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Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice

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World Journal of Diabetes 2025年第1期16卷 104-120页

作者： Wen-yan Xu Yuan-Yuan Dai Shi-Xian yang Hao Chen yan-qiang Huang Pei-Pei Luo Zhong-Heng Wei Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Wujin People’s Hospital Affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina

BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and *** To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic *** By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in *** skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of *** The MICs of betaine against microorganisms such as Staphylococcus aureus(***),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/*** root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of *** 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically *** diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound *** The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensit

关键词： Betaine ointment Staphylococcus aureus Drug resistance Skin infection Diabetes mellitus

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Exact Values of Some Geometric Constants of Orlicz Spaces

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Acta Mathematica Sinica,English Series 2007年第5期23卷 827-846页

作者： Ya qiang yan Department of Mathematics Suzhou University Suzhou 215006 P. R. China

We present the exact values of nonsquare constants, von Neumann-Jordan constants, Jung constants, packing constants, weakly convergent sequence coefficients and normal structure coefficients in a class of reflexive Or... 详细信息

关键词： Banach space Orlicz space geometric constant

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Polymeric partners breathe together: using gas to direct polymer self-assembly via gas-bridging chemistry

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Science China Chemistry 2022年第7期65卷 1401-1410页

作者： Zehao Gong Yixin Wang qiang yan State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan University200433China

The quest for a general and facile way to regulate polymer self-assembled nanostructures with low-to high-order ergodicity is an eternal theme in soft nanoparticle fabrication. Here we present an unprecedented gas-bridging strategy that allows to use gas to direct polymer self-assembly in continuous and tunable manners. Such system comprises a partner of frustrated Lewis polymers with bulky Lewis acid and base groups. They can together “breathe in” external gases to form gas-bridged structures between the two complementary moieties, which drive their mutual complexation and assemble into polymer nanoparticles of diverse geometries and dimensionalities. This strategy is applicable to a broad family of gas substances including but not limited to carbon oxides, nitrogen oxides, sulfur oxides, and even olefins;moreover, tailoring gas types and levels can dictate distinct assembling evolutionary pathways and deformable behaviors among spherical, fibrous, polymersomal, tubesomal and cubosomal morphologies. We also discover that the gas-based bonding chemistry is the mechanistic basis underlying the phase transitional control and phase window regulation. This will open a new direction of making bespoke polymer nanostructures with gas.

关键词： gas-bridging bond Lewis pair polymer dynamic covalent chemistry self-assembly tunable nanostructure

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Photoregulated supramolecular hydrogels driven by polyradical interactions

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Chinese Chemical Letters 2023年第7期34卷 340-344页

作者： Zehao Gong qiang yan State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan UniversityShanghai 200433China

Organic radical as a powerful tool has been extensively applied in synthetic chemistry. However, harnessing radical-mediated noncovalent interactions to fabricate soft materials remains elusive. Here we report a new category of supramolecular hydrogel system held by multiple radical-radical(polyradical) interactions, and its photosensitive cross-linking structure. A simple polyacrylamide with triarylamine(TAA)pendants is designed as the precursor. The TAA units in polymer can be converted into active TAA^(·+)radical cations with light and further associate each other via TAA^(·+)–TAA^(·+)stacking interactions to form stable supramolecular network. Temporal control of the light irradiation dictates the degree of radical stacks, thus regulating the mechanical performance of the resulting hydrogel materials on-demand. Moreover, the reversible collapse of this hydrogels can be promoted by adding radical scavenger or exerting reduction voltage.

关键词： Radical-radical interactions Polyradical Supramolecular hydrogel Polymer network Photoresponsiveness

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Electro-selective interconversion of living cationic and radical polymerizations

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Science China Chemistry 2019年第8期62卷 1023-1029页

作者： Jiannan Zhu Xiang Hao qiang yan State Key Laboratory of Molecular Engineering of Polymers Fudan University

Orchestrating conflicting polymerization mechanisms in a single polymerization process through one external stimulus is a prerequisite to achieve in-situ selective synthesis of different monomers. Here we report an electrochemically controlled mechanism transformation that enables selective activation of living cationic or radical polymerization via an alternating voltage and dual electrocatalysts. Using identical mixed-monomer condition, a variety of desired block copolymer structures, including diblock, multiblock, random, and tapered copolymers can be obtained by simply varying the periods or phases of the alternating potential. Moreover, merging this electro-interconverted polymerization with a flow-chemistry technique can streamline preparation of functional polymer materials with complex multiblock structure. This study would offer a new vision on large-scale electrochemical synthesis of sequence-defined polymers.

关键词： electrochemistry living polymerization mechanism interconversion radical cation

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Biological Stimuli-responsive Polymer Systems:Design,Construction and Controlled Self-assembly

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Chinese Journal of Polymer Science 2018年第3期36卷 347-365页

作者： Miao-Miao Xu Ren-Jie Liu qiang yan Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not *** to the importance of this burgeoning field,great efforts have been devoted and,up to now,polymer chemists have made a remarkable success in this prospective research *** this review,we systematically generalize the present state of biological stimuli-responsive polymer *** highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.

关键词： Biological stimuli Responsive polymer Controlled self-assembly Biomedicine

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Influence of mill modulus control gain on vibration in hot rolling mills

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Journal of Iron and Steel Research International 2020年第5期27卷 528-536页

作者： Jie-bin Qi Xin-xin Wang Xiao-qiang yan School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

The rolling mill vibration is characterized by the coupling effects among mechanical,electrical,hydraulic and interfacial *** influence of the mill modulus control gain in automatic gauge control on the vibration in hot rolling mills was ***,an experiment related to the mill modulus control gain was carried out in the hot rolling mill process,and it was found that the rolling mill vibration increases with the mill modulus control ***,based on the Sims rolling force method,the coupling dynamic model was established to explain this ***,the influence of mill modulus control gain on the vibration was analyzed numerically on the basis of the coupling dynamic ***,the agreement between the experimental results and the simulation results was confirmed and the measure reducing the mill modulus control gain was obtained to relieve mill vibration.

关键词： Rolling mill vibration Coupling dynamic model Automatic gauge control Mill modulus control gain Vibration suppression

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Calibration and data restoration of light field modulated imaging spectrometer

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Chinese Physics B 2018年第8期27卷 179-186页

作者： Li-Juan Su qiang-qiang yan yan Yuan Shi-Feng Wang Yu-Jian Liu Key Laboratory of Precision Opto-mechatronics Technology of Ministry of Education Beihang UniversityBeijing 100191China Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi＇an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi ＇ an 710119China

A light field modulated imaging spectrometer （LFMIS） can acquire the spatial-spectral datacube of targets of interest or a scene in a single shot. The spectral information of a point target is imaged on the pixels covered by a microlens. The pixels receive spectral information from different spectral filters to the diffraction and misalignments of the optical components. In this paper, we present a linear spectral multiplexing model of the acquired target spectrum. A calibration method is proposed for calibrating the center wavelengths and bandwidths of channels of an LFMIS system based on the liner-variable filter （LVF） and for determining the spectral multiplexing matrix. In order to improve the accuracy of the restored spectral data, we introduce a reconstruction algorithm based on the total least square （TLS） approach. Simulation and experimental results confirm the performance of the spectrum reconstruction algorithm and validate the feasibility of the proposed calibrating scheme.

关键词： light field modulated imaging spectrometer linear-variable filter spectral calibration spectral re-construction

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An active method suppressing rolling mill vibration: disturbance estimation and compensation algorithm

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Journal of Iron and Steel Research International 2019年第7期26卷 697-703页

作者： Xiao-qiang yan Jie-bin Qi Xin-xin Wang School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China

The rolling mill vibration not only seriously causes the strip thickness heterogeneity, but also damages the rolling mill equipment and its electrical components. Existing vibration suppression methods are passive and mainly tune mechanical, hydraulic, electrical and rolling process parameters. A new active vibration suppression method was thus proposed using the disturbance estimation and compensation algorithm. Firstly, the hydraulic-mechanical coupling model of the rolling mill vibration was established, and an active vibration suppressor was designed based on the extended state observer. Then, through the numerical simulation, it is found that the vibration energy is reduced by 35.3% using the vibration suppressor, and the vibration suppressor is valid when the vibration frequency is lower than 60 Hz Finally, the vibration suppressor was applied to the in-site manufacturing, and the expected vibration suppression was obtained. The method makes the produced steel strip have more uniform thickness and further significantly increases the finished product ratio.

关键词： Rolling mill vibration Active vibration suppression Disturbance estimation Compensation algorithm Extended state observer

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Lung Nodule Image Retrieval Based on Convolutional Neural Networks and Hashing

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Journal of Beijing Institute of Technology 2019年第1期28卷 17-26页

作者： yan qiang Xiaolan yang Juanjuan Zhao qiang Cui Xiaoping Du College of Computer Science and Technology Taiyuan University of Science and Technology Shanxi Coal Central Hospital

Lung medical image retrieval based on content similarity plays an important role in computer-aided diagnosis of lung *** recent years,binary hashing has become a hot topic in this field due to its compressed storage and fast query *** hashing methods often rely on highdimensional features based hand-crafted methods,which might not be optimally compatible with lung nodule ***,different hashing bits contribute to the image retrieval differently,and therefore treating the hashing bits equally affects the retrieval ***,an image retrieval method of lung nodule images is proposed with the basis on convolutional neural networks and ***,apre-trained and fine-tuned convolutional neural network is employed to learn multilevel semantic features of the lung *** components analysis is utilized to remove redundant information and preserve informative semantic features of the lung ***,the proposed method relies on nine sign labels of lung nodules for the training set,and the semantic feature is combined to construct hashing ***,returned lung nodule images can be easily ranked with the query-adaptive search method based on weighted Hamming *** experiments and evaluations on the dataset demonstrate that the proposed method can significantly improve the expression ability of lung nodule images,which further validates the effectiveness of the proposed method.

关键词： lung nodule image retrieval convolutional neural networks informative semantic features hashing

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