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Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： yan-qiang Huang Yuan-Feng Li Yong Liu Lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Focal mechanics and disaster characteristics of the 2024 M 7.6 Noto Peninsula Earthquake,Japan

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1378-1387页

作者： Guang-qi CHEN yan-qiang WU Ming-yao XIA Zhi-yuan LI School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300131China Graduate School of Engineering Kyushu UniversityFukuoka 819-0395Japan The First Monitoring and Application Center China Earthquake AdministrationTianjin 300180China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

On January 1,2024,a devastating M 7.6 earthquake struck the Noto Peninsula,Ishikawa Prefecture,Japan,resulting in significant casualties and property *** information from the first six days after the earthquake,this article analyzes the seismic source characteristics,disaster situation,and emergency response of this *** results show:1)The earthquake rupture was of the thrust type,with aftershock distribution showing a north-east-oriented belt-like feature of 150 km.2)Global Navigation Satellite System(GNSS)and Interferometric synthetic aperture radar(InSAR),observations detected significant westward to north-westward co-seismic displacement near the epicenter,with the maximum horizontal displacement reaching 1.2 m and the vertical uplift displacement reaching 4 m.A two-segment fault inversion model fits the observational data well.3)Near the epicenter,large Peak Ground Velocity(PGV)and Peak Ground Acceleration(PGA)were observed,with the maxima reaching 145 cm/s and 2681 gal,respectively,and the intensity reached the highest level 7 on the Japanese(Japan Meteorological Agency,JMA)intensity standard,which is higher than level 10 of the United States Geological Survey(USGS)Modified Mercalli Intensity(MMI)standard.4)The observation of the very rare multiple strong pulse-like ground motion(PLGM)waveform poses a topic worthy of research in the field of earthquake engineering.5)As of January 7,the earthquake had left 128 deaths and 560 injuries in Ishikawa Prefecture,with 1305 buildings completely or partially destroyed,and had triggered a chain of disasters including tsunamis,fires,slope failures,and road ***,this paper summarizes the emergency rescue,information dissemination,and other disaster response and management measures taken in response to this *** work provides a reference case for carrying out effective responses,and offers lessons for handling similar events in the future.

关键词： Noto Peninsula Earthquake earthquake rupture mechanism earthquake disaster emergency response pulse-like ground motion

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Graphene oxide/Al_(2)O_(3)-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu Jun-Cheng Jin Yi-Ke Xiao Xin-Xin Wang Ping-Yuan yan yan-qiang Cao Li-Yong Jiang Chuan-Xiang Sheng Ye-Feng Yu School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China School of Science Nanjing University of Science and TechnologyNanjing210094China School of Information Science and Technology Fudan UniversityShanghai 200433China

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： crossbar arrays offering

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Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can Hu yan-qiang Zhang Peng-Cheng Yu Yi Wang Zhi-Yuan Xu Huan-Ying Fu Xiang-Dong Cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade

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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo yan-qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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企业复杂核心技术的后发追赶及动力机制——基于华为无线网络技术的纵向案例研究

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科技进步与对策 2024年第5期41卷 150-160页

作者：张毅闫强北京邮电大学经济管理学院北京100876

基于技术组合创新理论,通过对华为无线网络技术后发追赶的纵向案例研究,建立复杂核心技术创新的五阶段模型,从复杂性和核心性两个方面建构复杂核心技术,分析复杂核心技术创新及后发追赶的主要困境与动力机制。研究发现,根据技术创新范... 详细信息

基于技术组合创新理论,通过对华为无线网络技术后发追赶的纵向案例研究,建立复杂核心技术创新的五阶段模型,从复杂性和核心性两个方面建构复杂核心技术,分析复杂核心技术创新及后发追赶的主要困境与动力机制。研究发现,根据技术创新范围、规模、复杂性与核心性形成过程,复杂核心技术创新过程分为产品原型、市场准入、边缘市场、核心技术及核心市场5个阶段;复杂核心技术的高市场转换成本导致后发者面临巨大困境以及先发者存在路径依赖,后发追赶需要长期大规模的研发投入,分别解决技术复杂性和核心性;技术复杂性和核心性均来源于技术组合创新以及市场需求,技术复杂性为核心性提供整体优势和经济动力,技术核心性进一步增强技术复杂性,形成技术的多层次网络结构与整体优势。研究结论完善了复杂核心技术创新的后发追赶理论,对后发企业实现关键核心技术突破具有重要的实践意义。

关键词：复杂核心技术创新阶段后发追赶动力机制华为研发

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气体调控的高分子自组装

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高分子学报 2024年第7期55卷 781-801页

作者：牟桂芳杨翠琴闫强复旦大学聚合物分子工程国家重点实验室高分子科学系上海200433

响应性高分子是智能高分子的重要组成部分,其可以感应外部刺激、通过改变高分子结构实现对高分子功能的精确调控.气体作为一种不同于常规物理或化学信号的“绿色”刺激方式,用于对高分子自组装过程的调控具有重要意义.然而,由于气体分... 详细信息

响应性高分子是智能高分子的重要组成部分,其可以感应外部刺激、通过改变高分子结构实现对高分子功能的精确调控.气体作为一种不同于常规物理或化学信号的“绿色”刺激方式,用于对高分子自组装过程的调控具有重要意义.然而,由于气体分子通常缺乏可控反应位点且调控过程难以量化控制,目前这一刺激-调控方式的发展相对缓慢.面对上述挑战,本文系统介绍了“气敏高分子”与“气筑高分子”两类新型气体调控的高分子组装系统.结合本课题组工作,总结了以生命体三大气体信号分子——硫化氢(H_(2)S)、一氧化碳(CO)和一氧化氮(NO)为刺激源,面向气敏高分子的设计与可控组装方面的研究进展;以及通过气体动态化学,以二氧化碳(CO_(2))等气体为连接单元,面向气筑高分子的结构设计、动态自组装及其功能应用方面的研究工作.

关键词：高分子自组装气体气敏高分子气筑高分子功能组装体

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金融科技促进居民消费的作用机制与路径研究

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西南金融 2024年第7期 15-25页

作者：敖华闫强贺州学院经济与管理学院广西贺州542899 西南财经大学北京研究院北京100032

本文基于金融科技的金融创新、科技创新和产业创新三大属性,从需求侧和供给侧两个角度出发,研究金融科技促进居民消费的作用机制与实现路径。金融科技作为连接金融、科技、产业的重要手段和关键环节,能够强化科技创新、产业发展和金融... 详细信息

本文基于金融科技的金融创新、科技创新和产业创新三大属性,从需求侧和供给侧两个角度出发,研究金融科技促进居民消费的作用机制与实现路径。金融科技作为连接金融、科技、产业的重要手段和关键环节,能够强化科技创新、产业发展和金融支持三者之间的紧密联系,推动“科技—产业—金融”良性循环。本文指出,除了金融创新属性之外,金融科技还具有科技创新属性和产业创新属性,这进一步拓展金融科技的内涵;金融科技促进居民消费可区分为直接和间接促进作用,直接促进作用由金融科技的金融创新属性决定,间接促进作用由金融科技的科技创新及产业创新属性决定。

关键词：金融科技金融创新居民消费消费金融消费升级经济增长扩大内需产业转型升级

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促环保与稳就业能否兼得?——基于环境质量约束性指标视角

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系统工程理论与实践 2024年第9期44卷 2854-2871页

作者：张昱曹思力张征宇闫强上海对外经贸大学国际经贸学院上海201620 浙江财经大学数量经济研究中心杭州310018 上海财经大学经济学院上海200433 贺州学院经济与管理学院贺州542899 浙江财经大学经济学院杭州310018

环境保护是高质量发展的重要推手,而在经济新常态背景和经济下行压力下,失业风险加剧.在污染治理过程中,能否实现促环保与稳就业的双赢局面?本文基于2018年中国劳动力动态调查数据库,构建了2014–2018年劳动力就业调整的面板数据,采用... 详细信息

环境保护是高质量发展的重要推手,而在经济新常态背景和经济下行压力下,失业风险加剧.在污染治理过程中,能否实现促环保与稳就业的双赢局面?本文基于2018年中国劳动力动态调查数据库,构建了2014–2018年劳动力就业调整的面板数据,采用双重差分法考察了“十三五”规划中PM2.5约束性指标对劳动力就业调整的影响.研究结果表明PM2.5约束性指标的提高会显著降低劳动力参与工作的概率.具体来看,随着约束性指标的提升,有工作的劳动力失去原有岗位的概率将明显上升,而失业劳动力再就业的概率可能发生下降,同时劳动力迁出居住地的概率也随之增加,但是劳动力更换工作的概率没有发生明显变化.以上结果在一系列稳健性检验后仍然成立.与此同时,劳动力的就业调整存在明显地区和个体异质性.规划颁布前环境规制程度高、产业高级化程度高的地区在指标影响下受到的负向冲击更小.约束性指标对于在制造业、建筑业工作以及教育程度低的劳动力的负向影响更大.机制检验表明,在PM2.5指标的影响下,高指标地区相对于低指标地区企业数量减少、生产规模缩小并且外商直接投资下降,从而进一步对劳动力的就业产生不利影响,并且这些负向影响均存在显著的地区差异.本文研究为中国在高质量发展进程中,权衡环境治理与稳定就业的关系提供了经验依据.

关键词：双重差分环境规制约束性指标劳动力就业

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Preparation of kakkatin derivatives and their anti-tumor activity

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World Journal of Clinical Oncology 2024年第8期15卷 1078-1091页

作者： Yu-Ying Jiang Hui-Hua Dong Wen-Ting Zhou Jia-Zi Luo Xian Wei yan-qiang Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Collaborative Innovation Center for Guangxi Ethnic Medicine The School of Chemistry and Pharmaceutical SciencesYoujiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Modern pharmacological studies have confirmed that plant-derived compounds from Puerariae flos(PF)has significant biological activities against liver damage,tumors and *** is an isoflavone polyphenolic compound isolated from PF ***,the effect of kakkatin and its derivatives on anti-tumor has not been well *** To design and synthesize a kakkatin derivative[6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one(HK)]to explore its anti-tumor biological *** Hept-6-yn-1-yl ethanesulfonate was introduced to replace hydrogen at the hydroxyl position of kakkatin phenol,and the derivative of kakkatin was prepared;the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to detect cell viability,a clone formation assay was adopted to detect cell proliferation,apoptosis,necrosis,and cell cycles were analyzed by Annexin V/propidium iodide staining and flow *** migration and invasion ability were evaluated by cell scratch assay and transwell *** potential mechanism of HK on hepatocellular carcinoma(HCC)SMMC-7721 cells was explored through network pharmacology and molecular docking,and finally real-time PCR assays was used to verify the potential targets and evaluate the biological activity of *** Compared with kakkatin,the modified HK did not significantly increase the inhibitory activity of gastric cancer MGC803 cells,but the inhibitory activity of HCC SMMC-7721 cells was increased by about 30 times,with an IC50 value of 2.5μM,and the tumor inhibition effect was better than cisplatin,which could significantly inhibit the cloning,invasion and metastasis of HCC SMMC-7721 cells,and induce apoptosis and G2/M cycle *** mechanism of action is mainly related to the upregulation of PDE3B and NFKB1 target proteins in the cAMP *** HK have a significant inhibitory effect on HCC SMMC-7721 cells,and the targets of their action may be PDE3B and NFKB1 prote

关键词： Kakkatin Derivative Hepatocellular carcinoma Anti-tumor Biological activity

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