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Implications of the Stellar Mass Density of High-z Massive Galaxies from JWST on Warm Dark Matter

Research in Astronomy and Astrophysics 2024年第1期24卷 128-134页

作者： Hengjie Lin yan gong Bin Yue Xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Science Center for China Space Station Telescope National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Center for High Energy Physics Peking UniversityBeijing 100871China

A significant excess of the stellar mass density at high redshift has been discovered from the early data release of James Webb Space Telescope(JWST),and it may require a high star formation efficiency.However,this will lead to large number density of ionizing photons in the epoch of reionization(EoR),so that the reionization history will be changed,which can arise tension with the current EoR observations.Warm dark matter(WDM),via the free streaming effect,can suppress the formation of small-scale structure as well as low-mass galaxies.This provides an effective way to decrease the ionizing photons when considering a large star formation efficiency in high-z massive galaxies without altering the cosmic reionization history.On the other hand,the constraints on the properties of WDM can be derived from the JWST observations.In this work,we study WDM as a possible solution to reconcile the JWST stellar mass density of high-z massive galaxies and reionization history.We find that,the JWST high-z comoving cumulative stellar mass density alone has no significant preference for either CDM or WDM model.But using the observational data of other stellar mass density measurements and reionization history,we obtain that the WDM particle mass with mw=0.51_(-0.12)^(+0.22) keV and star formation efficiency parameter f_(*)^(0)> 0.39 in 2σ confidence level can match both the JWST high-z comoving cumulative stellar mass density and the reionization history.

关键词： Cosmology (cosmology:)dark matter (cosmology:)large-scale structure of universe

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Deep neural network based on multi-level wavelet and attention for structured illumination microscopy

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 12-23页

作者： yanwei Zhang Song Lang Xuan Cao Hanqing Zheng yan gong School of Biomedical Engineering(Suzhou)Division of Life Sciencesand Medicine University of Science and Technology of China Hefei Anhui230026P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou Jiangsu 215163P.R.China School of Physical Science and Technology Suzhou University of Science and Technology Suzhou Jiangsu 215009P.R.China

Structured illumination microscopy(SIM)is a popular and powerful super-resolution(SR)technique in biomedical research.However,the conventional reconstruction algorithm for SIM heavily relies on the accurate prior knowledge of illumination patterns and signal-to-noise ratio(SNR)of raw images.To obtain high-quality SR images,several raw images need to be captured under high fluorescence level,which further restricts SIM’s temporal resolution and its applications.Deep learning(DL)is a data-driven technology that has been used to expand the limits of optical microscopy.In this study,we propose a deep neural network based on multi-level wavelet and attention mechanism(MWAM)for SIM.Our results show that the MWAM network can extract high-frequency information contained in SIM raw images and accurately integrate it into the output image,resulting in superior SR images compared to those generated using wide-field images as input data.We also demonstrate that the number of SIM raw images can be reduced to three,with one image in each illumination orientation,to achieve the optimal tradeoff between temporal and spatial resolution.Furthermore,our MWAM network exhibits superior reconstruction ability on low-SNR images compared to conventional SIM algorithms.We have also analyzed the adaptability of this network on other biological samples and successfully applied the pretrained model to other SIM systems.

关键词： Super-resolution reconstruction multi-level wavelet packet transform residual channel attention selective kernel attention

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Flux Balance Analysis Reveals Potential Anti-HIV-1 Metabolic Targets

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Infectious Diseases & Immunity 2024年第2期4卷 61-68页

作者： Runpeng Han Fei Luo Haisheng Yu Yajun yan yan gong Conghua Xie Liang Cheng Department of Radiation and Medical Oncology Medical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Frontier Science Center for Immunology and Metabolism Zhongnan Hospital of Wuhan UniversityState Key Laboratory of VirologyWuhan UniversityWuhan 430071China Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhou 510440China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Human immunodeficiency virus type 1(HIV-1)remains a persistent global health challenge.Therefore,a continuous exploration of novel therapeutic strategies is essential.A comprehensive understanding of how HIV-1 utilizes the cellular metabolism machinery for replication can provide insights into new therapeutic approaches.Methods:In this study,we performed a flux balance analysis using a genome-scale metabolic model(GEM)integrated with an HIV-1 viral biomass objective function to identify potential targets for anti–HIV-1 interventions.We generated a GEM by integrating an HIV-1 production reaction into CD4+T cells and optimized for both host and virus optimal states as objective functions to depict metabolic profiles of cells in the status for optimal host biomass maintenance or for optimal HIV-1 virion production.Differential analysis was used to predict biochemical reactions altered optimal for HIV-1 production.In addition,we conducted in silico simulations involving gene and reaction knock-outs to identify potential anti–HIV-1 targets,which were subsequently validated by human phytohemagglutinin(PHA)blasts infected with HIV-1.Results:Differential analysis identified several altered biochemical reactions,including increased lysine uptake and oxidative phosphorylation(OXPHOS)activities in the virus optima compared with the host optima.In silico gene and reaction knock-out simulations revealed de novo pyrimidine synthesis,and OXPHOS could serve as potential anti–HIV-1 metabolic targets.In vitro assay confirmed that targeting OXPHOS using metformin could suppress the replication of HIV-1 by 56.6%(385.4±67.5 pg/mL in the metformintreated group vs.888.4±32.3 pg/mL in the control group,P<0.001).Conclusion:Our integrated host-virus genome-scale metabolic study provides insights on potential targets(OXPHOS)for anti-HIV therapies.

关键词： HIV-1 Flux balance analysis Genome-scale metabolic models Viral biomass objective function Therapeutic target

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Plasmonic Ag nanoparticles decorated MIL-101(Fe) for enhanced photocatalytic degradation of bisphenol A with peroxymonosulfate under visible-light irradiation

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Chinese Chemical Letters 2024年第1期35卷 418-423页

作者： yan gong Yu Ding Qi Tang Fei Lian Chun Bai Ruiyi Xie Haijiao Xie Xu Zhao School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Hangzhou yanqu Information Technology Co. Ltd.Hangzhou 310003China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Collapse

Photocatalytic activation of peroxymonosulfate (PMS) has garnered a lot of interest in the field of wastewater treatment. Herein, a plasmonic Ag nanoparticles decorated MIL-101(Fe) hybrid was synthesized through a photodeposition process. Upon light irradiation, the Ag/MIL-101(Fe) exhibit reinforced photocatalytic activities for elimination of bisphenol A (BPA) with PMS. The optimized 2.0% Ag/MIL-101(Fe) composite presented the highest photocatalytic activity with kinetic constant k of 0.102 min-1, which was about 10-fold of the pristine MIL-101(Fe). Loading of plasmonic Ag into MIL-101(Fe) boosts photoinduced carrier separation and accelerates PMS activation to generate strong oxidative radicals. Photoelectrochemical tests and multiple spectroscopic studies confirmed the promoted charge carrier separation and transfer capability of Ag/MIL-101(Fe). Combining the results of radical trapping experiments and electron spin resonance (ESR), the formed SO4·-, ·OH, ·O2- and 1O2 had a significant role in the photocatalytic process. According to intermediate study, the degradation pathway was studied, and the possible mechanism was proposed.

关键词： Photocatalysis MOF Peroxymonosulfate Plasmonic Ag BPA

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Spin‑controlled topological phase transition in non‑Euclidean space

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Frontiers of Optoelectronics 2024年第1期17卷 67-76页

作者： Zhuochen Du Jinze Gao Qiuchen yan Cuicui Lu Xiaoyong Hu Qihuang gong State Key Laboratory for Mesoscopic Physics and Department of Physics Collaborative Innovation Center of Quantum Matter and Frontiers Science Center for Nano‑OptoelectronicsBeijing Academy of Quantum Information SciencesPeking UniversityBeijing 100871China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China Peking University yangtze Delta Institute of Optoelectronics Nantong 226010China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Hefei National Laboratory Hefei 230088China

Modulation of topological phase transition has been pursued by researchers in both condensed matter and optics research fields,and has been realized in Euclidean systems,such as topological photonic crystals,topological metamaterials,and coupled resonator arrays.However,the spin-controlled topological phase transition in non-Euclidean space has not yet been explored.Here,we propose a non-Euclidean configuration based on Mobius rings,and we demonstrate the spin-controlled transition between the topological edge state and the bulk state.The Mobius ring,which is designed to have an 8πperiod,has a square cross section at the twist beginning and the length/width evolves adiabatically along the loop,accompanied by conversion from transverse electric to transverse magnetic modes resulting from the spin-locked effect.The 8πperiod Mobius rings are used to construct Su–Schrieffer–Heeger configuration,and the configuration can support the topological edge states excited by circularly polarized light,and meanwhile a transition from the topological edge state to the bulk state can be realized by controlling circular polarization.In addition,the spin-controlled topological phase transition in non-Euclidean space is feasible for both Hermitian and non-Hermitian cases in 2D systems.This work provides a new degree of polarization to control topological photonic states based on the spin of Mobius rings and opens a way to tune the topological phase in non-Euclidean space.

关键词： Topological phase transition Non-Euclidean space Möbius ring Spin-locked effect

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Global research trends and prospects of cellular metabolism in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 527-542页

作者： yan-Chen Liu Zhi-Cheng gong Chao-Qun Li Peng Teng yan-yan Chen Zhao-Hui Huang Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through bibliometrics.AIM To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by visualization.METHODS Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer 1.6.19.RESULTS The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields.Meanwhile,China and the United States were two of the most prominent contri-butors in these four areas.In addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-Yuan Fang,Senji Hirasawa,Wei Jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in NM.CONCLUSION Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC.Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.

关键词： Cellular metabolism Colorectal cancer Glucose metabolism Amino acid metabolism Lipid metabolism Nucleotide metabolism

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Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

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Neural Regeneration Research 2024年第2期19卷 360-368页

作者： Leyi Huang Wenjie Xiao yan Wang Juan Li Jiaoe gong Ewen Tu Lili Long Bo Xiao Xiaoxin yan Lily Wan Department of Anatomy and Neurobiology Central South University Xiangya Medical SchoolChangshaHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Hunan Children’s HospitalChangshaHunan ProvinceChina Department of Neurology Brain Hospital of Hunan ProvinceChangshaHunan ProvinceChina

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug resistance.Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy.Metabotropic glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity.Dysregulated mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy.In this review,we first introduce the three groups of mGluRs and their associated signaling pathways.Then,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis.In addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized.We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关键词： antiepileptic drugs epileptogenesis metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials

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Recent progress in Prussian blue electrode for electrochromic devices

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Frontiers in Energy 2024年第2期18卷 160-186页

作者： Yongting ZHANG Wanzhong LI Hui gong Qianqian ZHANG Liang yan Hao WANG Key Laboratory for New Functional Materials of the Ministry of Education Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China School of Instrument Science and Engineering Southeast UniversityNanjing 210096China Beijing Aerospace Times Laser Inertial Technology Company Beijing 100094China

Great progress has been made in the electrochromic(EC)technology with potential applications in various fields.As one of the most promising EC materials,Prussian blue(PB)has attracted great attention due to its excellent EC performance,such as low cost,easy synthesis,rich color states,chemical stability,suitable redox potential,and fast color-switching kinetics.This review summarizes the recent progress in PB electrodes and devices,including several typical preparation techniques of PB electrodes,as well as the recent key strategies for enhancing EC performance of PB electrodes.Specifically,PB-based electrochromic devices(ECDs)have been widely used in various fields,such as smart windows,electrochromic energy storage devices(EESDs),wearable electronics,smart displays,military camouflage,and other fields.Several opportunities and obstacles are suggested for advancing the development of PB-based ECDs.This comprehensive review is expected to offer valuable insights for the design and fabrication of sophisticated PBbased ECDs,enabling their practical integration into realworld applications.

关键词： Prussian blue electrochromism energy storage smart windows

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Flow Field Characteristics of Multi-Trophic Artificial Reef Based on Computation Fluid Dynamics

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Journal of Ocean University of China 2024年第2期23卷 317-327页

作者： HUANG Junlin LI Jiao LI yan gong Pihai GUAN Changtao XIA Xu School of Engineering Ocean University of ChinaQingdao 266100China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesKey Laboratory of Sustainable Development of Marine FisheriesMinistry of Agriculture and Rural AffairsQingdao Key Laboratory for Marine Fish Breeding and BiotechnologyQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

On the basis of computational fluid dynamics,the flow field characteristics of multi-trophic artificial reefs,including the flow field distribution features of a single reef under three different velocities and the effect of spacing between reefs on flow scale and the flow state,were analyzed.Results indicate upwelling,slow flow,and eddy around a single reef.Maximum velocity,height,and volume of upwelling in front of a single reef were positively correlated with inflow velocity.The length and volume of slow flow increased with the increase in inflow velocity.Eddies were present both inside and backward,and vorticity was positively correlated with inflow velocity.Space between reefs had a minor influence on the maximum velocity and height of upwelling.With the increase in space from 0.5 L to 1.5 L(L is the reef lehgth),the length of slow flow in the front and back of the combined reefs increased slightly.When the space was 2.0 L,the length of the slow flow decreased.In four different spaces,eddies were present inside and at the back of each reef.The maximum vorticity was negatively correlated with space from 0.5 L to 1.5 L,but under 2.0 L space,the maximum vorticity was close to the vorticity of a single reef under the same inflow velocity.

关键词： artificial reef flow field characteristics computation fluid dynamics multi-trophic structure

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Study on creep deformation and energy development of underground surrounding rock under four‐dimensional support

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Deep Underground Science and Engineering 2024年第1期3卷 25-38页

作者： Zhanguo Ma Junyu Sun Peng gong Pengfei yan Nan Cui Ruichong Zhang School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhouChina Department of Mining Engineering Colorado School of MinesGoldenUSA

There is an urgent need to develop optimal solutions for deformation control of deep high‐stress roadways,one of the critical problems in underground engineering.The previously proposed four‐dimensional support(hereinafter 4D support),as a new support technology,can set the roadway surrounding rock under three‐dimensional pressure in the new balanced structure,and prevent instability of surrounding rock in underground engineering.However,the influence of roadway depth and creep deformation on the surrounding rock supported by 4D support is still unknown.This study investigated the influence of roadway depth and creep deformation time on the instability of surrounding rock by analyzing the energy development.The elastic strain energy was analyzed using the program redeveloped in FLAC3D.The numerical simulation results indicate that the combined support mode of 4D roof supports and conventional side supports is highly applicable to the stability control of surrounding rock with a roadway depth exceeding 520 m.With the increase of roadway depth,4D support can effectively restrain the area and depth of plastic deformation in the surrounding rock.Further,4D support limits the accumulation range and rate of elastic strain energy as the creep deformation time increases.4D support can effectively reduce the plastic deformation of roadway surrounding rock and maintain the stability for a long deformation period of 6 months.As confirmed by in situ monitoring results,4D support is more effective for the long‐term stability control of surrounding rock than conventional support.

关键词： coal mines elastic strain energy four‐dimensional support large roadway depth long‐term stability control plastic deformation surrounding rock

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