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Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

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World Journal of Clinical Cases 2021年第35期9卷 10781-10791页

作者： Ru-Jia Li Yuan-Yuan Dai Chun Qin Gan-Rong Huang yan-Chun Qin Yong-Yi Huang Zan-Song Huang Xian-Ke Luo yan-qiang Huang Research Center for the Prevention and Treatment of Drug Resistant Microbial Infections Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina National Hospital of Guangxi Zhuang Autonomous Region Nanning 530001Guangxi Zhuang Autonomous RegionChina

Helicobacter pylori(***)has a high rate of infection and antibiotic resistance and poses a serious threat to human *** of the main strategies to overcome drug resistance is to develop new treatment *** Chinese medicine(TCM)that is commonly used to treat many diseases in China can reduce drug resistance and increase the eradication rate of *** this paper,we review the research progress on TCM in the treatment of *** *** mechanism of action of TCM is reviewed and research and applications of TCM in the treatment of *** are ***,we discuss problems confronting the use of TCM for the treatment of *** infection and propose possible *** addition,the plans of TCM in *** treatment were also screened:Dampness-heat syndrome in the spleen and stomach,deficiency of spleen and stomach,and cold-heat complicated syndrome,and the effective components therein are *** antibacterial effect of TCM is relatively slow;for rapid improvement of the treatment effect of refractory *** gastritis,we provide an appropriate treatment regime combining TCM and Western medicine with immune-regulatory and synergistic antibacterial effects.

关键词： Helicobacter pylori Traditional Chinese medicine Treatment Antibacterial effect Antibiotic resistance

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一种免洗速干手消毒剂消毒性能的相关研究

中国消毒学杂志 2024年第8期41卷 569-572页

作者：周于张天宝苏贵斌周剑晏强姜朴唐非华中科技大学同济医学院公共卫生学院环境医学研究所环境与健康教育部重点实验室湖北武汉430030 湖北省疾病预防控制中心武汉同济美迪生科技有限公司

目的检测一种免洗速干过氧化氢-乙醇手消毒剂的消毒相关性能及毒性。方法采用悬液定量杀灭试验、理化试验和动物毒性试验方法,检测该消毒剂对细菌、真菌及病毒的杀灭性能及其安全性。结果该手消毒剂以过氧化氢和乙醇为主要复合杀菌组分... 详细信息

目的检测一种免洗速干过氧化氢-乙醇手消毒剂的消毒相关性能及毒性。方法采用悬液定量杀灭试验、理化试验和动物毒性试验方法,检测该消毒剂对细菌、真菌及病毒的杀灭性能及其安全性。结果该手消毒剂以过氧化氢和乙醇为主要复合杀菌组分,过氧化氢含量为1470 mg/L,乙醇含量为体积分数80.1%。用该手消毒剂原液作用0.5、1.0、1.5 min,对金黄色葡萄球菌、大肠埃希菌和铜绿假单胞菌的杀灭对数值均>6.00,对白念珠菌平均杀灭对数值>5.00;对脊髓灰质炎病毒Ⅰ型疫苗株的平均灭活对数值>4.00;用该手消毒剂原液作手擦拭消毒,作用1 min对手上自然菌的杀灭对数值>1.00。该手消毒剂密封包装经37℃储存3个月,其有效成分含量下降率均<10%;该手消毒剂的皮肤刺激试验结果表明属无刺激性;急性经口毒性试验结果表明,对小鼠的毒性属实际无毒;小鼠骨髓嗜多染红细胞微核试验呈阴性。结论该过氧化氢-乙醇手消毒剂对细菌繁殖体、真菌和病毒均具有快速杀灭效果,属实际无毒级物质,其储存性能稳定。

关键词：手消毒剂细菌真菌病毒消毒效果

BanXiaXieXin decoction treating gastritis mice with drug-resistant Helicobacter pylori and its mechanism

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World Journal of Gastroenterology 2023年第18期29卷 2818-2835页

作者： Xiao-Hua Li Jia-Yin Xu Xue Wang Li-Juan Liao Liang Huang yan-qiang Huang Zeng-Feng Zhang Duate School Guangxi Medical UniversityNanning 5330021Guangxi Zhuang Autonomous RegionChina Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Microbiology Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Helicobacter pylori(***)is the main pathogen that causes a variety of upper digestive *** drug resistance rate of *** is increasingly higher,and the eradication rate is increasingly *** antimicrobial resistance of *** is an urgent global *** has been confirmed that Banxia Xiexin decoction(BXXXT)demonstrates the effects of treating gastrointestinal diseases,inhibiting *** and protecting gastric *** purpose of the present study is to further explore the therapeutic effects of BXXXT on drug-resistant *** To confirm that BXXXT demonstrates therapeutical effects in vivo and in vitro on gastritis mice with drug-resistant *** and explain its mechanism to provide an experimental basis for promoting the application of *** The aqueous extract of BXXXT was gained by water decocting *** inhibitory effect of the aqueous extract on *** was detected by dilution in vitro;drug-resistant *** cells were used to build an acute gastritis model in ***,the model mice were treated with the aqueous extract of *** amount of *** colonization,the repair of gastric mucosal damage,changes of inflammatory factors,apoptosis,etc.,were *** terms of mechanism exploration,the main medicinal compositions of BXXXT aqueous extract and the synergistic bacteriostatic effects they had demonstrated were analyzed using mass spectrometry;the immune function of peripheral blood cells such as CD3+T and CD4+T of mice with gastritis before and after treatment with BXXXT aqueous extract was detected using a flow cytometry;the *** transcriptome and proteome after treatment with BXXXT aqueous extract were *** expressed genes were screened and verification was performed thereon with knockout *** The minimum inhibitory concentration of BXXXT aqueous extract against *** was 256-512μg/mL.A dose of 28 mg/kg BXXXT aqueous extract treatment produced bet

关键词： Banxia Xiexin decoction Helicobacter pylori Drug resistance Therapeutic effects Mechanism

High-resolution mid-infrared single-photon upconversion ranging

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Photonics Research 2024年第6期12卷 1294-1302页

作者： SHUHONG JIANG KUN HUANG TINGTING YU JIANAN FANG BEN SUN yan LIANG qiang HAO E.WU MING yan HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

New Refinement Relations of Z Specifications for Multiple Viewpoints Oriented Requirements Method

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 304-312页

作者： He yan xiang, Song qiang, Huang Qian School of Computer, State Key Laboratory of Software Engineering Wuhan University, Wuhan 430072, China School of Computer State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

In this paper we develop several new refinement relations of Z for multiple viewpoints oriented requirements method (MVORM). The original motivation is that we found the standard Z refinement relation is not adequate or correct when considering specifications that have temporal relationships of operations. The concept of temporal state variables is introduced into Z. Then new implementation relations are defined and new refinement relations are deduced, mainly for temporal state variables to process temporal relationships of operations. We use state transition systems to abstract the temporal state transitions. A simple example is used to show the procedures of MVORM. Finally some directions of further work are forwarded.

关键词： temporal state variable formal description language state transition system implementation relation refinement relation multiple viewpoints oriented requirements method

The properties of CdTe solar cells with ZnTe/ZnTe: Cu buffer layers

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High Technology Letters 2008年第1期14卷 57-60页

作者：宋慧瑾 Zheng Jiagui FengLianghuan yan qiang Lei Zhi Wu Lili Zhang Jingquan Li Wei Li Bing Institute of Solar Energy Materials and Devices Sichuan University Chengdu 610064 P.R. China Southwest Institute of Physics Chengdu 610041 P.R.China

CdS/CdTe solar cells with ZnTe/ZnTe： Cu buffer layers were fabricated and studied. The energy band structure of it was analyzed. The C-V, I-V characteristics and the spectral response show that the ZnTe/ZnTe：Cu buffer layers improve the back contact characteristic properties, the diode characteristics of the forward junction and the short-wave spectral response of the CdTe solar cells. The ZnTe/ZnTe-Cu buffer layers affect the solar cell conversion efficiencv and its fill factor.

关键词： ZnTe/ZnTe: Cu buffer layers CdTe solar cells co-evaporation deposition thin film

牛支原体灭活疫苗免疫程序及母源抗体消长规律研究

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中国奶牛 2024年第2期 30-35页

作者：王超丽吴洁王丹万姣白雪杨铭伟剡根强新疆西部牧业股份有限公司石河子832003 第八师畜牧兽医工作站石河子832003

为评价不同剂量的自主研发牛支原体灭活氢氧化铝佐剂疫苗对怀孕母牛免疫后抗体消长规律和免疫效果,本试验选择产前30~15d围产母牛70头,随机分为7组,每组10头牛,间隔15d,采用不同剂量免疫,定期采集初乳和犊牛血清,采用已建立的牛支原体间... 详细信息

为评价不同剂量的自主研发牛支原体灭活氢氧化铝佐剂疫苗对怀孕母牛免疫后抗体消长规律和免疫效果,本试验选择产前30~15d围产母牛70头,随机分为7组,每组10头牛,间隔15d,采用不同剂量免疫,定期采集初乳和犊牛血清,采用已建立的牛支原体间接ELISA检测方法检测初乳乳清和犊牛血清中的抗体滴度,统计分析其抗体消长规律。结果表明,使用自主研发牛支原体灭活氢氧化铝佐剂疫苗免疫怀孕母牛无红肿、发热等症状,是安全可靠的;用不同剂量疫苗免疫怀孕母牛,初乳乳清抗体中牛支原体Ig G抗体水平在奶牛分娩后3h达到一个峰值,随着奶牛产后时间的延长抗体水平呈逐步下降,在奶牛产后96h,抗体值均在0.3以下;A组的抗体最低,B组、C组、D组抗体均低于E组和F组;E组和F组抗体滴度较高,两者无差异。不同剂量疫苗免疫母牛所产犊牛哺食初乳后,犊牛血清中牛支原体Ig G抗体在犊牛出生后24h达到最高,随着犊牛日龄的增加,抗体滴度呈现逐步下降趋势;在A组、B组和C组抗体呈现层次不齐的状况,D组抗体水平高于A组、B组、C组,低于E组和F组;E组和F组抗体水平较高,且维持时间较长。研究结果为牛支原体疫苗的免疫程序制定提供了科学依据。

关键词：牛支原体疫苗母源抗体免疫程序间接ELISA 消长规律

Research on the quasi-isentropic driving model of aluminized explosives in the detonation wave propagation direction

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Defence Technology（防务技术） 2024年第2期32卷 596-618页

作者： Hongfu Wang yan Liu Fan Bai Chao He Yingliang Xu qiang Zhou Chuan Xiao Fenglei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China China Research and Development Academy of Machinery Equipment Beijing100089China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive formulations when driving metal flyer plates in the denotation wave propagation *** research results showed that the formulations with 43 μm aluminum(Al) powder particles(The particle sizes of Al powder were in the range of 2~43 μm) exhibited the optimal performance in driving flyer plates along the denotation wave propagation direction. Compared to the formulations with Al powder 13 μm, the formulations with Al powder 2 μm delivered better performance in accelerating metal flyer plates in the early stage, which, however, turned to be poor in the later stage. The CL-20-based explosives containing 25% Al far under-performed those containing 15% Al. Based on the proposed quasi-isentropic hypothesis, relevant isentropy theories, and the functional relationship between detonation parameters and entropy as well as Al reaction degree, the characteristic lines of aluminized explosives in accelerating flyer plates were theoretically studied, a quasi-isentropic theoretical model for the aluminized explosive driving the flyer plate was built and the calculation methods for the variations of flyer plate velocity, Al reaction degree, and detonation product parameters with time and axial positions were developed. The theoretical model built is verified by the experimental results of the CL-20-based aluminized explosive driving flyer plate. It was found that the model built could accurately calculate the variations of flyer plate velocity and Al reaction degree over time. In addition, how physical parameters including detonation product pressure and temperature varied with time and axial positions was identified. The action time of the positive pressure after the detonation of aluminized explosives was found prolonged and the downtrend of the temperature was

关键词： Aluminized explosive Flyer plate experiment Quasi-isentropic theoretical model Al reaction Driving characteristics

A human-sensitive frequency band vibration isolator for heavy-duty truck seats

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1733-1748页

作者： Qingqing LIU Shenlong WANG Ge yan Hu DING Haihua WANG qiang SHI Xiaohong DING Huijie YU School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechnoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China yanfeng Adient Seating Co. Ltd.Shanghai 201315China College of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001Zhejiang ProvinceChina

In this study,a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS)characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven ***,the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle,and are validated through the prototype restoring force ***,the harmonic balance method(HBM)is used to obtain the dynamic responses under harmonic excitation,and further the influence of pre-stretching on the dynamic characteristics and transmissibility is ***,the experimental prototype of the HFBVI is fabricated,and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP)of the proposed vibration *** experimental results indicate that the HFBVI can effectively suppress the frequency band(4-8 Hz)to which the human body is sensitive to vertical *** addition,under real random road spectrum excitation,the HFBVI can achieve low-frequency vibration isolation close to 2 Hz,providing new prospects for ensuring the health of heavy-duty truck drivers.

关键词： human-sensitive frequency band quasi-zero stiffness(QZS) heavy-duty truck seat real random road spectrum low-frequency vibration isolation