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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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焊头机构运动建模与仿真技术的研究

电子科技大学学报 2009年第2期38卷 317-320页

作者：袁清珂刘大慧曾德东颜旭晖广东工业大学机电工程学院广州510006

为了开发高速高精度焊头机构,确保全自动LED键合机的整机性能,在完成运动方案和结构参数设计后,研究了运用Pro/Engineer运动仿真模块Mechanism/Pro对整个焊头机构进行运动建模的技术与方法,包括机构模型创建、驱动控制等,进行了机构运... 详细信息

为了开发高速高精度焊头机构,确保全自动LED键合机的整机性能,在完成运动方案和结构参数设计后,研究了运用Pro/Engineer运动仿真模块Mechanism/Pro对整个焊头机构进行运动建模的技术与方法,包括机构模型创建、驱动控制等,进行了机构运动仿真;并对仿真结果进行了分析,验证了所设计的焊头机构的可行性和合理性。成功地将设计出的焊头机构应用到整机设备开发,满足了整机功能和性能的要求。该设备已投入实际生产运行。

关键词：键合机产品开发焊头机构运动学半导体设备制造虚拟样机

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han yan Su Yiming Zhou Minhui xu Jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-hui Li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： CHEN Wuxing CHEN Shuang YU yan ZHANG Jiangyi xu Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

注射用兰索拉唑联合美罗培南致严重血小板减少症1例

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中国新药与临床杂志 2017年第1期36卷 56-58页

作者：邓艳辉许静汪燕南方医科大学第三附属医院药学部广东广州510630

兰索拉唑（1ansoprazole）为苯并咪唑类衍生物，属于质子泵抑制剂。其分布于胃黏膜壁细胞的酸性环境后．转变为有活性的代谢物。这种代谢物与酸生成部位的H^＋-K^＋-ATP酶的巯基结合，通过抑制H^＋-K^＋-ATP酶的活性而抑制酸分泌。主要... 详细信息

兰索拉唑（1ansoprazole）为苯并咪唑类衍生物，属于质子泵抑制剂。其分布于胃黏膜壁细胞的酸性环境后．转变为有活性的代谢物。这种代谢物与酸生成部位的H^＋-K^＋-ATP酶的巯基结合，通过抑制H^＋-K^＋-ATP酶的活性而抑制酸分泌。主要用于治疗口服疗法不适用的伴有出血的消化性溃疡和预防应激性溃疡。

关键词：兰索拉唑美罗培南血小板减少药物不良反应

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu Xi xu Tianyi Huang Ying Wang Siyuan xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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光程长对光谱测量误差的影响

天津大学学报（自然科学与工程技术版） 2004年第10期37卷 906-909页

作者：汪嚥卢延辉王蕊徐可欣天津大学精密测试技术及仪器国家重点实验室天津300072

光程长的选择在光谱测量方法设计中非常重要,但实际测量中很难实现精确最佳光程长.从灵敏度的角度研究了在近红外光谱测量中,光程长和测量灵敏度之间的定量关系,讨论了它们对测量结果的影响:单位光程长吸光度越小,则光程长对测量误差的... 详细信息

光程长的选择在光谱测量方法设计中非常重要,但实际测量中很难实现精确最佳光程长.从灵敏度的角度研究了在近红外光谱测量中,光程长和测量灵敏度之间的定量关系,讨论了它们对测量结果的影响:单位光程长吸光度越小,则光程长对测量误差的影响越小,可选择光程长范围就越宽;大于最佳光程长区域相对于光程较小区域,光程长变化对测量结果影响较小,可选光程过窄,应通过减小单位光程吸光度来扩展可选区域.对于单个样品,当最佳光程长获取存在较大误差时,应使所选光程长落在大于最佳光程长区域;当一组样品分别对应不同最佳光程长时,也应选择较大光程.在10个光程长下,通过6000cm-1～5900cm-1长波段不同浓度葡萄糖水溶液光谱测量实验,对理论结果进行验证,二者吻合较好.

关键词：光程长灵敏度光程长选择范围测量误差

囊袋张力环应用对伴有悬韧带松弛的高度近视合并白内障患者的疗效

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国际眼科杂志 2023年第1期23卷 113-116页

作者：孟克青许衍辉董玮许建锋河北省眼科医院河北省眼科学重点实验室河北省眼部疾病临床医学研究中心河北省邢台市054001

目的:探讨伴有悬韧带松弛的高度近视合并白内障患者行超声乳化(Phaco)联合人工晶状体(IOL)植入术中囊袋张力环(CTR)的应用效果。方法:前瞻性研究。选取2020-04/2021-08于我院行Phaco联合IOL植入术的伴有悬韧带松弛的高度近视合并白内障... 详细信息

目的:探讨伴有悬韧带松弛的高度近视合并白内障患者行超声乳化(Phaco)联合人工晶状体(IOL)植入术中囊袋张力环(CTR)的应用效果。方法:前瞻性研究。选取2020-04/2021-08于我院行Phaco联合IOL植入术的伴有悬韧带松弛的高度近视合并白内障患者80例80眼,采用随机数字表法分为CTR组(40例40眼,行Phaco联合CTR及IOL植入术)和对照组(40例40眼,行Phaco联合IOL植入术)。比较两组患者手术前后最佳矫正远视力(BCDVA)、前囊口面积、IOL总倾斜度、主观视觉质量。结果:术后1、3、6mo,两组患者BCDVA均较术前改善(P<0.05),眼压均较术前降低(P<0.05),CTR组患者前囊口面积大于对照组,IOL总倾斜度低于对照组(P<0.001),两组患者主观视觉质量评分均较术前升高(P<0.05),且CTR组主观视觉质量评分高于对照组(P<0.001)。术后随访6mo内,CTR组患者术后并发症总发生率低于对照组(7.5%vs 25.0%,P<0.05)。结论:对伴有悬韧带松弛的高度近视合并白内障,Phaco联合IOL植入术中植入CTR有助于维持囊袋形态,减少囊袋收缩,稳定IOL位置,提高术后视觉质量,且并发症少。

关键词：高度近视白内障悬韧带囊袋张力环视觉质量