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Ovarian endometrioid carcinoma resembling sex cord-stromal tumor:A case report

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World Journal of Clinical Cases 2020年第12期8卷 2623-2628页

作者： Xiao-Xia Wei yan-mei he Wei Jiang Lei Li Department of Pathology West China Second University HospitalSichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Chengdu 610041Sichuan ProvinceChina

BACKGROUND Ovarian endometrioid carcinoma resembling sex cord-stromal tumor(ECSCSs)is *** SUMMARY We present a rare case of primary ECSCSs in the left ovary.A 39-year-old female patient had persistent dull pain in the lower abdomen for more than 1 mo,and she was initially diagnosed with pelvic inflammatory disease at a *** patient received transabdominal hysterectomy,bilateral salpingo-oophorectomy,and pelvic and para-aortic lymph node dissection at our hospital and finally diagnosed with *** the operation,the patient received eight courses of cisplatinum+etoposide+bleomycin chemotherapy treatment and no evidence of tumor recurrence or metastasis was found in a 2-year follow-up *** Ovarian endometrioid carcinoma is similar to the ovary sex cord-stromal tumor,especially when the cord-like structure is *** clinical diagnosis for this tumor is difficult before surgery and pathology *** necessary immunohistochemical markers are of positive significance for assisting diagnosis and differential diagnosis.

关键词： Endometrioid carcinoma Sex cord-stromal tumor Ovary Case report

Asymmetric Hydrogenation of Tetrapyridine-Type N-heteroarenes Using Phosphine-Free Ruthenium Diamine Catalysts

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Chinese Journal of Chemistry 2023年第24期41卷 3573-3578页

作者： Chenghao Li Shu-Xin Zhang Yu Feng yan-mei he Qing-Hua Fan Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of Chemistry Chinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

Chiral ruthenium-catalyzed enantioselective hydrogenation of tetrapyridine-type N-heteroarenes was firstly *** partial reduction of adjacent tetraheteroaromatic substrates proceeded smoothly in the presence of phosphine-free chiral cationic ruthenium diamine complexes,affording unprecedented high reactivity,enantioselecitivity and diastereoselectivity(up to 93%yield,>99%ee and 92:8 dr).The potential application of chiral tetradentate pyridine-amine products as chiral ligands has been demonstrated in the Cu-catalyzed asymmetric Friedel–Crafts alkylation reaction between indoles and nitroalkenes.

关键词： Asymmetric catalysis Chiral nitrogen ligands N-heteroarenes Hydrogenation Ruthenium

Asymmetric Hydrogenation of Bis(quinolin-2-yl)methanes:A Direct Access to Chiral 1,3-Diamines

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Chinese Journal of Chemistry 2018年第12期36卷 1169-1173页

作者： Bin Li Cong Xu yan-mei he Guo-Jun Deng Qing-Hua Fan Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences [CAS) and University of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Environmentally Friendly Chemistry of the Ministry of Education College of ChemistryXiangtan UniversityXiangtanHunan 411105China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071China

The asymmetric hydrogenation of bis(quinolin‐2‐yl)methanes was described, using chiral cationic ruthenium/monosulfonated diamine complexes to afford chiral bis(tetrahydroquinolin‐2‐yl)methanes in high yield with excellent enantioselectivity and diastereoselectivity. The subsequent transformation of these 1,3‐diamines to a new class of chiral 6‐membered N‐heterocyclic carbenes was also developed, which is important but difficult to access.

关键词： asymmetric catalysis hydrogenation chiral 1 3‐diamines heterocycles ruthenium

Asymmetric Transfer Hydrogenation of Naphthol and Phenol Derivatives with Cooperative heterogeneous and Homogeneous Catalysis

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CCS Chemistry 2023年第10期5卷 2277-2289页

作者： Xiaolin Li Wei Hao Niannian Yi yan-mei he Qing-Hua Fan Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

Asymmetric hydrogenation of all-carbon aromatics is still a long-standing challenge in the area of asymmetric *** date,asymmetric(transfer)hydrogenation of naphthols and phenols remains ***,we describe a new strategy for such asymmetric transformation via a bimetallic cooperative heterogeneous and homogeneous *** using HCOONa as the hydrogen source,various naphthols and phenols were partially hydrogenated in HFIP catalyzed by commercial Pd/C catalyst to give ketone *** adding the second chiral Ru-tethered-TsDPEN catalyst and MeOH realized the asymmetric reduction of the resulting ketones in a one-pot manner,furnishing chiral alcohols with good to excellent enantioselectivity(up to 99%ee).The use of HFIP is crucial for suppressing ketone over-reduction via heterogeneous *** importantly,tandem asymmetric transfer hydrogenation of naphthols was also achieved by tuning the volume ratio of mixed HFIP/MeOH solvent,affording chiral 1,2,3,4-tetrahyronaphthols with excellent enantioselectivity but relatively low yield and limited substrate scope.

关键词： enantioselective hydrogenation arenols bimetallic catalysis heterogeneous catalysis homogeneous catalysis

The Synthesis of Aromatic Hydrazones as Nitrogen-Containing Prostaglandin Congeners

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Chinese Chemical Letters 1998年第6期9卷 529-531页

作者： Guo Hao XIE yan mei he Yuan Liu WU(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China

We synthesized a series of hydrazones, a novel type of nitrogen-containing prostaglandins, from different aromatic hydrazines and variant 2-substituted amino-3-hydroxy bicycle [3.2.0]hept-6-ones IV.

关键词： aromatic hydrazine hydrazone nitrogen-containing prostaglandin

Tunable Unsymmetrical Chiral N-heterocyclic Carbene Ligands for Highly Diastereo-and Enantioselective Copper-Catalyzed Tandem Borylative Cyclization:Ligand Controlled Diastereoselectivity Reversal

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CCS Chemistry 2023年第9期5卷 2088-2100页

作者： Jiahong Han yan-mei he Yixiao Pan Faju Li Dongyu Li Wei Hao Qing-Hua Fan Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

A distinct class of C1-symmetric N-heterocyclic carbene(NHC)ligands possessing a chiral fused tetrahydroquinoline ring and a chiral N-arylmethyl group was designed and synthesized via an asymmetric catalytic synthesis *** copper(I)complexes were successfully applied to asymmetric borylation/cyclization tandem reactions,providing facile access to a broad range of chiral borylated 2,3-trans-3,4-cis-trisubstituted tetrahydroquinolines,which are synthetically important and otherwise difficult to access,in high yields with excellent enantioselectivities and *** single-crystal X-ray diffraction analyses of the Cu(I)complexes of L3 and L6 indicate that a crowded chiral pocket around the Cu(I)-metal center is created that is beneficial for the chiral induction in this asymmetric *** addition,chiral all-cis 2,3,4-trisubstituted tetrahydroquinolines were also prepared by using a less bulky C2-symmetric chiral NHC ligand.A plausible catalytic cycle and transition states were proposed to account for the observed diastereoselectivity reversal.

关键词： N-heterocycliccarbenes asymmetricca-talysis boron copper tandemreaction tetrahy-droquinolines

The Oxirane Ring Opening of 2,3-endo-epoxybicyclo[3. 2 .0] hept-6-one by Amines at Alumina Surface

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Chinese Chemical Letters 1998年第6期9卷 513-514页

作者： yan mei he Guo Hao XIE Ai Lian ZheNG Yuan Liu WU(Institute of Materia Medica, Chinese Academy of Medical Sciences, Bejing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China

Stereospecific (trans) and regioselective nucleophilic opening of the title epoxide (I) by different amines at the alumina surface are described.

关键词： Oxirane Ring Opening aliphatic amines aromatic amines

Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： GAO Chen-yan QIN Gao-feng ZheNG Ming-cui TIAN mei-jing he yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(Phe expressions of SYP and PSD95 in the BG were higher than those in the MG(Phe BG was higher than that in the MG(Phe intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(Phe MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(Phe levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang Wu Yi Shi Shun yan Hong-mei yan yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity