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Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： Hai-yan Wang De-Xiu Wu Ye Du Xiao-Tong lv Qian-Yuan Wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water

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Hydrogen release of NaBH_(4) below 60 ℃ with binary eutectic mixture of xylitol and erythritol additive

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Chinese Journal of Chemical Engineering 2024年第7期71卷 225-234页

作者： Yugang Shu Jiaguang Zheng Chengguo yan Ao Xia Meiling lv Zhenxuan Ma Zhendong Yao School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China

NaBH_(4) was widely regarded as a low-cost hydrogen storage material due to its high-mass hydrogen capacity of approximately 10.8%(mass)and high volumetric hydrogen capacity of around 115 g·L^(–1).However,it exhibits strong stability and requires temperatures above 500℃ for hydrogen release in practical *** this study,two polyhydric alcohols,xylitol and erythritol(XE),were prepared as a binary eutectic sugar alcohol through a grinding-melting *** binary eutectic sugar alcohol was used as a proton-hydrogen carrier to destabilize NaBH_(4).The 19NaBH_(4)-16XE composite material prepared by ball milling could start releasing hydrogen at 57.5℃,and the total hydrogen release can reach over 88.8%(4.45%(mass))of the theoretical *** the 19NaBH_(4)-16XE composite was pressed into solid blocks,the volumetric hydrogen capacity of the block-shaped composite could reach 67.2 g·L^(–1).By controlling the temperature,the hydrogen desorption capacity of the NaBH_(4)-XE composite material was controllable,which has great potential for achieving solid-state hydrogen production from NaBH_(4).

关键词： Hydrogen Desorption Binary mixture NaBH_(4) Xylitol Erythritol

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Impact of diabetes on the prognosis of hip fracture： a cohort study in the Chinese population

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Chinese Medical Journal 2013年第5期126卷 813-818页

作者： WANG Hong lv yan-wei LAN Ling ZHANG Quan CHEN Hai-ling ZHANG Guo-ying DENG Li-li LI Ju-fen Department of Endocrinology Beijing Jishuitan Hospital Beijing 100035 China Department of Traumatology and Orthopaedics Beijing Jishuitan Hospital Beijing 100035 China Biostatistics and Clinical Epidemiology Research Office ResearchInstitute of Traumatology and Orthopaedics of Beijing & BeijingJishuitan Hospital Beijing 100035 China

Background Diabetes has been associated with increased risk of fracture and impaired fracture healing. The aim of this study was to examine the influence of diabetes on perioperative complications, length of stay and ambulatory ability recovery in individuals with hip fracture, and to determine whether changes could be made to improve treatment outcome. Methods The study included 707 hip fracture patients treated at Beijing Jishuitan Hospital between July 2009 and December 2010. The medical history and perioperative complications were compared between non-diabetic and diabetic groups. Length of stay, days awaiting surgery, and days of hospitalization after surgery were also analyzed. Ambulatory ability was compared at 1-year follow-up using the Chi-square test and Fisher＇s exact test. An independent Student＇s t-test was used to compare normally distributed continuous data. Results Patients with diabetes were more likely than non-diabetic patients to develop cardiac perioperative complications （8.9% vs. 3.0%, P=0.021）, urinary tract infections （12.0% vs. 2.8%, P 〈0.001）, and gastrointestinal symptoms （15.0% vs. 6.8%, P=0.003）. No difference in perioperative complications was observed between the groups. Days awaiting surgery and length of hospital stay were both longer in the diabetic group （（8.0＋5.1） vs. （6.2＋3.7） days and （16.5＋3.8） vs. （13.3＋3.8） days, P 〈0.001, respectively）. Before the occurrence of fracture, patients with diabetes were less likely to be ambulatory outdoors （71.9% vs. 85.9%, P 〈0.001） and had more restricted walking ability. After at least 1-year follow-up, similar proportions of patients in the non-diabetic and diabetic groups （16.1% and 15.9%, respectively）, who were able to ambulate outdoors before the fracture, became housebound till the final follow-up. Conclusions Diabetics are at increased risk of specific complications and have a longer time to surgery and longer in-hospital stay, but generally have similar recovery to non-diabetics ther

关键词： diabetes mellitus hip fractures perioperative complications," mobility limitation

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Recent research and development of thick CVD tungsten coatings for fusion application

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Tungsten 2020年第1期2卷 83-93页

作者： Zhe Chen You‑Yun Lian Xiang Liu Fan Feng Bin‑You yan Jian‑Bao Wang yan‑Wei lv Jiu‑Peng Song Chun‑Jia Liu Lai‑Zhong Cai Southwestern Institute of Physics Chengdu 610041China China National R&D Center for Tungsten Technology Xiamen Tungsten Co.Ltd.Xiamen 361009China

As the interface closest to the edge plasma of a fusion reactor reacting deuterium(D)and tritium(T),plasma-facing material(PFM)need to withstand extreme service conditions with the high particle flux,high heat load,and neutrons with energy up to 14.1 ***(W)is the primary candidate of PFMs in future fusion reactors due to its high melting point,good thermal conductivity,excellent irradiation resistance,and low hydrogen/helium *** far,powder metallurgy is a leading route for the preparation of W-based *** alternative approach could be the coating technique,which has advantages on fabricating W PFMs and plasma-facing component(PFC)*** the past several years,inspiring results were achieved in the preparation process and performance evaluation of the W coating with high purity,excellent thermal conductivity,and thickness at the millimeter level by atmospheric pressure chemical vapor deposition(APCVD).No obvious grain growth and hardness decrease were observed when the annealing temperature was lower than 1500°C,indicating its good thermal *** as-deposited coating exhibited a comparable thermal shock resistance with the conventional W *** the polished sample showed a high crack threshold(0.33-0.44 GW·m^(−2))when exposed to edge localized mode like transient at room temperature,compared to the unpolished *** performance of the chemical vapor deposition(CVD)-W exposed to deuterium(D)plasma and fission neutron were also ***,the practicality of preparation of large-scale W-based PFM by this technique is also *** paper gives a short overview on the recent research and development status of the thick W coating prepared by APCVD at Xiamen Tungsten Co.,Ltd and Southwestern Institute of Physics for using as PFM and PFC in fusion devices.

关键词： Tungsten coatings Chemical vapor deposition Plasma-facing materials Plasma-facing component

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Chinese Association for the Study of Pain:Expert consensus on chronic postsurgical pain

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World Journal of Clinical Cases 2021年第9期9卷 2090-2099页

作者： Yi-Ming Liu Yi Feng yan-Qing Liu yan lv Yuan-Chang Xiong Ke Ma Xian-Wei Zhang Jin-Feng Liu Yi Jin Hong-Guang Bao Min yan Tao Song Qing Liu Department of Algology Peking University People’s HospitalBeijing 100044China Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Algology Air Force Medical University of PLAXi’an 710032Shaanxi ProvinceChina Department of Anesthesiology Changhai HospitalNaval Military Medical UniversityShanghai 200433China Department of Algology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Algology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Algology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Anesthesiology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Anesthesiology The Second Affiliated Hospital of Zhejiang University school of MedicineHangzhou 310058Zhejiang ProvinceChina Department of Algology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Algology The Affiliated T.C.M Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

Chronic postsurgical pain is a common surgical complication that severely reduces a patient’s quality of *** perioperative interventions and management strategies have been developed for reducing and managing chronic postsurgical *** the leadership of the Chinese Association for the Study of Pain,an editorial committee was formed for chronic postsurgical pain diagnosis and treatment by experts in relevant *** editorial committee composed the main content and framework of this consensus and established a working *** working group conducted literature review(1989-2020)using key words such as“surgery”,“post-surgical”,“post-operative”,“pain”,“chronic”,and“persistent”in different databases including MEDLINE,EMBASE,PubMed,Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic *** publications in the English language were *** types of literature included systematic reviews,randomized controlled studies,cohort studies and case *** consensus was written based on clinical practice combined with literature *** first draft of the consensus was rigorously reviewed and edited by all the editorial committee experts before being *** level of evidence was assessed by methodological experts based on the Oxford Centre for Evidence-Based Medicine Levels of *** strength of recommendation was evaluated by all editorial committee experts,and the opinions of most experts were adopted as the final *** recommendation level“strong”generally refers to recommendations based on high-level evidence and consistency between clinical behavior and expected *** recommendation level“weak”generally refers to the uncertainty between clinical behavior and expected results based on low-level evidence.

关键词： Chronic postsurgical pain Treatment Interventional Prevention

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腾冲火山及周边地区双差层析成像

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地球物理学报 2019年第8期62卷 2982-2990页

作者：华雨淋吕彦中国科学院地质与地球物理研究所中国科学院地球与行星物理重点实验室北京100029 中国科学院地球科学研究院北京100029 中国科学院大学北京100049

利用云南腾冲火山地区15个固定台站记录到的7923次地震的P波到时资料,采用双差层析成像方法,反演得到腾冲火山及周边地区地壳及上地幔顶部三维P波速度结构和地震重定位结果.研究发现,腾冲火山区域地壳内存在明显的地震波低速区,P波速度... 详细信息

利用云南腾冲火山地区15个固定台站记录到的7923次地震的P波到时资料,采用双差层析成像方法,反演得到腾冲火山及周边地区地壳及上地幔顶部三维P波速度结构和地震重定位结果.研究发现,腾冲火山区域地壳内存在明显的地震波低速区,P波速度低于整个区域地壳速度平均值超过15%,上地幔顶部存在规模较大的低速异常区.推测腾冲火山地区存在较大规模的地幔热物质上涌以及向地壳的侵入,热物质在地壳内以岩浆囊形式存储,并且壳内岩浆囊之间可能存在岩浆通道.通过联合反演获得的地震重定位结果显示,丛集地震位置更加集中,其展布特征与断裂构造具有显著的对应关系,表明研究区域断裂构造比较活跃.获得的高分辨率三维P波层析成像结果,为进一步认识火山地区岩浆存储特征以及地震分布与区域构造之间的关系提供了新的地震学依据.

关键词：双差层析成像腾冲火山地区岩浆囊

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以临床需求为导向的卵巢-附件肿瘤“3+X定”结构化报告的应用研究

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中国临床医学影像杂志 2024年第7期35卷 490-493,497页

作者：杨庆玲彭锐马丽娜袁蕾吕艳红刘淑娟宦怡郑敏文任静空军军医大学西京医院陕西西安710032

目的:探讨卵巢-附件肿瘤“3+X定”结构化报告(Structured reports,SR)在临床的应用价值。方法:本研究以临床需求为导向,提出“3+X定”影像诊断思路:在定位、定量、定性这“3定”基础上,针对不同系统不同疾病不定项增加诸如定期、定效等... 详细信息

目的:探讨卵巢-附件肿瘤“3+X定”结构化报告(Structured reports,SR)在临床的应用价值。方法:本研究以临床需求为导向,提出“3+X定”影像诊断思路:在定位、定量、定性这“3定”基础上,针对不同系统不同疾病不定项增加诸如定期、定效等“X定”,并结合卵巢-附件肿瘤最新诊疗指南,设计研发了卵巢-附件肿瘤的“3+X定”SR。回顾性分析2022年5月—2023年12月,我院12名妇科医生对放射科最终提交的339份卵巢-附件肿瘤MRI“3+X定”SR和自由文本式报告(Free text reports,FTR)在术语的规范性、回答关键临床问题、指导临床决策、为手术方案提供有效信息、获取有效信息的便捷性、对报告的信任度和报告整体质量方面的满意度。同时,比较24名放射科医生对两种卵巢-附件肿瘤MRI报告模板在便利性、实用性和诊断信心方面的满意度。采用Likert五分量表法填写调查问卷,满意度间比较采用Wilcoxon符号秩检验,P<0.05为结果有统计学意义。结果:妇科医生认为,相较于传统FTR,“3+X定”SR使用术语更加规范、更好地回答了关键临床问题、指导临床决策、为手术方案提供了更多有效信息,从报告中获取有效信息更便捷(P<0.05)。此外,妇科医生对“3+X定”SR的信任度更高,认为其整体质量明显高于FTR(P<0.001)。24名放射科医生认为“3+X定”SR在便利性、实用性和诊断信心方面的满意度均显著高于FTR(P<0.001)。结论:与传统的FTR相比,“3+X定”SR更受妇科医生和放射科医生欢迎,具有更好的临床应用价值。

关键词：卵巢肿瘤磁共振成像研究报告

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Neuroprotective effects of tetrandrine against vascular dementia

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Neural Regeneration Research 2016年第3期11卷 454-459页

作者： yan-ling lv Ze-zhi Wu Li-xue Chen Bai-xue Wu Lian-lian Chen Guang-cheng Qin Bei Gui Ji-ying Zhou Laboratory Research Center the First Affiliated Hospital of Chongqing Medical University Key Laboratory of Biorheological Science and Technology of the State Ministry of Education College of BioengineeringChongqing University

Tetrandrine is one of the major active ingredients in Menispermaceae Stephania tetrandra ***,and has specific therapeutic effects in ischemic cerebrovascular *** use in vascular dementia has not been studied ***,we investigated whether tetrandrine would improve behavioral and cellular impairments in a two-vessel occlusion rat model of chronic vascular *** weeks after model establishment,rats were injected intraperitoneally with 10 or 30 mg/kg tetrandrine every other day for 4 *** assessment in the Morris water maze showed that model rats had longer escape latencies in training trials,and spent less time swimming in the target quadrant in probe trials,than sham-operated ***,rats that had received tetrandrine showed shorter escape latencies and longer target quadrant swimming time than untreated model ***-eosin and Nissl staining revealed less neuronal necrosis and pathological damage,and more living cells,in the hippocampus of rats treated with tetrandrine than in untreated model *** blot assay showed that interleukin-1β expression,and phosphorylation of the N-methyl-D-aspartate 2B receptor at tyrosine 1472,were lower in model rats that received tetrandrine than in those that did *** present findings suggest that tetrandrine may be neuroprotective in chronic vascular dementia by reducing interleukin-1β expression,N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472,and neuronal necrosis.

关键词： nerve regeneration tetrandrine ischemic cerebrovascular disease vascular dementia N-methyl-D-aspartic acid receptor 2B N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472 interleukin-1β neuronal necrosis neural regeneration

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Removal Arsenic(V)Efficiency and Characteristics Using Modified Basic Oxygen Furnace Slag in Aqueous Solution

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Journal of Resources and Ecology 2022年第3期13卷 537-546页

作者： yanG Liyun GAO Mengdan lv yan LI Shaojie yanG Libing LI Shuwu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendaiMiyagi 980-8579Japan Metallurgical Technology Institute Central Iron and Steel Research InstituteBeijing 100053China

Basic oxygen furnace(BOF) slag, the solid waste produced in the steelmaking process, is reused in industry, agriculture and environmental treatment. However, as an adsorbent for wastewater, the removal effect of BOF slag on anionic pollutants needs to be improved. In this study, acid and alkali were used to modify BOF slag,and the removal efficiency and mechanism of arsenic(V) with modified BOF slag in solution were studied. The effects of the As(V) initial concentration, solution pH and reaction time on the removal efficiency were determined by batch experiments, and the removal mechanism of As(V) using modified BOF slag was studied by an adsorption kinetic model and isothermal adsorption model and the Fourier transform infrared spectroscopy(FTIR) and X-ray photoelectron spectroscopy(XPS) spectral analysis. The results showed that the slag modified by 15% sulfuric acid had the best removal effect on As(V), while the removal effect of As(V) by alkali-modified slag was not ideal. The removal rate of As(V) by acid-modified slag increased with the increase in the initial concentration, decreased slowly with the increase in pH and reached equilibrium in 180 min. The adsorption kinetic model and isothermal adsorption model of As(V) by acid-modified BOF slag showed that the chemical adsorption was the limiting *** FTIR and XPS analysis results showed that the silicate and ferrite in the acid-modified slag could remove As(V)in the solution by ion exchange to form an arsenate precipitate. Therefore, modified BOF slag can be used as a potential adsorbent for large scale arsenic polluted waterbody to realize the ecological utilization of industrial solid waste.

关键词： modified BOF slag As(V) removal efficiency removal mechanism

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-yan Qian Ping lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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