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Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells

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Current Medical Science 2018年第2期38卷 222-228页

作者： yan-qiang ZHOU Yin-tao ZHAO Xiao-yan ZHAO Cui LIANG Ya-wei XU Ling LI Yuan LIU Hai-bo yanG Department of Cardiology the First Affiliated Hospital of Zhengzhou University Henan 450052 China

Finding the novel drug from the effective components of traditional Chinese herbal medicine is a hotspot of the modem pharmacological research. Hyperoside （HYP） belongs to flavonoid glycosides, and it has various properties, such as anti-inflammation, anti-spasm, anti-diuretic, antitussive, lowering blood pressure, and lowering cholesterol effects as well as protective effects for the cardiac and cerebral blood vessels. The purpose of this study was to investigate the effects of HYP on inflammatory and apoptotic responses in vascular endothelial cells stimulated by lipopolysaccharide （LPS） and further to identify the possible mechanisms underlying these effects. In our study, human umbilical vein endothelial cells （HUVECs） were stimulated with 1 Bg/mL LPS in the presence or absence of HYP （10, 20 and 50 μmol/L）. Our results indicated that HYP alone exerted no cytotoxicity on HUVECs, while it had an upregulatory effect on the viability of HUVECs induced by LPS in a dose-dependent manner; increased mRNA expression of IL-1β, IL-6, TNFα and iNOS induced by LPS was attenuated after treatment with HYP both in a dose- and time-dependent manner; LPS-induced HUVECs apoptosis and cleaved-caspase 8, 9, 3 were all significantly reduced by HYP. Furthermore, the possible pathway involved in apoptosis and inflammation by HYP was detected, and the results showed that when treated with HYP, LPS-induced mitochondrial membrane instability was significantly inhibited through up-regulation of Bcl-2 and down-regulation of Bax. Furthermore, the expression of TLR4 and the phosphorylation of IκBα and p65 in LPS-treated cells were blocked by HYP. Our results suggested that HYP treatment prevented HUVECs from LPS- induced inflammation and apoptosis responses, which might be mediated by inhibiting TLR4/ NFκB pathway.

关键词： hyperoside lipopolysaccharide inflammation apoptosis human umbilical veinendothelial cells

Atomic-scale mechanism of effect of co-separation of elements at interface of ferrite and austenite on Cr-depleted zone of duplex stainless steel

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Journal of Iron and Steel Research International 2024年第3期31卷 710-718页

作者： yan-hui Hou Ze-kun Xu Shi-long Zhou Guang-qiang Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Three-dimensional atom-probe tomography and first-principles calculation combined with density functional theory were used to study the effect of the co-segregation of different elements formed during the solidification process of S32205 duplex stainless steel on the Cr-depleted zone at the interface between ferrite and *** was found that the co-segregation of different elements formed during the solidification process of duplex stainless steel can also form Cr-depleted zone at the interface between ferrite and ***,Mo,Si,B,C and P atoms promote co-segregation with Cr atoms,which promotes the formation of Cr-depleted zone at the interface between ferrite and austenite in duplex stainless *** and Si strongly promote the segregation of Cr at the interface between ferrite and austenite,thereby promoting the formation of Cr-depleted zone.B,C and P elements also promote the segregation of Cr element at the interface between ferrite and austenite and the formation of Cr-depleted zone,but their effect is weaker than that of Mo and Si *** conclusions provide a new theoretical basis for improving the intergranular corrosion performance of duplex stainless steel.

关键词： Duplex stainless steel Cr-depleted zone Intergranular corrosion Co-segregation First-principles calculation

PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors

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Rare Metals 2024年第7期43卷 3066-3073页

作者： Shu-Hua yang Wen-Qing Fu yan-Wei Cui Bing-qiang Cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors(ZHSs)owing to their abundant active sites,great conductivity,and stable physical and chemical ***,designing a proper preparation technique to regulate the microstructure of carbon fibers still remains a great ***,a poly vinylpyrrolidone/po-lyacry lonitrile(PVP/PAN)-derived porous carbon fiber is developed via the PVP/PAN blend electrospinning and hydrothermal selective PVP removal *** hydrothermal selective PVP removal strategy can effectively avoid a cross-linking between PVP and PAN during the traditional stabilization at air *** PVP/PAN-derived porous carbon fiber,the sufficient micropores provide abundant space for the Zn^(2+)storage,whereas the proper mesopores contribute to the fast ion *** hierarchical porous structures endow ZHSs with high specific capacity and high-rate *** ZHS assembled with the optimal PVP/PAN-derived porous carbon fiber(PVP-PANC-0.8)displays an outstanding specific capacity of 208 mAh·g^(-1),high rate capability(49.5%)from 0.5 to 5 A·g^(-1),and 72.25%capacity retention after 10,000 cycles at 0.5 A·g^(-1).

关键词： Zinc-ion hybrid supercapacitors Porous carbon fibers Hierarchical porous structures Electrospinning

Tracking coherent low frequency vibrational information of Rh101 in ground and excited electronic states by broadband transient grating spectroscopy

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Chinese Physics B 2018年第12期27卷 231-237页

作者： Wei Zhang Xiao-Song Liu Zan-Hao Wang Yun-Fei Song yan-qiang yang Department of Physics Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China

Time-and frequency-resolved broadband transient grating(BB-TG) spectroscopy is used to distinguish between ground-and excite-electronic state vibrational coherence at different wavelengths. Qualitative theoretical analysis using double-sided Feynman diagrams indicates that a superposition of ground and excited state vibrational coherence are contained in the ground state absorption(GSA) and stimulated emission(SE) overlap band, while only the excited state is contained in the excited state absorption(ESA) band. The TG experiment, in which a white light continuum(WLC) is adopted as a probe, is conducted with rhodamine101(Rh101~+) as the target molecule. Fourier analysis of TG dynamics in a positive delay time range at specific wavelengths enables us to distinguish the low-frequency vibrational modes of Rh101 in ground-and excite-electronic states.

关键词： transient grating Rh101 low-frequency Raman vibrational spectrum

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曹继刚从“肝虚肾实”论治勃起功能障碍

山东中医杂志 2024年第9期43卷 1006-1010页

作者：王齐开王望王然颜强姜兴宇曹继刚(指导) 湖北中医药大学湖北武汉430061

曹继刚教授认为“肝虚”“肾实”为勃起功能障碍的重要病机。“肝虚”即肝气血阴阳亏虚,致肝藏血和疏泄功能失司;“肾实”即风寒湿热瘀等实邪阻滞肾中,致肾藏精和主水功能下降。治疗上,“肝虚”治以补,顺气通达,肝阴虚以一贯煎加减,可... 详细信息

曹继刚教授认为“肝虚”“肾实”为勃起功能障碍的重要病机。“肝虚”即肝气血阴阳亏虚,致肝藏血和疏泄功能失司;“肾实”即风寒湿热瘀等实邪阻滞肾中,致肾藏精和主水功能下降。治疗上,“肝虚”治以补,顺气通达,肝阴虚以一贯煎加减,可搭配丹栀逍遥散,肝血虚以当归芍药散加减,肝气虚选补中益气汤合曲直汤,肝阳虚方选暖肝煎加减;“肾实”治以泻,疏泻病邪,肾风证以升麻胃风汤加温肾引经药治疗,肾湿证用十枣汤合龟鹿二仙膏,肾实寒选四逆散合济川煎,肾实热以舟车丸合生脉散加减,肾血瘀证处以四物汤合补阳还五汤。

关键词：勃起功能障碍肝虚肾实补肝泻肾风寒湿热瘀曹继刚

腹腔镜右半结肠切除同期行肝方叶转移癌切除1例

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罕少疾病杂志 2024年第5期31卷 7-8页

作者：汪圣毅闫强张俊义佘贤忠安徽医科大学第一附属医院普外科安徽合肥230022

目的分析腹腔镜下同期治疗结肠癌及其肝转移的过程,探讨腹腔镜同期手术在治疗结肠癌肝转移中的作用。方法回顾性分析2023年3月安徽医科大学第一附属医院1例结肠癌伴肝方叶转移患者的临床资料,同期行混合入路腹腔镜右半结肠切除、Glisso... 详细信息

目的分析腹腔镜下同期治疗结肠癌及其肝转移的过程,探讨腹腔镜同期手术在治疗结肠癌肝转移中的作用。方法回顾性分析2023年3月安徽医科大学第一附属医院1例结肠癌伴肝方叶转移患者的临床资料,同期行混合入路腹腔镜右半结肠切除、Glisson蒂横断法肝方叶转移癌切除。结果RO切除右半结肠及肝转移癌,术中出血量约50 mL,第4天拔引流管,无并发症,顺利出院。病理结果:结肠溃疡型低分化腺癌,肠周(12/21)个淋巴结有癌转移,低分化肝转移癌。结论腹腔镜同期行右半结肠切除和肝转移癌切除的治疗安全可行,采用新的手术路径和操作模式可保证手术安全,值得推广。

关键词：腹腔镜右半结肠切除术结肠癌肝转移腹腔镜肝切除术 Glisson蒂横断法

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中华鳖源按蚊伊丽莎白菌的分离鉴定及药敏特性研究

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水生生物学报 2024年第4期48卷 683-693页

作者：王玉柱蒋巍巍刘文舒路晶晶唐艳强肖海红郭小泽李思明江西省农业科学院畜牧兽医研究所南昌330200 四川农业大学动物科技学院成都611130

研究对从江西省抚州市南丰县某中华鳖养殖基地患病中华鳖(Trionyx sinensis)组织中分离培养得到的一株按蚊伊丽莎白菌(Elizabethkingia anophelis)疑似菌株进行鉴定和药敏特性研究。在无菌环境中解剖患病中华鳖得到肝脏、脾脏组织,匀浆... 详细信息

研究对从江西省抚州市南丰县某中华鳖养殖基地患病中华鳖(Trionyx sinensis)组织中分离培养得到的一株按蚊伊丽莎白菌(Elizabethkingia anophelis)疑似菌株进行鉴定和药敏特性研究。在无菌环境中解剖患病中华鳖得到肝脏、脾脏组织,匀浆后接种在LB培养基上,分离得到优势菌株EJX2021。对该菌株进行形态学观察、16S RNA基因序列测定和生理生化鉴定以鉴定菌株种类;进行人工回归感染、组织病理学观察、毒力因子分析和抗生素药物敏感性试验研究其致病能力和药物敏感性特征。从患病中华鳖中分离出一株优势菌株EJX2021,结合其表型特征、16S RNA基因序列测定和生理生化鉴定,确定其为按蚊伊丽莎白菌。在人工回归感染后,该菌株对中华鳖15d的LD50为1.62×10^(8)CFU/mL,95%置信区间为(0.78—3.37)×10^(8)CFU/mL;组织病理学观察肠道、肺脏、脾脏、肝脏等组织出现不同程度病变。毒力因子分析显示该菌株包含246个潜在毒力基因。药物敏感性试验显示该菌株为多重耐药菌株,对多西环素、米诺环素、卡那霉素、哌拉西林、恩诺沙星、氟苯尼考敏感,对头孢曲松、头孢哌酮中度敏感,对新霉素等15种抗生素具有耐药性。研究证明了按蚊伊丽莎白菌是能够导致中华鳖病害的一种病原菌,为该细菌导致中华鳖病害的检测、鉴别和防治提供科学依据。

关键词：按蚊伊丽莎白菌分离鉴定药敏特性中华鳖

TET甲基胞嘧啶双加氧酶2在心血管疾病发病机制中的研究进展

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赣南医学院学报 2024年第4期44卷 357-364页

作者：杨忠海高子雅严志强刘化进安徽理工大学安徽淮南232000 上海市奉贤区中心医院心内科上海奉贤201400 四川省成都市武侯区人民医院四川成都610000 上海市奉贤区中心医院中心实验室上海奉贤201400

心血管疾病(Cardiovascular disease,CVD)是中国人最主要的死亡原因。动脉粥样硬化、心肌细胞凋亡、心肌肥厚和纤维化是CVD主要的病理过程。基因的表观遗传修饰特别是DNA甲基化在CVD中起重要作用。研究表明,TET甲基胞嘧啶双加氧酶2(Ten-... 详细信息

心血管疾病(Cardiovascular disease,CVD)是中国人最主要的死亡原因。动脉粥样硬化、心肌细胞凋亡、心肌肥厚和纤维化是CVD主要的病理过程。基因的表观遗传修饰特别是DNA甲基化在CVD中起重要作用。研究表明,TET甲基胞嘧啶双加氧酶2(Ten-eleven translocation methylcytosine dioxygenase 2,TET2)参与基因表观遗传调控,TET2在CVD的发病机制中起重要作用。TET2可以调节心脏发育、改善动脉粥样硬化过程中内皮细胞功能障碍、调节血管平滑肌细胞表型转换、抑制免疫炎症反应和心肌细胞凋亡、心肌肥厚和纤维化。本文就TET2在CVD发病机制中的研究进展进行综述。

关键词： TET甲基胞嘧啶双加氧酶2 DNA甲基化心血管疾病动脉粥样硬化

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3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration

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Research 2024年第3期6卷 259-272页

作者： Yihang Zhang Fupo He qiang Zhang Haotian Lu Shengtao yan Xuetao Shi School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006P.R.China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641P.R.China Peking Union Medical College Graduate School Bejing 100730P.R.China Department of Emergency China-Japan Friendship HospitalBeijing 100029P.R.China.

The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect *** cranial bones are typical flat bones with sandwich structures,consisting of a diploe in the middle region and 2 outer compact *** this study,we originally developed 2 types of flat-bone-mimeticβ-tricalcium phosphate bioceramic scaffolds(Gyr-Comp and Gyr-Tub)by high-precision vat-photopolymerization-based 3-dimensional *** scaffolds had 2 outer layers and an inner layer with gyroid pores mimicking the diploe *** outer layers of Gyr-Comp scaffolds simulated the low porosity of outer tables,while those of Gyr-Tub scaffolds mimicked the tubular pore structure in the tables of flat *** Gyr-Comp and Gyr-Tub scaffolds possessed higher compressive strength and noticeably promoted in vitro cell proliferation,osteogenic differentiation,and angiogenic activities compared with conventional scaffolds with cross-hatch *** implantation into rabbit cranial defects for 12 weeks,Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood *** work provides an advanced strategy to prepare biomimetic biomaterials that fit the structural and functional needs of efficacious bone regeneration.

关键词： rabbit tables outer