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Influence of serum adiponectin level and SNP +45 polymorphism of adiponectin gene on myocardial fibrosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 721-728页

作者： Cheng-jun yan Su-mei LI qiang XIAO yan LIU Jian HOU Ai-fang CHEN Li-ping XIA Xiu-chang LI Department of Emergency Jining First People's Hospital School Hospital of Taishan Medical University Department of Echocardiography Affiliated Hospital of Taishan Medical University

Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardio- myocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene polymorphism on myocardial fibrosis. Our study investigates the influence of the SNP ＋45 polymorphism of the adi- ponectin gene and serum levels of adiponectin on myocardial fibrosis in patients with essential hypertension. A case-control study was conducted on 165 hypertensive patients and 126 normotensive healthy controls. The geno- types of adiponectin gene polymorphisms were detected by the polymerase chain reaction （PCR） method. Serum concentrations of procollagen were measured by a double antibody sandwich enzyme-linked immunosorbent assay （ELISA） in all subjects. The integrated backscatter score （IBS） was measured in the left ventricular myocardium using echocardiography. The serum levels of adiponectin in hypertensive patients were significantly lower than those in the normal control group （（2.69±1.0） μg/ml vs. （4.21±2.89） μg/ml, respectively, P〈0.001）. The serum levels of type-Ⅰ procoilagen carboxyl end peptide （PiCP） and type-Ⅲprocollagen ammonia cardinal extremity peptide （PIIINP） in the hypertension group were significantly higher than those in the control group. In the hypertension group, serum levels of adiponectin were significantly and negatively related to the average acoustic intensity and corrected acoustic intensity of the myocardium （t=0.46 and 0.61, respectively, P〈0.05 for both）. The serum levels of PICP and PIIINP were sig- nificantly different among the three genotypes of SNP ＋45 （P〈0.01）. Logistic regression analyses showed that sex and genotype （GG＋GT） were the major risk factors of myocardial fibrosis in hypertensive patients （OR=5.343 and 3.278, respectively, P〈0.05）. These data suggest that lower levels of adiponectin and SNP ＋45 polymorphism of the adi- ponectin gene are likely to play an important role in myocardial fibrosis

关键词： Hypertension Myocardial fibrosis Adiponectin gene Type-Ⅰ procollagen carboxyl end peptide (PICP) Type-Ⅲ procollagen ammonia cardinal extremity peptide (PIIINP)

Effects of hydrogenation temperature on room-temperature compressive properties of CMHT-treated Ti6Al4V alloy

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Journal of Materials Science & Technology 2021年第13期72卷 132-143页

作者： Baoguo Yuan Xing Liu Jiangfei Du qiang Chen Yuanyuan Wan Yunliang Xiang yan Tang Xiaoxue Zhang Zhongyue Huang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009PR China Beijing Aerospace New Trend Machinery and Equipment Co. Ltd.Beijing 100039PR China Southwest Technology and Engineering Research Institute Chongqing 400039PR China School of Mechanical Engineering Anhui Sanlian UniversityHefei 230601PR China

Compression tests were performed at room temperature to investigate the effects of hydrogenation temperature on compressive properties of Ti6 Al4 V alloy treated by continuous multistep hydrogenation treatment(CMHT).Pressure-composition isotherms and micro structures were also *** showed that the equilibrium hydrogen pressure increased,and the hydrogen absorption rate decreased with the increase of hydrogenation *** amounts ofβphase andα"martensite increased first and then decreased when Ti6 Al4 V alloy was treated by four times CMHT with the increase of hydrogenation *** temperature played a different role on the compressive properties of CMHT-treated Ti6 Al4 V *** ultimate compression of Ti6 Al4 V alloy treated by 11 times CMHT at850℃increased by 83.3%as compared to the as-received Ti6 Al4 V *** compressive properties of Ti6 Al4 V alloy were dependent on the amounts of different phases and microstructures when Ti6 Al4 V alloy was treated by CMHT at different temperatures.

关键词： Titanium alloy Continuous multistep hydrogenation treatment Hydrogenation temperature Plasticity

基于CDIO理念的海洋工程专业研究生工程实践能力培养体系建设

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教育教学论坛 2024年第9期 172-176页

作者：唐国强乔东生吕林闫晓惠大连理工大学港航与海洋工程学院辽宁大连116024

随着新时期海洋工程产业的快速发展,对海洋工程领域的专业人才提出了日益严格的要求,多学科的知识储备和出色的工程实践能力已成为不可或缺的素养。针对目前海洋工程专业研究生工程实践能力培养体系建设方面存在的一些不足之处,在CDIO... 详细信息

随着新时期海洋工程产业的快速发展,对海洋工程领域的专业人才提出了日益严格的要求,多学科的知识储备和出色的工程实践能力已成为不可或缺的素养。针对目前海洋工程专业研究生工程实践能力培养体系建设方面存在的一些不足之处,在CDIO理念的导向下,围绕实验平台建设、校企实践合作及科技创新训练三个方面,提出了一套研究生工程实践能力培养体系的改进方案。这些改进方案对于国内众多高校海洋工程专业研究生培养体系的建立具有直接参考价值,并为其他专业领域教学改革提供了示范和辐射推广作用。

关键词：研究生培养海洋工程 CDIO教学理念创新能力工程实践能力

Effect of Axial Magnetic Field on the Microstructure and Mechanical Properties of CrN Films Deposited by Arc Ion Plating

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Acta Metallurgica Sinica(English Letters) 2016年第6期29卷 546-553页

作者： yan-Hui Zhao Li Xu Chao-Qian Guo Wen-Jin yang Guo-qiang Lin Bao-Hai Yu Institute of Metal Research Chinese Academy of Sciences Key Laboratory of Materials Modification by Laser Ion and Electron Beams (Dalian University of Technology) Ministry of Education Dalian University of Technology

CrN films were deposited on the high-speed-steel substrates by arc ion plating. The effect of an axial magnetic field on the microstructure and mechanical properties was investigated. The chemical composition, microstructure, surface morphology, surface roughness, hardness and film/substrate adhesion of the film were characterized by X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscope（SEM）, surface morphology analyzer, Vickers microhardness test and scratch test. The results showed that the magnetic field puts much effect on the microstructure,chemical composition, hardness and film/substrate adhesion of the Cr N films. The N content increases and Cr content decreases when the magnetic flux density increases from 0 to 30 m T. All of the Cr N films were found to be substoichiometric. With an increase in the magnetic flux density, the film structures change in such way： Cr_2N →Cr_（2-N）＋CrN→CrN＋Cr_2N→*** SEM results showed that the number of macroparticles（MPs） on the film surface is significantly reduced when the magnetic flux density increases to 10 mT or higher. The surface roughness decreases with the magnetic field, which is attributed to the fewer MPs and sputtered craters on the film surface. The hardness value increases from 2074 HV_（0.025） at 0 mT（without magnetic field） and reaches a maximum value of 2509 HV_（0.025） at 10 m *** further increase in the magnetic flux density leads to a decrease in the film hardness. The critical load of film/substrate adhesion shows a monotonous increase with the increase in magnetic flux density.

关键词： Magnetic field Arc ion plating CrN films Hardness Adhesion

基于工程教育认证的机械设计制造及自动化专业面向产出的毕业要求达成评价体系构建与实践

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湖北第二师范学院学报 2024年第2期41卷 84-90页

作者：葛瑜殷志锋晁艳普胡万强许昌学院电气与机械工程学院河南许昌461000

面向产出的毕业要求达成评价是工程教育专业认证的核心环节,以许昌学院机械设计制造及其自动化专业为对象,对毕业要求达成评价和持续改进机制进行重构,明确毕业要求观测点与支撑课程之间的对应关系,通过收集分析数据,完成基于课程目标... 详细信息

面向产出的毕业要求达成评价是工程教育专业认证的核心环节,以许昌学院机械设计制造及其自动化专业为对象,对毕业要求达成评价和持续改进机制进行重构,明确毕业要求观测点与支撑课程之间的对应关系,通过收集分析数据,完成基于课程目标达成的定量评价和基于问卷调查的定性评价,并基于最终达成效果,制定持续改进措施。通过优化完善评价体系和评价方法,持续改进教育教学工作,为提升专业的人才培养质量提供重要的支撑作用。

关键词：毕业要求达成评价面向产出持续改进

Fast and Error-Bounded Space-Variant Bilateral Filtering

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Journal of Computer Science & Technology 2019年第3期34卷 550-568页

作者： Meng-Ke Yuan Long-Quan Dai Dong-Ming yan Li-qiang Zhang Jun Xiao Xiao-Peng Zhang National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Technology Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Remote Sensing Science School of GeographyBeijing Normal UniversityBeijing 100875China

The traditional space-invariant isotropic kernel utilized by a bilateral filter(BF)frequently leads to blurry edges and gradient reversal artifacts due to tlie existence of a large amount of outliers in the local averaging ***,the efficient and accurate cstiinatioii of space-variant k(4rnels which adapt to image structures,and the fast realization of the corresponding space-variant bilateral filtering are challenging *** address these problems,we present a space-variant BF(SVBF).and its linear time and error-bounded acceleration ***,we accurately estimate spacevariant,anisotropic kernels that vary with image structures in linear time through structure tensor and mininnini spanning ***,we perform SVBF in linear time using two error-bounded approximation methods,namely,low-rank tensor approximation via higher-order singular value decomposition and exponential sum *** proposed SVBF can efficiently achieve good edge-preserving *** validate the advantages of the proposed filter in applications including:image denoising,image enhancement,and image focus *** results(leinonstrate that our fast and error-bounded SVBF is superior to state-of-the-art methods.

关键词： error-bounded acceleration edge-aware smoothing space-variant bilateral filtering

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肉桂化学成分及药理作用质量标志物研究进展

化学分析计量 2024年第10期33卷 119-126页

作者：李先芝毛琼丽刘洋解倩倩朱艳胡杨石豪李强杨强劲牌有限公司中药保健食品质量与安全湖北省重点实验室湖北大冶435100

综述了肉桂药材化学成分及质量标志物分析的研究进展。肉桂药材的化学成分多,含有多种挥发性物质,以及多糖类、多酚类、黄酮类、酯类、醛类等多种成分,对各类成分分析进展进行了检索和汇总分析。对基于成分特有性的中药质量标志物(Q-Mar... 详细信息

综述了肉桂药材化学成分及质量标志物分析的研究进展。肉桂药材的化学成分多,含有多种挥发性物质,以及多糖类、多酚类、黄酮类、酯类、醛类等多种成分,对各类成分分析进展进行了检索和汇总分析。对基于成分特有性的中药质量标志物(Q-Marker)预测分析、基于成分可测性的Q-Marker预测分析、基于成分有效性的Q-Marker预测分析、基于成分传递性的Q-Marker预测分析进行了检索与分析。肉桂药材化学成分种类多,不同类型的Q-Marker,在开展肉桂药材深度研究与不同维度的质量差异性研究方面,需要应用情况选择适宜的研究对象。

关键词：肉桂化学成分质量标志物

Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

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World Journal of Gastroenterology 2020年第27期26卷 3938-3951页

作者： Jia-yan Huang Jia-Wu Li Wen-Wu Ling Tao Li yan Luo Ji-Bin Liu qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Anesthesiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)differ in treatment and prognosis,warranting an effective differential diagnosis between *** LR-M category in the contrast-enhanced ultrasound(CEUS)liver imaging reporting and data system(LI-RADS)was set up for lesions that are malignant but not specific to ***,a substantial number of HCC cases in this category elevated the diagnostic *** To investigate the possibility and efficacy of differentiating ICC from HCC classified in the LR-M category according to the CEUS *** Patients with complete CEUS records together with pathologically confirmed ICC and LR-M HCC(HCC classified in the CEUS LI-RADS LR-M category)between January 2015 and October 2018 were included in this retrospective *** ICC was assigned a category as per the CEUS *** enhancement pattern,washout timing,and washout degree between the ICC and LR-M HCC were compared using theχ2 *** regression analysis was used for prediction of *** operating characteristic(ROC)curve analysis was used to investigate the possibility of LR-M criteria and serum tumor markers in differentiating ICC from LR-M *** A total of 228 nodules(99 ICCs and 129 LR-M HCCs)in 228 patients were *** mean sizes of ICC and LR-M HCC were 6.3±2.8 cm and 5.5±3.5 cm,respectively(P=0.03).Peripheral rim-like arterial phase hyperenhancement(APHE)was detected in 50.5%(50/99)of ICCs vs 16.3%(21/129)of LR-M HCCs(P0.05).Marked washout was observed in 23.2%(23/99)of ICCs and 7.8%(10/129)of LR-M HCCs(P=0.002),while this feature did not show up alone either in ICC or LR-M *** hyperenhancement was detected in 15.2%(15/99)of ICCs and 37.2%(48/129)of LR-M HCCs(P<0.001).The logistic regression showed that rim APHE,carbohydrate antigen 19-9(CA 19-9),and alpha fetoprotein(AFP)had significant correlation

关键词： Diagnosis Contrast enhanced ultrasound Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver imaging reporting and data system

Microstructural evolution and enhanced mechanical properties of Mg?Gd?Y?Zn?Zr alloy via centrifugal casting, ring-rolling and aging

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Journal of Magnesium and Alloys 2022年第1期10卷 131-141页

作者： Zhenduo Ma Guo Li qiang Peng Xiaodong Peng Daolun Chen HanzhuZhang yan yang Guobing Wei Weidong Xie International Joint Laboratory for Light Alloys(Ministry of Education) Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Department of'Mechanical and Industrial Engineering Ryerson UniversityTorontoOntario M5B 2K3Canada Industrial engineering institute Ningxia PolytechnicNingxia 750021China

A ring-shaped Mg?8.5 Gd?4 Y?1 Zn?0.4 Zr(wt%) alloy was manufactured via centrifugal casting and ring-rolling process. The effects of accumulative ring-rolling reduction amount on the microstructure, texture, and tensile properties of the alloy were investigated. The results indicate that the microstructure of centrifugal cast alloy consists of equiaxed grains and network-like eutectic structure present at grain boundaries. The ring-rolled alloy exhibits a characteristic bimodal microstructure composed of fine dynamic recrystallized(DRXed) grains with weak basal texture and coarse un-DRXed grains with strong basal texture, along with the presence of LPSO phase. With increasing amount of accumulative ring-rolling reduction, the coarse un-DRXed grains are refined via the formation of increasing amount of fine DRXed grains. Meanwhile, the dynamic precipitation of Mg5 RE phase occurs, generating a dispersion strengthening effect. A superior combination of strength and ductility is achieved in the ring-rolled alloy after an accumulative rolling reduction of 80%. The tensile strength of this ring-rolled alloy after peak aging is further enhanced, reaching 511 MPa, while keeping a reasonable ductility. The salient strengthening mechanisms identified include the grain boundary strengthening of fine DRXed grains, dispersion strengthening of dynamic precipitated Mg;RE phase, short fiber strengthening of LPSO lamellae/rods, and precipitation strengthening of nano-sized prismatic β precipitates and basal γ precipitates.

关键词： High strength magnesium alloy Centrifugal casting Ring rolling Aging Mechanical property