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Sesquiterpene Esters from Salvia roborowskii

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Chinese Chemical Letters 2003年第11期14卷 1156-1158页

作者： Ya LI Ning LOU yan qi wu Xian Feng LIN Yu LI National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim.... 详细信息

关键词： Salvia roborowskii Labiatae sesquiterpene germacrane.

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减震结构阻尼器优化布置混合算法

吉林大学学报（工学版） 2024年第8期54卷 2267-2274页

作者：阎奇武邹忠亮中南大学土木工程学院长沙410083 广州市城市规划勘测设计研究院建筑设计一所广州510060

为提高现有减震结构阻尼器优化布置计算效率和性能,提出了一种差分进化和人工电场混合算法。该算法采用Tent混沌映射初始化改善种群分布质量和多样性,引入变异交叉选择机制维持种群中优势个体的进化避免趋于局部最优。通过测试函数算例... 详细信息

为提高现有减震结构阻尼器优化布置计算效率和性能,提出了一种差分进化和人工电场混合算法。该算法采用Tent混沌映射初始化改善种群分布质量和多样性,引入变异交叉选择机制维持种群中优势个体的进化避免趋于局部最优。通过测试函数算例和混凝土框架结构的阻尼器优化布置算例,对比各优化算法的寻优计算性能及收敛速度。研究结果表明:差分进化和人工电场混合算法具有较好的全局寻优能力,收敛速度快,优化后结构减震性能好。

关键词：结构工程差分进化算法人工电场算法混合算法减震结构阻尼器优化布置

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Splenic vasculopathy in portal hypertension patients

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World Journal of Gastroenterology 2006年第17期12卷 2737-2741页

作者： Tao Li Ji-Yuan Ni yan-wu qi Hai-yang Li Tong Zhang Zhen yang Department of Hepatic Surgery Tongji Hosptal Tongji medical College Huazhong University of Science and Technology Wuhan 430030 Hubei province China

AIM： To investigate the interaction between portal hypertension, splanchnic hyperdynamic circulation and splanchnic vasculopathy by observing splenic arterial and venous pathological changes and the role of extracellular matrix in the pathogenesis of portal hypertensive vasculopathy by measuring the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients. METHODS： Morphological changes of splenic arteries and veins taken from portal hypertensive patients （n = 20） and normal controls （n = 10） were observed under optical and electron microscope. Total RNA was extracted and the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients （n= 20） was semi-quantitatively detected using reverse transcription-polymerase chain reaction （RT-PCR）. RESULTS： Under optical microscope, splenic arterial intima was destroyed and internal elastic membrane and medial elastic fibers of the splenic arterial walls were degenerated and broken. Splenic venous intima became remarkably thick. Endothelial cells were not intact with formation of mural thrombus. The tunica media became thickened significantly due to hypertrophy of smooth muscles. Fibers and connective tissues were increased obviously. Under electron microscope, smooth muscle cells of the splenic arteries were degenerated and necrotized. Phenotypes of smooth muscle cells changed from constrictive into synthetic type. Red blood cells and platelets accumulated around the damaged endothelial cells. Synthetic smooth muscle cells were predominant in splenic veins and their cytoplasma had plentiful rough endoplasmic reticulum ribosomes and Golgi bodies. Along the vascular wall, a lot of collagen fibers were deposited, the intima was damaged and blood components accumulated. There was no significant difference in the expression of type Ⅰ procollagen mRNA in splenic venous wall between the patients with portal hypertension and those without

关键词： Portal hypertension Splanchnic hyperdynamic circulation Splanchnic vasculopathy

Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： qi-Rong Jiang Da-wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

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组合连梁与墙肢节点恢复力模型试验研究

中南大学学报（自然科学版） 2009年第2期40卷 504-511页

作者：阎奇武唐莹莹陈康华中南大学土木建筑学院湖南长沙410075 长沙市代建工程建设指挥部湖南长沙410008

为了建立平面内钢-混凝土组合梁与混凝土墙肢节点的恢复力模型,进行2个足尺平面内钢-混凝土组合连梁与混凝土墙肢节点的低周反复荷载试验,研究节点的破坏机理,得到节点的低周反复荷载作用下的滞回曲线。利用统计分析软件SPSS,采用对平... 详细信息

为了建立平面内钢-混凝土组合梁与混凝土墙肢节点的恢复力模型,进行2个足尺平面内钢-混凝土组合连梁与混凝土墙肢节点的低周反复荷载试验,研究节点的破坏机理,得到节点的低周反复荷载作用下的滞回曲线。利用统计分析软件SPSS,采用对平面内钢-混凝土组合梁与混凝土墙肢节点滞回曲线的回归分析,考虑强度和刚度退化规律,建立平面内钢-混凝土组合梁与混凝土墙肢节点的恢复力模型。实验结果表明:平面内钢-混凝土组合梁与混凝土墙肢节点的低周反复荷载试验滞回曲线呈弓形,骨架曲线呈倒"Z"形,平面内钢-混凝土组合梁与混凝土墙肢节点有较好的延性和较强的耗能能力。

关键词：组合连梁剪力墙恢复力模型

钢筋砼柱分段截面离散屈服面模型法的空间非线性分析

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湖南大学学报（自然科学版） 2000年第6期27卷 85-90页

作者：阎奇武沈蒲生湖南大学土木工程学院湖南长沙410082

引进子结构技术 ,将塑性区的截面离散建立在砼多轴弹塑性硬化松驰本构模型基础上 ,采用屈服面理论 ,提出了分段截面离散的屈服面模型法 .计算分析表明 ,理论分析与实验结果吻合良好 ,可用于研究压、双弯。

关键词：空间非线性分析钢盘砼柱屈服面模型法

我国农村订单定向医学生免费培养计划的政策分析

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中国卫生政策研究 2017年第5期10卷 34-38页

作者：王碧艳吴琪俊广西中医药大学公共卫生与管理学院广西南宁530200

本文对我国16个省2016年农村订单定向医学生免费培养计划政策文件内容进行分析,发现我国定向医学生招收人数主要由国家确定并下达给各省,招收学生以农村生源为主,招生类别主要为本科生,招生专业为临床医学和中医学。该项政策目前存在定... 详细信息

本文对我国16个省2016年农村订单定向医学生免费培养计划政策文件内容进行分析,发现我国定向医学生招收人数主要由国家确定并下达给各省,招收学生以农村生源为主,招生类别主要为本科生,招生专业为临床医学和中医学。该项政策目前存在定向医学生招收人数与基层医疗卫生机构对人才的实际需求数脱钩、定向医学生培养周期过长、培养模式缺乏针对性、与乡镇卫生院的合同签署工作难以完成等问题,建议应按照基层医疗卫生机构对卫生技术人才的需求确定定向医学生招收人数、创新设立三年制学士学位以缩短培养周期、创新定向医学生培养模式、采取多种措施进一步吸引和留住农村卫生人才等。

关键词：农村定向医学生政策分析

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi Yin Jiannan wu Junqiang yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

珠海市“十二五”经济发展评价指标体系与发展目标研究

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特区经济 2011年第10期 31-32页

作者：齐延信吴燕苏武江廖爱红北京理工大学珠海学院广东珠海519085

本文通过建立珠海"十二五"经济发展评价指标体系,提出了珠海"十二五"经济发展目标,以期为珠海市"十二五"规划的编制提供参考。

关键词：十二五经济发展指标体系预测方法