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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Landscape Stability Assessment and Simulation Analysis Under Urban Expansion:A Case Study of Hangzhou, China

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Chinese Geographical Science 2025年第02期 311-325页

作者： PEI Hui ZHANG Lin ZHOU Minli NIE Wenbin ZHOU shihao shi yan PAN Jianyun College of Landscape Architecture Zhejiang Agriculture and Forestry University Huzhou Spatial Planning Compilation and Research Center Anji County Huzhou City Township Planning and Management Station Institute of Ecological Civilization & Institute of Carbon Neutrality Zhejiang A&F University

In recent years, rapid urbanization has had a profound impact on landscape stability. As a typical example of China's rapid urbanization, Hangzhou has also experienced significant landscape changes, which have profoundly affected its ecological *** Hangzhou as an example, this study integrates land use change data from 1980 to 2020, combines dynamic simulation and ecological modeling techniques, and carries out a comprehensive analysis of historical trends and future predictions, to provide valuable insights into the complex interactions between urban expansion and landscape stability. The results indicate that: 1) between 1980 and2020, Hangzhou experienced a significant increase in construction land at the expense of arable land, leading to a gradual decline in landscape stability, though the downward trend has slowed in recent years. 2) The spatial distribution of landscape stability shows clear aggregation patterns, with lower stability concentrated in economically active flatlands and higher stability in the mountainous western regions. 3) By 2040, further urban expansion is predicted to occur alongside increased landscape integration, reflecting the positive effects of ecological protection strategies. This study highlights the universal challenges of balancing economic growth with ecological stability in rapidly urbanizing regions. The combination of advanced simulation models and spatiotemporal analysis demonstrates a replicable framework for assessing urban expansion's ecological impacts. These findings underscore the importance of tailoring urban planning and ecological policies to address regional disparities, providing valuable insights for sustainable urban development and landscape management globally.

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刑事涉案财产处置中的实体法问题

社会科学辑刊 2025年第1期 138-149,239页

作者：时延安中国人民大学刑事法律科学研究中心中国人民大学法学院

完善刑事涉案财产处置法律制度及机制,应从实体和程序两个方面进行分析、论证和设计。明晰涉案财产的法律属性,有利于明确刑事诉讼过程中不同情形下涉案财产处置的规范性质,进而有利于形成相应的法律规则,即为确保侦查活动顺利进行应完... 详细信息

完善刑事涉案财产处置法律制度及机制,应从实体和程序两个方面进行分析、论证和设计。明晰涉案财产的法律属性,有利于明确刑事诉讼过程中不同情形下涉案财产处置的规范性质,进而有利于形成相应的法律规则,即为确保侦查活动顺利进行应完善针对涉案财物的强制措施,为确保刑事裁判能够充分、及时地执行应构建针对涉案财物的保全措施。处理涉案财产应维护犯罪嫌疑人、被告人或者犯罪人的合法财产权益,为此可以确定三条规则,即除违禁品之外的、排他性占有的财物,在法院作出刑事裁判前应推定占有合法;违法所得的计算应根据不法行为及其要件进行判断;追缴违法所得不得侵犯犯罪人的合法财产利益。为妥善处置刑事涉案财产,结合相关司法解释规定,涉案财产的处置次序应为:人身损害赔偿中的医疗费用,退赔被害人的损失,其他民事债务,违法所得追缴,供犯罪所用的本人财物,罚金,没收财产。

关键词：涉案财产处置对物强制措施刑事保全财产权益

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Investigations of inelastic cross sections of H_(2)O molecule by He^(2+) and C^(6+) projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： Guo-Zhuang Li Cheng-Ye Sun Rui Cheng yan-shi Zhang Liang-Wen Chen Sheng Zhang Xin-Xia Li Lei yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H_(2)O molecules using He^(2+) and C^(6+) projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were *** illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

全民健身公共服务智慧化风险评估方法——以山西省太原市为例

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上海体育大学学报 2025年第2期49卷 75-83页

作者：石岩刘瀚钰山西大学体育学院山西太原030006

提出基于“改进熵权法-TOPSIS法-灰色关联分析法”的全民健身公共服务智慧化风险多属性评估方法,运用5M1E理论框架,结合随机森林算法筛选风险指标,采用改进熵权法计算评估指标权重,其中包括科学健身培训(权重为0.115)、隐私保护度(权重... 详细信息

提出基于“改进熵权法-TOPSIS法-灰色关联分析法”的全民健身公共服务智慧化风险多属性评估方法,运用5M1E理论框架,结合随机森林算法筛选风险指标,采用改进熵权法计算评估指标权重,其中包括科学健身培训(权重为0.115)、隐私保护度(权重为0.144)、5G基础设施覆盖率(权重为0.072)等24项指标。采用TOPSIS法对风险事件进行排序,并运用灰色关联分析验证结果。筛选山西省太原市全民健身公共服务智慧化风险事件,将智慧化风险指数分为轻度(风险指数范围为[0,0.34))、中度(风险指数范围为[0.34,0.39))、重度(风险指数范围为[0.39,0.45))和特度(风险指数范围为[0.45,1])4个等级,并详细描述每个等级的特征及其影响。通过实证研究验证了该方法能够精准揭示智慧化服务中的潜在风险,并能为制定有针对性的风险管理策略提供科学依据,为智慧化公共服务领域的风险评估研究开辟了新路径。

关键词：智慧化风险评估方法全民健身公共服务 5M1E 改进熵权法 TOPSIS法灰色关联分析

The GECAM ground search system for gamma-ray transients

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 165-178页

作者： Ce Cai yan-Qiu Zhang Shao-Lin Xiong Ping Wang Jian-Hui Li Xiao-Bo Li Cheng-Kui Li Yue Huang shi-Jie Zheng Li-Ming Song Shuo Xiao Qi-Bin Yi Yi Zhao Sheng-Lun Xie Rui Qiao yan-Qi Du Zhi-Wei Guo Wang-Chen Xue Chao Zheng Jia-Cong Liu Chen-Wei Wang Wen-Jun Tan Yue Wang Jin-Peng Zhang Chao-yang Li Guo-Ying Zhao Xiao-Yun Zhao Xiao-Lu Zhang Zhen Zhang Wen-Xi Peng Xiang Ma Jing-yan shi Dong-Ya Guo Jin Wang Xin-Qiao Li Xiang-yang Wen Zheng-Hua An Fan Zhang College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal University Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences University of Chinese Academy of Sciences School of Physics and Electronic Science Guizhou Normal University Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal University School of Physics and Optoelectronics Xiangtan University School of Computer and Information Dezhou University Institute of Astrophysics Central China Normal University

In the era of time-domain, multi-messenger astronomy, the detection of transient events on the high-energy electromagnetic sky has become more important than ever. The gravitational wave high-energy electromagnetic counterpart all-sky monitor（GECAM）is a dedicated mission to monitor gamma-ray transients, launched in December, 2020. A real-time on-board trigger and location software, using the traditional signal-to-noise ratio（SNR） method for blind search, is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time search. In this work, we developed a ground-based pipeline for GECAM to search for various transients, especially for weak bursts missed by on-board software. This pipeline includes both automatic and manual mode, offering options for blind search and targeted search. The targeted search is specifically designed to search for interesting weak bursts, such as gravitational wave-associated gamma-ray bursts（GRBs）. From the ground search of the data in the first year, GECAM has been triggered by 54 GRBs and other transients, including soft gamma-ray repeaters, X-ray binaries, solar flares, terrestrial gamma-ray flashes. We report the properties of each type of triggers, such as trigger time and light curves. With this search pipeline and assuming a soft Band spectrum, the GRB detection sensitivity of GECAM is increased to about 1.1 × 10-8erg cm-2s-1（10-1000 ke V, burst duration of 20 s）. These results demonstrate that the GECAM ground search system（both blind search and targeted search） is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.

关键词： gamma-ray sources gravitational waves data analysis gamma-ray telescopes

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“脱颖而出”之“颖”字研究

汉语学报 2025年第1期 120-128页

作者：袁舫言实商务印书馆汉语编辑中心 100710 中国社会科学院大学语用系 100010

“脱颖而出”之“颖”在现代辞书中,或释“锥子尖”,或释“嵌锥针的两片铁或环”,或释“锥子上的环”,莫衷一是,给读者造成困惑。本文对与“脱颖而出”所出时代较接近的古代文献中“颖”的用例及其相关注疏进行梳理,并依据古文字形,结... 详细信息

“脱颖而出”之“颖”在现代辞书中,或释“锥子尖”,或释“嵌锥针的两片铁或环”,或释“锥子上的环”,莫衷一是,给读者造成困惑。本文对与“脱颖而出”所出时代较接近的古代文献中“颖”的用例及其相关注疏进行梳理,并依据古文字形,结合其他古代文献,分析“颖”的本义,认为其本义为禾穗;又从词义引申的一般规律出发,从时间维度引申和空间维度引申构建“颖”的意义系统;最后,从逻辑、事理、语法、音韵、词汇等方面论证“脱颖而出”之“颖”义为锥针(锥桯)。

关键词： “脱颖而出” “颖”字的意义词义引申意义系统构建

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美国技术封锁对中国技术型跨境并购的影响

科学学研究 2025年第1期43卷 38-48页

作者：马述忠李诗燕吴鹏浙江大学中国数字贸易研究院浙江杭州310058 浙江财经大学经济学院浙江杭州310018

本文基于证券数据公司全球并购(SDC M&A)数据库,运用DID方法探究美国技术封锁对中国向第三方经济体技术型跨境并购的影响。研究发现:美国对华技术封锁总体上促进了中国向第三方经济体实施技术型跨境并购,这一结论在变换识别策略、变换... 详细信息

本文基于证券数据公司全球并购(SDC M&A)数据库,运用DID方法探究美国技术封锁对中国向第三方经济体技术型跨境并购的影响。研究发现:美国对华技术封锁总体上促进了中国向第三方经济体实施技术型跨境并购,这一结论在变换识别策略、变换样本、伪证检验等一系列稳健性检验后以然成立。机制分析表明,美国技术封锁刺激了中国投资者向高可替代性或与中国高技术部门联系密切的经济体的技术型跨境并购,因此可以认为技术封锁带来的替代效应大于消极示范效应。此外,东道国与美国的政治经济关系并不构成美国技术封锁影响中国向第三方经济体技术型并购的重要因素。异质性分析发现,美国技术封锁显著促进了中国在电信软件和医疗领域对第三方经济体的跨境并购,但在能源和交通领域的影响不显著。

关键词：技术型跨境并购技术封锁双重差分