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The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses

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hLife 2024年第3期2卷 141-146页

作者： Cong Sun jia-Wen yang Chu Xie Xin-yan Fang Guo-Long Bu Ge-Xin zhao Dan-Ling Dai Zheng liu Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangdongChina Cryo-electron Microscopy Center Southern University of Science and TechnologyGuangdongChina Department of Biology Southern University of Science and TechnologyGuangdongChina

Human herpesviruses(HHV),including the alpha,beta,andgamma subfamilies,are enveloped viruses with broad prevalence,establishing life-time latent infections and inducing a variety of diseases[1].Among them,herpes simplex virus(HSV),consists of two HSV-1 and HSV-2 variants,ubiquitouslyaffecting global populations[2].As an enveloped virus,HSV features a repertoire of glycoproteins such as glycoproteins D(gD),glycoproteins H(gH),glycoproteins L(gL),and glycoproteins B(gB),to orchestrate host cell recognition and infection[3,4].

关键词： diseases neutral envelope

Global research trends and prospects of cellular metabolism in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 527-542页

作者： yan-Chen liu Zhi-Cheng Gong Chao-Qun Li Peng Teng yan-yan Chen zhao-Hui Huang Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through *** To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by *** Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer *** The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three ***,China and the United States were two of the most prominent contri-butors in these four *** addition,Gang wang,Wei jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-yuan Fang,Senji Hirasawa,Wei jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in *** Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in *** metabolic vulnerability appears to be a promising direction in CRC therapy.

关键词： Cellular metabolism Colorectal cancer Glucose metabolism Amino acid metabolism Lipid metabolism Nucleotide metabolism

Cross section measurement for the^(232)Th(n,f)reaction in the 4.50−5.40 MeV region using a time projection chamber

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Chinese Physics C 2024年第10期48卷 157-167页

作者： Haofan Bai Han Yi yankun Sun Yiwei Hu Jie liu Zepeng Wu Cong Xia Wenkai Ren Wentian Cao Tieshuan Fan Guohui Zhang Ruirui Fan yang Li Wei jiang Yonghao Chen You Lv Changjun ning Weihua jia Zhiyong Zhang Haolei Chen Zhen Chen Maoyuan zhao Changqing feng Shubin liu State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China National Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi'an 710024China Department of Nuclear Science and Technology School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

Accurate cross sections of neutron induced fission reactions are required in the design of advanced nuclear systems and the development of fission *** projection chambers(TPCs),with their track reconstruction and particle identification capabilities,are considered the best detectors for high-precision fission cross section *** TPC developed by the back-streaming white neutron source(Back-n)team of the China Spallation Neutron Source(CSNS)was used as the fission fragment detector in *** this study,the cross sections of the ^(232)Th(n,f)reaction at five neutron energies in the 4.50−5.40 MeV region were *** fission fragments and α particles were well identified using our TPC,which led to a higher detection efficiency of the fission fragments and smaller uncertainty of the measured cross *** is the first measurement of the ^(232)Th(n,f)reaction using a TPC for the detection of fission *** uncertainties less than 5%,our cross sections are consistent with the data in different evaluation libraries,including JENDL-4.0,ROSFOND-2010,CENDL-3.2,ENDF/B-VⅢ.0,and BROND-3.1,whose uncertainties can be reduced after future improvement of the measurement.

关键词： ^(232)Th(n,f)fission cross section time projection chamber(TPC) ^(232)Th

蒙脱石与复合菌剂配施提高田菁改良盐渍土的效果

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植物营养与肥料学报 2024年第2期30卷 331-341页

作者：关欣王丹丹刘佳凝宋恩泽严龙王洪凤解志红山东农业大学资源与环境学院山东泰安271018 山东蓬勃生物科技有限公司山东泰安271018

【目的】田菁具有较强的固氮和耐盐能力,因此已经成为改良盐碱地的先锋植物。通过蒙脱石与复合菌剂配施提升田菁的耐盐能力,为其更好地改良盐碱土壤提供技术支撑。【方法】采用盆栽试验方法进行研究。将供试土壤与蛭石、珍珠岩按照3∶1... 详细信息

【目的】田菁具有较强的固氮和耐盐能力,因此已经成为改良盐碱地的先锋植物。通过蒙脱石与复合菌剂配施提升田菁的耐盐能力,为其更好地改良盐碱土壤提供技术支撑。【方法】采用盆栽试验方法进行研究。将供试土壤与蛭石、珍珠岩按照3∶1∶1的体积混匀并灭菌后,用于制备NaCl浓度为0、100、200 mmol/L的3组土壤,每组土壤中设置空白对照(CK)、加蒙脱石(M)、加复合菌剂(J)、加蒙脱石和复合菌剂(M+J)4个处理,田菁生长60天后收获,测量田菁生物量和土壤理化性质变化。【结果】复合菌剂中的假单胞菌Pseudomonadaceae ***3和大肠杆菌Escherichia coli ND2B相比于其他内生菌有较强的促生能力。在盐浓度0、100、200 mmol/L土壤上,田菁植株高度、地上部干重及叶片叶绿素含量、净光合效率、酶活均表现为CK

关键词：盐胁迫田菁蒙脱石微生物菌剂脱盐率土壤养分

Bimodal growth of Fe islands on graphene

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Chinese Physics B 2024年第6期33卷 553-557页

作者：顾翊晟俞俏滟刘荡孙蓟策席瑞骏陈星森薛莎莎章毅杜宪宁旭辉杨浩管丹丹刘晓雪刘亮李耀义王世勇刘灿华郑浩贾金锋 Key Laboratory of Artificial Structures and Quantum Control TD Lee InstituteShenyang National Laboratory for Materials ScienceSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

Magnetic metals deposited on graphene hold the key to applications in spintronics. Here, we present the results of Fe islands grown on graphene/Si C(0001) by molecular beam epitaxy, which are investigated by scanning tunneling microscopy. The two types of islands distinguished by flat or round tops are revealed, indicating bimodal growth of Fe. The atomic structures on the top surfaces of flat islands are also clearly resolved. Our results may improve the understanding of the mechanisms of metals deposited on graphene and pave the way for future spintronic applications of Fe/graphene systems.

关键词： graphene magnetism molecular beam epitaxy scanning tunneling microscopy

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基于里德伯原子天线的低频电场波形测量

物理学报 2024年第7期73卷 82-89页

作者：张学超乔佳慧刘瑶苏楠刘智慧蔡婷何军赵延霆王军民山西大学光电研究所量子光学与光量子器件国家重点实验室太原030006 山西大学物理电子工程学院太原030006 山西大学激光光谱研究所量子光学与光量子器件国家重点实验室太原030006 山西大学省部共建极端光学协同创新中心太原030006

里德伯原子的高极化率可以实现电磁场的多维度参数测量.本文利用室温里德伯原子构建原子天线,基于原子天线将低频电场幅度信息转化为强度信息,从而实现低频电场的参数测量.实验采用双光子激发制备铯原子里德伯态,通过阶梯型电磁感应透明... 详细信息

里德伯原子的高极化率可以实现电磁场的多维度参数测量.本文利用室温里德伯原子构建原子天线,基于原子天线将低频电场幅度信息转化为强度信息,从而实现低频电场的参数测量.实验采用双光子激发制备铯原子里德伯态,通过阶梯型电磁感应透明(electromagnetically induced transparency,EIT)光谱实现里德伯原子量子态的检测,基于内置电极技术在室温原子气室导入k Hz频段低频电场.电场中里德伯原子的Stark频移会在EIT过程导致双光子失谐,从而引起EIT光谱频移和强度变化.在弱电场条件下,EIT光谱频移可以忽略,EIT透射强度与输入低频电场强度近似为线性关系,基于该效应可以实现低频电场的波形、幅度、频率等参数测量.

关键词：里德伯原子电磁感应透明光谱低频电场波形

增大冷速和退火对Al_(50)Ni_(50)合金耐蚀性能的改善

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 769-785页

作者：刘瀚泽闫芝成陈其张昊冯玉齐志港王兆萱潘少鹏贾义勇王伟民山东大学材料科学与工程学院材料液固结构演变与加工教育部重点实验室济南250061 太原理工大学材料科学与工程学院太原030002 华美新材料(菏泽)有限公司菏泽274000

通过周向速度(S_(c))分别为21和42 m/s的熔带甩带法制备单相Al_(50)Ni_(50)条带,然后采用多种实验方法研究在不同温度下退火Al_(50)Ni_(50)条带的显微组织和腐蚀行为。随着S_(c)从21 m/s提高到42 m/s,相应的铸态和退火条带的(100)晶体... 详细信息

通过周向速度(S_(c))分别为21和42 m/s的熔带甩带法制备单相Al_(50)Ni_(50)条带,然后采用多种实验方法研究在不同温度下退火Al_(50)Ni_(50)条带的显微组织和腐蚀行为。随着S_(c)从21 m/s提高到42 m/s,相应的铸态和退火条带的(100)晶体取向因子F(100)增大,再结晶的障碍减少以及钝化膜的总电阻增大。S_(c)=42m/s的铸态条带比21 m/s的铸态和退火的条带具有更稳定、更致密的Al_(2)O_(3)钝化膜,并可以通过在700℃退火进一步提升。因此,提高冷却速率和选择适当温度进一步退火可以提高AlNi条带的耐腐蚀性能。

关键词： AlNi合金快速凝固取向因子再结晶腐蚀性为

Current situation and development of hematopoietic cell transplantation centers:A nationwide survey in China

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Chinese Medical Journal 2024年第13期137卷 1626-1628页

作者： Yi Fan Mimi Xu yuqing Tu yu Hu Qifa liu Weili zhao Xiaohui Zhang Zimin Sun Ting Niu jianda Hu Juan Li Lin liu Li liu Sanbin wang Sujun Gao Yongrong Lai Xianmin Song Zhenyu Li Jingbo wang Zhongxing jiang Yajing Xu Jinsong yan Pengcheng He jianmin yang jia Chen yang Xu Xiaojun Huang Depei Wu On behalf of the National Clinical Research Center for Hematologic Diseases(NCRCH)at Suzhou National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow UniversityJiangsu Institute of HematologySuzhouJiangsu 215000China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510510China State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineShanghai Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 215200China Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyPeking UniversityBeijing 100044China Department of Hematology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Hematology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Hematology Fujian Medical University Union HospitalFuzhouFujian 350001China Department of Hematology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Hematology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Hematology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038China Department of Hematology General Hospital of Kunming Military Region of the People’s Liberation Army(PLA)KunmingYunan 650100China Department of Hematology and Oncology Bethune First Hospital Of Jilin UniversityChangchunJilin 130021China Department of Hematology The First Affiliated Hospital of Guangxi Medical UniversityGuilinGuangxi 530021China Department of Hematology Shanghai General HospitalShanghai 201620China Department of Hematology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221004China Department of Hematology Aerospace Center HospitalBei

To the Editor:Hematopoietic cell transplantation(HCT)is a vital modality to cure severe hematological disorders.[1]Global or regional summarized data of HCT are annually reported by the Chinese Blood and Marrow Transplantation Registry Group(CBMTRG),European Society for Blood and Marrow Transplantation(EBMT)and Center for International Blood and Marrow Transplant Research(CIBMTR).It is shown that the number of transplants is continuously increasing,particularly in China in recent years.[2]Since the donor accessibility is significantly addressed by the well-established protocol of haplo-identical HCT(haplo-HCT).

关键词： Blood hematopoietic centers

Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第3期10卷 211-219页

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan yu Xiaofan Lei Shixiong Li Junsheng Zhai yuanren Ma Long He Qiheng liu Chenglong liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi zhao Zhikang wang Shuang Sun Wei Guo Min Zheng Shuai Zhang jia Deng Xiaofeng liu Xingju Ye Xun Zhang Qian wang Rong Zhang yan Zhang Shaosen wang Chengjun yang Ziwen Zhang Nijia Wu Mingxing Sun jian Zhou yujia Shi Zhiyong Ma Yonggang Zhou jianpo yu Shaochen Li jiaxi Lu Junli Gao Faliang wang Wenjing Chen yanming Zhu Xingen Zhang Dong zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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