检索结果-南通市图书馆

Synthesis and Anti-tumor Activity of Novel Glycyrrhetinic Acid Derivatives

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第2期28卷 214-219页

作者： MENG yan-qiu DING Jia-qi LIU Yuan NIE Hui-hui GUAN Sai ZOU Chao ZHAO Na CHEN Hong CAO Bo Department of Pharmaceutical Engineering Shenyang University of Chemical TechnologyShenyang 110142P.R.China Department of Pharmacognosy Medical College of Chinese People's Armed Police ForcesTianjin 300162P R.China

Twenty-five derivatives of glycyrrhetinic acid（GA） modified on the A-ring,at C30 and C11 positions were *** in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells（HeLa）,human hepatocellular liver carcinoma cells（HepG2） and human gastric carcinoma cells（BGC-823）] was evaluated by standard MTT[3-（4,5-dimethyl-2-thiazol-yl）-2,5-diphenyl-2H-tetrazolium bromide] *** the tested derivatives were found to have stronger cell growth inhibitory than their parent compound *** them,compounds 3a,5a,and 8d have similar activity on HeLa cell line,and compound 8a has similar activity on HeLa,HepG2 and BGC-823 cell lines as Gefitinib.

关键词： Glycyrrhetinic acid derivative Anti-tumor activity Structure modification

Therapeutic and inducing effect of corneal crosslinking on infectious keratitis

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第12期9卷 1820-1823页

作者： Liang-Zhu Jiang Shi-yan qiu Zhi-Wei Li Xiao Zhang Xiang-Chen Tao Guo-Ying Mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University Department of Ophthalmology the People's Hospital of Linyi Department of Pediatrics the People's Hospital of Linyi

The corneal crosslinking （CXL） with riboflavin and ultraviolet-A （UVA） is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis.

关键词： corneal crosslinking keratitis theraputic and inducing effect

Effects of pulse energy ratios on plasma characteristics of dual-pulse fiber-optic laser-induced breakdown spectroscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2022年第2期31卷 387-397页

作者： Yu-Hua Hang yan qiu Ying Zhou Tao Liu Bin Zhu Kaixing Liao Ming-Xin Shi Fei Xue Suzhou Nuclear Power Research Institute Suzhou 215004China Key Laboratory for Physical Electronics and Devices of the Ministry of Education Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

Laser-induced plasmas of dual-pulse fiber-optic laser-induced breakdown spectroscopy with different pulse energy ratios are studied by using the optical emission spectroscopy(OES)and fast *** energy of the two laser pulses is independently adjusted within 0–30 m J with the total energy fixed at 30 m *** inter-pulse delay remains 450 ns *** the energy share of the first pulse increases,a similar bimodal variation trend of line intensities is *** two peaks are obtained at the point where the first pulse is half or twice of the second one,and the maximum spectral enhancement is at the first *** bimodal variation trend is induced by the change in the dominated mechanism of dual-pulse excitation with the trough between the two peaks caused by the weak coupling between the two *** increasing the first pulse energy,there is a transition from the ablation enhancement dominance near the first peak to the plasma reheating dominance near the second *** calculations of plasma temperature and electron number density are consistent with the bimodal trend,which have the values of 17024.47 K,2.75×10^(17)cm;and 12215.93 K,1.17×10^(17)cm;at a time delay of 550 *** addition,the difference between the two peaks decreases with time *** the increase in the first pulse energy share,the plasma morphology undergoes a transformation from hemispherical to shiny-dot and to oblate-cylinder structure during the second laser irradiation from the recorded images by using an intensified charge-coupled device(ICCD)***,the peak expansion distance of the plasma front first decreases significantly from 1.99 mm in the single-pulse case to 1.34 mm at 12/18(dominated by ablation enhancement)and then increases slightly with increasing the plasma reheating *** variations in plasma dynamics verify that the change of pulse energy ratios leads to a transformation in the dual-pulse excitation mechanism.

关键词： fiber-optic laser-induced breakdown spectroscopy(FO-LIBS) dual-pulse excitation pulse energy ratio spectral enhancement

Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第8期20卷 935-938页

作者： Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing yan Sun qiu Ye Wu Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CYP51）. Their structures were confirmed by MS and ^1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. The results showed that all title compounds exhibited activity against fungi tested to some extent. Compounds 3c, 3d, 7a, 7b and 7e exhibited more potent antifungal activities against nearly all fungi tested except AspergiUus fumigatus than fluconazole. ？2009 qiu Ye Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： Triazole Synthesis Antifungal activity

Tribenuron-Methyl Resistant Shepherd's Purse (Capsella bursa-pastoris (L.) Medik.) in Hebei Province of China

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2011年第8期10卷 1241-1245页

作者： WANG Gui-qi CUI Hai-lan ZHANG Hong-jun ZHANG yan-qiu LIU Xue LI Xiang-ju FAN Cui-qin Institute of Food and Oil Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 000P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection （IPP）Chinese Academy of Agricultural Sciences （CAAS）Beijing 100193P.R.China Institute for the Control of Agrochemicals Ministry of AgricultureBeijing 100125P.R.China

Shepherd＇s purse seeds were collected from winter wheat fields and road sides in Hebei Province,*** sensitivities to tribenuron-methyl were evaluated in a whole plant dose response assay in the *** revealed that HB-1,HB-2,HB-3,HB-4,HB-6,HB-7,HB-17,HB-18,HB-19,HB-20,HB-21,and HB-22 populations were susceptible to tribenuron-methyl characterised by very low GR50 values of about 0.10 g *** the other hand,populations HB-15 and HB-16 had moderate resistance to tribenuron-methyl with resistance indices （RI） ranging from 10-100 folds,whilst populations HB-5,HB-8,HB-9,HB-10,HB-11,HB-12,HB-13,and HB-14 expressed high level of resistance to tribenuron-methyl with resistance indices over *** proportion of moderate resistance level was about 9.09%,and that of high resistance was about 36.36%.

关键词： ALS inhibitor tribenuron-methyl resistance shepherd's purse (Capsella bursa-pastoris (L.) Medik.)

Promoting an ideal ecosystem through the arts

在线全文

学校读者我要写书评

暂无评论

中国周刊 2004年第1期 13-15页

作者： Li yan qiu Qian

Each year, from May to August, the Tibetan antelopes will gather in herds, migrate and give birth to their offspring. As the original planner of the TV series "Blue Sky and Wild Land", the reporter and the TV crew together explored the Zhuoer Lake, the centre of Hoh Xil Wildlife Protection Reserve in Qinghai Province. With the support of the personnel working in the protection reserve, the team started the tough but exciting shooting experience of ecological scenes. The director and screenwriter of this TV series has expressed that in the

关键词： Lake Promoting an ideal ecosystem through the arts Wild

Relationship of Parental Indica-Japonica Indexes with Yield and Grain Quality Traits of Japonica Hybrid Rice in Northern China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rice science 2010年第3期17卷 199-205页

作者： WANG yan-rong qiu Fu-lin HUA Ze-tian DAI Gui-jin Rice Research Institute of Liaoning Province Skenyang 110101 China

Taking the main parents （10 male sterile lines and 10 restorer lines） and their 100 combinations of japonica hybrid rice in northern China as materials, the relationships of parental indica-japonica indexes determined by the methods of the Cheng’s index as well as simple sequence repeat （SSR） markers with yield and grain quality traits of hybrid rice were studied. For the parents, the Cheng’s index （Chi） ranged from 13.5 to 19.3 and the indica index in SSR markers （ADi） were from 0.12 to 0.38. The classification of parents by Chi was not completely consistent with that by ADi. The Chi of male parent was more closely related to hybrid traits than that of female parent, as contrasted to ADi. At the same time, the difference between parents （PD） in Chi was more closely related to hybrid traits than that in ADi. The indica-japonica indexes of parents and their difference between parents appeared quadratic relationship to hybrid traits with the critical extremum. The directions of the correlation of indica-japonica indexes of parents and their differences with hybrid yield traits were on the opposition to those with hybrid grain quality traits. Therefore, the female parent should match the male parent moderately in indica-japonica index to obtain the optimum of hybrid traits, high yield as well as good quality.

关键词： japonica hybrid rice indica-japonica index Cheng’s index simple sequence repeat yield rice quality

Research Progress of Nickel Iron Bimetallic Series Electrocatalytic Materials

在线全文

学校读者我要写书评

暂无评论

Expert Review of Chinese Chemical

Expert Review of Chinese Chemical 2024年第2期2卷 23-26页

作者： yan qiu Wenjing Ma College of Chemistry and Chemical Engineering Lanzhou Jiaotong University Qingdao university of science and technology

Hydrogen energy has become one of the recognized clean energy sources worldwide due to its advantages such as low cost,renewable energy,and green environmental *** water is currently one of the most promising solutions for providing hydrogen *** iron bimetallic electrocatalysts have abundant sources,low cost,clean and pollution-free properties,and strong catalytic performance,This article mainly reviews the development and research of bimetallic nickel iron oxides and nickel iron alloys in recent years,and explores their synthesis methods,properties,and stability in depth.

关键词： electrochemistry bimetallic nickel ferroelectric catalyst hydrogen evolution reaction oxygen evolution reaction

Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2010年第8期29卷 721-728页

作者： Su-Mei Cao Jie-Kai YU qiu-yan Chen Ning-Wei Li yan-Qun Xiang Chao-Nan Qian Xun HU Chang-Qing Zhang Dan Xie Xiang Guo State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Epidemiology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Cancer Institute Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 P. R. China Department of Nasopharyngeal Carcinoma Sun Yat-senUniversity Cancer Center Guangzhou Guangdong 510060 P. R. China Research Institute Sun Yat-sen University Cancer CenterGuangzhou Guangdong 510060 P. R. China

Background and Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult due to the insufficient specificity of the conventional examination method. This study was to investigate potential and consistent biomarkers for NPC, particularly for early detection of NPC. Methods: A proteomic pattern was identified in a training set (134 NPC patients and 73 control individuals) using the surface-enhanced laser desorption and ionization-mass spectrometry (SELDI-MS), and used to screen the test set (44 NPC patients and 25 control individuals) to determine the screening accuracy. To confirm the accuracy, it was used to test another group of 52 NPC patients and 32 healthy individuals at 6 months later. Results: Eight proteomic biomarkers with top-scored peak mass/charge ratios (m/z) of 8605 Da, 5320 Da, 5355 Da, 5380 Da, 5336 Da, 2791 Da, 7154 Da, and 9366 Da were selected as the potential biomarkers of NPC with a sensitivity of 90.9% (40/44) and a specificity of 92.0% (23/25). The performance was better than the current diagnostic method by using the Epstein-Barr virus (EBV) capsid antigen IgA antibodies (VCA/IgA). Similar sensitivity (88.5%) and specificity (90.6%) were achieved in another group of 84 samples. Conclusion: SELDI-MS profiling might be a potential tool to identify patients with NPC, particularly at early clinical stages.

关键词：激光解吸电离蛋白质组鼻咽癌表面增强质谱法生物标志物 SELDI 血清