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TMR Integrative Nursing 2021年第4期5卷 140-144页

作者： yan-qiu Hao Xiang-Shu Cui School of Nursing Yanbian UniversityYanjiJilinChina

As the social environment keeps changing college students'employment anxiety increases rather than decreases,the mental health of college students during the new crown epidemic has attracted the attention of the state and *** literature review,we analyzed the concept,measurement tools,and influencing factors of employment anxiety in the context of the new crown epidemic,aiming to propose measures and theoretical basis for improving career planning of nursing college students in the future,improving the quality of nursing talent training and alleviating employment anxiety of nursing college students in colleges and universities.

关键词： Nursing college students New crown Career choice anxiety Employment anxiety Review

Study on Markedness in Linguistics

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Sino-US English Teaching 2015年第9期12卷 667-671页

作者： ZHANG yan-qiu TIAN Feng-juan Changchun University Changchun China

Markedness Theory is one of the most important theories in structural linguistics. Its academic significance has long attracted more scholars and linguists. This paper intends to explore markedness from both formal and semantic perspectives： formal markedness, distributional markedness, and semantic markedness. These three types of markedness are accounted for in detail from their definitions to their characteristics. Then the relationship of these three types of markedness is explicated. The ultimate aim of this paper is to give an insight to markedness phenomenon not only from linguistic form or structure, but from its semantic distinctions and pragmatic use. The study also aims to help foster the greater application of Markedness Theory to other linguistic fields＇ study

关键词： markedness Markedness Theory formal markedness distributional markedness semantic markedness

In the Spirit of Benevolence:Taking Action to Fight Against the COVID-19 Pandemic

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Chinese Medicine and Culture 2022年第3期5卷 176-181页

作者： Xu-Jie Wang Wan-Tong Zhang Xue-Xue Zhang Jia-Xi Li qiu-yan Li Wei-Liang Weng Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China Graduate school China Academy of Chinese Medical SciencesBeijing 100700China Graduate school Shanxi University of Chinese MedicineTaiyuan 030024China

Confucian doctors are representative of traditional Chinese medicine(TCM)practitioners with excellent moral character and medical knowledge,they are not hidden in the depths of ancient documents but are a guiding inspiration for professional medical personnel *** doctors are representative group of benevolence in Confucian philosophy and demonstrate the scientific and humanistic spirit of Confucian philosophy and demonstrate the scientific and humanistic spirit of Confucianism in their medical *** are also leading medical practitioners who uphold professional ethics in their pursuits of scientific research,clinical diagnosis&treatment,and *** TCM and Confucian doctors played important roles during the outbreak of the coronavirus disease 2019(COVID-19)pandemic in *** virtue of the superb medical skills of Confucian doctors,integrated Chinese and Western medicine can quickly alleviate patients’symptoms,increase cure rates,reduce mortality rates,thus saving *** the results of extensive clinical trials,this integrated therapy is now understood to be a beneficial treatment for *** combination of TCM and Western medicine is a major feature of COVID-19 prevention and control in *** particular,TCM plays a significant role in the fight against the COVID-19 pandemic with its unique advantages.

关键词： Benevolence Confucian doctor COVID-19 Chinese medicine Integrated Chinese and Western medicine Medical ethics

A General Method for QTL Mapping in Multiple Related Populations Derived from Multiple Parents

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Rice science 2009年第1期16卷 45-50页

作者： AO yan HU Zhi-qiu TANG Zai-xiang WANG Xue-feng XU Chen-wu Jiangsu Provincial Key Laboratory of Crop Genetics ＆ Physiology Yangzhou University Yangzhou 225009 China

It＇s well known that incorporating some existing populations derived from multiple parents may improve QTL mapping and QTL-based breeding programs. However, no general maximum likelihood method has been available for this strategy. Based on the QTL mapping in multiple related populations derived from two parents, a maximum likelihood estimation method was proposed, which can incorporate several populations derived from three or more parents and also can be used to handle different mating designs. Taking a circle design as an example, we conducted simulation studies to study the effect of QTL heritability and sample size upon the proposed method. The results showed that under the same heritability, enhanced power of QTL detection and more precise and accurate estimation of parameters could be obtained when three F2 populations were jointly analyzed, compared with the joint analysis of any two F2 populations. Higher heritability, especially with larger sample sizes, would increase the ability of QTL detection and improve the estimation of parameters. Potential advantages of the method are as follows： firstly, the existing results of QTL mapping in single population can be compared and integrated with each other with the proposed method, therefore the ability of QTL detection and precision of QTL mapping can be improved. Secondly, owing to multiple alleles in multiple parents, the method can exploit gene resource more adequately, which will lay an important genetic groundwork for plant improvement.

关键词： related population quantitative trait locus gene mapping maximum likelihood estimation

群组密码的对等VPN系统及多播密钥分发协议

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软件学报 2019年第9期30卷 2815-2829页

作者：朱岩尹昊王秋艳北京科技大学计算机与通信工程学院北京100083 中国计量科学研究院北京100013

互联网经济的发展,使得企业在大范围内建立连接各种分支机构网络的需求日益强烈,原有采用集中式网关模式的 VPN 逐渐转向采用对等技术的 VPN 系统.现有采用两方密钥交换方法的对等 VPN 技术更适用于两两通信,而在多节点通信中,由于隧道... 详细信息

互联网经济的发展,使得企业在大范围内建立连接各种分支机构网络的需求日益强烈,原有采用集中式网关模式的 VPN 逐渐转向采用对等技术的 VPN 系统.现有采用两方密钥交换方法的对等 VPN 技术更适用于两两通信,而在多节点通信中,由于隧道密钥相互独立,不同隧道加密的累计延迟将增加消息同步接收的困难.针对这一问题,提出一种被称为 GroupVPN的对等 VPN框架,通过设计具有非中心化、高扩展性的多播密钥分发协议,提高对等 VPN中的多播通信效率.该框架在安全隧道层的基础上新增了便于动态群组管理、高效密钥分发的群组管理层,结合公钥群组密码下的广播加密方案,实现具有选择和排除模式的高效密钥分发,保证协议在 SDH假设下满足数据私密性、数据完整性、身份真实性这 3 方面安全性要求.实验分析结果表明:该协议的通信耗时和密钥存储开销与群组规模无关,可将通信延迟限制在会话密钥共享阶段,提高系统性能.

关键词：虚拟专用网安全多播密钥分发群组密码广播加密

Comprehensive overview of human serum albumin glycation in diabetes mellitus

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World Journal of Diabetes 2021年第7期12卷 1057-1069页

作者： Hong-yan qiu Ning-Ning Hou Jun-Feng Shi Yong-Ping Liu Cheng-Xia Kan Fang Han Xiao-Dong Sun Department of Endocrinology The Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

The presence of excess glucose in blood is regarded as a sweet hurt for patients with *** serum albumin(HSA)is the most abundant protein in human plasma,which undergoes severe non-enzymatic glycation with glucose in patients with diabetes;this modifies the structure and function of ***,the advanced glycation end products produced by glycated HSA can cause pathological damage to the human body through various signaling pathways,eventually leading to complications of *** potential glycation sites on HSA have different degrees of sensitivity to glucose *** review provides a comprehensive assessment of the in vivo glycation sites of HSA;it also discusses the effects of glycation on the structure and function of ***,it addresses the relationship between HSA glycation and diabetes ***,it focuses on the value of non-enzymatic glycation of HSA in diabetes-related clinical applications.

关键词： Diabetes mellitus Human serum albumin Non-enzymatic glycation Advanced glycation end products Glycation sites Diabetic complications

Syntheses and properties of 1,3-bis-(1H-imidazole-4,5-dicarboxylic acid)propane

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Syntheses and properties of 1,3-bis-(1H-imidazole-4,5-dicarb...

Electroacupuncture in Treatment of Acute Gastrointestinal Injury in Patients with Severe Traumatic Brain Injury:A Multicenter Randomized Controlled Trial

河南省化学会2016年学术年会

作者： yan-qiu yang yan-ju Liu Huai-xia yang College of Pharmacy Henan University of Chinese Medicine

The imidazolecarboxylic compounds have excellent reactivity and physiological activity due to the charateristics of imidazole and carboxylic acid compounds. It attracted our great interest in exploring something deeper in this field. 1,3-bis-(1H-imidazole-4,5-dicarboxylic acid)propane was synthesized from O-phenylenediamine and glutaric acid. The study of p H titration indicated that the deprotonation process of compound included three steps, which was deprotonated in p H range of 0.50-6.40, 7.6-10.79, 11.2-14.00,respectively. The UV-Vis spectroscopy and fluorescence spectroscopy showed that the compound had a selectivity for Cu and Zn over other metal ions such as Cr, Pb, Ag+, Cd, Ni, Mg and Co. The results of human serum albumin(HSA) binding study indicated that the fluorescence intensity of HSA was decreased considerably upon the addition of the compound through a static quenching mechanism.

关键词： imidazolecarboxylic acid ph ions sensing HSA

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Chinese Journal of Integrative Medicine 2023年第8期29卷 721-729页

作者： XING Xi JIANG Rong-lin LEI Shu ZHI Yi-hui ZHU Mei-fei HUANG Li-quan HU Ma-hong LU Jun FANG Kun WANG qiu-yan Department of ICU the First Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineHangzhou(310000)China Department of ICU Tongde Hospital of ZhejiangTongdeZhejiang Province(310000)China Department of ICU Xinhua Hospital of ZhejiangHangzhou(310000)China Department of ICU Zhejiang integrated Traditional Chineseand Western Medicine HospitalHangzhou(310000)China Department of ICU Hangzhou Hospital of Traditional Chinese MedicalHangzhou(310000)China

Objective: To evaluate whether electroacupuncture(EA) would improve gastrointestinal function and clinical prognosis in patients with severe traumatic brain injury(TBI) complicocted by acute gastrointestinal injury(AGI). Methods: This multicenter, single-blind trial included patients with TBI and AGI admitted to 5Chinese hospitals from September 2018 to December 2019. A total of 500 patients were randomized to the control or acupuncture groups using a random number table, 250 cases in each group. Patients in the control group received conventional treatment, including mannitol, nutritional support, epilepsy and infection prevention, and maintenance of water, electrolytes, and acid-base balance. While patients in the acupuncture group received EA intervention at bilateral Zusanli(ST 36), Shangjuxu(ST 37), Xiajuxu(ST 39), Tianshu(ST 25), and Zhongwan(RN 12) acupoints in addition to the conventional treatment, 30 min per time, twice daily,for 7 d. The primary endpoint was 28-d mortality. The secondary endpoints were serum levels of D-lactic acid(D-lac), diamine oxidase(DAO), lipopolysaccharide(LPS), motilin(MTL) and gastrin(GAS), intra-abdominal pressure(IAP), bowel sounds, abdominal circumference, AGI grade, scores of gastrointestinal failure(GIF),Glasgow Coma Scale(GCS), Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ), Sequential Organ Failure Assessment(SOFA), and Multiple Organ Dysfunction Syndrome(MODS), mechanical ventilation time,intense care unit(ICU) stay, and the incidence of hospital-acquired pneumonia. Results: The 28-d mortality in the acupuncture group was lower than that in the control group(22.80% vs. 33.20%, P<0.05). Compared with the control group, the acupuncture group at 7 d showed lower GIF, APACHE Ⅱ, SOFA, MODS scores, D-lac,DAO, LPS, IAP, and abdominal circumference and higher GCS score, MTL, GAS, and bowel sound frequency(all P<0.05). In addition, the above indices showed simillar changes at 7 d compared with days 1 and 3 in the EA grou

关键词： electroacupuncture traumatic brain injury acute gastrointestinal injury multicenter randomized controlled trial

World Journal of GastroenterologyDevelopment and validation of a risk prediction score for the severity of acute hypertriglyceridemic pancreatitis in Chinese patients

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World Journal of Gastroenterology 2022年第33期28卷 4846-4860页

作者： Zi-Yu Liu Lei Tian Xiang-Yao Sun Zong-Shi Liu Li-Jie Hao Wen-Wen Shen yan-qiu Gao Hui-Hong Zhai Department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical CenterLos AngelesCA 91010United States Department of Orthopedics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Geriatric Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180Guangdong ProvinceChina

BACKGROUND The frequency of acute hypertriglyceridemic pancreatitis(AHTGP) is increasing worldwide. AHTGP may be associated with a more severe clinical course and greater mortality than pancreatitis caused by other causes. Early identification of patients with severe inclination is essential for clinical decision-making and improving prognosis. Therefore, we first developed and validated a risk prediction score for the severity of AHTGP in Chinese *** To develop and validate a risk prediction score for the severity of AHTGP in Chinese *** We performed a retrospective study including 243 patients with AHTGP. Patients were randomly divided into a development cohort(n = 170) and a validation cohort(n = 73). Least absolute shrinkage and selection operator and logistic regression were used to screen 42 potential predictive variables to construct a risk score for the severity of AHTGP. We evaluated the performance of the nomogram and compared it with existing scoring systems. Last, we used the best cutoff value(88.16) for severe acute pancreatitis(SAP) to determine the risk stratification *** Age, the reduction in apolipoprotein A1 and the presence of pleural effusion were independent risk factors for SAP and were used to construct the nomogram(risk prediction score referred to as AAP). The concordance index of the nomogram in the development and validation groups was 0.930 and 0.928, respectively. Calibration plots demonstrate excellent agreement between the predicted and actual probabilities in SAP patients. The area under the curve of the nomogram(0.929) was better than those of the Bedside Index of Severity in AP(BISAP), Ranson, Acute Physiology and Chronic Health Evaluation(APACHE II), modified computed tomography severity index(MCTSI), and early achievable severity index scores(0.852, 0.825, 0.807, 0.831 and 0.807, respectively). In comparison with these scores, the integrated discrimination improvement and decision curve ana

关键词： Nomogram Severity Acute pancreatitis Prediction model

Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells redeems palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

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中国病理生理杂志 2012年第11期 2032-2033页

作者： TIAN Dai,qiu yan-yan,LI Xiao-bo,ZHI Xiu-ling,WANG Xin-hong,YIN Lian-hua,NING yan-xia(Department of Physiology and Pathophysiology,Shanghai Medical College,Fudan University,Shanghai 200032,China)

AIM:Endothelial dysfunction is a well documented evidence for onset of atherosclerosis and other cardiovascular ***-dogenic acute regulatory protein(StAR),one of the cholesterol transporters,plays an important role in maintenance of intracellular lipid ***,the effect of StAR in endothelial dysfunction is not completely *** acid(PA)has been

关键词： acid Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells redeems palmitic acid-induced inflammation and reduction in nitric oxide bioavailability