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A Hybrid Algorithm Based on Binary Chemical Reaction Optimization and Tabu Search for Feature Selection of High-Dimensional Biomedical Data

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Tsinghua Science and Technology 2018年第6期23卷 733-743页

作者： Chaokun yan Jingjing ma Huimin Luo Jianxin Wang the School of Computer and Information Engineering Henan UniversityKaifeng 475000 China School of Information Science and Engineering Central South University Changsha 410083 China

In recent years, there have been rapid developments in various bioinformatics technologies, which have led to the accumulation of a large amount of biomedical data. The biomedical data can be analyzed to enhance assessment of at-risk patients and improve disease diagnosis, treatment, and prevention. However, these datasets usually have many features, which contain many irrelevant or redundant information. Feature selection is a solution that involves finding the optimal subset, which is known to be an NP problem because of the large search space. Considering this, a new feature selection approach based on Binary Chemical Reaction Optimization algorithm （BCRO） and k-Nearest Neighbors （KNN） classifier is presented in this paper. Tabu search is integrated with CRO framework to enhance local search capacity. KNN is adopted to evaluate the quality of selected candidate subset. The results for an experiment conducted on nine standard medical datasets demonstrate that the proposed approach outperforms other state-of-the-art methods.

关键词： feature selection biomedical data chemical reaction optimization tabu search

Annoyance Rate Evaluation Method on Ride Comfort of Vehicle Suspension System

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Chinese Journal of Mechanical Engineering 2014年第2期27卷 296-303页

作者： TANG Chuanyin ZHANG Yimin ZHAO Guangyao ma yan School of Mechanical Engineering and Automation Northeastern University Shenyang Academy of Instrumentation Science

The existing researches of the evaluation method of ride comfort of vehicle mainly focus on the level of human feelings to vibration. The level of human feelings to vibration is influenced by many factors, however, the ride comfort according to the common principle of probability and statistics and simple binary logic is tmable to reflect these uncertainties. The random fuzzy evaluation model from people subjective response to vibration is adopted in the paper, these uncertainties are analyzed from the angle of psychological physics. Discussing the traditional evaluation of ride comfort during vehicle vibration, a fuzzily random evaluation model on the basis of annoyance rate is proposed for the human body＇s subjective response to vibration, with relevant fuzzy membership function and probability distribution given. A half-car four degrees of freedom suspension vibration model is described, subject to irregular excitations from the road surface, with the aid of software matlab/Simulink. A new kind of evaluation method for ride comfort of vehicles is proposed in the paper, i.e., the annoyance rate evaluation method. The genetic algorithm and neural network control theory are used to control the system. Simulation results are obtained, such as the comparison of comfort reaction to vibration environments between before and after control, relationship of annoyance rate to vibration frequency and weighted acceleration, based on ISO 2631 / 1 （1982）, ISO 2631-1 （1997） and annoyance rate evaluation method, respectively. Simulated assessment results indicate that the proposed active suspension systems prove to be effective in the vibration isolation of the suspension system, and the subjective response of human being can be promoted from very uncomfortable to a little uncomfortable. Furthermore, the novel evaluation method based on annoyance rate can further estimate quantitatively the number of passengers who feel discomfort due to vibration. A new analysis method of vehicl

关键词： evaluation method ride comfort annoyance rate genetic algorithm neural network

A dynamic influence model of social network hotspot based on grey system

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Science China(Information Sciences) 2015年第12期58卷 63-74页

作者： XIAO YunPeng ma Jing LIU yanBing yan ZhiXian Chongqing University of Posts and Telecommunications (CQUPT) Swiss Federal Institute of Technology (EPFL)

The outbreak of hotspot in social network may contain complex dynamic genesis. Using user behavior data from hotspots in social network, we study how different user groups play different roles for a hotspot topic. Firstly, by analyzing users’ behavior records, we mine group situation that promotes the *** major attributions in a hotspot outbreak, such as individual, peer and group triggers, are defined formally according to the view-point of social identity, social interaction, retweet depth and opinion leader. Secondly,for the problem of the uneven and sparse data in each stage of hotspot topic’s life cycle, we propose a dynamic influence model based on grey system to formalize the effect of different groups. Then the process of hotspot evolution driven by distinct crowd is showed dynamically. The experimental result confirms that the model is able not only to qualify users’ influence on a hotspot topic but also to predict effectively an upcoming change in a hotspot topic.

关键词： social network hotspot topic grey system influence model dynamic evolution

Biological control of aflatoxin contamination of crops

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 787-792页

作者： yan-ni YIN Lei-yan yan Jin-hua JIANG Zhong-hua ma Institute of Biotechnology Zhejiang University Hangzhou 310029 China

Aflatoxins produced primarily by two closely related fungi, Aspergillus flavus and Aspergillus parasiticus, are mutagenic and carcinogenic in animals and humans. Of many approaches investigated to manage aflatoxin contamination, bio-logical control method has shown great promise. Numerous organisms, including bacteria, yeasts and nontoxigenic fungal strains of A. flavus and A. parasiticus, have been tested for their ability in controlling aflatoxin contamination. Great successes in reducing aflatoxin contamination have been achieved by application of nontoxigenic strains of A. flavus and A. parasiticus in fields of cotton, peanut, maize and pistachio. The nontoxigenic strains applied to soil occupy the same niches as the natural occurring toxigenic strains. They, therefore, are capable of competing and displacing toxigenic strains. In this paper, we review recent development in biological control of aflatoxin contamination.

关键词： Aflatoxin Aspergillus Biocontrol Food safety

Design and Optimization for the Occupant Restraint System of Vehicle Based on a Single Freedom Model

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 492-497页

作者： ZHANG Junyuan ma Yue CHEN Chao ZHANG yan State Key Laboratory of Automobile Simulation and Control Jilin University

Throughout the vehicle crash event, the interactions between vehicle, occupant, restraint system (VOR) are complicated and highly non-linear. CAE and physical tests are the most widely used in vehicle passive safety development, but they can only be done with the detailed 3D model or physical samples. Often some design errors and imperfections are difficult to correct at that time, and a large amount of time will be needed. A restraint system concept design approach which based on single-degree-of-freedom occupant-vehicle model (SDOF) is proposed in this paper. The interactions between the restraint system parameters and the occupant responses in a crash are studied from the view of mechanics and energy. The discrete input and the iterative algorithm method are applied to the SDOF model to get the occupant responses quickly for arbitrary excitations (impact pulse) by maTLAB. By studying the relationships between the ridedown efficiency, the restraint stiffness, and the occupant response, the design principle of the restraint stiffness aiming to reduce occupant injury level during conceptual design is represented. Higher ridedown efficiency means more occupant energy absorbed by the vehicle, but the research result shows that higher ridedown efficiency does not mean lower occupant injury level. A proper restraint system design principle depends on two aspects. On one hand,the restraint system should lead to as high ridedown efficiency as possible, and at the same time, the restraint system should maximize use of the survival space to reduce the occupant deceleration level. As an example, an optimization of a passenger vehicle restraint system is designed by the concept design method above, and the final results are validated by maDYMO, which is the most widely used software in restraint system design, and the sled test. Consequently, a guideline and method for the occupant restraint system concept design is established in this paper.

关键词： vehicle crash occupant restraint system concept design single-degree-of-freedom occupant-vehicle model

Geochronology of the Guyang Granite-Greenstone Terrene and the Implications for Continental Crust Growth

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1499-1500页

作者： ma Xudong ZHONG yan MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences Tianjin Center China Geological Survey

The North China Craton （NCC） is the largest and oldest one among the worldwide cratons. It preserves important imprints of the Earth＇s early history, including crust formation, stabilization and reworking. The Yinshan Block （YB） constitutes the northwestern part of NCC, and contains extensive exposure of Archean rocks （Fig. 1）.

关键词： Ga Cr Geochronology of the Guyang Granite-Greenstone Terrene and the Implications for Continental Crust Growth NCC

PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway

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Biomedical and Environmental Sciences 2023年第3期36卷 241-252页

作者： WEN Shi Yuan LIU yan Tong WEI Bing yan ma Jie Qiong CHEN yan yan College of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030000ShanxiChina School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanxi Key Laboratory of Experimental Animals and Animal Models for Human Diseases Laboratory Animal CenterShanxi Medical UniversityTaiyuan 030000ShanxiChina School of Medicine Jiangsu UniversityZhenjiang 212001JiangsuChina

Objective Programmed cell death 6(PDCD6), a Ca~(2+)-binding protein, has been reported to be aberrantly expressed in all kinds of tumors. The aim of this study was to explore the role and mechanism of PDCD6 in hepatocellular carcinomas(HCCs).Methods The expression levels of PDCD6 in liver cancer patients and HCC cell lines were analyzed using bioinformatics and Western blotting. Cell viability and metastasis were determined by methylthiazol tetrazolium(MTT) and transwell assays, respectively. And Western blotting was used to test related biomarkers and molecular pathway factors in HCC cell lines. LY294002, a PI3K inhibitor inhibiting AKT, was used to suppress the AKT/GSK3β/β-catenin pathway to help evaluate the role of this pathway in the HCC carcinogenesis associated with *** The analysis of The Cancer Genome Atlas Database suggested that high PDCD6 expression levels were relevant to liver cancer progression. This was consistent with our finding of higher levels of PDCD6 expression in HCC cell lines than in normal hepatocyte cell lines. The results of MTT, transwell migration, and Western blotting assays revealed that overexpression of PDCD6 positively regulated HCC cell proliferation, migration, and invasion. Conversely, the upregulation of PDCD6 expression in the presence of an AKT inhibitor inhibited HCC cell proliferation, migration, and invasion. In addition, PDCD6promoted HCC cell migration and invasion by epithelial-mesenchymal transition. The mechanistic investigation proved that PDCD6 acted as a tumor promoter in HCC through the AKT/GSK3β/β-catenin pathway, increasing the expression of transcription factors and cellular proliferation and *** PDCD6 has a tumor stimulative role in HCC mediated by AKT/GSK3β/β-catenin signaling and might be a potential target for HCC progression.

关键词： PDCD6 Hepatocellular carcinoma Proliferation Metastasis

Numerical simulation on directional solidification and heat treatment processes of turbine blades

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China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu Ju-huai ma Qing-yan Xu School of materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation

Cutaneous sensory nerve as a substitute for auditory nerve in solving deaf-mutes' hearing problem: an innovation in multi-channel-array skin-hearing technology

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Neural Regeneration Research 2014年第16期9卷 1532-1540页

作者： Jianwen Li yan Li Ming Zhang Weifang ma Xuezong ma College of Electric & Information Engineering Shaanxi University of Science & Technology Skin-Hearing Research Institute Shaanxi University of Science & Technology Library of Shaanxi University of Science & Technology College of Computer Science Xi’an Polytechnic University

The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice sig- nals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequen- cy analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to dis- tinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes＇ hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized.

关键词： nerve regeneration peripheral nerve skin-hearing multi-channel electrode array aid deaf band-pass filter voice NSFC grant neural regeneration