.9 mol·L^(-1),the as-obtained Co-Fe-B@g-C_(3)N_(4)/NF exhibited the twisted ribbon structure with more distinct three-dimensional hierarchy and the smaller particle size,showing the good catalytic property for the hydrolysis of NaBH_(4)*** H_(2)generation rate of Co-Fe-B@g-C_(3)N_(4)/NF and binary Co-B@g-C_(3)N_(4)/NF under visible light irradiation surpassed the value under natural *** apparent activation energy of Co-Fe-B@g-C_(3)N_(4)/NF(45.0 kJ·mol^(-1))under visible light irradiation was obviously reduced when compared with the natural condition(48.4 kJ·mol^(-1))and binary Co-B@g-C_(3)N_(4)/NF(60.6 kJ·mol^(-1))under visible light ***,the catalytic performance of the optimized Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst was superior to most of the reported non-noble metal and even noble metal ***,it illustrated that the catalytic H_(2)production performance of Co-Fe-B@g-C_(3)N_(4)/NF thin film was distinctly improved after the introduction of light and multicomponent recombination.

关键词： Sodium borohydride Co-Fe-B@g-C_(3)N_(4)/NF catalyst Chemical deposition Hydrogen production