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Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM

China Ocean Engineering 2024年第1期38卷 156-168页

作者： WANG Li-xian deng yan-wen YE yang-sha deng Zheng-zhi Key Laboratory of High Performance Ship Technology(Wuhan University of Technology) Ministry of EducationWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China Institute of Port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China

The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave *** that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is *** order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational ***,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate *** newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being *** influence of the length of the two damping layers has been ***,these findings are also validated against previous results for several *** validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect *** effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also *** is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission ***,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers.

关键词： dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer

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Significant risk factors for intensive care unit-acquired weakness:A processing strategy based on repeated machine learning

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World Journal of Clinical Cases 2024年第7期12卷 1235-1242页

作者： Ling Wang deng-yan Long Intensive Care Unit People's Hospital of Qiandongnan Miao and Dong Autonomous PrefectureKaili 556000Guizhou ProvinceChina

BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse ***,there is a lack of effective preventive *** To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and *** Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU *** data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were *** relationships between these variables and ICU-AW were *** iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic *** Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW ***,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical *** most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechani

关键词： Intensive care unit-acquired weakness Risk factors Machine learning Prevention Strategies

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Tissue distribution of cadmium and its effect on reproduction in Spodoptera exigua

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Journal of Integrative Agriculture 2024年第1期23卷 195-204页

作者： Honghua Su Menglu Wu Yong yang yan deng Yizhong yang Qingming Sun College of Plant Protection Yangzhou UniversityYangzhou 225009China Institute of Fruit Tree Research Guangdong Academy of Agricultural Sciences/Key Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural Affairs/Guangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China

Vegetable fields are often contaminated by heavy metals,and Spodoptera exigua is a major vegetable pest which is stressed by heavy metals mainly by *** this study,cadmium accumulation in the tissues of *** exposed to cadmium and its effects on the growth and development of the parents and the offspring were *** the stress of different concentrations of cadmium(0.2,3.2,and 51.2 mg kg^(-1)),the cadmium content in each tissue of *** increased in a dose-dependent *** the larval stage,the highest cadmium accumulation was found in midgut in all three cadmium treatments,but at the adult stage,the highest cadmium content was found in fat *** addition,the cadmium content in ovaries was much higher than in *** *** was stressed by cadmium and the F_(2)generation was not fed a cadmium-containing diet,the larval survival,pupation rate,emergence rate and fecundity of the F_(2)generation were significantly reduced in the 51.2 mg kg^(-1)treatment compared to the corresponding *** in the F_(2)generation of the 3.2 mg kg^(-1)treatment,the fecundity was significantly lower than in the parental *** fecundity of the only-female stressed treatment was significantly lower than that of the only-male stressed treatment at the 3.2 and 51.2 mg kg^(-1)cadmium exposure *** only mothers were stressed at the larval stage,the fecundity of the F_(2)generation was significantly lower than that of the F1generation in the 51.2 mg kg^(-1)treatment,and it was also significantly lower than in the 3.2 and 0.2 mg kg^(-1)*** results of our study can provide useful information for forecasting the population increase trends under different heavy metal stress conditions and for the reliable environmental risk assessment of heavy metal pollution.

关键词： heavy metal pollution cadmium Spodoptera exigua tissue distribution reproduction

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Coordination structure regulation in non-flammable electrolyte enabling high voltage lithium electrochemistry

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Journal of Energy Chemistry 2024年第9期96卷 282-290页

作者： Zhiwen deng Ye Jia yan deng Changhaoyue Xu Xuemei Zhang Qiujie He Jianan Peng Hao Wu Wenlong Cai College of Materials Science and Engineering Sichuan UniversityChengdu 610064SichuanChina Engineering Research Center of Alternative Energy Materials and Devices Sichuan UniversityChengdu 610064SichuanChina

High-voltage battery systems bring significant increases in energy density but are also accompanied by fast degradation of electrochemical performance and serious safety ***,Li^(+)coordination structure regulation was conducted to formulate a non-flammable electrolyte,which consists of 1.5 M lithium bis(fluor sulfonyl)imide(LiFSI)in triethyl phosphate and methyl 2,2,2-trifluoromethyl carbonate(FEMC).The renamed TEP-FEMC-FEC(TFF)electrolyte exhibits an FSI^(−)-dominated solvation structure contributed by the weakly-solvating ability of *** generated inorganic-rich interfacial layers are conducive to stabilizing the phase transition of high-voltage cathodes while suppressing the dendritic growth on lithium metal or co-intercalation behavior in graphite *** TFF electrolyte enables LiCoO_(2)||Li batteries to achieve capacity maintenance over 79%after 400 cycles with high-rate of 5 C at an ultra-high voltage of 4.6 V,and an outstanding capacity exceeding 100 mA h g^(−1)even at a super-high current density of 20 ***,the Ah-level LiCoO_(2)||graphite pouch cells also exhibit high capacity retention and satisfactory safety performance even under fast *** work provides a novel research direction for the pursuit of high energy density non-flammable electrolytes.

关键词： Non-flammable Solvation structure High-voltage Lithium batteries

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Transition metals for stabilizing lithium metal anode:advances and perspectives

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Tungsten 2024年第1期6卷 212-229页

作者： Si-Cheng Miao Ye Jia Zhi-Wen deng yan deng Ruo-Xuan Chen Xue-Mei Zhang Chang-Haoyue Xu Meng Yao Wen-Long Cai Department of Advanced Energy Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610064China

As the capacity of lithium-ion batteries gradually reaches its limit,the high-capacity characteristics of lithium metal batteries(LMBs)make them one of the most promising electrochemical energy storage devices ***,uncontrolled lithium dendrite growth can cause poor cell performance and severe safety issues,seriously slowing down the commercialization of *** metals(TMs)are lithiophilic materials that effectively stabilize lithium metal anode(LMA)and inhibit dendrite ***,the growth of lithium dendrites and the performance of TMs in stabilizing lithium metals are comprehensively discussed in this ***,we elucidated the formation mechanisms of lithium dendrite,and we put forward several strategies to suppress lithium dendrite formation based on the understanding of these ***,the application of TMs and their compounds to stabilize LMA and their corresponding mechanisms are comprehensively ***,further research perspectives of TMs in stabilizing LMA are emphasized in detail.

关键词： Transition metals Lithium metal batteries Lithium dendrite Solid electrolyte interphase Formation mechanism

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Mitigation strategies for soil acidification based on optimal nitrogen management

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 229-242页

作者： Pengshun WANG Donghao XU Prakash LAKSHMANAN yan deng Qichao ZHU Fusuo ZHANG College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China National Academy of Agriculture Green Development China Agricultural UniversityBeijing 100193China Interdisciplinary Research Center for Agriculture Green Development in yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400716China Sugarcane Research Institute Guangxi Academy of Agricultural SciencesNanning 530007China Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia 4067BrisbaneQueenslandAustralia

Soil acidification is a serious constraint to food production *** review explores its primary causes,with a focus on the role of nitrogen fertilizer,and suggests mitigation strategies based on optimal N *** acidification is determined by the leaching of weak acid mainly caused by climate and soil conditions,whereas the use of ammonium-based fertilizers,nitrate leaching and removal of base cations(BCs)by crop harvesting mostly accounts for anthropogenic *** addition,low soil acid buffering capacity,mainly determined by soil parent materials and soil organic matter content,also accelerates *** study proposes targeted mitigation strategies for different stages of soil acidification,which include monitoring soil carbonate content and p H of soils with p H>6.5(e.g.,calcareous soil),use of alkaline amendments for strongly acidic soils(p H<5.5)with aluminum toxicity risk to p H between 5.5 and 6.5,and decreasing acidification rates and supplementing BCs to maintain this optimal p H range,especially for soils with low acid buffering *** mitigation involves optimizing the rate and form of N fertilizers used,regulating N transformation processes,and establishing an integrated soil–crop management system that balances acid production and soil buffering capacity.

关键词： Soil acidification nutrient management nitrogen soil buffering capacity

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Systematic Evaluation of Guidelines for the Diagnosis and Treatment of Hepatitis E Virus Infection

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 739-749页

作者： Ting Gu Cai-Ying Zheng yan-Qin deng Xiao-Feng yang Wei-Min Bao Ying-Mei Tang Department of Gastroenterology Second Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunmingYunnanChina Second Affiliated Hospital of Kunming Medical University KunmingYunnanChina Department of Colorectal Surgery The First People’s Hospital of Yunnan ProvinceKunmingYunnanChina

Background and Aims:The hepatitis E virus(HEV)is a zoonotic disease,and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised *** the past decade,guidelines for diagnosing and treating HEV infection have been *** study aimed to systematically assess the quality of current guidelines for diagnosing and treating HEV infection,and we analyzed the differences in guideline quality and primary recommendations and explored possible reasons for these ***:Guidelines published between 2013 and 2022 were searched,and studies were identified using selection *** study assessed the quality of the included guidelines using the Appraisal of Guidelines for Research and Evaluation tool,extracted the primary recommendations in the guidelines,determined the highest level of evidence supporting the recommendations,and reclassified the evidence using the Oxford Centre for Evidence-Based Medicine grading ***:Seven guidelines were included in the final *** quality of the guidelines varied *** discrepancies may have been caused by the lack of external experts,the failure to consider influencing factors in guideline application,and the lack of consideration of the public’s *** of the heterogeneity in primary recommendations revealed differences in algorithms for managing chronic HEV infection,the dosage of ribavirin,and a low level of evidence supporting the primary ***:Guideline quality and primary recommendations vary *** by guideline developers and researchers would facilitate updating and applying guidelines for diagnosing and treating HEV infection.

关键词： Hepatitis E virus Guidelines Diagnosis Treatment Systematic Evaluation

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Greenhouse gas emissions mitigation and economic viability of sugar crops in China

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 397-408,I0004页

作者： Linsheng yanG Xiaozhong WANG Wushuai ZHANG Prakash LAKSHMANAN yan deng Xiaojun SHI Xinping CHEN Fusuo ZHANG Interdisciplinary Research Center for Agriculture Green Development in yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400716China Key Laboratory of Low-carbon Green Agriculture in Southwestern China(Ministry of Agriculture and Rural Affairs) Southwest UniversityChongqing 400716China Rice Research Institute Anhui Academy of Agricultural SciencesHefei 230031China Key Laboratory of Sugarcane Biotechnology and Genetic Improvement(Guangxi) Ministry of Agriculture and Rural AffairsGuangxi Key Laboratory of Sugarcane Genetic ImprovementGuangxi Academy of Agricultural SciencesSugarcane Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007China Center for Resources Environment and Food SecurityChina Agricultural UniversityBeijing 100193China

Climate change mitigation is a major challenge of human ***,to this end,many countries including China are committed to achieving carbon neutrality within a few *** is a major sugarcane and sugar beet producing country and has one of the largest carbon footprint for sugarcane and sugar beet production globally.A comprehensive study was conducted on sugarcane and sugar beet crops grown in China for greenhouse gas(GHG)emissions mitigation potential,economic crop production from a sustainable sugar production ***-term trend analysis showed that yield and GHG emissions of sugarcane and sugar beet crops increased but the ratio of income to cost *** equation model analysis revealed nitrogen fertilizer and labor as the major drivers of GHG emissions for both sugarcane and sugar *** sugarcane and sugar beet,the path coefficient of N fertilizer were‒0.964 and‒0.835 and that of labor were 0.771 and 0.589,*** transitioning the current cropping system to an improved model with optimized labor,N input and machinery use,the GHG emissions and total annual cost of sugarcane and sugar beet production can be reduced by 32%and 24%,respectively,by 2030,compared to a business-as-usual *** is the first integrated and comparative study of environmental and economic sustainability of sugarcane and sugar beet production in *** findings will enable all stakeholders of Chinese sugarcane and sugar beet industries to transform them into environmentally and economically sustainable sugar production.

关键词： Economic profits GHG emissions labor input nitrogen input sugar

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Automated screening of primary cell-based aptamers for targeting and therapy of pancreatic cancer

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Chinese Chemical Letters 2024年第2期35卷 300-304页

作者： Zhukang Guo Baijiang Jin Yile Fang Lian Jin Song Li yan deng Zhu Chen Hui Chen Yuanying Zhang Rabia Usman Nongyue He State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China Department of Molecular Biology Jiangsu Cancer HospitalNanjing 210009China

Although it has been developed for many years, nucleic acid aptamer screening technology still fails to be widely used, a considerable part of it is due to the variability of tumor cell morphology, which leads to the use of immortalized cell lines in the laboratory to screen nucleic acid aptamers for recognition ability of tumor cells in the diseased *** address this, primary cells that can be stably passaged were isolated and extracted from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice in this ***, an automated screening instrument for nucleic acid aptamers developed autonomously by our group was used to perform efficient aptamer screening using a limited number of cells, and the obtained nucleic acid aptamers were affinity verified at the cellular ***, to answer the question of the cell growth environment difference on the recognition ability of nucleic acid aptamers, we verified its targeting ability to tumors in vivo on a nude mice xenograft tumor model, and further used a common antitumor drug doxorubicin combined with nucleic acid aptamers to verify the drug loading ability of this aptamer combined with the targeting therapeutic ability.

关键词： Aptamer Cell-SELEX Automatic instrument Combination therapy Pancreatic cancer

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Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3600-3623页

作者： Li-Li Yin Ping-Qian Qi Yun-Fei Hu Xiao-Jun Fu Rui-Shan He Meng-Meng Wang yan-Juan deng Su-Yi Xiong Qi-Wen Yu Jin-Ping Hu Lv Zhou Zhi-Bin Zhou Ying Xiong Huan deng The Affiliated Rehabilitation Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Fourth Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second College of Clinical Medicine Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Tumor Immunology Institute Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of General Medicine The Second College of Clinical MedicineJiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors Jiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Colorectal polyps,which are characterized by a high recurrence rate,represent preneoplastic conditions of the *** to unclear mechanisms of pathogenesis,first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic *** recent studies suggest a mechanistic link between intestinal dysbiosis and polyps,the exact compositions and roles of bacteria in the mucosa around the lesions,rather than feces,remain *** To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal *** Mucosal samples were collected from four patients consistently with adenomatous polyps(Ade),seven consistently with non-Ade(Pol),ten with current Pol but previous Ade,and six healthy individuals,and bacterial patterns were evaluated by 16S rDNA *** discriminant analysis and Student’s t-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp ***’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical *** The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy *** changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps,but also existed in histologically normal tissue 10 cm distal from the *** differences in bacterial diversity were observed in the mucosa from individuals with normal conditions,Pol,and *** abundance of Gram-negative bacteria,including Klebsiella,Plesiomonas,and Cronobacter,was observed in Pol group and Ade group,suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful ***,age and gender were linked to bacteria changes,indicating the potential involvement of sex hormone

关键词： Dysbiosis Biopsy Polyp Bacteria Colorectum

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