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Science China(Life Sciences) 2015年第2期58卷 208-211,1-2页

作者： yan YiWu LIU Qiang LI ning DU JianChao LI Xiao LI Chang JIN ningYi JIANG ChengYu State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Biochemistry and Molecular Biology Peking Union Medical College Tsinghua University Genetic Engineering Laboratory Institute of Military Veterinary Academy of Military Medical Sciences State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China Hospital Sichuan University

Dear Editor,Since the first recognized case of human infection with avian influenza H5NI virus in 1997, the worldwide spread and re-emergence of this highly pathogenic influenza virus have led to 694 human infection cases. Of these cases, 402 died from 2003 to 2015 （http：//***/influenza/ human animal_interface/EN_GIP_20150106Cumulative- ***？ua=l）, with a morbidity rate of 57.9%, which is much higher than that of seasonal influenza H1N1 virus.

关键词：病毒感染禽流感血管紧张素Ⅱ 急性肺损伤受体阻滞剂 H5N1 小鼠治疗

Association between sarcopenic overweight and left ventricular diastolic dysfunction and remodeling in patients with type 2 diabetes

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Chinese Medical Journal 2021年第20期134卷 2489-2491页

作者： Yong-Ze Zhang Ling-ning Huang Xi-Mei Shen Jie Lin Feng-Ying Zhao Sun-Jie yan Department of Endocrinology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Fujian Province Clinical Research Center for Metabolic Diseases FuzhouFujian 350005China Diabetes Research Institute of Fujian Province FuzhouFujian 350005China Metabolic Diseases Research Institute The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China

To the Editor:Left ventricular(LV)hypertrophy and diastolic dysfunction are prevalent in patients with type 2 diabetes mellitus(T2DM)[1]and contribute to an increased rate of cardiovascular *** multifactorial pathological state may be linked to overweight and ***,the definitions of obesity based on body mass index(BMI)resulted in discrepancies in the impact on cardiometabolic risk in different ***,the exact association between overweight/obesity and diabetic cardiomyopathy is yet ***,age-related decline in muscle mass and strength,also showed an association with cardiovascular disease.[2]Moreover,individuals with high BMI but low muscle mass may not be noticeable but need to be *** have demonstrated that sarcopenic overweight and obesity are associated with variable cardiometabolic *** may coexist with sarcopenia or ***,research on the association between sarcopenia and LV diastolic function,LV remodeling,and the association with sarcopenic overweight and obesity is *** study sought to investigate whether sarcopenia and sarcopenic overweight and obesity are independently related to preclinical LV diastolic dysfunction and LV remodeling in patients with T2DM.

关键词： diastolic remodeling obesity

黄河三角洲不同土地利用方式下土壤重金属分析评价

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鲁东大学学报（自然科学版） 2023年第3期39卷 193-202页

作者：贾少宁申发颜宁王若菲刘苏慧于洋栗云召杨继松于君宝鲁东大学资源与环境工程学院山东烟台264039 鲁东大学滨海生态高等研究院山东烟台264039

为研究河口三角洲不同土地利用方式下土壤中重金属的分布规律,选取黄河三角洲为研究对象,对湿地、退耕还湿、林地、农田4种不同土地利用方式下28个样点的0~60 cm土壤进行分层取样,测定土壤pH、粒径、有机质以及8种重金属的含量(As、Cd... 详细信息

为研究河口三角洲不同土地利用方式下土壤中重金属的分布规律,选取黄河三角洲为研究对象,对湿地、退耕还湿、林地、农田4种不同土地利用方式下28个样点的0~60 cm土壤进行分层取样,测定土壤pH、粒径、有机质以及8种重金属的含量(As、Cd、Cr、Ni、Cu、Pb、Zn、Mn)。结果表明:土壤中As、Cd、Cr、Ni、Cu、Pb、Zn、Mn的平均含量分别为9.86、0.13、55.49、25.81、12.63、16.59、55.94、498.80 mg·kg^(-1),其中Cd是超标最严重的金属,As、Cd、Ni、Pb、Mn的含量在不同用地类型间差异显著,可能由于受海水影响,As元素在东部沿海区域含量较高,Cd、Cr、Ni、Zn、Mn含量分布南高北低,湿地和退耕还湿土壤中As含量明显高于同一深度的林地和农田,除As和Cd外,其他重金属在农田的含量显著高于其他用地类型。相关性分析表明:Cr、Ni、Cu、Zn、Cd、Mn、Pb的来源相同或相似,As与它们的来源不同;颗粒物粒径越小越易吸附重金属。内梅罗综合污染指数表明,研究区存在不同程度的污染,且污染程度随深度增加而减小。

关键词：重金属用地类型内梅罗综合污染指数黄河三角洲

Analysis of the clinical features and risk factors of death in patients with mushroom poisoning

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Emergency and Critical Care Medicine 2023年第1期3卷 18-22页

作者： yan yang Ruifei Shao Jinfang Xue Xiran Lou Deyuan ning Guobing Chen Medical Faculty Kunming University of Science and TechnologyKunmingYunnanChina Emergency Department The First People’s Hospital of Yunnan ProvinceKunmingYunnanChina

Background:Wild edible mushrooms are rich in nutrition and popular with people;however,few laboratory studies are available about the predictability of outcomes among patients with mushroom ***,this study aimed to analyze the clinical features and death risk factors of patients with mushroom ***:Patients with mushroom poisoning admitted to the hospital from 2015 to 2021 were retrospectively ***:A total of 197 patients with mushroom poisoning were enrolled in this study,of which 100(50.76%)were males,and the mortality was 10.66%(21/197).Patients who died were more likely to have demonstrated a long latency,high alanine aminotransferase,aspartate aminotransferase,direct bilirubin,total bilirubin(TB),activated partial thromboplastin time,prothrombin time,international normalized ratio,creatinine,and blood urea *** logistic regression analysis indicated that TB level greater than or equal to 34.2μmol/L had the greatest lethal risk and could increase the risk of death by 14.588 times(odds ratio:15.588;95%confidence interval:2.088-116.351),which indicated that TB was an independent risk factor of death in patients with acute mushroom ***:Bilirubin concentration was associated with the increased likelihood of *** bilirubin was the independent risk factor of mushroom poisoning.

关键词： Clinical features Mushroom poisoning Prognosis Risk factors

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大类招生模式下林学专业实践教学体系的构建

西南师范大学学报（自然科学版） 2012年第11期37卷 133-137页

作者：辜夕容严宁珍刘芸杨水平练彩霞马明刘玉民姚荣江刘亚敏何丙辉刘益军西南大学资源环境学院重庆400716

大类招生是21世纪教育教学改革的重大举措,目的是培养适应社会发展的"厚基础、宽口径、强能力、高素质"的高层次应用型人才.为适应大类招生模式,在遵循实践性、目标性、层次性和系统性原则的基础上,结合林学专业自身特点,构建出"一个中... 详细信息

大类招生是21世纪教育教学改革的重大举措,目的是培养适应社会发展的"厚基础、宽口径、强能力、高素质"的高层次应用型人才.为适应大类招生模式,在遵循实践性、目标性、层次性和系统性原则的基础上,结合林学专业自身特点,构建出"一个中心、两类场所、三大模块、四种形式"的实践教学体系,调动了学生学习的主观能动性,增强了学生综合分析能力和自主创新意识,取得了显著成效.

关键词：大类招生林学实践教学

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卫气虚证诊断规范的构建思路与方法

北京中医药大学学报 2024年第8期47卷 1180-1184页

作者：车钰文王天芳焦扬赵燕吴志松吴秀艳刘兆兰薛晓琳李宁北京中医药大学中医学院北京102488 北京中医药大学房山医院北京中医药大学东方医院

卫气虚证作为临床常见的中医基本证候,在实际应用中缺乏规范的、可操作性强的诊断规范。通过前期文献研究,本文提出基于证候要素从“卫外不固”“气虚”两个维度构建面向全病域的卫气虚证定性诊断标准,并配合诊断条目量化评定表的构建思... 详细信息

卫气虚证作为临床常见的中医基本证候,在实际应用中缺乏规范的、可操作性强的诊断规范。通过前期文献研究,本文提出基于证候要素从“卫外不固”“气虚”两个维度构建面向全病域的卫气虚证定性诊断标准,并配合诊断条目量化评定表的构建思路,尝试由课题组核心成员先行制订规范草案,再通过德尔菲法专家问卷咨询及名义群体法达成共识,最终经临床验证评价规范的诊断能力与可重复性,以期为证候的规范化、标准化研究提供思路。

关键词：卫气卫气虚证诊断规范思路与方法

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口腔印模清洗方法的改进

护理研究 2012年第5期26卷 421-421页

作者：潘丽娜黄翀严宁广东省深圳市第五人民医院

[目的]改进口腔印模清洗方法。[方法]将口腔器械90件随机分为A组(传统手工清洗组)、B组(冷冻清洗组)、C组(速效净浸泡清洗组),比较3组清洗效果。[结果]3组清洗合格率比较差异有统计学意义(P<0.05)。[结论]口腔器械污染严重,速效净浸泡... 详细信息

[目的]改进口腔印模清洗方法。[方法]将口腔器械90件随机分为A组(传统手工清洗组)、B组(冷冻清洗组)、C组(速效净浸泡清洗组),比较3组清洗效果。[结果]3组清洗合格率比较差异有统计学意义(P<0.05)。[结论]口腔器械污染严重,速效净浸泡清洗法提高清洁效果及护士工作效率。

关键词：口腔印模清洗改进

Hepatic perivascular epithelioid cell tumor:Clinicopathological analysis of 26 cases with emphasis on disease management and prognosis

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World Journal of Gastroenterology 2021年第35期27卷 5967-5977页

作者： Shan Zhang Pan-Pan yang Yu-Chen Huang Hong-Chun Chen De-Li Chen Wen-Tian yan ning-ning yang Yuan Li Nan Li Zhen-Zhong Feng Department of Pathology The Second People’s Hospital of HefeiHefei 230011Anhui ProvinceChina Department of Pathology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Perivascular epithelioid cell tumor(PEComa)is an uncommon tumor of mesenchymal *** of PEComa in the liver are extremely *** To analyze the clinicopathological features and treatment of hepatic PEComa and to evaluate the prognosis after different *** Clinical and pathological data of 26 patients with hepatic PEComa were *** cases were analyzed by immunohistochemistry and clinical *** This study included 17 females and 9 males,with a median age of 50 *** were located in the left hepatic lobe in 13 cases,in the right lobe in 11,and in the caudate lobe in *** median tumor diameter was 6.5 *** microscopy revealed that the tumor cells were mainly composed of epithelioid *** cytoplasm contained heterogeneous eosinophilic *** were thick-walled blood vessels,around which tumor cells were radially *** analysis of pigment-derived and myogenic markers in PEComas revealed that 25 cases were HMB45(+),23 were Melan-A(+),and 22 SMA(+).TFE3 and Desmin were negative in all *** the fluorescence in situ hybridization samples were negative for TFE3 gene break-apart *** tissues were collected by extended hepatic lobe resection or simple hepatic tumor resection as the main *** follow-up was 62.5 *** of the patients had metastasis or recurrence,and there were no deaths due to the *** Hepatic PEComa highly expresses melanin and smooth muscle markers,and generally exhibits an inert biological *** prognosis after extended hepatic lobe resection and simple hepatic tumor resection is semblable.

关键词： Hepatic tumor Perivascular epithelioid cells PEComa Immunohistochemistry Treatment Prognosis

基于Meta分析的复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)的药物经济学评价

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中国药物经济学 2024年第2期19卷 26-31页

作者：王一竹张蕾李晓宁崔鑫谢雁鸣中国中医科学院中医临床基础医学研究所北京100700

目的对复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)进行成本-效果分析。方法基于复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)的Meta分析获得效果指标。计算复方龙血竭胶囊和复方丹... 详细信息

目的对复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)进行成本-效果分析。方法基于复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)的Meta分析获得效果指标。计算复方龙血竭胶囊和复方丹参胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)的成本-效果比,通过软件Tree Age Pro构建决策树模型进行成本-效果分析和敏感性分析。结果以心绞痛疗效显效率作为短期疗效参数,用药模拟周期为4周(28 d),结果显示在提高心绞痛疗效显效率方面复方龙血竭胶囊优于复方丹参胶囊,差异有统计学意义(P<0.05);复方龙血竭胶囊的治疗成本高于复方丹参胶囊,而复方龙血竭胶囊相对于复方丹参胶囊的增量成本-效果比为3 046.91元,小于人均可支配收入的10%。敏感性分析结果显示,基础分析结果相对稳健。结论根据2020年人均可支配收入作为患者意愿支付(WTP)阈值的假设,与复方丹参胶囊相比,复方龙血竭胶囊治疗冠状动脉粥样硬化性心脏病稳定型心绞痛(心血瘀阻证)可能更具有成本-效果优势。

关键词：复方龙血竭胶囊冠状动脉粥样硬化性心脏病稳定型心绞痛心血瘀阻证药物经济学

Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing

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Journal of Genetics and Genomics 2017年第9期44卷 469-472页

作者： Yubing He Tao Zhang ning yang Meilian Xu Lang yan Lihao Wang Rongchen Wang Yunde Zhao National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Section of Cell and Developmental Biology University of California San Diego

Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop *** ability to cut DNA at specific locations in the genome to ... 详细信息

关键词： RGR Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing