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Ti_(3)C_(2)T_(x)/SnO_(2)P–N heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： Yue Zhang Ming-Yue Wang Xiao-Guang San yan-Bai shen Guo-sheng Wang Lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily life.However,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical application.Therefore,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important topic.In this study,Ti_(3)C_(2)Tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good longterm stability.Density functional theory(DFT)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with formaldehyde.Meanwhile,Ti_(3)C_(2)T_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room temperature.Moreover,the formation of p-n heterostructures between SnO_(2)and Ti_(3)C_(2)T_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde gas.This perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： Ti_(3)C_(2)T_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFT calculations

Establishment of an Iron Deficiency Model by Iron Depletion in Pregnant Rats

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Biomedical and Environmental Sciences 2024年第2期37卷 210-215页

作者： CHEN Xi HAN Chao ZHAO Jin Peng shen Shi WANG Li Yuan REN Shou WANG Tong Lei MA yan XU Ze Chao HUO Jun sheng Key Laboratory of Trace Element Nutrition National Health Commission of the People’s Republic of ChinaNational Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China

Anemia,a global public health problem,has significant adverse consequences on the cognitive development of children and the work capacity of adults;affecting social and economic development.Globally,roughly 43%of children under five years of age,38%of pregnant women,and 29%of nonpregnant women had anemia.Anemia during pregnancy significantly increases the risk of low birth weight and preterm birth.A 10 g/L increase in hemoglobin has been estimated to decrease the risk of maternal and perinatal mortality by 29%and 28%.

关键词： mortality pregnancy anemia

Sedimentary and Heavy Mineral Records for the Oligocene-Miocene Exhumation of the Easternmost Tianshan

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Journal of Earth Science 2024年第2期35卷 449-461页

作者： yan Ding Tianyi shen Guocan Wang Junliang Ji School of Earth Sciences Center for Global TectonicsChina University of GeosciencesWuhan430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan430078China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan430074China

The topography of the Harlik Mountain has a strong impact on the formation of current arid climate in the Turpan-Hami Basin.However,it is still controversial if Harlik Mountain experienced significant exhumation during the Middle to Late Cenozoic according to the previous thermochronology studies.The features of the Oligocene to Miocene sediments in the foreland basin could provide productive information for resolving the debates.The peak ages of detrital apatite fission track analysis of the Oligocene–Miocene sandstone in the Turpan-Hami Basin are well comparable with the cooling age records of the Harlik Mountain rocks,indicating that the Oligocene–Miocene Taoshuyuanzi Formation in the basin was mostly derived from the Harlik Mountain.The stratigraphic sequence exhibits coarsening upward,reflecting that the source area was in a tectonically active period during the deposition process.Heavy mineral assemblages also suggest that the unstable minerals in the sediment increased significantly at the end of the deposition.Moreover,the proportion of apatite increased up-section,while the garnet content decreased significantly,indicating that the Carboniferous metamorphic rocks have been gradually eroded out and more intrusive rocks have been exposed to the surface.These observations suggest that the Harlik Mountain experienced exhumation during the Oligocene to Miocene,and the denudation depth afterward was probably less than 2.5 km according to the previously apatite(U-Th)/He data.The Oligocene–Miocene exhumation probably acted as one of the triggers for the heavy drought of the Turpan-Hami Basin during the Middle–Late Neogene.

关键词： Turpan-Hami Basin Harlik Mountain Taoshuyuanzi Formation Oligocene–Miocene uplift sedimentology structural geology

Detection of Nonlinear Behavior Induced by Hard Limiting in Voltage Source Converters in Wind Farms Based on Higher-order Spectral Analysis

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 630-645页

作者： Zetian Zheng Shaowei Huang Qiangsheng Bu Chen shen Jun yan State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjingChina

In recent years, sub-synchronous oscillation accidents caused by wind power integration have received extensive attention. The recorded constant-amplitude waveforms can be induced by either linear or nonlinear oscillation mechanisms. Hence, the nonlinear behavior needs to be distinguished prior to choosing the analysis method. Since the 1960s, the higher-order statistics(HOS) theory has become a powerful tool for the detection of nonlinear behavior(DNB) in production quality control wherein it has mainly been applied to mechanical condition monitoring and fault diagnosis. This study focuses on the hard limiters of the voltage source converter(VSC) control systems in the wind farms and attempts to detect the nonlinear behavior caused by bi-or uni-lateral saturation hard limiting using the HOS analysis. First, the conventional describing function is extended to obtain the detailed frequency domain information on the bi-and uni-lateral saturation hard limiting. Furthermore, the bi-and tri-spectra are introduced as the HOS, which are extended into bi-and tri-coherence spectra to eliminate the effects of the linear parts on the harmonic characteristics of hard limiting in the VSC control system, respectively. The effectiveness of the HOS in the DNB and the classification of the hard-limiting types is proven, and its detailed derivation and estimation procedure is presented. Finally, the quadratic and cubic phase coupling in the signals is illustrated, and the performance of the proposed method is evaluated and discussed.

关键词： Bi-coherence spectrum detection of nonlinear behavior hard limiting higher-order statistics tri-coherence spectrum voltage source converter wind farms.

Investigation of Ce/BEA as a passive NOx adsorber:1.The occurrences of cerium and adsorption behavior

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Journal of Rare Earths 2024年第7期42卷 1265-1271页

作者： Minghui Yu Yiying Ding Xiaojie Yu Siwei yan Meiqing shen Jianqiang Wang Jun Wang Gurong shen School of Materials Science and Engineering Tianjin University School of Chemical Engineering and Technology Tianjin University National Rare Earth Catalysis Research Institute

Ce/BEA has great potential as a passive NOxabsorber（PNA） to reduce the NOxemissions during the cold start phase especially in diesel engine for its high resistance to CO and suitable NOxdesorption temperature range.However,as a novel material,its physical and chemical properties still remain unknown.In this work,Ce/BEA was synthesized by ion-exchange method to identify the active species in NOxadsorption,compared with aggregated Ce species in Ce/SiAlOxprepared by impregnation method.X-ray diffraction（XRD）,high resolution-transmission electron microscopy（HR-TEM） and aberration-correctedscanning transmission electron microscopy（AC-STEM） were performed to confirm the isolated single atom formation of Ce species in Ce/BEA.UV-vis diffraction reflection spectra（DRS） and X-ray photoelectron spectroscopy（XPS） were conducted to find the difference of chemical environment between the isolated Ce species and aggregated ones.PNA performance evaluation and temperature programmed reduction of hydrogen（H2-TPR） results show the high NOxstorage capacity and active oxygen species quantity in Ce/BEA.It is also found that the main NOxadsorption species are Ce4+-O*rather than Ce3+.NOx-diffuse reflectance infrared Fourier transform spectroscopy（NOx-DRIFTS） confirms that the bidentate nitrite species are the critical NOxadsorption intermediates and the conception of NOxadsorption and desorption processes is proposed.

关键词： Ce/BEA Isolated Ce species Passive NOx absorber Rare earths

Impact of transcranial electrical stimulation on serum neurotrophic factors and language function in patients with speech disorders

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World Journal of Clinical Cases 2024年第10期12卷 1742-1749页

作者： Li Sun Kai Xiao Xiao-yan shen Shu Wang Department of Rehabilitation Medicine General Hospital of the Yangtze River ShippingWuhan 430010Hubei ProvinceChina

BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.

关键词： Transcranial electrical stimulation Serum neurofactor levels Developmental level Language features

Combined effects of sea urchin-like structure and mixed Cu^(+)/Cu^(0)states on promoting C_(2)formation in electrocatalytic CO_(2)reduction

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 63-73页

作者： Mengqing Shan Dongsheng Lu Jiatong Dong shen yan Jinyu Han Hua Wang Collaborative Innovation Center of Chemical Science and Engineering Key Laboratory for Green Chemical Technology of the Ministry of EducationSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300354China

Surface engineering and Cu valence regulation are essential factors in improving the C_(2)selectivity during the electrochemical reduction of CO_(2).Herein,we present a sea urchin-like CuO/Cu_(2)O catalyst derived from rhombic dodecahedra Cu_(2)O through one-step oxidation/etching method where the mixed Cu^(+)/Cu^(0)states are formed via in situ reduction during electrocatalysis.The combined effects of the morphology and the mixed Cu^(+)/Cu^(0)states on C–C coupling are evaluated by the Faradaic efficiency of C_(2)and the C_(2)/C1 ratio obtained in an H-cell.R-Cu^(O)/Cu_(2)O exhibited 49.5%Faradaic efficiency of C_(2)with a C_(2)/C1 ratio of 3.1 at−1.4 V vs.reversible hydrogen electrode,which are 1.5 and 3.2 times higher than those of R-Cu_(2)O,respectively.Using a flow-cell,68.0%Faradaic efficiency of C_(2)is achieved at a current density of 500 mA·cm^(−2).The formation of the mixed Cu^(+)/Cu^(0)states was confirmed by in situ Raman spectra.Additionally,the sea urchin-like structure provides more active sites and enables faster electron transfer.As a result,the excellent C_(2)production on R-CuO/Cu_(2)O is primarily attributed to the synergistic effects of the sea urchin-like structure and the stable mixed Cu^(+)/Cu^(0)states.Therefore,this work presents an integrated strategy for developing Cu-based electrocatalysts for C_(2)production through electrochemical CO_(2)reduction.

关键词： CO_(2)electrolysis sea urchin-like structure Cu^(+)/Cu^(0) C_(2)products

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

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Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang yan Liu Yuping shen Qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers.The structure,regulation,and function of RRM2 and its inhibitors were discussed.RRM2 gene can produce two transcripts encoding the same ORF.RRM2 expression is regulated at multiple levels during the processes from transcription to translation.Moreover,this gene is associated with resistance,regulated cell death,and tumor immunity.In order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different mechanisms.Thus,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor microenvironment.Moreover,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

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Neural Regeneration Research 2024年第8期19卷 1828-1834页

作者： Yongjiang Zhang Shiyi Yin Run Song Xiaoyi Lai Mengmeng shen Jiannan Wu Junqiang yan Key Laboratory of Neuromolecular Biology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains elusive.Prohibitin-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains unclear.Protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum stress.Parkin is regulated by PERK and is a target of the unfolded protein response.It is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh Parkin.In this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s disease.We used adeno-associated virus to knockdown PHB2 expression.Our res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s disease.Ove rexpression of PHB2 inhibited these abnormalities.We also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s disease.We found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted mitophagy.In addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of PERK.These findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin.

关键词： endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 mitophagy oxidative stress Parkin Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2