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中医预培其损序贯疗法对胚胎反复移植失败患者新鲜周期相关指标的影响

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中国中西医结合杂志 2012年第6期32卷 763-765页

作者：于莎匡延平齐聪上海中医药大学附属曙光医院妇科上海200021 上海交通大学附属第九人民医院生殖科上海200011

目的探讨中医(补肾健脾)预培其损序贯疗法对胚胎反复移植失败(repeated implantation fail-ure,RIF)患者新鲜周期相关指标的影响。方法将既往行体外受精-胚胎移植(in virto fertilization and em-bryo transfer,IVF-ET)或卵母细胞单精... 详细信息

目的探讨中医(补肾健脾)预培其损序贯疗法对胚胎反复移植失败(repeated implantation fail-ure,RIF)患者新鲜周期相关指标的影响。方法将既往行体外受精-胚胎移植(in virto fertilization and em-bryo transfer,IVF-ET)或卵母细胞单精子显微注射(intracytoplasmic sperm injection,ICSI)失败3次及以上的患者,行新鲜取卵/移植周期共60例,分为治疗组(中药结合IVF/ICSI)与对照组(单纯IVF/ICSI),每组30例,比较两组外源性促性腺激素(gonadotropin,Gn)用量、超排卵(controlled ovarian hyperstimulation,COH)时间、移植日子宫内膜厚度、获得卵数、受精数、胚胎数、优质胚胎数、妊娠率及种植率等各项指标的差异。结果治疗组单周期人均获得胚胎(7.5±4.9)个,优质胚胎(5.1±3.8)个,两者较对照组(5.1±3.2,3.2±1.8)均明显升高,差异均有统计学意义(P0.05)。结论中医预培其损序贯疗法结合超排卵有利于胚胎数量和质量的双重提高,有望增加RIF患者的累计妊娠率。

关键词：试管婴儿预培其损序贯疗法胚胎数量优胚数量

Clinical Outcomes of Transfer Vitrified-Thawed Day 4,8-Cell Embryos into Endometrium Prepared for Day 3 Embryos

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Reproductive and Developmental Medicine 2018年第2期2卷 95-99页

作者： Ji-Qiang Si Hannah Ya-Ning Chang yan-Ping kuang Qi-Feng Lyu Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai 200001People’s Republic of China

Objective:To determine the clinical outcomes of transfer of day 3,8-cell embryos into endometrium prepared for day 3 ***:This study performed a retrospective analysis of 1,190 retarded *** embryos underwent extended culture in vitro to select and vitrify day 4,8-cell embryos,followed by 176 frozen embryo transfer cycles(study group),matching 660 transfer cycles with single frozen day 3,8-cell embryos as the control(control group).Results:The study group achieved successful implantation rates,clinical pregnancy rate,and live-birth rates(20.45%,15.91%,14.20%,respectively),although these were lower than that in the control group(30.45%,27.42%,and 20.91%;P=0.009,0.002,and 0.046,respectively).The miscarriage rate was similar to that in the control group(4.55%vs.3.33%,P>0.05),and the mean birth weight of the study group was higher than that in the control group(3,556±381 g vs.3,311±570 g,P=0.012).Conclusions:Transfer of frozen day 4,8-cell embryos into endometrial prepared for day 3 embryos can be a new and safe alternative for patients with delayed embryos.

关键词： Extended Culture Frozen Embryo Transfer Implantation Rate Retarded Embryo Synchronization

Reading of Qin Bamboo Slips

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China Book International 2024年第2期 88-91页

作者： Zhao yan kuang Yu Chen Dietrich Tschanz School of Liberal Arts Northeast Normal University Department of East Asian Studies at Rutgers University in New Jersey Confucius Institute at Rutgers University Rutgers University in New Jersey University Chinese of Zurich University of Pennsylvania Rutgers University

This book contains a total of 44 articles in 16 groups of Qin bamboo slips,through the interpretation of characters,words,sentence analysis,chapter identification,and interpretation of literary meaning,the original esoteric and difficult documents are dismantled layer by layer,and the relevant historical background is introduced,in an effort to enable readers to obtain a complete background of knowledge needed to understand Qin bamboo slips.

关键词： meaning Bamboo enable

CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes

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Research 2024年第1期2023卷 509-523页

作者： Chao Chen Xiaoqing Yi Panpan Liu Jie Li Bei yan Detian Zhang Lei Zhu Pian Yu Lei Li Jiaxiong Zhang Yehong kuang Shuang Zhao Wu Zhu Cong Peng Xiang Chen Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology ChangshaHunanChina Furong Laboratory ChangshaHunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Psoriasis is a chronic inflammatory skin disease featuring rapid proliferation of epidermal *** elevated glycolysis flux has been reported in psoriasis,the molecular mechanisms underlying its pathogenesis remain *** investigated the role of the integral membrane protein CD147 in psoriasis pathogenesis,observing its high expression in psoriatic skin lesions of humans and imiquimod(IMQ)-induced mouse *** mouse models,genomic deletion of epidermal CD147 markedly attenuated IMQ-induced psoriatic *** found that CD147 interacted with glucose transporter 1(Glut1).Depletion of CD147 in the epidermis blocked glucose uptake and glycolysis in vitro and in *** CD147-knockout mice and keratinocytes,oxidative phosphorylation was increased in the epidermis,indicating CD147's pivotal role in glycolysis reprogramming during pathogenesis of *** non-targeted and targeted metabolic techniques,we found that epidermal deletion of CD147 significantly increased the production of carnitine and α-ketoglutaric acid(α-KG).

关键词： CD147 pathogenesis markedly

Genetic diversity analysis of Penicillium marneffei isolated from AIDS patients in Guangdong, China using randomly amplified polymorphic DNA

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Chinese Medical Journal 2012年第5期125卷 823-827页

作者： LI Ling-hua HU Feng-yu CHEN Wan-shan CAI Wei-ping SONG Wei-nan kuang yan-ling TANG Xiao-ping Department of Infectious Diseasesand Guangzhou No. 8 People＇s Hospital GuangzhouGuangdong 510060 China Institutefor Infectious DiseasesandGuangzhou No. 8 People＇s Hospital GuangzhouGuangdong 510060 China

Background Penicillium mameffei （P. marneffe~） is an emerging pathogenic fungus that can cause invasive mycosis in patients with AIDS. The epidemiological features of P. marneffeiinfection in AIDS patients in Guangdong province remain unclear so far. This study aimed to investigate the genetic diversity within a population of 163 P. mameffei isolates obtained from AIDS patients and search for the dominant clinical strains in Guanqdong province.

关键词： penicillium marneffei randomly amplified polymorphic DNA acquired immune deficiency syndrome genetic diversity

Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 758-771页

作者： Xin Han yan Ning Xinyue Dou Yiwen Wang Qiyuan Shan Kao Shi Zeping Wang Chuan Ding Min Hao Kuilong Wang Mengyun Peng Haodan kuang Qiao yang Xianan Sang Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou311400China

Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying *** vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw *** ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)*** note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and *** interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through *** conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.

关键词： Liver fibrosis SIRT3 Cornus officinalis AMPK Caspase6

基于混合方法的老年髋部骨折术后患者的居家照护需求及照护资源整合期望的研究

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中国实用护理杂志 2023年第25期39卷 1972-1978页

作者：邝妍程蕾邝远芳夏振兰广州医科大学护理学院广州510182 广州医科大学附属第三医院创伤骨科广州510150

目的探究老年髋部骨折术后患者的居家照护需求及居家资源整合期望,以掌握老年髋部骨折术后患者的需求,为出院后健康照护指导提供依据。方法采用一致性平行设计的混合研究方法,对2021年6月至2022年4月广州医科大学附属第三医院的15例老... 详细信息

目的探究老年髋部骨折术后患者的居家照护需求及居家资源整合期望,以掌握老年髋部骨折术后患者的需求,为出院后健康照护指导提供依据。方法采用一致性平行设计的混合研究方法,对2021年6月至2022年4月广州医科大学附属第三医院的15例老年髋部骨折术后患者进行半结构式访谈,同时以便利抽样法选取134例老年髋部骨折术后患者用国际居民评估工具家庭护理评估量表进行健康问题调查,综合资料结果进行分析。结果通过对访谈资料进行分析归纳提取出两大主题:居家照护需求多元化、居家照护服务资源整合度不够。髋部骨折术后老年患者共触发25个健康问题,健康问题主要集中在日常生活活动能力受限、社会活动不足,社会交往受限、临床健康问题(跌倒风险、营养问题、疼痛,心血管与呼吸系统问题、健康促进不足、乏力)等方面。结论对于老年髋部骨折术后患者,应在出院时加强康复指导,整合居家照护资源提供过渡阶段多元化护理服务,促进患者康复行为的形成与持续,改善患者的临床结局。

关键词：老年人髋部骨折居家照护需求混合方法研究

大数据与人工智能背景下的网络舆情治理:作用、风险和路径

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北京工业大学学报（社会科学版） 2021年第6期21卷 1-10页

作者：李明德邝岩西安交通大学传播内容智能理解研究中心陕西西安710049 西安交通大学新闻与新媒体学院陕西西安710049 西安交通大学马克思主义学院陕西西安710049

大数据技术和人工智能技术作为强有力的信息化手段,为网络舆情治理工作提供了全新的信息资源、技术手段和治理范式,在一定程度上实现了网络舆情治理的全面化、自动化、科学化、精准化和个性化,增强了网络舆情治理的效能;同时,大数据与... 详细信息

大数据技术和人工智能技术作为强有力的信息化手段,为网络舆情治理工作提供了全新的信息资源、技术手段和治理范式,在一定程度上实现了网络舆情治理的全面化、自动化、科学化、精准化和个性化,增强了网络舆情治理的效能;同时,大数据与人工智能在网络舆情治理中仍存在着算法呈现舆情与真实社会民意存在偏差、舆情预测干涉和情绪分析复杂性导致舆情误判、虚假新闻和信息茧房问题误导舆情引导决策等问题。在此基础上,针对网络舆情治理面临的隐私伦理、数据垄断、数据滥用信息管理风险等新挑战,提出了具体的解决措施:优化技术升级,推进网络舆情治理综合化技术发展;完善舆情治理法制和理念,实现舆情数据管理应用机制升级;壮大人才队伍,培养复合型舆情治理专业人才;加强平台自律,提升公众的网络媒介素养和算法素养。

关键词：国家治理跨学科融合网络舆情治理大数据人工智能

算法治理研究述评:演进脉络分析与理论体系构建

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情报杂志 2023年第3期42卷 158-166页

作者：邝岩许晓东华中科技大学公共管理学院武汉430074

[研究目的]智能算法已深度嵌入了社会生活的各个方面,并在公共治理领域成为了强大的治理工具。然而,针对算法治理的研究仍较为分散,有待对相关文献进行梳理并构建相应的理论体系。[研究方法]以“算法治理”“算法规制”和“算法权力”... 详细信息

[研究目的]智能算法已深度嵌入了社会生活的各个方面,并在公共治理领域成为了强大的治理工具。然而,针对算法治理的研究仍较为分散,有待对相关文献进行梳理并构建相应的理论体系。[研究方法]以“算法治理”“算法规制”和“算法权力”为主题,在CNKI和WoS数据库中进行检索并筛选出契合研究主题的文献。利用Citespace软件对算法治理研究的学科、关键词、时间序列进行分析,进而梳理出算法治理的演进脉络及理论体系。[研究结论]算法治理的研究遵循着技术产生、应用、评估、优化的发展逻辑,主要包含算法技术、应用场景、运转特征、风险问题和路径构建5个研究维度。由于算法技术的迅速迭代,相关研究仍需针对技术的发展保持敏感并深入细化的分析其对当前治理模式的影响。

关键词：算法治理算法风险算法伦理 Citespace 理论体系演进脉络